Journal of AaposPub Date : 2025-03-21DOI: 10.1016/j.jaapos.2025.104182
Dania A Rahal, Mohamed M Khodeiry, Qais Dihan, Paul H Phillips, Abdelrahman M Elhusseiny
{"title":"Characteristics and publication rate of registered clinical trials in amblyopia.","authors":"Dania A Rahal, Mohamed M Khodeiry, Qais Dihan, Paul H Phillips, Abdelrahman M Elhusseiny","doi":"10.1016/j.jaapos.2025.104182","DOIUrl":"https://doi.org/10.1016/j.jaapos.2025.104182","url":null,"abstract":"<p><p>We assessed amblyopia clinical trials completed prior to September 1, 2021, on ClinicalTrials.gov. Of the 54 clinical trials included, 42 yielded publications (78%). Publication rate was found to be associated with non-industry sponsorship (P = 0.004), and the relationship with late-phase trial status approached significance (P = 0.05).</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104182"},"PeriodicalIF":1.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2025-03-15DOI: 10.1016/j.jaapos.2025.104181
Zara Saleem, Theodora Vorias, David Skanchy, Francine Moriguchi, Madison Jordan, Elizabeth Jones, Caroline Hogan, Christopher Gappy, Sharon F Freedman, Olivia J Killeen
{"title":"Pediatric residents' perceptions of eye care curriculum and training.","authors":"Zara Saleem, Theodora Vorias, David Skanchy, Francine Moriguchi, Madison Jordan, Elizabeth Jones, Caroline Hogan, Christopher Gappy, Sharon F Freedman, Olivia J Killeen","doi":"10.1016/j.jaapos.2025.104181","DOIUrl":"https://doi.org/10.1016/j.jaapos.2025.104181","url":null,"abstract":"<p><p>To understand the perspectives of pediatric residents regarding their ophthalmic training, an anonymous 17-question survey was administered to pediatric residents at five large, geographically diverse US programs. Participants' levels of agreement with statements addressing their confidence in providing eye care, knowledge about managing common eye problems, and satisfaction with ophthalmic curricula were collated and assessed. Of 173 respondents, 91% were not confident performing instrument-based vision screening, and less than half felt confident using a wall chart to test visual acuity. Seventy percent of respondents felt confident performing an eye examination, including red reflex test or pupil examination. Regarding common eye problems, 22.5% chose an inappropriate management of viral conjunctivitis and 20.2% would not urgently refer an infant with asymmetric red reflexes to ophthalmology. Dissatisfaction with their eye care training was noted by 68%.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104181"},"PeriodicalIF":1.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2025-03-14DOI: 10.1016/j.jaapos.2025.104180
Sameh H Abdelbaky, Hesham Ibrahim Shahin, Rania El Essawy, Magda Salah, Kareem B Elessawy
{"title":"Frontalis flap advancement versus PTFE (Gore-Tex) frontalis sling operations in the management of congenital blepharoptosis.","authors":"Sameh H Abdelbaky, Hesham Ibrahim Shahin, Rania El Essawy, Magda Salah, Kareem B Elessawy","doi":"10.1016/j.jaapos.2025.104180","DOIUrl":"https://doi.org/10.1016/j.jaapos.2025.104180","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the functional and aesthetic outcomes of two surgical techniques used to correct severe congenital ptosis with poor levator function (LF): frontalis muscle (FM) flap advancement and frontalis sling (FS) surgery.</p><p><strong>Methods: </strong>This prospective interventional randomized comparative study included 42 eyelids of 34 children with severe congenital ptosis and poor LF. The children were randomly divided into two groups, with 21 eyelids of 19 patients undergoing FM flap advancement, and 21 eyelids of 15 patients undergoing FS surgery. The follow-up period was 6 months.</p><p><strong>Results: </strong>At 6 months' follow-up, both groups showed comparable improvement in margin reflex distance 1 (MRD1) (3 ± 1.7 vs 3 ± 1.5 mm). Eyelid contour was satisfactory in 91% of flap and 76% of sling procedures. Lid crease was satisfactory in 95% of flap and 81% of sling procedures (P = 0.41 and 0.34, resp.). Complications in flaps included hematoma (38%), eyelid \"pop\" (10%), lash ptosis (10%), and lagophthalmos (5%); in slings, infection (10%). Undercorrection rates and recurrence rates did not differ significantly between flap (24% and 14%, resp.) and sling groups (19% and 24%, resp.).</p><p><strong>Conclusions: </strong>In our study cohort, FM flap advancement yielded comparable results to those of conventional FS surgeries for correcting congenital ptosis with poor LF in children.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104180"},"PeriodicalIF":1.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2025-03-13DOI: 10.1016/j.jaapos.2025.104179
Michael T Curley, Gena Heidary, Eric D Gaier, Ryan Gise
{"title":"Retinal findings in pediatric idiopathic intracranial hypertension.","authors":"Michael T Curley, Gena Heidary, Eric D Gaier, Ryan Gise","doi":"10.1016/j.jaapos.2025.104179","DOIUrl":"10.1016/j.jaapos.2025.104179","url":null,"abstract":"<p><strong>Background: </strong>Pediatric and adult idiopathic intracranial hypertension (IIH) have distinct clinical features. Retinal manifestations associated with adult IIH are well known and can limit visual function; however, data detailing these manifestations in pediatric IIH are sparse. The purpose of this study was to identify the range and effects of retinal manifestations in pediatric IIH focusing on associated visual and structural outcomes.</p><p><strong>Methods: </strong>The medical records of IIH patients from an academic children's hospital between 1998 and 2022 were reviewed retrospectively. Patients meeting diagnostic criteria for IIH without other concomitant retinal disease of alternate etiology were included. We evaluated demographics, visual function, and structural correlates longitudinally, and discernible retinal pathology based on fundus photography and optical coherence tomography was recorded.</p><p><strong>Results: </strong>Of the 253 patients with IIH, 24 (9.5%) had retinal manifestations, including 20 (7.9%) with retinal folds, 15 (5.9%) with macular exudates, 11 (4.3%) with subretinal fluid and 1 (0.4%) with a choroidal neovascular membrane. Baseline (P < 0.001) and final (P = 0.013) visual acuities were significantly lower in patients with retinal findings than those without. Eight patients (33.3%) had persistent retinal damage after the resolution of optic nerve edema. The presence of optic nerve atrophy after treatment was significantly higher in patients with retinal findings than those without (P < 0.001).</p><p><strong>Conclusions: </strong>In our study cohort, retinal pathology was seen in a minority of pediatric IIH patients and persisted in many cases following resolution of papilledema. Retinal pathology in pediatric IIH was associated with worse visual function and outcomes and likely reflects worse disease severity. The extent to which retinal disease in IIH might contribute to vision loss remains unclear.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104179"},"PeriodicalIF":1.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2025-03-12DOI: 10.1016/j.jaapos.2025.104178
Jintong Liu, Rebecca G Edwards Mayhew, Lauren M Imbornoni, Jennifer L Jung, Scott C N Oliver, Nicholas K Foreman, Jean M Mulcahy Levy, Molly Hemenway, Emily A McCourt
{"title":"Pediatric MEK inhibitor-associated retinopathy: 8-year experience at a tertiary academic center and report of 2 cases.","authors":"Jintong Liu, Rebecca G Edwards Mayhew, Lauren M Imbornoni, Jennifer L Jung, Scott C N Oliver, Nicholas K Foreman, Jean M Mulcahy Levy, Molly Hemenway, Emily A McCourt","doi":"10.1016/j.jaapos.2025.104178","DOIUrl":"10.1016/j.jaapos.2025.104178","url":null,"abstract":"<p><strong>Background: </strong>An adverse effect of mitogen-activated protein kinase (MEK) inhibitors is MEK inhibitor-associated retinopathy (MEKAR), a fluid collection between the retinal pigment epithelium (RPE) and interdigitation zone (IZ) seen in up to 90% of adults taking these medications. MEKAR is not well described in children. The purpose of this study was to characterize MEKAR screening practices, identify cases of MEKAR, and describe their clinical presentations in children.</p><p><strong>Methods: </strong>We conducted a retrospective study at our tertiary care pediatric hospital, examining pediatric patients who underwent MEK inhibitor (MEK-i) therapy between 2015 and 2023. We describe 2 cases of pediatric MEKAR that arose during the study period.</p><p><strong>Results: </strong>Of 152 patients identified, 104 met inclusion criteria. Trametinib was the most used MEK-i, with plexiform neurofibroma being the predominant indication for therapy. Optical coherence tomography macula screenings were predominantly performed in clinic, with varying screening intervals (mean, 9.85 months; median, 6.5 months). We identified 2 cases of pediatric MEKAR, both of which improved or resolved without altering MEK-i dosage. Our study suggests a lower rate of MEKAR in pediatric patients compared with adults, although limitations in screening frequency and duration may influence this observation.</p><p><strong>Conclusions: </strong>Our findings underscore the importance of systematic MEKAR screening protocols in pediatric patients receiving MEK-i therapy, facilitating early detection and monitoring of ocular toxicity. When MEKAR develops, the risks of stopping treatment must be weighed against the risks of retinopathy, although in our patients, MEKAR resolved without alterations to their medication regimen.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104178"},"PeriodicalIF":1.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2025-03-10DOI: 10.1016/j.jaapos.2025.104177
Harry Mason, Caroline Kilduff, Saurabh Jain
{"title":"Small-angle vertical strabismus treatment in the elderly.","authors":"Harry Mason, Caroline Kilduff, Saurabh Jain","doi":"10.1016/j.jaapos.2025.104177","DOIUrl":"10.1016/j.jaapos.2025.104177","url":null,"abstract":"<p><p>Small vertical fusion amplitudes complicate the management of small-angle vertical strabismus in the elderly, and innovative procedures have the potential to facilitate effective treatment options in these patients. To identify and evaluate alternative procedures for the treatment of small-angle vertical strabismus in the elderly, we conducted a comprehensive literature search in PubMed and Google Scholar. Here, we identify and evaluate new surgical techniques that target small-angle vertical strabismus, including graded partial tenotomy, partial tendon recession, minitenotomy, and miniplication. All procedures have shown promise in offering alternatives to standard recession surgery, although patient selection appears to be paramount in optimizing outcomes. Further study is required to validate their efficacy and evaluate long-term outcomes.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104177"},"PeriodicalIF":1.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2025-03-07DOI: 10.1016/j.jaapos.2025.104164
Christina M Ambrosino, Xinxing Guo, Andrew Nguyen, Medha Kallem, Xi Dai, Nicholas Kourgialis, Michael X Repka, David S Friedman, Megan E Collins
{"title":"Practices of a United States school-based vision program in referring children to community eye care.","authors":"Christina M Ambrosino, Xinxing Guo, Andrew Nguyen, Medha Kallem, Xi Dai, Nicholas Kourgialis, Michael X Repka, David S Friedman, Megan E Collins","doi":"10.1016/j.jaapos.2025.104164","DOIUrl":"10.1016/j.jaapos.2025.104164","url":null,"abstract":"<p><strong>Background: </strong>School-based vision programs (SBVPs) can increase children's access to eye care services, yet some children have needs beyond the scope of SBVPs and require referral to community providers. We describe the referral practices of a large United States SBVP.</p><p><strong>Methods: </strong>A retrospective, cross-sectional analysis was conducted using data from pre-Kindergarten through grade 12 students (5-22 years of age) who underwent an SBVP eye examination after a failed vision screening. Data on student demographics, refractive error, and school-level indicators of socioeconomic disadvantage were extracted. The proportion of students referred to community eye care was assessed. Mixed-effects logistic regression models were implemented to understand associations between referral status and student-or school-level characteristics.</p><p><strong>Results: </strong>Of 97,107 students, 72,814 (75.0%) received eyeglasses and 13,884 (14.3%) were referred to community providers. Referrals were more common among younger students and those with greater school-level indicators of socioeconomic disadvantage. Compared with students with emmetropia, students with high hyperopia (OR = 7.21; 95% CI, 5.77-9.01) and high myopia (OR =3.70; 95% CI, 3.36-4.05) were more likely to be referred. Frequent referral reasons included refractive error (42.1%), amblyopia suspect (26.6%), and uncorrectable vision (26.1%). Nonreferred students were more likely to receive eyeglasses prescriptions (85.9% vs 9.4%).</p><p><strong>Conclusions: </strong>SBVPs can address most uncorrected refractive error within the school setting, but a substantial proportion of students need further evaluation. Young students and those with high refractive error are more likely to require referral. SBVPs may benefit from developing resources and community networks to support students' referral completion.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104164"},"PeriodicalIF":1.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2025-03-07DOI: 10.1016/j.jaapos.2025.104169
Eunseok Kang, Suk-Gyu Ha
{"title":"Comparative analysis of clinical features following inferior oblique recession surgery for unilateral congenital superior oblique palsy.","authors":"Eunseok Kang, Suk-Gyu Ha","doi":"10.1016/j.jaapos.2025.104169","DOIUrl":"10.1016/j.jaapos.2025.104169","url":null,"abstract":"<p><strong>Purpose: </strong>To assess changes in three clinical features (hypertropia in primary gaze, head tilt, and fundus extorsion) following inferior oblique recessions in patients with unilateral congenital superior oblique palsy (SOP).</p><p><strong>Methods: </strong>We retrospectively reviewed medical records of patients with unilateral congenital SOP who underwent inferior oblique recession at our center between 2020 and 2023. Patients were excluded if they had amblyopia, hypertropia >20<sup>Δ</sup> in primary gaze, bilateral SOP, acquired SOP due to head trauma, neurological causes, or cerebrovascular diseases, or a history of previous strabismus surgery. The pre- and postoperative measurements of hypertropia in primary gaze, head tilt, and fundus extorsion were analyzed, and postoperative improvement was calculated as the percentage reduction from the preoperative value. Correlations between outcomes with regard to the amount of postoperative improvement were analyzed.</p><p><strong>Results: </strong>A total of 81 patients were included. Mean preoperative hypertropia was 11.6<sup>Δ</sup>, head tilt was 15.1°, and fundus extorsion was 11.0°. The postoperative follow-up period was 15.4 months. The average amount of postoperative improvement was 77% for hypertropia, 58% for head tilt, and 75% for fundus extorsion. Improvements in hypertropia and fundus extorsion were significantly correlated (R<sup>2</sup> = 0.403, P < 0.001); however, improvements in hypertropia and head tilt (R<sup>2</sup> = 0.0011, P = 0.36) and head tilt and extorsion (R<sup>2</sup> = 2.190, P = 0.967) were not significantly correlated.</p><p><strong>Conclusions: </strong>Hypertropia in primary gaze and fundus extorsion improved more than head tilt, and the improvements were significantly correlated.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104169"},"PeriodicalIF":1.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2025-03-07DOI: 10.1016/j.jaapos.2025.104173
Tung Thanh Hoang, Thuong Duc Ho, Prem S Subramanian
{"title":"Pediatric isolated oculomotor nerve palsy induced by peduncular atypical teratoid/rhabdoid tumor: case report and literature review.","authors":"Tung Thanh Hoang, Thuong Duc Ho, Prem S Subramanian","doi":"10.1016/j.jaapos.2025.104173","DOIUrl":"10.1016/j.jaapos.2025.104173","url":null,"abstract":"<p><p>Central nervous system atypical teratoid/rhabdoid tumor (ATRT) is a rare and highly aggressive malignancy. We present the case of a 4-year-old girl with ATRT whose initial clinical sign was acute isolated oculomotor nerve palsy. While initial imaging was interpreted as normal, repeat cerebral magnetic resonance imaging with contrast indicated a compressive lesion in the left side of interpeduncular cistern. The patient underwent a craniotomy for tumor removal but expired before the first planned chemotherapy course.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104173"},"PeriodicalIF":1.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medial rectus recession combined with bridge faden procedure in esotropia associated with poor vision in the deviating eye.","authors":"Aslı İnal, Erdem Erdogdu, Muhittin Taskapili, Birsen Gökyigit","doi":"10.1016/j.jaapos.2025.104170","DOIUrl":"10.1016/j.jaapos.2025.104170","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the postoperative outcomes of medial rectus recession combined with modified posterior fixation surgery (bridge faden) in esotropia associated with poor vision in the deviating eye.</p><p><strong>Methods: </strong>In this retrospective study, the surgical outcomes of patients who underwent medial rectus recession combined with the bridge faden procedure for esotropia with poor vision in the deviating eye from April 2016 to May 2023 were assessed. The demographic characteristics of the patients and near and distance deviations were determined using the prism cover or the Krimsky test preoperatively and at follow-up of 1 month, 6 months, and 1 year. Orthophoria or ±10<sup>Δ</sup> deviation in postoperative near and distance deviations were considered surgical successes. The Wilcoxon signed-rank test was used for statistical analysis. A P value of <0.05 was considered statistically significant.</p><p><strong>Results: </strong>A total of 57 patients (34 males) were included. Mean patient age was 19 ± 12 years; mean follow-up, 27 ± 33 months. Near deviations improved from a mean of 33 ± 8<sup>Δ</sup> preoperatively to 4 ± 7<sup>Δ</sup> at 1 year (P < 0.05), and distance deviations improved from a mean of 27 ± 10<sup>Δ</sup> preoperatively to 3 ± 7<sup>Δ</sup> at 1 year (P < 0.05). The surgical success rate at final follow-up was 86%.</p><p><strong>Conclusions: </strong>In our cohort of patients with sensory esotropia associated with poor vision in the deviating eye, our procedure provided long-term improvement in near and distance deviation.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104170"},"PeriodicalIF":1.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}