Journal of AaposPub Date : 2024-12-30DOI: 10.1016/j.jaapos.2024.104093
Kerri McInnis-Smith, Todd Abruzzo, Monique Riemann, Luis F Goncalves, Aparna Ramasubramanian
{"title":"Utility of color Doppler imaging in patients with retinoblastoma treated by intra-arterial chemotherapy.","authors":"Kerri McInnis-Smith, Todd Abruzzo, Monique Riemann, Luis F Goncalves, Aparna Ramasubramanian","doi":"10.1016/j.jaapos.2024.104093","DOIUrl":"10.1016/j.jaapos.2024.104093","url":null,"abstract":"<p><strong>Background: </strong>There are no clinical parameters that predict response to intra-arterial chemotherapy (IAC), which is a first-line treatment for primary and recurrent unilateral retinoblastoma. We evaluated the utility of ophthalmic ultrasound with color Doppler imaging to predict retinoblastoma response to IAC treatment.</p><p><strong>Methods: </strong>The medical records of 14 retinoblastoma patients (20 eyes) treated with IAC were reviewed retrospectively. Baseline clinical information and ultrasound metrics were obtained from the medical record, including tumor volume, resistive index (RI) and pulsatility index (PI) of both the central retinal artery (CRA) and tumor feeding vessel (FV). Tumor volume was recorded [from repeat assessment 3-6 weeks after initial IAC.</p><p><strong>Results: </strong>Median baseline tumor volume was 0.40 cm<sup>3</sup> (range, 0.01-2.3); median percent change in volume after initial IAC was 71% (range, 50%-81%). Tumors with baseline volume of <1 cm<sup>3</sup> were associated with increased CRA RI (median, 0.73) and PI (median, 1.36) compared with larger tumors (median, CRA RI 0.60 [P = 0.04]; median, CRA PI, 1.03 [P = 0.03]) as well as higher FV RI (median, 0.72) and PI (median, 1.40) than larger tumors (median FV RI, 0.63 [P = 0.02]; median FV PI, 1.01 [P = 0.001]). None of the included Doppler parameters were significantly associated with change in tumor volume following IAC.</p><p><strong>Conclusions: </strong>In this pilot study, we found that retinoblastoma tumor volume is correlated with various Doppler characteristics of the CRA and feeder artery. Further studies are required to elucidate potential ocular blood flow patterns that may predict response to IAC.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104093"},"PeriodicalIF":1.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2024-12-27DOI: 10.1016/j.jaapos.2024.104091
Daniel G Nelson, G Baker Hubbard, Amy K Hutchinson
{"title":"Outcomes after unilateral bevacizumab treatment for infants with asymmetric retinopathy of prematurity.","authors":"Daniel G Nelson, G Baker Hubbard, Amy K Hutchinson","doi":"10.1016/j.jaapos.2024.104091","DOIUrl":"10.1016/j.jaapos.2024.104091","url":null,"abstract":"<p><p>In this retrospective study of asymmetric retinopathy of prematurity (ROP) cases treated with unilateral intravitreal bevacizumab (IVB), half of the treated patients did not require further IVB, whereas the other half required sequential IVB at a mean of 12 days after initial treatment.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104091"},"PeriodicalIF":1.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2024-12-01Epub Date: 2024-11-09DOI: 10.1016/j.jaapos.2024.104035
Serina S Applebaum, Anuoluwapo Sopeyin, Alaa Mohamedali, Erin Walsh, Jill Rotruck, Valentine Y Njike, Martha A Howard
{"title":"Comparison of the GoCheck Kids and Spot Screener photoscreening devices for the detection of amblyopia risk factors using 2021 AAPOS recommendations.","authors":"Serina S Applebaum, Anuoluwapo Sopeyin, Alaa Mohamedali, Erin Walsh, Jill Rotruck, Valentine Y Njike, Martha A Howard","doi":"10.1016/j.jaapos.2024.104035","DOIUrl":"10.1016/j.jaapos.2024.104035","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the Spot Vision Screener (SPOT) to the GoCheck Kids mobile application (GCK) in the evaluation of amblyopia risk factors (ARFs), according to updated 2021 AAPOS guidelines for instrument-based pediatric vision screening.</p><p><strong>Methods: </strong>SPOT, GCK using horizontal and vertical images (two-photo mode), and a complete eye examination (CEE) were performed on children ages ≥1 to <7 years referred to a pediatric ophthalmologist from October 2020 to December 2022 for a failed vision screen based on manufacturer guidelines. The primary outcomes were sensitivity, specificity, and positive predictive value (PPV) for each photoscreener.</p><p><strong>Results: </strong>Of 267 subjects included, 42% had one or more 2021 guideline ARFs after CEE. Overall, for SPOT and GCK, respectively, the sensitivity was 0.765 and 0.748, specificity was 0.769 and 0.755, and PPV was 0.728 and 0.712 (P > 0.05 for all). In participants ≥4 years old, SPOT had higher ARF sensitivity than GCK (0.900 and 0.750, resp.; P = 0.005), while among participants <4 years old, SPOT had lower sensitivity than GCK (0.487 and 0.744 respectively; P = 0.004). There were no statistically significant differences between SPOT and GCK in specificity among the younger (0.750 and 0.676 resp.) or older (0.785 and 0.823, resp.) cohorts, or in strabismus detection. The performance of the SPOT and GCK was evaluated using receiver operating characteristics (ROC) curves. Area under the curve (AUC) ranged from 0.857 to 0.980 for SPOT and 0.809 to 0.931 for GCK.</p><p><strong>Conclusions: </strong>Overall, SPOT, and GCK had similar values for sensitivity, specificity, and PPV to identify patients with ARFs using the 2021 AAPOS guidelines.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104035"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2024-12-01Epub Date: 2024-11-19DOI: 10.1016/j.jaapos.2024.104056
James W Corbett, James K Redmayne, Heather C Russell
{"title":"Trigemino-abducens synkinesis: serial review over 4 years.","authors":"James W Corbett, James K Redmayne, Heather C Russell","doi":"10.1016/j.jaapos.2024.104056","DOIUrl":"10.1016/j.jaapos.2024.104056","url":null,"abstract":"<p><p>Congenital cranial dysinnervation disorders involve abberant connections between cranial nerves, often resulting in synkinetic activation of target muscles. Marcus-Gunn jaw winking ptosis and Duane retraction syndrome are some of the more well-known examples of this phenomenon. We present serial video of a child with congenital trigemino-abducens synkinesis, a lesser known congenital cranial dysinnervation disorder, to demonstrate the characteristics of this likely under-diagnosed presentation.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104056"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2024-12-01Epub Date: 2024-11-15DOI: 10.1016/j.jaapos.2024.104047
William J Johnson, Derek P Bitner, Cole Bacig
{"title":"Incidence of strabismus surgery after vitreoretinal surgery.","authors":"William J Johnson, Derek P Bitner, Cole Bacig","doi":"10.1016/j.jaapos.2024.104047","DOIUrl":"10.1016/j.jaapos.2024.104047","url":null,"abstract":"<p><p>Strabismus following other intraocular surgery has several well-described etiologies. Vitreoretinal surgeries are the most likely to require retrobulbar anesthesia and exoplants, two commonly associated risk factors for postoperative strabismus. A reliable assessment of the incidence of strabismus secondary to other ocular surgery has not been established. We report a large cohort of vitreoretinal surgery cases performed in the same multispecialty practice with the area's only adult strabismus surgeon. We specifically examined strabismus surgery as the inclusion criteria, because nonsurgical management of postoperative strabismus typically indicates more benign and less-complex presentations. We found 7 cases of strabismus surgery following 4,176 retina surgeries (0.17%), one of which had a prior history of strabismus surgery. Of the 6 others, 2 had a scleral buckle placed, and a further 2 had a course consistent with a typical block infiltration strabismus.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104047"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retinal arteriovenous malformation and cerebral cavernous malformation in a 6-year-old child.","authors":"Wiktoria Milczyńska, Nicole Tay, Alexandros Kogiantis","doi":"10.1016/j.jaapos.2024.104046","DOIUrl":"10.1016/j.jaapos.2024.104046","url":null,"abstract":"<p><p>Retinal arteriovenous malformations (AVMs) are rare congenital, nonhereditary vascular anomalies of the retina. We report the case of a 6-year-old child presenting with recurrent frontal headaches. Funduscopy examination revealed an AVM in the right eye, inferior to the optic nerve head. Optical coherence tomography and retinal imaging confirmed the presence of an AVM measuring 3 disk diameters. Magnetic resonance imaging of the head revealed a cavernous malformation in the right frontal subcortical region.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104046"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2024-12-01Epub Date: 2024-11-09DOI: 10.1016/j.jaapos.2024.104036
Miharu Mihara, Ken Kakeue, Ryoi Tamura, Atsushi Hayashi
{"title":"Characteristics of horizontal saccades in children with intermittent exotropia.","authors":"Miharu Mihara, Ken Kakeue, Ryoi Tamura, Atsushi Hayashi","doi":"10.1016/j.jaapos.2024.104036","DOIUrl":"10.1016/j.jaapos.2024.104036","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the peak velocity and gain of horizontal saccades in children diagnosed with intermittent exotropia (IXT) and to compare these measurements with those obtained from children without strabismus.</p><p><strong>Methods: </strong>Participants included children ≤12 years of age with IXT and no history of strabismus surgery and children without strabismus. The peak velocity and gain of horizontal saccades recorded using an eye tracker were analyzed.</p><p><strong>Results: </strong>A total of 48 children (including 38 with IXT) were included. In the IXT group, the angles of deviation at near were 30.3<sup>Δ</sup> ± 13.5<sup>Δ</sup>; at distance, 30.6<sup>Δ</sup> ± 10.5<sup>Δ</sup>. Stereopsis was ≤60 arcsec in 29 patients and 80-400 arcsec in 9 patients. In the IXT group, the peak velocity and gain of the adduction saccade tended to be greater than those of the abduction saccade, but not significantly. The no-strabismus group exhibited a similar trend, with a stronger tendency in the dominant eye, reaching statistical significance.</p><p><strong>Conclusions: </strong>Both the children with IXT and children without strabismus showed a dominance of adduction in their saccades; however, this dominance was weaker in children with IXT.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104036"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2024-12-01Epub Date: 2024-11-23DOI: 10.1016/j.jaapos.2024.104058
Robert W Arnold, Kyle A Smith
{"title":"Evaluation of 3D tablet-based stereoacuity test ASTEROID in children with normal and abnormal visual acuity.","authors":"Robert W Arnold, Kyle A Smith","doi":"10.1016/j.jaapos.2024.104058","DOIUrl":"10.1016/j.jaapos.2024.104058","url":null,"abstract":"","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104058"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2024-12-01Epub Date: 2024-11-15DOI: 10.1016/j.jaapos.2024.104051
Muhammad Z Chauhan, Kaersti L Rickels, J Anthony Chacko, Ahmed B Sallam, Qais Dihan, Paul H Phillips, Joseph G Chacko, Abdelrahman M Elhusseiny
{"title":"Self-reported history of childhood vision impairment among older adults screened for dementia.","authors":"Muhammad Z Chauhan, Kaersti L Rickels, J Anthony Chacko, Ahmed B Sallam, Qais Dihan, Paul H Phillips, Joseph G Chacko, Abdelrahman M Elhusseiny","doi":"10.1016/j.jaapos.2024.104051","DOIUrl":"10.1016/j.jaapos.2024.104051","url":null,"abstract":"<p><p>We investigated the relationship between self-reported history of visual impairment in youth and the development of dementia in later life using data from the Panel Study of Income Dynamics (PSID) household survey, which included the Eight-item Informant Interview to Differentiate Aging and Dementia (AD-8) screen. Adults with a reported history of childhood visual impairment were found to have significantly higher odds of positive dementia screening. After adjusting for confounders, we found a twofold increase in those reporting early visual impairment compared with those who did not report early visual impairment.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104051"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}