Journal of AaposPub Date : 2025-01-22DOI: 10.1016/j.jaapos.2025.104110
Sayuri Sekimitsu, Megan E Collins, Nazlee Zebardast
{"title":"US children from non-English-speaking households are less likely to undergo vision testing.","authors":"Sayuri Sekimitsu, Megan E Collins, Nazlee Zebardast","doi":"10.1016/j.jaapos.2025.104110","DOIUrl":"10.1016/j.jaapos.2025.104110","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the association between primary household language and vision testing among children living in the United States from 2016 to 2020.</p><p><strong>Methods: </strong>This analysis used data for children aged 3-17 years from the National Survey of Children's Health (NSCH), combining survey responses from 2016 to 2020. Primary household language and whether vision testing occurred were determined by survey responses. Complex samples logistic regression models, adjusted for insurance coverage, income (relative to the federal poverty level), race/ethnicity, educational level of household adult, and survey year, were developed to determine the likelihood of vision testing as a function of household English-language usage.</p><p><strong>Results: </strong>Among the 150,603 NSCH respondents, 9,750 (6.47%) were from non-English-speaking households. These children were less likely to undergo vision testing compared with those from English-speaking households (75.8% vs 67.6% [P < 0.001]). State requirements for vision screening among preschoolers and school-age children were associated with increased likelihood of vision testing (P < 0.05) among 3- to 5- and 12- to 17- year-olds; stratified by primary household language, this effect was greater among those from non-English-speaking households.</p><p><strong>Conclusions: </strong>In this nationally representative sample, children from non-English-speaking households were less likely than those from English-speaking ones to receive vision testing, highlighting the need to address language services, health literacy, and other potential barriers to vision services in this population.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104110"},"PeriodicalIF":1.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2025-01-21DOI: 10.1016/j.jaapos.2025.104107
Randy Nguyen, Sharon H O'Neil, Mark S Borchert, Melinda Y Chang
{"title":"Adaptive functioning and relationship to visual behavior in children with cerebral/cortical visual impairment.","authors":"Randy Nguyen, Sharon H O'Neil, Mark S Borchert, Melinda Y Chang","doi":"10.1016/j.jaapos.2025.104107","DOIUrl":"10.1016/j.jaapos.2025.104107","url":null,"abstract":"<p><strong>Background: </strong>Cerebral/cortical visual impairment (CVI) is a leading cause of pediatric visual impairment in developed countries and is associated with neurologic conditions that may impair adaptive functioning or skills required to perform everyday tasks (eg, communication, socialization, and daily living skills). Adaptive behavior in children with CVI has not been systematically studied, and the relationship between visual function and adaptive function in CVI is unknown.</p><p><strong>Methods: </strong>We prospectively recruited 49 children with CVI (mean age, 4 ± 3 years). Adaptive behavior was evaluated using the Vineland Adaptive Behavior Scale, 3rd edition (VABS-III). Visual acuity was assessed by a pediatric neuro-ophthalmologist using the six-level Visual Behavior Scale (VBS). The relationship between VBS and VABS-III scores was assessed using a Spearman correlation coefficient and a multiple regression model to correct for age, sex, and neurologic and ophthalmologic comorbidities.</p><p><strong>Results: </strong>In our cohort, mean adaptive behavior scores in children with CVI were below the 1st percentile on all VABS-III domains and subdomains. Visual acuity, as assessed by VBS, was significantly associated with VABS-III total adaptive behavior composite score (P = 0.04), socialization (P = 0.03) domain, and interpersonal (P = 0.04), play and leisure (P = 0.04), and personal (P = 0.01) subdomains.</p><p><strong>Conclusions: </strong>Children with CVI have significantly reduced adaptive functioning. Visual behavior is correlated with socialization and some daily living skills. Future longitudinal studies should evaluate whether adaptive functioning increases as visual acuity improves in children with CVI, which may have prognostic implications.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104107"},"PeriodicalIF":1.2,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2025-01-21DOI: 10.1016/j.jaapos.2025.104104
Abdelrahman M Elhusseiny, Jessica Chau, Francisco Altamirano-Lamarque, Muhammad Z Chauhan, Isdin Oke, Jean Adomfeh, Bharti R Nihalani, Deborah K VanderVeen
{"title":"Association of neighborhood Child Opportunity Index with visual outcomes in children with unilateral pediatric cataract.","authors":"Abdelrahman M Elhusseiny, Jessica Chau, Francisco Altamirano-Lamarque, Muhammad Z Chauhan, Isdin Oke, Jean Adomfeh, Bharti R Nihalani, Deborah K VanderVeen","doi":"10.1016/j.jaapos.2025.104104","DOIUrl":"10.1016/j.jaapos.2025.104104","url":null,"abstract":"<p><strong>Purpose: </strong>To demonstrate the association between neighborhood quality, using the Child Opportunity Index (COI), and the visual outcomes in children with unilateral pediatric cataract.</p><p><strong>Methods: </strong>We retrospectively reviewed the medical records of patients ≤18 years of age who presented at Boston Children's Hospital between 2000 and 2022 with unilateral cataracts and underwent cataract extraction. The collected data included patient demographics, residential addresses, the reason for the initial presentation, the age at presentation, the morphology of the cataract, and the final visual acuity. The COI was used as a metric of neighborhood quality. We analyzed the association between the COI scores and the final visual acuity.</p><p><strong>Results: </strong>We included a total of 80 patients in the study. The mean age at presentation was 2.59 ± 2.97 years. The most common reason for the initial presentation was a failed vision screen (27.5%), followed by an abnormal red reflex (25.0%). Posterior cataract was the most common type of cataract (66.3%). In the adjusted analysis, we found that a lower overall COI (β = -0.17; 95% CI, -0.31 to -0.02; P = 0.02) was associated with higher logMAR visual acuity (ie, worse visual acuity) at the final follow-up visit. Lower education and health and environment COI subdomains were associated with higher logMAR visual acuity at the final follow-up visit (P = 0.01 and P = 0.02, resp.).</p><p><strong>Conclusions: </strong>Neighborhood environment quality is a potentially important variable for predicting visual outcomes in pediatric cataracts. Lower COI scores were associated with worse visual outcomes.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104104"},"PeriodicalIF":1.2,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2025-01-21DOI: 10.1016/j.jaapos.2025.104106
Jonathan D Shirian, Justin C Muste, Jonathan E Sears, Elias I Traboulsi
{"title":"Outcomes and comparative analysis of therapeutic approaches for choroidal neovascular membranes associated with optic nerve head drusen in pediatric patients.","authors":"Jonathan D Shirian, Justin C Muste, Jonathan E Sears, Elias I Traboulsi","doi":"10.1016/j.jaapos.2025.104106","DOIUrl":"10.1016/j.jaapos.2025.104106","url":null,"abstract":"<p><strong>Background: </strong>Choroidal neovascular membranes (CNVM) associated with optic nerve head drusen (ONHD) are rare but vision threatening. A variety of treatments, including laser photocoagulation, subretinal surgery, and anti-VEGF injections, are effective but pose risks, particularly in pediatric patients, underscoring the need for a comprehensive review.</p><p><strong>Methods: </strong>A systematic review was conducted using PubMed, Embase, and Web of Science. Studies with treated pediatric cases of ONHD and CNVM were included. Age >18 years, non-English-language articles, minimal/irrelevant data, and duplicate studies were excluded. Data about patient characteristics, treatment details, and visual outcomes were extracted.</p><p><strong>Results: </strong>Of 309 screened publications, 28 studies with 29 patients were included. Of the 19 pediatric patients (22 eyes) receiving anti-VEGF treatment, best-corrected visual acuity (BCVA) improved from 0.84 ± 0.60 logMAR to 0.13 ± 0.15 logMAR (P < 0.0001). In the surgical or laser treatment cohort of 10 patients (12 eyes), BCVA improved from 0.76 ± 0.43 logMAR to 0.18 ± 0.15 logMAR (P = 0.0025). Anti-VEGF treatment was equally effective as surgical or laser treatment. We found no significant difference in the number of injections needed among anti-VEGF agents utilized (ranibizumab, aflibercept, and bevacizumab). No cases developed systemic or extraocular complications with anti-VEGF treatments. One case (5%) had a recurrence of CNVM after treatment.</p><p><strong>Conclusions: </strong>This study reinforces the equal efficacy of surgical, laser, and anti-VEGF treatments for CNVM associated with ONHD in pediatric patients. No adverse outcomes of anti-VEGF therapy were reported.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104106"},"PeriodicalIF":1.2,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2024-12-31DOI: 10.1016/j.jaapos.2024.104101
Weiliang Wang, Sharon F Freedman, David K Wallace, S Grace Prakalapakorn
{"title":"Quantitative comparison of vascular characteristics of plus disease images published over time: International Classification of Retinopathy of Prematurity.","authors":"Weiliang Wang, Sharon F Freedman, David K Wallace, S Grace Prakalapakorn","doi":"10.1016/j.jaapos.2024.104101","DOIUrl":"10.1016/j.jaapos.2024.104101","url":null,"abstract":"<p><p>Plus disease was first defined in the original International Classification of retinopathy of prematurity (ICROP) publication in 1984. Over time, the definition of plus disease has evolved, and each ensuing ICROP publication has included example plus disease images. Because plus disease is often present when treatment is indicated, it is important to evaluate whether the retinal vascular characteristics (ie, dilation and tortuosity) depicted in these example images have remained the same or changed over time. Using a semiautomated computer program to trace and quantitatively analyze the retinal vessels in all example plus disease images published in three iterations of ICROP over time, the most recent ICROP publication (ICROP3) consistently exhibited the lowest amount of vascular dilation and tortuosity. This suggests a potential shift towards less tortuous and dilated retinal vessels in example plus disease images published in ICROP3, possibly indicating a lowering of the threshold for diagnosing plus disease and treatment of retinopathy of prematurity.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104101"},"PeriodicalIF":1.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2024-12-31DOI: 10.1016/j.jaapos.2024.104097
Yapei Zhang, Marguerite C Weinert, Andrew J Schneier, Lisa H Merck, David G Hunter, Eric D Gaier
{"title":"Acquired torticollis due to an ocular surface foreign body.","authors":"Yapei Zhang, Marguerite C Weinert, Andrew J Schneier, Lisa H Merck, David G Hunter, Eric D Gaier","doi":"10.1016/j.jaapos.2024.104097","DOIUrl":"10.1016/j.jaapos.2024.104097","url":null,"abstract":"<p><p>Ocular torticollis is traditionally attributed to eye misalignment, nystagmus, ptosis, or refractive error. We present 3 pediatric cases of acquired torticollis caused by a foreign body beneath the upper eyelid. The head posturing presumably developed to minimize contact of the foreign body with the corneal surface and mitigate ocular discomfort. Torticollis resolved in all cases after removal of the foreign bodies. These cases demonstrate that acquired torticollis in a child can be a clinical sign of an ocular surface foreign body.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104097"},"PeriodicalIF":1.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2024-12-31DOI: 10.1016/j.jaapos.2024.104096
Jia Jia Zhang, Michael T B Nguyen, Eric D Gaier
{"title":"Ocular neuromyotonia after peribulbar block.","authors":"Jia Jia Zhang, Michael T B Nguyen, Eric D Gaier","doi":"10.1016/j.jaapos.2024.104096","DOIUrl":"10.1016/j.jaapos.2024.104096","url":null,"abstract":"<p><p>A man in his 60s developed an intermittent, variable left hypotropia with symptomatic diplopia following nasal pterygium surgery in the left eye. No tropia was present for most of the day, but a variable left hypotropia of 25<sup>Δ</sup> could be provoked with downgaze. There was no history of radiation or other trauma. Magnetic resonance imaging of the brain and orbits with gadolinium was unremarkable. The patient was diagnosed with suspected ocular neuromyotonia secondary to the peribulbar block and temporarily managed with Fresnel prism. A trial of oral carbamazepine partially improved symptoms. He ultimately underwent a left inferior rectus recession with near complete resolution of his symptoms.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104096"},"PeriodicalIF":1.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2024-12-31DOI: 10.1016/j.jaapos.2024.104102
Andrew Kaler, Natario Couser
{"title":"Ocular and neurological manifestations of the FDXR-related disorder.","authors":"Andrew Kaler, Natario Couser","doi":"10.1016/j.jaapos.2024.104102","DOIUrl":"10.1016/j.jaapos.2024.104102","url":null,"abstract":"<p><p>The FDXR-related disorder is caused by pathogenic variants in the FDXR gene. Including our case, a total of 47 patients have been reported. The most common genotypes are the homozygous c.1174C>T (p.R392W) variant and homozygous c.916C>T (p.R306C) variant. Optic atrophy is the most common feature (89%), but many other ocular manifestations have not previously been characterized. Our review of the existing literature reveals other common ocular findings of myopia, nystagmus, strabismus, retinal dystrophy, attenuation of retinal vessels, and cataracts. Common neurological symptoms include movement disorder, sensorineural hearing loss, developmental delay/regression, and hypotonia.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104102"},"PeriodicalIF":1.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2024-12-31DOI: 10.1016/j.jaapos.2024.104095
Mackenzie A Campbell, Nathan C Grove, Robert S McDuffie, Emily A Auer, Arden J McReynolds, Emily A McCourt, Erica M Wymore, Naresh Mandava, Brandie D Wagner, Marc T Mathias, Scott C N Oliver, Jennifer L Jung, Anne M Lynch
{"title":"The relationship between discordant birth weight in twin pairs and the development of retinopathy of prematurity.","authors":"Mackenzie A Campbell, Nathan C Grove, Robert S McDuffie, Emily A Auer, Arden J McReynolds, Emily A McCourt, Erica M Wymore, Naresh Mandava, Brandie D Wagner, Marc T Mathias, Scott C N Oliver, Jennifer L Jung, Anne M Lynch","doi":"10.1016/j.jaapos.2024.104095","DOIUrl":"10.1016/j.jaapos.2024.104095","url":null,"abstract":"<p><p>The association of low birth weight and development of retinopathy of prematurity (ROP) is well established for singletons; however, the association of birth weight and ROP in twins of discordant weight is understudied. Using an ROP registry, we investigated whether smaller twins were at greater risk for developing any stage ROP (stage 1 or greater in either eye) compared with their larger siblings, after adjusting for birth weight and gestational age. Discordance was defined as a birth weight difference of >25%. In a cohort of 2,083 infants (2006-2021), 36 discordant twin pairs were identified. The smaller twin had an increased odds of developing any ROP (OR = 2.7; 95% CI, 1.3-5.9; P = 0.01) compared with the larger sibling. This relationship was no longer significant following adjustment for gestational age and birth weight (adjusted OR = 0.92; CI, 0.11-7.43; P = 0.94). The results suggest that although the smaller twins in discordant pairs are at an increased risk of any stage ROP, this risk is driven by low birth weight conditional on gestational age.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104095"},"PeriodicalIF":1.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2024-12-31DOI: 10.1016/j.jaapos.2024.104099
Vijitha S Vempuluru, Dilip K Mishra, Swathi Kaliki
{"title":"Intravitreal topotecan injection-induced conjunctival fibrosis mimicking extraocular extension of retinoblastoma: a rare complication.","authors":"Vijitha S Vempuluru, Dilip K Mishra, Swathi Kaliki","doi":"10.1016/j.jaapos.2024.104099","DOIUrl":"10.1016/j.jaapos.2024.104099","url":null,"abstract":"<p><p>A 3-year-old girl treated with intravenous chemotherapy for bilateral retinoblastoma (RB) and a standard technique of intravitreal topotecan for vitreous seeds in the left eye developed a conjunctival nodule at the injection site. Ultrasound biomicroscopy showed normal underlying sclera and ciliary body. Fundus examination of the left eye showed partly calcified vitreous seeds. Suspecting extraocular RB extension, we performed extended enucleation. Histopathology revealed partially regressed intraocular RB, and the conjunctival nodule showed subepithelial cystic degeneration with fibroblastic proliferation, a rare complication hitherto not reported with intravitreal or subconjunctival topotecan injections.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104099"},"PeriodicalIF":1.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}