Journal of Aapos最新文献_第10页

Increase in blood derived mitochondrial DNA copy number in strabismus patients 斜视患者血液中线粒体 DNA 拷贝数的增加。

IF 1.2 4区医学

Journal of Aapos Pub Date : 2024-12-01 DOI: 10.1016/j.jaapos.2024.104042

Zainab Zehra PhD , Muhammad Amn Zia MS , Sorath Noorani Siddiqui MD , Christopher S. von Bartheld MD , Maleeha Azam PhD , Raheel Qamar PhD

{"title":"Increase in blood derived mitochondrial DNA copy number in strabismus patients","authors":"Zainab Zehra PhD , Muhammad Amn Zia MS , Sorath Noorani Siddiqui MD , Christopher S. von Bartheld MD , Maleeha Azam PhD , Raheel Qamar PhD","doi":"10.1016/j.jaapos.2024.104042","DOIUrl":"10.1016/j.jaapos.2024.104042","url":null,"abstract":"<div><h3>Background</h3><div>Abnormalities in mitochondrial energy homeostasis can lead to various disorders, including ocular motility aberrations. Previous studies have suggested the involvement of mitochondrial aberrations in strabismus etiology. We compared the blood-derived mitochondrial DNA (mtDNA) copy number from comitant strabismus patients with that from age-matched controls, and also compared expression of mitochondrial biogenesis genes in a separate set of extraocular muscle samples from strabismic and control subjects.</div></div><div><h3>Methods</h3><div>Blood samples from 93 strabismic (39 esotropic, 54 exotropic) and 93 control subjects were analyzed for mtDNA copy number through quantitative polymerase chain reaction. We also examined the expression of 6 genes involved in mitochondrial biogenesis in cDNA obtained from extraocular muscles of a separate group of 26 strabismus patients and 4 healthy controls.</div></div><div><h3>Results</h3><div>The mtDNA content was significantly higher in strabismus patients as compared to the control group, both overall (fold change, 1.39; <em>Z</em> = −2.43 [<em>P</em> = 0.01]) and in strabismus subgroups (esotropia: fold change,1.42; <em>Z</em> = 2.59 [<em>P</em> = 0.0096]; exotropia: fold change, 1.41, <em>Z</em> = 3.35 [<em>P</em> = 0.00078]). No significant difference was observed in the expression of the examined biogenesis genes between strabismus and control groups.</div></div><div><h3>Conclusions</h3><div>Our results suggest an association between mtDNA copy number and strabismus; however, further studies are required to elucidate the significance of altered mtDNA in strabismus and its possible significance with regard to the etiology of strabismus.</div></div>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"28 6","pages":"Article 104042"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated intraocular pressure in a child with Stickler syndrome after scleral buckle surgery for retinal detachment 一名患有 Stickler 综合征的儿童在接受巩膜扣带手术治疗视网膜脱离后眼压升高。

IF 1.2 4区医学

Journal of Aapos Pub Date : 2024-12-01 DOI: 10.1016/j.jaapos.2024.104043

Abdelrahman M. Anter MD , Seyyedehfatemeh Ghalibafan MD , Louis Z. Cai MD, Connie M. Wu MD, Elena Bitrian MD, Nicolas A. Yannuzzi MD

引用次数: 0

Access to vision care for children from immigrant and nonimmigrant households: evidence from the National Survey of Children’s Health 2018-2019 移民和非移民家庭儿童获得视力保健的机会：来自 2018-2019 年全国儿童健康调查的证据。

IF 1.2 4区医学

Journal of Aapos Pub Date : 2024-12-01 DOI: 10.1016/j.jaapos.2024.104044

Afua O. Asare OD, PhD , Brian C. Stagg MD, MS , Carole Stipelman MD, MPH , Heather T. Keenan MD, PhD , Melissa Watt PhD , Guilherme Del Fiol MD, PhD , Marielle P. Young MD , Justin D. Smith PhD

{"title":"Access to vision care for children from immigrant and nonimmigrant households: evidence from the National Survey of Children’s Health 2018-2019","authors":"Afua O. Asare OD, PhD , Brian C. Stagg MD, MS , Carole Stipelman MD, MPH , Heather T. Keenan MD, PhD , Melissa Watt PhD , Guilherme Del Fiol MD, PhD , Marielle P. Young MD , Justin D. Smith PhD","doi":"10.1016/j.jaapos.2024.104044","DOIUrl":"10.1016/j.jaapos.2024.104044","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate whether immigrant generation is associated with caregiver-reported receipt of vision testing.</div></div><div><h3>Methods</h3><div>Nationally representative data from the 2018-2019 National Survey of Children’s Health was used. The primary exposure was immigrant generation, with first generation defined as child and all reported parents born outside the United States; second generation, as child born in the United States but at least one parent born outside the United States; and third generation, as all parents in the household born in the United States. The main outcome was caregiver-reported vision testing during the previous 12 months. Odds ratios adjusted for sociodemographic characteristics and 95% confidence intervals were computed based on immigrant generation.</div></div><div><h3>Results</h3><div>The sample included 49,442 US children 3-17 years of age. The proportion of children who had vision testing in any setting was lower for first- (60.3%) than third-generation children (74.6%; aOR = 0.54; 95% CI, 0.41-0.71). This association remained after excluding children without health coverage. For Hispanic children, both first- (aOR = 0.58; 95% CI, 0.36-0.94) and second-generation children (aOR = 0.73; 95% CI, 0.55-0.96) had lower odds of a vision test in any setting compared with third-generation Hispanic children.</div></div><div><h3>Conclusions</h3><div>First-generation children had lower odds of vision testing than third-generation children, even when adjusting for sociodemographic characteristics, especially in Hispanic households.</div></div>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"28 6","pages":"Article 104044"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Term infant brain MRI after ROP treatment by anti-VEGF injection versus laser therapy 抗血管内皮生长因子注射与激光疗法治疗视网膜病变后的足月婴儿脑磁共振成像。

IF 1.2 4区医学

Journal of Aapos Pub Date : 2024-12-01 DOI: 10.1016/j.jaapos.2024.104038

Monica Manrique MD , Michael Pham DO , Sudeepta Basu MD , Jonathan Murnick MD, PhD , Md Sohel Rana MBBS, MPH , Taeun Chang MD , Christabel Chan MD , Emile Vieta-Ferrer MD , Catherine Sano BS , Catherine Limperopoulos MD , Marijean Miller MD

{"title":"Term infant brain MRI after ROP treatment by anti-VEGF injection versus laser therapy","authors":"Monica Manrique MD , Michael Pham DO , Sudeepta Basu MD , Jonathan Murnick MD, PhD , Md Sohel Rana MBBS, MPH , Taeun Chang MD , Christabel Chan MD , Emile Vieta-Ferrer MD , Catherine Sano BS , Catherine Limperopoulos MD , Marijean Miller MD","doi":"10.1016/j.jaapos.2024.104038","DOIUrl":"10.1016/j.jaapos.2024.104038","url":null,"abstract":"<div><h3>Background</h3><div>Intravitreal injection of anti–vascular endothelial growth factor (anti-VEGF) agents is used to treat posterior type 1 retinopathy of prematurity (ROP). Recent reports indicate that anti-VEGF therapy may be associated with white matter brain injury, according to animal studies, and neurodevelopmental impairments in children born preterm. We investigated whether type 1 ROP treated with bevacizumab is associated with structural brain injury on infant term magnetic resonance images (MRIs) in very low birth weight infants compared with those treated with laser ablation.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed the medical records of very low birth weight infants from 2006 to 2021 with type 1 ROP who had been treated with laser or anti-VEGF therapy. Intravitreal bevacizumab injection was used for type 1 ROP in zone 1 or very posterior zone 2 or when laser treatment was not feasible. A pediatric neuroradiologist reviewed brain MRIs at term equivalent age (36-46 weeks’ postmenstrual age) and classified infants for severity (no/mild vs moderate/severe) of overall brain and white matter injury using the validated Kidokoro scoring system.</div></div><div><h3>Results</h3><div>Fifty-two infants met inclusion criteria: 35 (67%) treated with laser and 17 (33%) with bevacizumab. Moderate-to-severe brain injury scores were not statistically different between bevacizumab and laser treatment groups in either continuous or binary adjusted analyses, for either the overall score or the white matter subscore.</div></div><div><h3>Conclusions</h3><div>Severity of structural injury on term brain MRI (total and white matter) did not differ between infants with type 1 ROP treated with anti-VEGF agent (bevacizumab) and those treated with laser ablation.</div></div>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"28 6","pages":"Article 104038"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of infantile acute polymicrobial dacryocystitis due to Serratia marcescens, Haemophilus aphrophilus, and Prevotella intermedia 一例罕见的婴幼儿急性多菌性泪囊炎病例，病原体包括大肠沙雷氏菌、阿弗氏嗜血杆菌和中间普雷沃特氏菌。

IF 1.2 4区医学

Journal of Aapos Pub Date : 2024-12-01 DOI: 10.1016/j.jaapos.2024.104019

Marina Shenouda , Agni Kakouri MD , Timothy J. McCulley MD , Ying Chen MD

引用次数: 0

Long-term follow-up of ocular involvement in hereditary mucoepithelial dysplasia 遗传性粘液上皮发育不良眼部受累的长期随访。

IF 1.2 4区医学

Journal of Aapos Pub Date : 2024-10-01 DOI: 10.1016/j.jaapos.2024.103997

Sepehr Feizi MD, MSc , Mohammadreza Tahavvori MD , Seyed-Bagher Hosseini MD , Goldis Espandar MD , Peyman Mohammadi Torbati MD , Hamed Esfandiari MD

引用次数: 0

Long-term outcomes of Ahmed glaucoma drainage device capsulectomies in pediatric glaucoma patients 小儿青光眼患者接受艾哈迈德青光眼引流装置囊切除术的长期疗效。

IF 1.2 4区医学

Journal of Aapos Pub Date : 2024-10-01 DOI: 10.1016/j.jaapos.2024.104002

Sharmila Segar MD , Amanda Ismail MD , Riya Shah BS , Chaesik Kim BSEE , Aditi Kappagantu BS , John Roarty MD

{"title":"Long-term outcomes of Ahmed glaucoma drainage device capsulectomies in pediatric glaucoma patients","authors":"Sharmila Segar MD , Amanda Ismail MD , Riya Shah BS , Chaesik Kim BSEE , Aditi Kappagantu BS , John Roarty MD","doi":"10.1016/j.jaapos.2024.104002","DOIUrl":"10.1016/j.jaapos.2024.104002","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the long-term outcomes associated with Ahmed glaucoma device capsulectomy in pediatric patients at a single institution over a period of nearly 10 years, from 2011 to 2021.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed the medical records of pediatric glaucoma patients with FP-7 Ahmed glaucoma device capsulectomies performed by three surgeons. Surgical success was defined as post-capsulectomy IOP of <21 mm Hg at most recent follow-up without need for additional procedures, regardless of topical medications.</div></div><div><h3>Results</h3><div>A total of 22 capsulectomies of 22 eyes of 18 patients aged 1-17 years were reviewed. Median post-capsulectomy follow-up was 5.8 years. Etiologies of glaucoma were primary congenital glaucoma (50%), anterior segment dysgenesis (32%), Sturge-Weber syndrome (14%), and angle recession (5%). Pre-capsulectomy IOP was 30 ± 6.2 mm Hg, with first postoperative IOP of 15 ± 8.0 mm Hg. Surgical success was achieved with 5 capsulectomies (23%), with follow-up of 1.5-5.9 years. Post-capsulectomy complications included short-term hypotony in 1 eye (5%) and macular edema in 1 eye (5%). Eleven of 22 eyes (50%) had at least one repeat placement of Ahmed glaucoma device, with median time to repeat surgery of 80 months.</div></div><div><h3>Conclusions</h3><div>In pediatric glaucoma patients with glaucoma drainage device encapsulation, capsulectomy likely does not prevent additional surgery in most children over the long term, but may serve as a temporizing measure before other interventions.</div></div>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"28 5","pages":"Article 104002"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of age on congenital nasolacrimal duct obstruction probing and stent intubation outcomes in pediatric Down syndrome patients 年龄对小儿唐氏综合征患者先天性鼻泪管阻塞探查和支架插管结果的影响。

IF 1.2 4区医学

Journal of Aapos Pub Date : 2024-10-01 DOI: 10.1016/j.jaapos.2024.104010

Yulia Haraguchi BA , Zeina Salem MD , Noor Ghali MS , Arianne Zeng BS , Faruk H. Örge MD

{"title":"The effect of age on congenital nasolacrimal duct obstruction probing and stent intubation outcomes in pediatric Down syndrome patients","authors":"Yulia Haraguchi BA , Zeina Salem MD , Noor Ghali MS , Arianne Zeng BS , Faruk H. Örge MD","doi":"10.1016/j.jaapos.2024.104010","DOIUrl":"10.1016/j.jaapos.2024.104010","url":null,"abstract":"<div><h3>Purpose</h3><div>To examine the effect of age at time of congenital nasolacrimal duct obstruction (CNLDO) intervention on symptom resolution and reoperation rates in patients with Down syndrome (DS).</div></div><div><h3>Methods</h3><div>The medical records of patients with DS and CNLDO between 2012 and 2021 were reviewed retrospectively. Age at the time of first stent placement was utilized to categorize patients into age groups <3 and >3 years of age. Epiphora resolution at last office visit and restenting rate were used as outcome measures.</div></div><div><h3>Results</h3><div>A total of 49 patients with DS and CLNDO were identified between 2012 and 2021; of these, 17 had received surgical stent placement with appropriate follow-up. Epiphora resolution (<em>X</em><sup><em>2</em></sup><sub><em>1</em></sub> <em>=</em> 0.78, <em>P</em> = 0.33), restenting rate (<em>X</em><sup><em>2</em></sup><sub><em>1</em></sub> = 2.84, <em>P</em> = 0.09), cumulative stent duration (<em>P</em> = 0.33) and number of stent placement operations (<em>P</em> = 0.98) were not significantly different between the age groups. There was no significant difference between stent duration <1 year or >1 year with regard to epiphora resolution (<em>X</em><sup><em>2</em></sup><sub><em>1</em></sub> = 0.91, <em>P</em> = 0.34).</div></div><div><h3>Conclusions</h3><div>Success of stent placement and reoperation rates among patients with DS and CNLDO were not associated with age and duration of stent intubation. Intervention at later ages may still be beneficial for symptom resolution in patients with DS.</div></div>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"28 5","pages":"Article 104010"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant molluscum contagiosum with preseptal cellulitis 巨型软疣伴有隔前蜂窝织炎。

IF 1.2 4区医学

Journal of Aapos Pub Date : 2024-10-01 DOI: 10.1016/j.jaapos.2024.103989

Amitouj S. Sidhu BMed, MD , Josefina Herrera MD , Shereen Aiyub MD, MMed , Nicole S. Graf FRCPA , Trent Sandercoe PhD, FRANZCO , Krishna Tumuluri FRANZCO

引用次数: 0

The use of trypan blue to enhance intraoperative visualization during congenital lacrimal fistulectomy 在先天性泪道瘘管切除术中使用胰蓝增强术中可视性。

IF 1.2 4区医学

Journal of Aapos Pub Date : 2024-10-01 DOI: 10.1016/j.jaapos.2024.104016

Omar Solyman MD, FRCS , Abdelrahman M. Elhusseiny MD, MSc , Richard C. Allen MD, PhD

引用次数: 0