年龄对小儿唐氏综合征患者先天性鼻泪管阻塞探查和支架插管结果的影响。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 DOI:10.1016/j.jaapos.2024.104010

Yulia Haraguchi BA , Zeina Salem MD , Noor Ghali MS , Arianne Zeng BS , Faruk H. Örge MD

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引用次数: 0

摘要

目的：研究先天性鼻泪管阻塞（CNLDO）干预时的年龄对唐氏综合征（DS）患者症状缓解和再次手术率的影响：方法：对2012年至2021年间唐氏综合征和先天性鼻泪管阻塞患者的病历进行回顾性研究。首次放置支架时的年龄被用来将患者划分为 3 岁年龄组。结果显示，共有 49 名 DS 和 CNLDO 患者接受了支架植入治疗：结果：2012 年至 2021 年间，共发现了 49 例 DS 和 CLNDO 患者；其中 17 例接受了手术支架置入并进行了适当的随访。不同年龄组的外虹膜消退率（X21=0.78，P=0.33）、再支架植入率（X21=2.84，P=0.09）、累计支架植入时间（P=0.33）和支架植入手术次数（P=0.98）无显著差异。支架持续时间 1 年与上睑下垂缓解程度无明显差异（X21 = 0.91，P = 0.34）：结论：DS和CNLDO患者的支架置入成功率和再次手术率与年龄和支架插管持续时间无关。结论：DS 和 CNLDO 患者的支架置入成功率和再次手术率与年龄和支架插管持续时间无关。

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The effect of age on congenital nasolacrimal duct obstruction probing and stent intubation outcomes in pediatric Down syndrome patients

Purpose

To examine the effect of age at time of congenital nasolacrimal duct obstruction (CNLDO) intervention on symptom resolution and reoperation rates in patients with Down syndrome (DS).

Methods

The medical records of patients with DS and CNLDO between 2012 and 2021 were reviewed retrospectively. Age at the time of first stent placement was utilized to categorize patients into age groups <3 and >3 years of age. Epiphora resolution at last office visit and restenting rate were used as outcome measures.

Results

A total of 49 patients with DS and CLNDO were identified between 2012 and 2021; of these, 17 had received surgical stent placement with appropriate follow-up. Epiphora resolution (X²₁ = 0.78, P = 0.33), restenting rate (X²₁ = 2.84, P = 0.09), cumulative stent duration (P = 0.33) and number of stent placement operations (P = 0.98) were not significantly different between the age groups. There was no significant difference between stent duration <1 year or >1 year with regard to epiphora resolution (X²₁ = 0.91, P = 0.34).

Conclusions

Success of stent placement and reoperation rates among patients with DS and CNLDO were not associated with age and duration of stent intubation. Intervention at later ages may still be beneficial for symptom resolution in patients with DS.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.