一名12岁女孩的alk阳性间变性大细胞淋巴瘤最初诊断为神经结节病。

IF 1.2 4区医学 Q3 OPHTHALMOLOGY

Journal of Aapos Pub Date : 2025-02-01 DOI:10.1016/j.jaapos.2024.104098

Camille P. Hicks MD , Lauren K. Eng MD , Heather L. Valdin MD , Molly E. Sonenklar MD , Anita D. Dhanrajani MBBS , Estelle Oertling MD , Alejandro Leon MD

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引用次数: 0

摘要

我们报告一例罕见的视神经病变，由间变性淋巴瘤激酶阳性（ALK+）间变性大细胞淋巴瘤（ALCL）伴视神经浸润引起，患者为一名12岁女孩，因椎间盘水肿两次住院治疗后出现急性单侧视力丧失、复视和头痛。她有一个假定的诊断为神经结节病和经验性治疗已开始与高剂量皮质类固醇。持续恶化的视力促使我们的设施。颈部淋巴结活检组织病理学检查显示ALK+ ALCL伴中枢神经系统受累。病人开始化疗后视力恢复了。本病例强调了视神经炎鉴别时考虑恶性肿瘤的重要性。

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ALK-positive anaplastic large cell lymphoma initially diagnosed as neurosarcoidosis in a 12-year-old girl

We present a rare case of optic neuropathy due to anaplastic lymphoma kinase–positive (ALK+) anaplastic large cell lymphoma (ALCL) with optic nerve infiltration in a 12-year-old girl who presented with acute unilateral vision loss, diplopia, and headache after two prior hospitalizations at an outside facility for disk edema. She had a presumptive diagnosis of neurosarcoidosis and empiric treatment had been initiated with high-dose corticosteroids. Ongoing worsening of vision prompted presentation at our facility. Histopathological examination from a cervical lymph node biopsy revealed ALK+ ALCL with central nervous system involvement. The patient’s vision returned after initiation of chemotherapy. This case highlights the importance of considering malignancy in the differential for optic neuritis.

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来源期刊

Journal of Aapos 医学-小儿科

CiteScore

2.40

自引率

12.50%

发文量

159

审稿时长

55 days

期刊介绍： Journal of AAPOS presents expert information on children''s eye diseases and on strabismus as it affects all age groups. Major articles by leading experts in the field cover clinical and investigative studies, treatments, case reports, surgical techniques, descriptions of instrumentation, current concept reviews, and new diagnostic techniques. The Journal is the official publication of the American Association for Pediatric Ophthalmology and Strabismus.