Journal of Aapos最新文献_第5页

Increase in blood derived mitochondrial DNA copy number in strabismus patients. 斜视患者血液中线粒体 DNA 拷贝数的增加。

IF 1.2 4区医学

Journal of Aapos Pub Date : 2024-12-01 Epub Date: 2024-11-13 DOI: 10.1016/j.jaapos.2024.104042

Zainab Zehra, Muhammad Amn Zia, Sorath Noorani Siddiqui, Christopher S von Bartheld, Maleeha Azam, Raheel Qamar

{"title":"Increase in blood derived mitochondrial DNA copy number in strabismus patients.","authors":"Zainab Zehra, Muhammad Amn Zia, Sorath Noorani Siddiqui, Christopher S von Bartheld, Maleeha Azam, Raheel Qamar","doi":"10.1016/j.jaapos.2024.104042","DOIUrl":"10.1016/j.jaapos.2024.104042","url":null,"abstract":"Background: Abnormalities in mitochondrial energy homeostasis can lead to various disorders, including ocular motility aberrations. Previous studies have suggested the involvement of mitochondrial aberrations in strabismus etiology. We compared the blood-derived mitochondrial DNA (mtDNA) copy number from comitant strabismus patients with that from age-matched controls, and also compared expression of mitochondrial biogenesis genes in a separate set of extraocular muscle samples from strabismic and control subjects.Methods: Blood samples from 93 strabismic (39 esotropic, 54 exotropic) and 93 control subjects were analyzed for mtDNA copy number through quantitative polymerase chain reaction. We also examined the expression of 6 genes involved in mitochondrial biogenesis in cDNA obtained from extraocular muscles of a separate group of 26 strabismus patients and 4 healthy controls.Results: The mtDNA content was significantly higher in strabismus patients as compared to the control group, both overall (fold change, 1.39; Z = -2.43 [P = 0.01]) and in strabismus subgroups (esotropia: fold change,1.42; Z = 2.59 [P = 0.0096]; exotropia: fold change, 1.41, Z = 3.35 [P = 0.00078]). No significant difference was observed in the expression of the examined biogenesis genes between strabismus and control groups.Conclusions: Our results suggest an association between mtDNA copy number and strabismus; however, further studies are required to elucidate the significance of altered mtDNA in strabismus and its possible significance with regard to the etiology of strabismus.","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104042"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated intraocular pressure in a child with Stickler syndrome after scleral buckle surgery for retinal detachment. 一名患有 Stickler 综合征的儿童在接受巩膜扣带手术治疗视网膜脱离后眼压升高。

IF 1.2 4区医学

Journal of Aapos Pub Date : 2024-12-01 Epub Date: 2024-11-14 DOI: 10.1016/j.jaapos.2024.104043

Abdelrahman M Anter, Seyyedehfatemeh Ghalibafan, Louis Z Cai, Connie M Wu, Elena Bitrian, Nicolas A Yannuzzi

引用次数: 0

Term infant brain MRI after ROP treatment by anti-VEGF injection versus laser therapy. 抗血管内皮生长因子注射与激光疗法治疗视网膜病变后的足月婴儿脑磁共振成像。

IF 1.2 4区医学

Journal of Aapos Pub Date : 2024-12-01 Epub Date: 2024-11-14 DOI: 10.1016/j.jaapos.2024.104038

Monica Manrique, Michael Pham, Sudeepta Basu, Jonathan Murnick, Md Sohel Rana, Taeun Chang, Christabel Chan, Emile Vieta-Ferrer, Catherine Sano, Catherine Limperopoulos, Marijean Miller

{"title":"Term infant brain MRI after ROP treatment by anti-VEGF injection versus laser therapy.","authors":"Monica Manrique, Michael Pham, Sudeepta Basu, Jonathan Murnick, Md Sohel Rana, Taeun Chang, Christabel Chan, Emile Vieta-Ferrer, Catherine Sano, Catherine Limperopoulos, Marijean Miller","doi":"10.1016/j.jaapos.2024.104038","DOIUrl":"10.1016/j.jaapos.2024.104038","url":null,"abstract":"Background: Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) agents is used to treat posterior type 1 retinopathy of prematurity (ROP). Recent reports indicate that anti-VEGF therapy may be associated with white matter brain injury, according to animal studies, and neurodevelopmental impairments in children born preterm. We investigated whether type 1 ROP treated with bevacizumab is associated with structural brain injury on infant term magnetic resonance images (MRIs) in very low birth weight infants compared with those treated with laser ablation.Methods: We retrospectively reviewed the medical records of very low birth weight infants from 2006 to 2021 with type 1 ROP who had been treated with laser or anti-VEGF therapy. Intravitreal bevacizumab injection was used for type 1 ROP in zone 1 or very posterior zone 2 or when laser treatment was not feasible. A pediatric neuroradiologist reviewed brain MRIs at term equivalent age (36-46 weeks' postmenstrual age) and classified infants for severity (no/mild vs moderate/severe) of overall brain and white matter injury using the validated Kidokoro scoring system.Results: Fifty-two infants met inclusion criteria: 35 (67%) treated with laser and 17 (33%) with bevacizumab. Moderate-to-severe brain injury scores were not statistically different between bevacizumab and laser treatment groups in either continuous or binary adjusted analyses, for either the overall score or the white matter subscore.Conclusions: Severity of structural injury on term brain MRI (total and white matter) did not differ between infants with type 1 ROP treated with anti-VEGF agent (bevacizumab) and those treated with laser ablation.","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104038"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Access to vision care for children from immigrant and nonimmigrant households: evidence from the National Survey of Children's Health 2018-2019. 移民和非移民家庭儿童获得视力保健的机会：来自 2018-2019 年全国儿童健康调查的证据。

IF 1.2 4区医学

Journal of Aapos Pub Date : 2024-12-01 Epub Date: 2024-11-14 DOI: 10.1016/j.jaapos.2024.104044

Afua O Asare, Brian C Stagg, Carole Stipelman, Heather T Keenan, Melissa Watt, Guilherme Del Fiol, Marielle P Young, Justin D Smith

{"title":"Access to vision care for children from immigrant and nonimmigrant households: evidence from the National Survey of Children's Health 2018-2019.","authors":"Afua O Asare, Brian C Stagg, Carole Stipelman, Heather T Keenan, Melissa Watt, Guilherme Del Fiol, Marielle P Young, Justin D Smith","doi":"10.1016/j.jaapos.2024.104044","DOIUrl":"10.1016/j.jaapos.2024.104044","url":null,"abstract":"Purpose: To investigate whether immigrant generation is associated with caregiver-reported receipt of vision testing.Methods: Nationally representative data from the 2018-2019 National Survey of Children's Health was used. The primary exposure was immigrant generation, with first generation defined as child and all reported parents born outside the United States; second generation, as child born in the United States but at least one parent born outside the United States; and third generation, as all parents in the household born in the United States. The main outcome was caregiver-reported vision testing during the previous 12 months. Odds ratios adjusted for sociodemographic characteristics and 95% confidence intervals were computed based on immigrant generation.Results: The sample included 49,442 US children 3-17 years of age. The proportion of children who had vision testing in any setting was lower for first- (60.3%) than third-generation children (74.6%; aOR = 0.54; 95% CI, 0.41-0.71). This association remained after excluding children without health coverage. For Hispanic children, both first- (aOR = 0.58; 95% CI, 0.36-0.94) and second-generation children (aOR = 0.73; 95% CI, 0.55-0.96) had lower odds of a vision test in any setting compared with third-generation Hispanic children.Conclusions: First-generation children had lower odds of vision testing than third-generation children, even when adjusting for sociodemographic characteristics, especially in Hispanic households.","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"104044"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of infantile acute polymicrobial dacryocystitis due to Serratia marcescens, Haemophilus aphrophilus, and Prevotellaintermedia. 一例罕见的婴幼儿急性多菌性泪囊炎病例，病原体包括大肠沙雷氏菌、阿弗氏嗜血杆菌和中间普雷沃特氏菌。

IF 1.2 4区医学

Journal of Aapos Pub Date : 2024-12-01 Epub Date: 2024-10-16 DOI: 10.1016/j.jaapos.2024.104019

Marina Shenouda, Agni Kakouri, Timothy J McCulley, Ying Chen

引用次数: 0

Acute and chronic optical coherence tomography findings in partial optic nerve head avulsion. 视神经头部分撕脱的急性和慢性光学相干断层扫描结果。

IF 1.2 4区医学

Journal of Aapos Pub Date : 2024-11-26 DOI: 10.1016/j.jaapos.2024.104060

Hari R Anandarajah, Steven Seto, Roxana Y Godiwalla, Smith Ann M Chisholm, Judy E Kim, Ryan D Walsh

引用次数: 0

Ocular manifestations of SREBF1-associated hereditary mucoepithelial dysplasia. SREBF1相关遗传性粘液上皮发育不良的眼部表现。