Journal of Clinical Densitometry最新文献

{"title":"Graves' disease and bone mineral density: a scoping review of the impact of graves’ disease on spinal health","authors":"Mira Al Shoufy ,&nbsp;Jamil Nasrallah ,&nbsp;Kholoud Al Jebawi ,&nbsp;Hady El Etry ,&nbsp;Murtaja Satea Shafeea ,&nbsp;Ibrahim Hassan ,&nbsp;Haya Mohamed ,&nbsp;Naseeb Danaf ,&nbsp;Hossam Tharwat Ali","doi":"10.1016/j.jocd.2025.101621","DOIUrl":"10.1016/j.jocd.2025.101621","url":null,"abstract":"<div><div>Graves' disease, an autoimmune hyperthyroid disorder, negatively affects bone health by increasing osteoclast activity, leading to decreased bone mineral density (BMD) and heightened osteoporosis risk. Bone loss may persist even after thyroid levels normalize, possibly due to thyroid-stimulating hormone receptor antibodies (TRAb). This scoping review evaluates the impact of Graves' disease and its treatment on BMD, focusing on TRAb's role in bone loss. Using Arksey and O’Malley's framework, we searched Medline/PubMed, Scopus, Web of Science, and Cochrane Library for English-language studies on the effects of Graves' disease on adult spine-related bone health. From 2,226 records, 16 studies met the inclusion criteria after screening titles, abstracts, and full texts. Studies focusing primarily on postmenopausal women and older men consistently showed reduced BMD in patients with Graves' disease, especially in the lumbar spine. Elevated TRAb levels correlated with lower BMD, suggesting that TRAb contributes to ongoing bone loss despite achieving an euthyroid state. Anti-thyroid drug therapy partially improved BMD, but bone loss often persisted. Combining bisphosphonates with anti-thyroid therapy enhanced BMD recovery more than anti-thyroid therapy alone. Graves' disease affects bone health through thyroid hormone excess and TRAb-mediated autoimmunity, with persistent bone loss even after achieving an euthyroid state. High-risk groups like postmenopausal women and older men require targeted strategies addressing both thyroid and skeletal health. Future research should focus on therapies targeting TRAb and improving osteoporosis prevention to enhance outcomes.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101621"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145435550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reframing the BMI–BMD–TBS triad in type 2 diabetes: Clinical and policy implications","authors":"Amit Kumar Gupta,&nbsp;Anusha Putcha,&nbsp;Varshini Vadhithala,&nbsp;Sachin Kumar","doi":"10.1016/j.jocd.2025.101659","DOIUrl":"10.1016/j.jocd.2025.101659","url":null,"abstract":"","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101659"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic and body composition alterations in normal-weight adults with prediabetes: A DEXA-based analysis","authors":"Sami Bahçebaşı ,&nbsp;Banu Açmaz ,&nbsp;Ahmet Savranlar","doi":"10.1016/j.jocd.2025.101662","DOIUrl":"10.1016/j.jocd.2025.101662","url":null,"abstract":"<div><div><em>Introduction:</em> This study examines clinical, biochemical, and body composition differences between healthy and prediabetic normal-weight individuals (BMI 18.5-24.9 kg/m²), with a focus on central fat distribution.</div><div><em>Methods:</em> Sixty participants (30 prediabetic, 30 healthy) underwent clinical evaluations, including body composition analysis using DEXA.</div><div><em>Results:</em> <strong>• Women:</strong> Multivariate regression analysis demonstrated that the android-to-gynoid fat ratio remained an independent and significant predictor of prediabetes (<em>p</em> = 0.014).</div><div><strong>• Men:</strong> GFR and creatinine levels were significantly impaired (<em>p</em> = 0.008, <em>p</em> = 0.019). Central fat distribution, especially trunk fat, correlated with fasting glucose, although this association lost significance after age adjustment.</div><div><em>Discussion:</em> In women, prediabetes is associated with impaired glucose metabolism and central fat accumulation, particularly reflected by an elevated DEXA-derived android/gynoid fat ratio, highlighting a “normal-weight obesity” phenotype even in individuals with normal BMI. In men, central fat distribution, especially the trunk-to-limb fat ratio, is linked to glucose metabolism; however, this relationship diminishes after adjusting for age, suggesting that age-related fat redistribution may modulate metabolic risk. Additionally, early renal dysfunction, as indicated by reduced eGFR, is evident in men with prediabetes<strong>,</strong> underscoring the importance of comprehensive metabolic and renal assessment. These findings emphasize the clinical relevance of body composition–based screening<strong>,</strong> particularly using DEXA-derived regional fat ratios, to identify high-risk normal-weight individuals and enable timely preventive interventions.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101662"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Danish Nationwide osteoporosis cohort trials environment (NOCTE) – a DXA dataset for the 1900-1960 birth cohort","authors":"Benjamin Bakke Hansen ,&nbsp;Bryan Haddock ,&nbsp;Niklas Rye Jørgensen ,&nbsp;Peter Vestergaard ,&nbsp;Uffe Kock Wiil ,&nbsp;Lars Folkestad ,&nbsp;Sören Möller ,&nbsp;Nicholas Fuggle ,&nbsp;Bente Langdahl ,&nbsp;Katrine Hass Rubin ,&nbsp;Bo Abrahamsen","doi":"10.1016/j.jocd.2025.101653","DOIUrl":"10.1016/j.jocd.2025.101653","url":null,"abstract":"<div><div><em>Background:</em> Osteoporosis is a common, underdiagnosed condition causing increased risk of fracture. While dual-energy X-ray absorptiometry (DXA) is the diagnostic standard, this may not be successfully targeted to individuals at the highest risk. This study presents an extensive nationwide dataset characterizing DXA-scanning practices in Denmark.</div><div><em>Methodology:</em> In this study, we identified all Danish residents from the birth cohort 1900-1960, with a first DXA scan between 2010-2022 to form the Nationwide Osteoporosis Cohort Trials Environment (NOCTE) dataset. These individuals were matched 1:5 to a non-scanned reference population by birth year, sex, and region of residence. Individual data were linked to national registers for comprehensive sociodemographic and clinical information.</div><div><em>Results:</em> The final cohort included 263,651 individuals who underwent DXA scanning. At their first scan, 33% of women and 17% of men had osteoporosis. Compared to the matched reference, the scanned cohort had similar socioeconomic profiles but substantially different clinical profiles. Scanned individuals had a much higher prevalence of prior major osteoporotic fractures, prior systemic glucocorticoid exposure, and overall comorbidity burden.</div><div><em>Conclusion:</em> Referral for DXA in Denmark is driven by clinical risk rather than socioeconomic status, reflecting an equitable resource allocation. However, a significant diagnostic gap persists, as many high-risk individuals with prior fractures did not receive a DXA. The NOCTE cohort is a new, powerful resource for developing strategies to help close this gap.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101653"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative diagnostic performance of dual-energy X-ray absorptiometry and other radiological modalities in osteoporosis detection: a systematic review","authors":"Siraj Fahad Wally ,&nbsp;Muwaffaq F. Wali ,&nbsp;Osama Adnan Hariri ,&nbsp;Rasha E. Alotiabi ,&nbsp;Badr K Waked ,&nbsp;Najla M. Almudayni ,&nbsp;Faisal M. Khashab ,&nbsp;Batool A. Alshahrani ,&nbsp;Khalid M. Aljaaly ,&nbsp;Abdulrahman O. Alzahrani","doi":"10.1016/j.jocd.2025.101637","DOIUrl":"10.1016/j.jocd.2025.101637","url":null,"abstract":"<div><div>A serious worldwide health issue, osteoporosis is characterized by weakened bones and a higher risk of fracture. Though alternative imaging modalities like quantitative ultrasound (QUS), radiographic absorptiometry (RA), quantitative computed tomography (QCT), and radiofrequency echographic multispectrometry (REMS) have emerged as viable diagnostic or screening tools, dual-energy X-ray absorptiometry (DEXA) is still the gold standard for measuring bone mineral density (BMD). The purpose of this systematic review was to evaluate the clinical usefulness, diagnostic accuracy, and dependability of different radiographic modalities for osteoporosis detection. In order to find papers published between 2001 and 2023 comparing DEXA with other radiographic modalities for osteoporosis diagnosis, a thorough search of the PubMed, Scopus, and ScienceDirect databases was undertaken. There were ten studies that qualified. Study design, demographic characteristics, imaging methods, diagnostic thresholds, and performance metrics (sensitivity, specificity, and correlation coefficients) were among the data that were extracted. Across studies, DEXA consistently demonstrated high precision and strong correlation with fracture risk, confirming its role as the reference standard. QUS showed moderate agreement with DEXA, supporting its use as a screening tool but not for diagnostic confirmation. RA provided good reproducibility but lower sensitivity compared with DEXA. QCT exhibited superior sensitivity (up to 91%) and early trabecular bone detection but was limited by higher cost and radiation exposure. Emerging evidence for REMS demonstrated strong correlation with DEXA (r = 0.85–0.90), comparable diagnostic accuracy, and the advantage of being radiation-free and portable. DEXA remains the gold standard for osteoporosis diagnosis; however, QCT and REMS show promising diagnostic accuracy and may complement DEXA for early detection and longitudinal monitoring. QUS and RA can serve as cost-effective screening tools, particularly in settings where DEXA is unavailable. Further large-scale, prospective studies with standardized diagnostic thresholds are needed to validate these findings and optimize imaging strategies for osteoporosis management.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101637"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145514708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between changes in calcium concentration and bone mineral density by anti-bone resorptive therapy","authors":"Akira Horikawa ,&nbsp;Yuji Kasukawa ,&nbsp;Michio Hongo ,&nbsp;Akihisa Sano ,&nbsp;Naohisa Miyakoshi","doi":"10.1016/j.jocd.2025.101642","DOIUrl":"10.1016/j.jocd.2025.101642","url":null,"abstract":"<div><div><em>Background:</em> Hypocalcemia after initiating antiresorptive therapy is well documented, but the association between early changes in serum-corrected calcium (Ca) concentration and long-term bone mineral density (BMD) response in osteoporosis remains unclear. This study compared early Ca changes and BMD outcomes in patients treated with zoledronic acid or denosumab.</div><div><em>Methodology:</em> In this retrospective study, 67 outpatients with osteoporosis received either zoledronic acid (n = 25) or denosumab (n = 42). Baseline BMD, serum-corrected Ca concentration, bone turnover markers, estimated glomerular filtration rate (eGFR), and 25-hydroxyvitamin D [25(OH)D] were recorded. Serum-corrected Ca concentration and eGFR were reassessed at 1 week, 6 months, and 12 months and BMD was measured at baseline, 6 months, and 12 months. To prevent hypocalcemia, patients received different vitamin D regimens according to standard practice (active vitamin D3 for zoledronic acid and combined natural and active vitamin D for denosumab). Multivariate regression has been adjusted for age, baseline BMD, 25(OH)D, eGFR, and TRACP-5b.</div><div><em>Results:</em> A significant decrease in serum-corrected Ca at 1 week was observed in both groups. The magnitude of this decrease was negatively associated with lumbar spine BMD change at 12 months (zoledronic acid: r = −0.59, p = 0.0077; denosumab: r = −0.52, p = 0.0067). This association remained significant after multivariate adjustment. ROC analysis showed that Ca decrease predicted greater BMD gains (AUC 0.909 for zoledronic acid and AUC 0.81 for denosumab), but these results should be interpreted with caution due to the small sample size and different vitamin D regimens.</div><div><em>Conclusions:</em> Early decreases in serum-corrected Ca concentration after antiresorptive therapy were associated with greater BMD gains at 12 months, independent of baseline vitamin D, renal function, and bone turnover markers. This study is exploratory and preliminary in nature, and its findings should be interpreted with caution.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101642"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145551600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing the effect of osteoporosis drug treatments on femoral strength using 3D-DXA finite elements modelling","authors":"Carlos Ruiz Wills ,&nbsp;Muhammad Qasim ,&nbsp;Renaud Winzenrieth ,&nbsp;Silvana Di Gregorio ,&nbsp;Luis Del Río ,&nbsp;Ludovic Humbert ,&nbsp;Jérôme Noailly","doi":"10.1016/j.jocd.2025.101663","DOIUrl":"10.1016/j.jocd.2025.101663","url":null,"abstract":"<div><div>Osteoporotic hip fracture represents a high social and economic burden in western countries. Pharmacological treatments aim to limit/reverse the loss of bone mineral density (BMD). BMD is monitored through dual energy X-ray absorptiometry (DXA). Biomechanical analysis, through 3D-DXA finite element (FE) femur models, has been shown to potentially improve fracture risk prediction. Yet, the capability of 3D-DXA FE simulations to capture the effects of pharmacological treatments on bone strength remains unexplored. Thus, this study aims to evaluate simulated changes in bone strength in subjects with different osteoporosis treatments using 3D-DXA FE models. A cohort of 155 subjects was used to generate the patient-specific FE models. Osteoporosis treatments included Alendronate (AL, <em>n</em> = 54), Denosumab (DMAB, <em>n</em> = 33), Teriparatide (TPTD, <em>n</em> = 31), and Naïve (NAÏVE, <em>n</em> = 37). Bone was modelled as BMD-dependent elasto-plastic material. Lateral fall was simulated, and bone FE-strength changes from baseline were assessed. Integral FE-strength significantly increased by 3.1% and 4.0% in the AL and DMAB groups, respectively. Trabecular and cortical FE-strength significantly increased by 2.2% and 1.9%, respectively with DMAB. Load-bearing capacity increased in both the cortical and trabecular bone of the femoral neck with DMAB and AL, while it only increased in the trabecular bone with TPTD. 3D-DXA FE analysis might help clinicians to better monitor the effects of pharmacological treatments and potentially improve personalised treatment plans for subjects with osteoporosis.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101663"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoporosis prediction from Frontal Lumbar Spine X-rays","authors":"Ryusei Inamori ,&nbsp;Tomoya Kobayashi ,&nbsp;Eichi Takaya ,&nbsp;Junya Iwazaki ,&nbsp;Carlos Makoto Miyauchi ,&nbsp;Saori Ikumi ,&nbsp;Yoshikazu Okamoto ,&nbsp;Cheng Wei Lin ,&nbsp;Sheng Che Hsiao ,&nbsp;Qingzong Tseng ,&nbsp;Shinya Sonobe","doi":"10.1016/j.jocd.2025.101666","DOIUrl":"10.1016/j.jocd.2025.101666","url":null,"abstract":"<div><div><em>Background:</em> This study aimed to evaluate the performance of DeepXray™ Spina, a software that estimates bone mineral density (BMD) and T-scores from frontal lumbar spine X-ray (FLS-X), in predicting osteoporosis.</div><div><em>Methodology:</em> Patients from a Japanese cohort who underwent both FLS-X and dual-energy X-ray absorptiometry (DXA) using Hologic systems within 30 days at Tohoku University Hospital (May 2014-April 2024) were included. BMD was estimated from FLS-X using DeepXray™ Spina, which was developed using dataset from a Taiwanese Cohort. BMD assessed by DXA (observed BMD) and BMD estimated from FLS-X by DeepXray™ Spina (estimated BMD) were compared using Pearson’s correlation coefficient (PCC) and normalized root mean square error (NRMSE). T-scores were converted to osteoporosis classifications as normal, osteopenia, or osteoporosis following the World Health Organization criteria. Classification performance was evaluated by accuracy, sensitivity, specificity, Cohen’s kappa, and quadratic-weighted Cohen’s kappa.</div><div><em>Results:</em> The correlation between estimated and observed BMD was strong, with a PCC of 0.901 and an NRMSE of 0.070. For osteoporosis classification, the accuracy, sensitivity, specificity, and Cohen’s kappa were as follows: 0.902, 1.000, 0.842, and 0.803 for normal; 0.854, 0.729, 0.924, and 0.673 for osteopenia; 0.951, 0.810, 1.000, and 0.863 for osteoporosis. The quadratic-weighted Cohen’s kappa was 0.884.</div><div><em>Conclusion:</em> This study evaluated the performance of Deep Xray™ Spina in predicting osteoporosis from FLS-X. The software is a practical and reliable tool for predicting osteoporosis, with high performance and robustness.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101666"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual estimation of vertebral marrow fat on lumbar MRI as a screening tool for osteoporosis: A retrospective study","authors":"Liqa A Rousan ,&nbsp;Naser Obeidat ,&nbsp;Nour Abdo ,&nbsp;Tarek Ajam ,&nbsp;Hamzeh Al-Zoubi ,&nbsp;Leena Alshira’h ,&nbsp;Hamad Saif ,&nbsp;Abdulla Albaqshi ,&nbsp;Khaled J Zaitoun","doi":"10.1016/j.jocd.2025.101658","DOIUrl":"10.1016/j.jocd.2025.101658","url":null,"abstract":"<div><div><em>Background:</em> Osteoporosis is the most common metabolic bone disease in the elderly. This study aimed to assess whether routine T1-weighted MR images can visually indicate the presence of osteoporosis by estimating vertebral bone marrow fat content.</div><div><em>Methods:</em> Lumbar spine MRI and DEXA scans from 320 patients (performed within a 6-month interval) were retrospectively reviewed. Two radiologists independently graded the percentage of high T1 signal within the L4 vertebral body into &lt;50 % or ≥50 %, representing marrow fat content. Visual fat scores were compared with T-scores from DEXA scans. Inter-reader agreement was assessed using Cohen's and Fleiss' kappa statistics. Spearman’s correlation was used to evaluate the association between MRI grading and DEXA scores.</div><div><em>Results:</em> Of the 320 patients (mean age 56.8 years; 80.3 % female), 48.4 % had osteopenia or osteoporosis. Visual MRI grading yielded 141 patients with &lt;50 % and 179 with ≥50 % marrow fat. A weak but statistically significant correlation was observed between MRI visual fat scores and DEXA T-scores (ρ = 0.139, <em>p</em> = 0.013). Inter-reader agreement was moderate (Cohen’s kappa = 0.509, 95 % CI: 0.415 to 0.603).</div><div><em>Conclusion:</em> Routine T1-weighted lumbar spine MRI may serve as an opportunistic screening tool for osteoporosis. Visual estimation of vertebral marrow fat content shows potential to identify patients who may benefit from further DEXA evaluation.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101658"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145839786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Antihypertensive Drugs and Osteoporosis in Postmenopausal Women: The ADiOS Study","authors":"Pelin Analay ,&nbsp;Murat Kara ,&nbsp;Hatice Gülgün Fırat ,&nbsp;Ahmet Furkan Çolak ,&nbsp;Kübra Erdoğan ,&nbsp;Mahmud Fazıl Aksakal ,&nbsp;Berkay Yalçınkaya ,&nbsp;Kübranur Demirel ,&nbsp;Hazal Sevinç ,&nbsp;Sena Küçüktoksöz ,&nbsp;Hilmi Berkan Abacıoğlu ,&nbsp;Mustafa Güngör Albayrak ,&nbsp;Alpaslan Fatih Kaynar ,&nbsp;Orhun Tunahan Cingöz ,&nbsp;Ahmad Jasem Abdulsalam ,&nbsp;Özgür Kara ,&nbsp;Ahmet Sertçelik ,&nbsp;Bayram Kaymak ,&nbsp;Banu Çakır ,&nbsp;Levent Özçakar","doi":"10.1016/j.jocd.2025.101607","DOIUrl":"10.1016/j.jocd.2025.101607","url":null,"abstract":"<div><div><em>Introduction:</em> Hypertension (HT) and osteoporosis (OP) are common chronic diseases that often coexist in postmenopausal women. This study aimed to investigate the association between the use of antihypertensive medications and the presence of OP.</div><div><em>Methods:</em> We retrospectively analyzed the medical records of 4166 postmenopausal women. Demographic data, age, weight, height, comorbidities, medications and bone mineral density values were collected for all patients screened/followed for OP between 2023 and 2024.</div><div><em>Results:</em> Out of 4166 postmenopausal women, 1659 (39.8 %) were diagnosed with OP. After adjusting for potential confounders using binary logistic regression, diabetes mellitus [OR=0.785 (95 % CI=0.667-0.925) <em>p = </em>0.004] and hyperlipidemia [OR=0.826 (95 % CI=0.698-0.978) <em>p = </em>0.026] were negatively associated with OP. Among the antihypertensive medications (<em>N = </em>2144); furosemide use [OR=1.918 (95 % CI=1.157-3.182) <em>p = </em>0.012] was positively associated with OP, while thiazide use showed a negative association [OR=0.769 (95 % CI=0.619-0.954) <em>p = </em>0.017].</div><div><em>Conclusions:</em> Thiazide use was associated with a lower likelihood of OP, while furosemide use was linked to increased odds (about 1.9 times). Further research with larger samples and stratified analyses of antihypertensive classes is warranted to better understand these associations.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 4","pages":"Article 101607"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144711872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}