Journal of Clinical Densitometry最新文献

{"title":"Mobile home exercise application accelerating bone mineral density among postmenopausal osteoporosis Japanese women with bazedoxifene: An open-label, non-randomized, pilot study","authors":"Yohei Yamamoto ,&nbsp;Daisuk Inoue ,&nbsp;Reiko Inoue ,&nbsp;Kazuhide Inage ,&nbsp;Yasuaki Murata ,&nbsp;Tomonori Shigemura ,&nbsp;Miki Morimoto ,&nbsp;Kenta Kono ,&nbsp;Yusuke Rokuta","doi":"10.1016/j.jocd.2025.101639","DOIUrl":"10.1016/j.jocd.2025.101639","url":null,"abstract":"<div><div><em>Objectives:</em> This study developed a home exercise application, LongLifeSupport, which provides basic daily exercise videos and an automatic recording calendar. Exercise plays an important role in bone health, as it positively influences bone mineral density (BMD). However, its effects on drug treatment remain unclear. This pilot study aimed to determine the effects of exercise on BMD, quality of life (QOL), and physical function among patients with osteoporosis.</div><div><em>Methods:</em> Fifty patients with untreated osteoporosis were included, non-randomized, and equally divided into two groups: the application group or the pamphlet group. Both groups started bazedoxifene treatment and exercised for 52 weeks. At 24 and 52 weeks, we assessed BMD (lumbar spine, femoral neck, and total hip), serum parameters, EuroQol five dimensions (EQ-5D), short physical performance battery score, and short test battery score for locomotive syndrome.</div><div><em>Results:</em> At 52 weeks, the percentage changes from baseline in femoral neck and total hip BMD (5.6% and 2.5%, respectively) were significantly greater in the application group than in the pamphlet group (2.1% and 1.0%, respectively). The application group revealed a significantly higher adherence rate (70.8%) compared to the pamphlet group (52.2%) and significant improvements between baseline and 52 weeks in the EQ-5D visual analog scale, two-step test (stage and value) using a short test battery for locomotive syndrome, and chair stand seconds of the short physical performance battery.</div><div><em>Conclusions:</em> Home exercise with bazedoxifene significantly improved BMD, QOL, and physical ability compared to pamphlets. Hence, this application provides an effective exercise program and may be utilized for elderly women with osteoporosis.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101639"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145514682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence and persistence of daily and twice-weekly teriparatide treatment in postmenopausal women with high-risk of fracture","authors":"Takeshi Mochizuki ,&nbsp;Koichiro Yano ,&nbsp;Katsunori Ikari ,&nbsp;Ken Okazaki","doi":"10.1016/j.jocd.2025.101641","DOIUrl":"10.1016/j.jocd.2025.101641","url":null,"abstract":"<div><div><em>Background:</em> This study aimed to determine the differences in adherence and persistence between a daily and twice-weekly teriparatide regimens in postmenopausal women at high risk of fracture.</div><div><em>Methods:</em> Ninety-eight postmenopausal women diagnosed with a high risk for fractures were enrolled and randomized into two groups to receive daily (D-TPTD) or twice-weekly (TW-TPTD) teriparatide. Adherence, measured using the medication possession ratio (MPR), and persistence were measured for both groups. MPR was calculated as the number of days the patient was actually covered by the administered medication divided by the number of days of the study period, which was theoretically 24 months.</div><div><em>Results:</em> The persistence rates at 24 months in the <span>d</span>-TPTD and TW-TPTD groups were 66.7 % and 59.6 %, respectively, with no significant difference between the two. Additionally, adherence and persistence in patients without vertebral fracture at baseline were lower than those with vertebral fracture. In the Cox proportional hazards analysis, treatment persistence in patients without vertebral fracture was lower than that in patients with vertebral fracture (<em>p</em> = 0.027; hazard ratio, 0.369; 95 % confidence intervals, 0.15–0.89).</div><div><em>Conclusion:</em> There was no difference in adherence and persistence between the two groups at 24 months after treatment initiation. High adherence and retention to teriparatide can be expected in postmenopausal women at a high risk of vertebral fractures.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101641"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145551572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference data for peripheral quantitative computed tomography for assessment of bone geometry and strength in Indian children and youth","authors":"Anuradha Khadilkar ,&nbsp;Chirantap Oza ,&nbsp;Neha Kajale ,&nbsp;Vaman Khadilkar ,&nbsp;Alex Ireland ,&nbsp;Dipali Ladkat ,&nbsp;Vivek Patwardhan ,&nbsp;Raja Padidela ,&nbsp;M. Zulf Mughal","doi":"10.1016/j.jocd.2025.101665","DOIUrl":"10.1016/j.jocd.2025.101665","url":null,"abstract":"<div><div><em>Introduction:</em> Currently, there is a paucity of data for bone geometry and strength parameters for Indian children. This is essential because of differences in stature, body composition, and bone outcomes between Indian children and Western populations on which existing reference data are based. As dual energy X-ray absorptiometry is size dependent, we conducted the present study with the objective of generating age and sex-specific reference centile curves for peripheral quantitative computed tomography (pQCT) for Indian children and adolescents.</div><div><em>Methods:</em> A cross-sectional, observational study was conducted from November 2017 to July 2022 on 961 (501 boys) healthy children aged 8 to 18 years from Pune, India. The XCT-2000 pQCT scanner (Stratec Inc, GmbH, Pforzheim, Germany) was used to measure volumetric trabecular density at 4 % site and volumetric cortical density, polar stress-strain index, cortical thickness, and muscle area at 66 % site of left radius.</div><div><em>Results:</em> We have presented percentile curves for total, trabecular, and cortical density for age, as well as cortical area and cortical thickness for height. A maximum increase in total volumetric density to the preceding age group of 10.7 % was observed in boys at the age of 17 years, whereas a maximum increase of 8 % was observed in girls at the age of 15 years. Average increase in trabecular density was 0.2 % per year. Cortical density was significantly higher in girls (8.7 %) from the age of 13 years as compared to boys. Cortical thickness was significantly higher in girls (13.3 %) as compared to boys at 12 years, while it was higher in boys (9.1 %) at 16 years and 18 years. A steep increase was observed in the cortical area for height and cortical thickness for height in both sexes.</div><div><em>Conclusion:</em> We have established reference curves for pQCT parameters in Indian children and adolescents to aid in the assessment of pediatric bone geometry.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101665"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total-body versus knee-specific dual-energy X-ray absorptiometry scans for assessing bone mineral density surrounding the knee joint in collegiate athletes with and without an anterior cruciate ligament reconstruction","authors":"Keith A. Knurr ,&nbsp;James P. Lyon ,&nbsp;Neil C. Binkley ,&nbsp;Tamara A. Scerpella ,&nbsp;Bryan C. Heiderscheit","doi":"10.1016/j.jocd.2025.101657","DOIUrl":"10.1016/j.jocd.2025.101657","url":null,"abstract":"<div><div>Following anterior cruciate ligament reconstruction (ACLR), athletes demonstrate reduced bone mineral density (BMD) surrounding the knee that persists for years. These changes have been identified using total-body and site-specific dual-energy X-ray absorptiometry (DXA) scans. It is unknown whether these two scan types provide comparable measures of BMD. This study assessed the agreement between total-body and knee-specific DXA scans for measuring BMD of the distal femur and proximal tibia in Division I collegiate athletes with and without an ACLR. We further assessed the influence of surgical hardware on BMD with and without the use of the manual artifact correction tool in athletes post-ACLR. Collegiate athletes (healthy: 46; post-ACLR: 20) were included. Regions of interest (ROI) were placed at the 5 % and 15 % lengths of the distal femur and the proximal tibia to assess BMD of each limb on total-body and knee-specific scans. BMD values for each limb and between-limb asymmetry were compared between scan types at each ROI using Bland-Altman analyses. Mean differences are reported as total-body minus knee-specific values. Total-body scans provided significantly lower BMD than knee-specific scans for all ROIs (-0.102 to -0.038 g/cm², all p-values &lt; 0.01) except for the tibia 5 % (0.047 g/cm², <em>p</em> &lt; 0.01) in healthy athletes. No differences in between-limb asymmetry were detected between scan types in healthy athletes (-0.78 % to 0.56 %; all p-values &gt; 0.11). Athletes post-ACLR had more pronounced differences in BMD between scan types (-0.245 to -0.064 g/cm², all p-values &lt; 0.02) and wider limits of agreement when surgical hardware was present, but this effect was mitigated when the manual artifact correction tool was used to exclude hardware (-0.122 to -0.008 g/cm², p-values from &lt;0.01 to 0.57). Despite differences in absolute BMD, this study supports the use of total-body scans for assessing between-limb asymmetry in knee-specific regions in healthy athletes and in athletes post-ACLR when excluding hardware.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101657"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145684165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Radiation therapy–Associated bone attenuation loss in anorectal cancer: Need for standardized imaging and clinical correlation” [Journal of Clinical Densitometry Volume 28 (2025) 101629]","authors":"Parth Aphale,&nbsp;Himanshu Shekhar,&nbsp;Shashank Dokania","doi":"10.1016/j.jocd.2025.101655","DOIUrl":"10.1016/j.jocd.2025.101655","url":null,"abstract":"","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101655"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone density, structure, and estimated strength in children with congenital heart disease. A CHAMPS* cohort study","authors":"Marta C. Erlandson ,&nbsp;Matthew S. Chapelski ,&nbsp;Chantelle L. Baril ,&nbsp;Charissa Pockett ,&nbsp;Scott Pharis ,&nbsp;Kristi D. Wright ,&nbsp;Corey R. Tomczak","doi":"10.1016/j.jocd.2025.101636","DOIUrl":"10.1016/j.jocd.2025.101636","url":null,"abstract":"<div><div><em>Introduction:</em> Children with congenital heart disease (CHD) have lower levels of physical activity, lower birth weights, and lower nutrient intake compared to their typically developing peers (TDP); which can put children with CHD at increased risk of impaired skeletal development. Therefore, the purpose of this study was to assess the bone architecture of children with CHD compared to TDP. Our secondary objective was to evaluate differences between CHD lesion complexity.</div><div><em>Methods:</em> Forty-two children with CHD 7 to 15 years of age (10.9±2.5) were age and sex-matched to 41 TDP. Peripheral quantitative computed tomography (pQCT) scans were obtained at the distal (4%) and shaft (65%, 66%) sites for the radius and tibia, respectively. pQCT bone parameters were compared between groups using multiple analysis of covariance (MANCOVA), using sex, age, height, weight, maturity, and physical activity as covariates.</div><div><em>Results:</em> There were no significant differences between children with CHD and TDP at the distal radius or distal tibia (<em>p</em>&gt;0.05). Children with CHD had significantly lower total area, cortical content, cortical area, cortical thickness, and polar stress-strain index at the radial and tibial shaft compared to TDP (<em>p</em>&lt;0.05). When sub-dividing children with CHD by lesion severity, the complex CHD group had significantly lower cortical content, cortical area, cortical thickness, and polar stress-strain index at the radius and tibia shaft when compared to TDP (<em>p</em>&lt;0.05). Additionally, children with complex lesions had greater cortical density at the radius and tibia shaft when compared to TDP (<em>p</em>&lt;0.05). Finally, children with simple lesions had greater cortical density at the radius shaft when compared to TDP (<em>p</em>&lt;0.05).</div><div><em>Conclusion:</em> Children with complex CHD had worse bone parameters when compared to TDP. Children with complex CHD lesions may be at increased risk of impaired bone density, structure, and estimated strength at both the radius and tibia shaft.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101636"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of DXA acquisition mode on bone mineral density and longitudinal monitoring: Evidence from the Manitoba BMD registry","authors":"Sajjad Aftabi ,&nbsp;William D. Leslie","doi":"10.1016/j.jocd.2025.101660","DOIUrl":"10.1016/j.jocd.2025.101660","url":null,"abstract":"<div><div>Dual-energy X-ray absorptiometry (DXA) is the gold standard for assessing bone mineral density (BMD), but technical factors such as acquisition mode may affect measurement. On GE Healthcare DXA systems, Thin and Thick modes are often recommended for underweight and obese patients, respectively, while Standard mode is the default. Using the Manitoba Bone Density Program, a population-based registry, we analyzed paired same-day BMD measurements for the lumbar spine (n = 240), total hip (n = 432), and femoral neck (n = 431) obtained in Standard and nonstandard modes. Agreement was assessed by linear regression, Pearson correlation, Bland–Altman plots, and classification of BMD change using site-specific least significant change (LSC) thresholds. Paired Standard and nonstandard modes showed very strong correlations (r ≥ 0.97) with regression slopes approximating unity and intercepts approximating zero. Mean biases were negligible at the lumbar spine (−0.002 g/cm²), total hip (+0.001 g/cm²), and femoral neck (+0.001 g/cm²). Overall Standard versus nonstandard mode change agreement was near-perfect at the spine (Cohen’s κ 0.89) and total hip (κ 0.81), and substantial at the femoral neck (κ 0.75). All observed scan mode differences fell well below established LSC thresholds. These findings demonstrate that Thin and Thick acquisition modes produce BMD results that are effectively interchangeable with Standard mode.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101660"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graves' disease and bone mineral density: a scoping review of the impact of graves’ disease on spinal health","authors":"Mira Al Shoufy ,&nbsp;Jamil Nasrallah ,&nbsp;Kholoud Al Jebawi ,&nbsp;Hady El Etry ,&nbsp;Murtaja Satea Shafeea ,&nbsp;Ibrahim Hassan ,&nbsp;Haya Mohamed ,&nbsp;Naseeb Danaf ,&nbsp;Hossam Tharwat Ali","doi":"10.1016/j.jocd.2025.101621","DOIUrl":"10.1016/j.jocd.2025.101621","url":null,"abstract":"<div><div>Graves' disease, an autoimmune hyperthyroid disorder, negatively affects bone health by increasing osteoclast activity, leading to decreased bone mineral density (BMD) and heightened osteoporosis risk. Bone loss may persist even after thyroid levels normalize, possibly due to thyroid-stimulating hormone receptor antibodies (TRAb). This scoping review evaluates the impact of Graves' disease and its treatment on BMD, focusing on TRAb's role in bone loss. Using Arksey and O’Malley's framework, we searched Medline/PubMed, Scopus, Web of Science, and Cochrane Library for English-language studies on the effects of Graves' disease on adult spine-related bone health. From 2,226 records, 16 studies met the inclusion criteria after screening titles, abstracts, and full texts. Studies focusing primarily on postmenopausal women and older men consistently showed reduced BMD in patients with Graves' disease, especially in the lumbar spine. Elevated TRAb levels correlated with lower BMD, suggesting that TRAb contributes to ongoing bone loss despite achieving an euthyroid state. Anti-thyroid drug therapy partially improved BMD, but bone loss often persisted. Combining bisphosphonates with anti-thyroid therapy enhanced BMD recovery more than anti-thyroid therapy alone. Graves' disease affects bone health through thyroid hormone excess and TRAb-mediated autoimmunity, with persistent bone loss even after achieving an euthyroid state. High-risk groups like postmenopausal women and older men require targeted strategies addressing both thyroid and skeletal health. Future research should focus on therapies targeting TRAb and improving osteoporosis prevention to enhance outcomes.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101621"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145435550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reframing the BMI–BMD–TBS triad in type 2 diabetes: Clinical and policy implications","authors":"Amit Kumar Gupta,&nbsp;Anusha Putcha,&nbsp;Varshini Vadhithala,&nbsp;Sachin Kumar","doi":"10.1016/j.jocd.2025.101659","DOIUrl":"10.1016/j.jocd.2025.101659","url":null,"abstract":"","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101659"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic and body composition alterations in normal-weight adults with prediabetes: A DEXA-based analysis","authors":"Sami Bahçebaşı ,&nbsp;Banu Açmaz ,&nbsp;Ahmet Savranlar","doi":"10.1016/j.jocd.2025.101662","DOIUrl":"10.1016/j.jocd.2025.101662","url":null,"abstract":"<div><div><em>Introduction:</em> This study examines clinical, biochemical, and body composition differences between healthy and prediabetic normal-weight individuals (BMI 18.5-24.9 kg/m²), with a focus on central fat distribution.</div><div><em>Methods:</em> Sixty participants (30 prediabetic, 30 healthy) underwent clinical evaluations, including body composition analysis using DEXA.</div><div><em>Results:</em> <strong>• Women:</strong> Multivariate regression analysis demonstrated that the android-to-gynoid fat ratio remained an independent and significant predictor of prediabetes (<em>p</em> = 0.014).</div><div><strong>• Men:</strong> GFR and creatinine levels were significantly impaired (<em>p</em> = 0.008, <em>p</em> = 0.019). Central fat distribution, especially trunk fat, correlated with fasting glucose, although this association lost significance after age adjustment.</div><div><em>Discussion:</em> In women, prediabetes is associated with impaired glucose metabolism and central fat accumulation, particularly reflected by an elevated DEXA-derived android/gynoid fat ratio, highlighting a “normal-weight obesity” phenotype even in individuals with normal BMI. In men, central fat distribution, especially the trunk-to-limb fat ratio, is linked to glucose metabolism; however, this relationship diminishes after adjusting for age, suggesting that age-related fat redistribution may modulate metabolic risk. Additionally, early renal dysfunction, as indicated by reduced eGFR, is evident in men with prediabetes<strong>,</strong> underscoring the importance of comprehensive metabolic and renal assessment. These findings emphasize the clinical relevance of body composition–based screening<strong>,</strong> particularly using DEXA-derived regional fat ratios, to identify high-risk normal-weight individuals and enable timely preventive interventions.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101662"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}