Journal of Clinical Densitometry最新文献

{"title":"Associations between Bone Mineral Density and WOMAC Scores in Healthy Individuals: Insights from the Qatar Biobank","authors":"Mohammed Al-Hamdani ,&nbsp;Farah Issa ,&nbsp;Marah Abdulla ,&nbsp;Saja A. Abdallah ,&nbsp;Amal Al-Haidose ,&nbsp;Atiyeh M. Abdallah","doi":"10.1016/j.jocd.2024.101547","DOIUrl":"10.1016/j.jocd.2024.101547","url":null,"abstract":"<div><div><em>Background:</em> Bone mineral density (BMD) is an indicator of bone health that predicts future bone fractures. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is used to assess the severity of symptoms related to pain, stiffness, and function in diseased hip and knee joints. Here we assessed whether BMD measured at specific sites predicts WOMAC scores in healthy individuals whilst controlling for sociodemographic variables.</div><div><em>Methodology:</em> BMD, sociodemographic, and WOMAC data were collected from 1764 healthy adult individuals attending the Qatar Biobank (QBB). Multiple linear regression was used to examine associations between sociodemographic factors, total body BMD and BMD related to specific skeletal sites (including femoral (femoral neck and trochanter), trunk, pelvis and total spine), and the three WOMAC subscales (pain, stiffness, and physical function).</div><div><em>Results:</em> After controlling for sociodemographic variables, total body and specific BMD measures did not predict pain. However, BMD measures significantly contributed to predicting stiffness after controlling for sociodemographic variables (R² = 0.065, ΔF(7, 1724) = 3.34, p = 0.002), with a higher total body BMD associated with increased stiffness and a higher trunk BMD associated with decreased stiffness. Total body BMD measures also significantly contributed to predicting compromised physical function (R² = 0.091, ΔF(7, 1724) = 3.762, p &lt; 0.001) after controlling for sociodemographic variables, with a higher total body BMD associated with an increase in compromised physical function.</div><div><em>Conclusion:</em> Total body BMD seems to be a more important predictor of stiffness and physical function than specific skeletal sites BMD measures. Monitoring BMD may have important implications for osteoarthritis patients.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 1","pages":"Article 101547"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proceedings of the 2024 Santa Fe Bone Symposium: Update on the Management of Osteoporosis and Rare Bone Diseases","authors":"E. Michael Lewiecki ,&nbsp;John P. Bilezikian ,&nbsp;Amanda Clark ,&nbsp;Michael T. Collins ,&nbsp;Deborah M. Kado ,&nbsp;Joseph Lane ,&nbsp;Bente Langdahl ,&nbsp;Michael R. McClung ,&nbsp;Peter J. Snyder ,&nbsp;Emily M. Stein","doi":"10.1016/j.jocd.2024.101559","DOIUrl":"10.1016/j.jocd.2024.101559","url":null,"abstract":"<div><div>The 24^th Annual Santa Fe Bone Symposium (SFBS) was held in Santa Fe, New Mexico, USA, on August 2-3, 2024. This was a “hybrid” meeting, with in-person and real-time remote participants representing a broad range of geographical locations and medical disciplines. The focus was on new developments in the care of patients with osteoporosis, other metabolic bone diseases, and inherited skeletal disorders. The most current medical evidence was presented and discussed with consideration of implications for patient management. Topics included an update on clinical uses of osteoanabolic agents, management of patients discontinuing denosumab, bone health optimization for orthopedic surgery, estrogen and testosterone in the management of osteoporosis, osteoporosis treatment in the very old, overview of rare bone diseases, treat-to-target for osteoporosis, and a progress report on global activities of Bone Health ECHO. There were two highly interactive faculty panel discussions – one with case presentations by attendees and another with open microphone for all topics of interest. Endocrinology fellows, selected from attendees of the Santa Fe Fellows Workshop on Metabolic Bone Diseases, held the two days preceding the SFBS, participated with presentations of oral abstracts. Ancillary events addressed modern approaches to menopause and bone health, case studies of management of patients at very high fracture risk, and management of patients with rare bone diseases, such as hypophosphatasia, fibrodysplasia ossificans progressiva, X-linked hypophosphatemia, and hypoparathyroidism. These proceedings of the SFBS present the clinical highlights of the plenary sessions and the discussions that followed.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 1","pages":"Article 101559"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of Skeletal Muscle Mass, Length of Sports Experience, and Sexual Maturity with Bone Density and Geometry in Adolescent Athletes","authors":"Mateus Augusto Bim ,&nbsp;Tiago Rodrigues de Lima ,&nbsp;Rafael Martins ,&nbsp;Clair Costa Miranda ,&nbsp;Rômulo Araújo Fernandes ,&nbsp;Andreia Pelegrini","doi":"10.1016/j.jocd.2025.101562","DOIUrl":"10.1016/j.jocd.2025.101562","url":null,"abstract":"<div><div><em>Objective:</em> To identify the relationship between length of sports experience, muscle mass, and sexual maturity with bone mineral density (BMD) and geometry in adolescent basketball and track and field athletes.</div><div><em>Method:</em> The study included adolescent (11–18 years) athletes, of both sexes, who practiced basketball (<em>n</em> = 26) or track and field (<em>n</em> = 24). Skeletal muscle mass was measured by bioelectrical impedance analysis. Data on sports training and sexual maturity were collected through a questionnaire. Total body, lumbar, femoral, and forearm BMD were determined by dual-energy X-ray absorptiometry. Femoral scans were used to generate bone geometry measurements (femur strength index, cross-sectional area, cross-sectional moment of inertia, section modulus, and buckling ratio). Bone outcomes were compared between modalities by the Mann–Whitney <em>U</em>-test or Student's <em>t</em>-test and by analysis of covariance with adjustment for sports experience, sexual maturity, and skeletal muscle mass.</div><div><em>Results:</em> In the crude analysis, the basketball group had higher mean values for height, body weight, muscle mass, femoral neck BMD, cross-sectional area, and cross-sectional moment of inertia. In the covariate-adjusted analysis, the track and field group had higher total-body-less-head (0.995 <em>vs.</em> 1.035, <em>p</em> = 0.043), lumbar (1.012 <em>vs.</em> 1.107, <em>p</em> = 0.005), and radial (0.734 <em>vs.</em> 0.800, <em>p</em> = 0.005) BMD. Muscle mass was the main covariate influencing bone parameters, followed by sexual maturity.</div><div><em>Conclusion:</em> Skeletal muscle mass was the main determinant of bone outcomes in adolescent athletes, followed by sexual maturity, underscoring the importance of considering these variables when assessing bone health in this population.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 1","pages":"Article 101562"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Calibration of Areal Bone Mineral Densities and Body Composition between DMS Stratos and Hologic Horizon A Dual-Energy X-ray Absorptiometers: The Effect of Body Mass Index","authors":"Laurent Maïmoun ,&nbsp;Sandrine Alonso ,&nbsp;Krishna Kunal Mahadea ,&nbsp;Julien Dubois ,&nbsp;Tom Paunet ,&nbsp;Florentin Kucharczak ,&nbsp;Lisa Maïmoun Nande ,&nbsp;Vincent Boudousq ,&nbsp;Thibault Mura ,&nbsp;Denis Mariano-Goulart","doi":"10.1016/j.jocd.2024.101553","DOIUrl":"10.1016/j.jocd.2024.101553","url":null,"abstract":"<div><div><em>Purpose:</em> The aim of this study was to investigate the correlations between areal bone mineral density (aBMD) and body composition measured by two dual-energy X-ray absorptiometers (DXA), the DMS Stratos® (STR) and the Hologic Horizon A® (HRZ), and then generate cross-calibration equations between the two scanners.</div><div><em>Methods:</em> Repeat scans were obtained from 251 adults (85 % female), 36 ± 14 years old with mean body mass index (BMI) of 28.7 ± 11.1 kg/m2, using HRZ (fan-beam technology) and STR (pencil-beam technology). aBMD was measured at whole body [WB], femoral neck [FN], total hip [TH], lumbar spine [LS] and radius, while fat mass [FM] and lean tissue mass [LTM] were determined at whole body and at android and gynoid subregions.</div><div><em>Results:</em> Compared to HRZ, STR underestimated both aBMD at WB and radius and LTM at WB and android and gynoid regions. Conversely, STR overestimated aBMD at FN, TH, LS and FM at WB android and gynoid regions. Except for WB bone mineral content (r = 0.87) and WB aBMD (r = 0.84), there were strong correlations of aBMD and body composition between the two DXAs (r &gt; 0.91; p &lt; 0.0001). Several of the parameters that required the determination of specific cross-calibration equations because of the significant bias between the two DXAs were found to be influenced by BMI.</div><div><em>Conclusions:</em> Although the data from the STR and the HRZ were highly correlated for aBMD and body composition parameters, a systematic measurement bias between two DXAs was observed. The development of cross-calibration equations fully corrected these differences and they may thus be useful for multicenter studies when scans are performed with STR and HRZ.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 1","pages":"Article 101553"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Executive Summary of the 2023 Adult Position Development Conference of the International Society for Clinical Densitometry: DXA Reporting, Follow-up BMD Testing and Trabecular Bone Score Application and Reporting’ Journal of Clinical Densitometry Volume 27, Issue 1, January–March 2024, 101435","authors":"Christopher Shuhart ,&nbsp;Angela Cheung ,&nbsp;Ranjodh Gill ,&nbsp;Linsey Gani ,&nbsp;Heenam Goel ,&nbsp;Auryan Szalat","doi":"10.1016/j.jocd.2024.101548","DOIUrl":"10.1016/j.jocd.2024.101548","url":null,"abstract":"","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 1","pages":"Article 101548"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Health ECHO Case Report: Significant Elevation in Bone Turnover Markers and Progression of Vertebral Fractures After Denosumab Discontinuation Followed by a PTH-Analog","authors":"Yevgeniya Kushchayeva ,&nbsp;Sergiy Kushchayev ,&nbsp;Kimberly Dunn ,&nbsp;Iryna Pestun ,&nbsp;Micol S. Rothman ,&nbsp;E. Michael Lewiecki","doi":"10.1016/j.jocd.2024.101551","DOIUrl":"10.1016/j.jocd.2024.101551","url":null,"abstract":"<div><div>Bone Health ECHO (Extension for Community Healthcare Outcomes) is a virtual community of practice, where healthcare professionals have met via videoconferencing weekly since 2015. This model of learning is focused on short didactics and the presentation of real but de-identified patient cases followed by highly interactive discussions. These are often clinical situations with diagnostic and therapeutic dilemmas that are not readily addressed by randomized placebo-controlled clinical trials and clinical practice guidelines. Here we present the case of a woman with postmenopausal osteoporosis with adverse consequences following discontinuation of denosumab and uncertainties on next steps for management. This case highlights the relevance of selection of the initial bone-targeted medication and the sequence of therapy in osteoporosis management.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 1","pages":"Article 101551"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Health ECHO Case Report: High Bone Mass in a Patient with Chronic Kidney Disease","authors":"Zhanna Belaya ,&nbsp;Elena Przhiyalkovskaya ,&nbsp;Elizaveta Mamedova ,&nbsp;Sofia Gronskaia ,&nbsp;Natalia Tarbaeva ,&nbsp;Margarita Sharova ,&nbsp;Sergey Popov ,&nbsp;Michael Lewiecki","doi":"10.1016/j.jocd.2024.101554","DOIUrl":"10.1016/j.jocd.2024.101554","url":null,"abstract":"<div><div>Bone Health ECHO (Extension of Community Healthcare Outcomes) is a growing family of online educational programs. Its mission is to enhance delivery of best practice skeletal healthcare worldwide. Each program typically consists of a didactic lecture and discussion of clinical cases with diagnostic and treatment dilemmas. Here we present a Bone Health ECHO case of a 39-year-old man who has received hemodialysis for 12 years. This case is characterized by the development of chronic kidney disease - mineral and bone disorder (CKD-MBD) which was managed using conservative treatment to maintain phosphate and calcium levels within the reference range in spite of severe secondary hyperparathyroidism, after the patient declined parathyroidectomy. Although this patient had multiple vertebral fractures with height loss, his bone mineral density was higher than expected for his age and gradually increased over the period of observation. Whole-exome sequencing showed a heterozygous, likely pathogenic variant in <em>LEMD3</em> gene (13 exon HG38, chr12:65246271dup, с.2682dup in a heterozygous state), which may explain the high bone mass phenotype. As a result of the ECHO presentation, we decided that successful treatment of CKD-MBD would be the most effective approach to managing his bone fragility. His high bone mass phenotype was most likely associated with <em>LEMD3</em> gene variant. This patient does not require any specific anti-osteoporotic treatment at this time; however, he is likely to benefit from parathyroid surgery.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 1","pages":"Article 101554"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcaneal Bone Mineral Assessment in Elite Female Trail Runners","authors":"Javier Espasa-Labrador ,&nbsp;John O. Osborne ,&nbsp;Álex Cebrián-Ponce ,&nbsp;Silvia Puigarnau ,&nbsp;Toni Planas ,&nbsp;Quim Rosales ,&nbsp;Amigó, Alfredo Irurtia ,&nbsp;Marta Carrasco-Marginet","doi":"10.1016/j.jocd.2024.101555","DOIUrl":"10.1016/j.jocd.2024.101555","url":null,"abstract":"<div><div>This study aimed to assess the calcaneal bone mineral density (BMD) of elite female trail runners and evaluate its reliability using a novel DXA method. It also examined the relationship between calcaneal BMD and other regions of interest to better understand bone health in this specific population. A cross-sectional study was conducted with 35 elite female trail runners from the Spanish national team. BMD was measured at six anatomical regions using DXA, with particular focus on the calcaneus. Intra- and inter-rater reliability were evaluated using intraclass correlation coefficients (ICC). Descriptive statistics and correlations between calcaneal BMD and other anatomical sites, such as the lumbar spine and femoral neck, were analyzed. Calcaneal BMD showed excellent reliability (ICC = 0.95–0.98), confirming the robustness of the proposed measurement method. The mean calcaneal BMD (0.660 ± 0.105 g·cm²) was higher than that of non-athletes but lower than athletes from other endurance sports, such as road running. Significant correlations were found between calcaneal BMD and other regions, including the femoral neck (r = 0.58) and lumbar spine (r = 0.50), indicating that calcaneal BMD may provide complementary information for assessing bone health. The study confirms the reliability of calcaneal BMD measurement in elite female trail runners and highlights its potential as a useful complementary tool for monitoring bone health. Further longitudinal studies are needed to determine whether calcaneal BMD can serve as an indicator for stress fractures and other bone-related injuries in endurance athletes.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 1","pages":"Article 101555"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Approach to Identify Forearm “Slot Error”","authors":"G. Gottinger,&nbsp;N. Binkley,&nbsp;D. Krueger","doi":"10.1016/j.jocd.2024.101557","DOIUrl":"10.1016/j.jocd.2024.101557","url":null,"abstract":"","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 1","pages":"Article 101557"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Traditional Chinese Medicine Kidney-Tonifying Methods on Osteoporosis or Bone Loss in HR+ Breast Cancer Patients Following Endocrine Therapy","authors":"Jie Luo ,&nbsp;Peng Jiang ,&nbsp;Liming Xu","doi":"10.1016/j.jocd.2024.101558","DOIUrl":"10.1016/j.jocd.2024.101558","url":null,"abstract":"<div><div><em>Objective:</em> This study aims to systematically assess the therapeutic effects of Traditional Chinese Medicine (TCM) kidney-tonifying methods on osteoporosis in HR+ breast cancer patients after endocrine therapy, and to explore their clinical application value.</div><div><em>Methods:</em> This systematic review and meta-analysis adhered to the PRISMA guidelines and aimed to evaluate the impact of TCM kidney-tonifying methods on osteoporosis in HR+ breast cancer patients after endocrine therapy. Literature searches were conducted through October 2024 in databases including CBM, CNKI, Wanfang Data, PubMed, Web of Science, Cochrane Central, VIP, and renowned TCM databases such as TCM Online. Randomized controlled trials reporting lumbar spine bone density, femoral neck bone density, osteocalcin levels, pain VAS scores, and drug safety were included. The Cochrane tool was used for quality assessment, and meta-analysis was performed using RevMan 5.3 and Stata software.</div><div><em>Results:</em> This meta-analysis included 25 studies, covering 1795 patients. The combined results showed significant improvements in lumbar spine bone density (SMD = 0.98, 95 % CI: 0.52–1.44, <em>P</em> &lt; 0.0001), femoral neck bone density (SMD = 0.73, 95 % CI: 0.35–1.10, <em>P</em> = 0.0001), and osteocalcin levels (SMD = 1.23, 95 % CI: 0.52–1.93, <em>P</em> = 0.0007) in patients treated with TCM kidney-tonifying methods compared to those in the control group. There was also a significant reduction in pain VAS scores (SMD = −1.14, 95 % CI:1.55 to −0.72, <em>P</em> &lt; 0.00001). The safety data indicated no significant adverse reactions associated with the treatment.</div><div><em>Conclusion:</em> TCM kidney-tonifying methods can significantly improve osteoporosis symptoms post-endocrine therapy in HR+ breast cancer patients, enhance bone density, and effectively reduce pain, demonstrating good safety and potential clinical value. Future research should further validate these findings through large-scale, multi-center randomized controlled trials to optimize treatment strategies.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 1","pages":"Article 101558"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}