Journal of Clinical Densitometry最新文献

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Evaluating lower limits of body fat percentage in athletes using DXA.
IF 1.7 4区 医学
Journal of Clinical Densitometry Pub Date : 2025-01-20 DOI: 10.1016/j.jocd.2025.101564
Tamara Hew-Butler, Edward Kerr, Gloria Martinez Perez, Jordan Sabourin, Valerie Smith-Hale, Ruben Mendoza
{"title":"Evaluating lower limits of body fat percentage in athletes using DXA.","authors":"Tamara Hew-Butler, Edward Kerr, Gloria Martinez Perez, Jordan Sabourin, Valerie Smith-Hale, Ruben Mendoza","doi":"10.1016/j.jocd.2025.101564","DOIUrl":"https://doi.org/10.1016/j.jocd.2025.101564","url":null,"abstract":"<p><p>Body fat percentage (BF%) is routinely measured in athletes to monitor training and dietary interventions. Dual energy x-ray absorptiometry (DXA) is widely considered the gold standard body composition measurement technique, but DXA BF% values measure consistently higher than other techniques. Therefore, the main purpose of this study is to determine the lowest DXA-estimated whole-body fat mass in free-living athletes with unrestricted access to food. In this cross-sectional analyses, 732 participants across 18 competitive sports (643 athletes; 88 %) plus two (male and female) \"non-athlete\" male and female cohorts (89 non-athletes; 12 %) underwent a whole-body DXA scan using a Horizon A Hologic™ device (software version 13.6.0.5; TBAR 1209), performed and analyzed by a single operator. The average BF % in 454 males (20.9 ± 3.8 years) was 18.2 ± 4.9 % (range 10.3 - 37.2 %), with basketball players having the lowest BF% (15.3 ± 2.6 %) and non-athletes having the highest BF% (21.6 ± 5.4 %) (1-way ANOVA between 10 teams: F = 12.3; p < 0.0001). The average BF% in 278 females (21.3 ± 5.5 years) was 27.1 ± 5.1 % (range 16.2 - 45.3 %), with runners having the lowest BF% (23.5 ± 3.5 %) and non-athletes having the highest BF% (31.7 ± 6.3 %) (1-way ANOVA between 10 teams F = 12.9; p < 0.0001). In absolute values (kg), the average body fat for males was 19.9 ± 8.0 kg (range 6.7 - 62.0 kg) and 18.9 ± 6.4 kg (range 9.2 - 49.7 kg) for females. These data suggest that the lower limits of whole-body fat mass in free-living competitive athletes is approximately 10 % for males and 16 % for females. Whether these DXA-derived fat thresholds represent \"healthy\" levels, or how much of these DXA-derived fat depots represent essential fat stores located within lean soft tissue mass, remains unclear.</p>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 2","pages":"101564"},"PeriodicalIF":1.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of two strength training modalities (hypertrophy vs. contrast training) on muscular strength, bone health parameters and quality of life in a group of older adults with low skeletal muscle mass index.
IF 1.7 4区 医学
Journal of Clinical Densitometry Pub Date : 2025-01-15 DOI: 10.1016/j.jocd.2025.101563
Amal Antoun, Eric Watelain, Antonio Pinti, Nour Khalil, Abdel-Jalil Berro, Elie Maliha, Youssef Bassim, Rawad El Hage
{"title":"Influence of two strength training modalities (hypertrophy vs. contrast training) on muscular strength, bone health parameters and quality of life in a group of older adults with low skeletal muscle mass index.","authors":"Amal Antoun, Eric Watelain, Antonio Pinti, Nour Khalil, Abdel-Jalil Berro, Elie Maliha, Youssef Bassim, Rawad El Hage","doi":"10.1016/j.jocd.2025.101563","DOIUrl":"https://doi.org/10.1016/j.jocd.2025.101563","url":null,"abstract":"<p><p>The main aim of the current study was to compare the effects of two strength training modalities (hypertrophy vs. contrast training) on bone health parameters, physical performance and quality of life in a group of subjects aged 60 and above with low skeletal muscle mass index (SMI). 45 older adults voluntarily participated in this study, but only 41 (22 women and 19 men) completed it. The participants were assigned to 3 different groups: control group (CG; n = 15), contrast training group (CTG; n = 13) and hypertrophy training group (HTG; n = 13). The duration of the training protocol was six months. The experimental groups performed two sessions of strength training per week; the duration of each session was forty-five minutes. Several measurements (which included anthropometrics, body composition, bone parameters, maximal strength parameters, physical performance parameters, fracture risk and quality of life) were performed in the three groups before and after the six-month training period. The different measurements of the protocol were carried out under the same conditions with identical materials and investigators for all the participants and for each approach. The current study has demonstrated that the two training modalities show common benefits such as improving maximal strength, physical performance and quality of life parameters but have no significant effects on bone mineral density (BMD) and bone mineral content (BMC). The influence of training was marked more for improving maximal strength and reducing fracture risk for the contrast training group (who performs movements at high speed) compared to the hypertrophy training group (who performs movements at spontaneous speed). In conclusion, this study shows that both resistance training programs are effective in improving maximal strength, physical performance and quality of life in older adults with low SMI. However, this 6-month intervention was not sufficient to significantly increase BMC nor BMD values in this population.</p>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 2","pages":"101563"},"PeriodicalIF":1.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship of skeletal muscle mass, length of sports experience, and sexual maturity with bone density and geometry in adolescent athletes. 青少年运动员骨骼肌质量、运动经验长度和性成熟程度与骨密度和几何形状的关系。
IF 1.7 4区 医学
Journal of Clinical Densitometry Pub Date : 2025-01-10 DOI: 10.1016/j.jocd.2025.101562
Mateus Augusto Bim, Tiago Rodrigues de Lima, Rafael Martins, Clair Costa Miranda, Rômulo Araújo Fernandes, Andreia Pelegrini
{"title":"Relationship of skeletal muscle mass, length of sports experience, and sexual maturity with bone density and geometry in adolescent athletes.","authors":"Mateus Augusto Bim, Tiago Rodrigues de Lima, Rafael Martins, Clair Costa Miranda, Rômulo Araújo Fernandes, Andreia Pelegrini","doi":"10.1016/j.jocd.2025.101562","DOIUrl":"https://doi.org/10.1016/j.jocd.2025.101562","url":null,"abstract":"<p><strong>Objective: </strong>To identify the relationship between length of sports experience, muscle mass, and sexual maturity with bone mineral density (BMD) and geometry in adolescent basketball and track and field athletes.</p><p><strong>Method: </strong>The study included adolescent (11-18 years) athletes, of both sexes, who practiced basketball (n = 26) or track and field (n = 24). Skeletal muscle mass was measured by bioelectrical impedance analysis. Data on sports training and sexual maturity were collected through a questionnaire. Total body, lumbar, femoral, and forearm BMD were determined by dual-energy X-ray absorptiometry. Femoral scans were used to generate bone geometry measurements (femur strength index, cross-sectional area, cross-sectional moment of inertia, section modulus, and buckling ratio). Bone outcomes were compared between modalities by the Mann-Whitney U-test or Student's t-test and by analysis of covariance with adjustment for sports experience, sexual maturity, and skeletal muscle mass.</p><p><strong>Results: </strong>In the crude analysis, the basketball group had higher mean values for height, body weight, muscle mass, femoral neck BMD, cross-sectional area, and cross-sectional moment of inertia. In the covariate-adjusted analysis, the track and field group had higher total-body-less-head (0.995 vs. 1.035, p = 0.043), lumbar (1.012 vs. 1.107, p = 0.005), and radial (0.734 vs. 0.800, p = 0.005) BMD. Muscle mass was the main covariate influencing bone parameters, followed by sexual maturity.</p><p><strong>Conclusion: </strong>Skeletal muscle mass was the main determinant of bone outcomes in adolescent athletes, followed by sexual maturity, underscoring the importance of considering these variables when assessing bone health in this population.</p>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 1","pages":"101562"},"PeriodicalIF":1.7,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of lumbar vertebral bone quality using T1-weighted MRI: Can it differentiate normal, osteopenia, and osteoporosis?
IF 1.7 4区 医学
Journal of Clinical Densitometry Pub Date : 2025-01-09 DOI: 10.1016/j.jocd.2025.101561
Sevde Nur Emir, Gülbanu Güner
{"title":"Evaluation of lumbar vertebral bone quality using T1-weighted MRI: Can it differentiate normal, osteopenia, and osteoporosis?","authors":"Sevde Nur Emir, Gülbanu Güner","doi":"10.1016/j.jocd.2025.101561","DOIUrl":"https://doi.org/10.1016/j.jocd.2025.101561","url":null,"abstract":"<p><strong>Background: </strong>Osteoporosis, a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration, poses a significant public health challenge globally. While the gold standard for diagnosing osteoporosis is dual-energy X-ray absorptiometry (DXA), its use is limited by factors like spinal deformities and artifacts. This study aims to explore the potential of routine T1-weighted MRI sequences in predicting osteopenia and osteoporosis through the vertebral bone signal (VB) to cerebrospinal fluid signal (CSF) ratio.</p><p><strong>Methodology: </strong>We conducted a retrospective study of patients who underwent both DXA and lumbar MRI within a six-month interval between 2020 and 2023. Excluding patients with known vertebral fractures, bone tumors, heterogeneous bone marrow, or endplate signal changes due to degenerative alterations, we divided the patients into normal, osteopenic, and osteoporotic groups based on their DXA T-scores. The T1-weighted sagittal MRI sequences were analyzed, and the T1 VB/CSF ratios were calculated for each vertebra (L1-L4).</p><p><strong>Results: </strong>The study included 376 patients, with an average age of 60.8 ± 9.1 years. Statistically significant differences were found in the T1 VB/CSF ratios across the normal, osteopenic, and osteoporotic groups (p < 0.05). The L1 vertebra demonstrated the highest diagnostic performance for predicting osteoporosis, with an AUC of 0.75, a sensitivity of 88.1 %, and a specificity of 84.5 %. For differentiating osteopenia from normal, the L1 vertebra achieved an AUC of 0.68, with a sensitivity of 78.2 % and a specificity of 76.4 %. The optimal cut-off values were determined as 3.62 for osteopenia and 3.80 for osteoporosis.</p><p><strong>Conclusion: </strong>The T1 VB/CSF ratio derived from routine lumbar MRI sequences provides a promising, radiation-free tool for opportunistic screening of osteoporosis and osteopenia. Given the frequent use of lumbar MRI for patients with spinal complaints, this method could facilitate early diagnosis and intervention, guiding high-risk patients towards further DXA evaluation and management.</p>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 2","pages":"101561"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143041926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bone Health ECHO Case Report: Is it Paget's Disease? 骨健康回声病例报告:是佩吉特病吗?
IF 1.7 4区 医学
Journal of Clinical Densitometry Pub Date : 2025-01-02 DOI: 10.1016/j.jocd.2024.101550
Melissa F Cohen, Rachel Pessah-Pollack, E Michael Lewiecki
{"title":"Bone Health ECHO Case Report: Is it Paget's Disease?","authors":"Melissa F Cohen, Rachel Pessah-Pollack, E Michael Lewiecki","doi":"10.1016/j.jocd.2024.101550","DOIUrl":"https://doi.org/10.1016/j.jocd.2024.101550","url":null,"abstract":"<p><p>A 54-year-old woman was referred by her rheumatologist for evaluation of an elevated serum alkaline phosphatase (ALP) in the setting of polyarthritis. The metabolic work-up was significant for an elevated bone fraction of alkaline phosphatase isoenzymes, and high bone turnover markers, including fasting C- telopeptide (CTX). A diagnosis of Paget's disease of bone (PDB) was considered. A whole-body nuclear bone scan showed diffuse increased uptake in the calvarium, suggestive of PDB, with no other localizing areas of increased uptake. Skull X-rays show mild sclerosis and medullary expansion of the posterior parietal bones and occiput, interpreted by the radiologist as unlikely to be PDB with a high level of uncertainty. Bone density testing with dual-energy X-ray absorptiometry showed low bone mass (osteopenia) with fracture probability that was below the treatment threshold. The case was presented and discussed on Bone Health ECHO, a virtual community of practice with the aim of enhancing global capacity to deliver best practice skeletal health care. The results of the discussion are presented here.</p>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 1","pages":"101550"},"PeriodicalIF":1.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proceedings of the 2024 Santa Fe Bone Symposium: Update on the Management of Osteoporosis and Rare Bone Diseases. 2024年圣达菲骨研讨会论文集:骨质疏松症和罕见骨疾病管理的最新进展。
IF 1.7 4区 医学
Journal of Clinical Densitometry Pub Date : 2024-12-28 DOI: 10.1016/j.jocd.2024.101559
E Michael Lewiecki, John P Bilezikian, Amanda Clark, Michael T Collins, Deborah M Kado, Joseph Lane, Bente Langdahl, Michael R McClung, Peter J Snyder, Emily M Stein
{"title":"Proceedings of the 2024 Santa Fe Bone Symposium: Update on the Management of Osteoporosis and Rare Bone Diseases.","authors":"E Michael Lewiecki, John P Bilezikian, Amanda Clark, Michael T Collins, Deborah M Kado, Joseph Lane, Bente Langdahl, Michael R McClung, Peter J Snyder, Emily M Stein","doi":"10.1016/j.jocd.2024.101559","DOIUrl":"https://doi.org/10.1016/j.jocd.2024.101559","url":null,"abstract":"<p><p>The 24<sup>th</sup> Annual Santa Fe Bone Symposium (SFBS) was held in Santa Fe, New Mexico, USA, on August 2-3, 2024. This was a \"hybrid\" meeting, with in-person and real-time remote participants representing a broad range of geographical locations and medical disciplines. The focus was on new developments in the care of patients with osteoporosis, other metabolic bone diseases, and inherited skeletal disorders. The most current medical evidence was presented and discussed with consideration of implications for patient management. Topics included an update on clinical uses of osteoanabolic agents, management of patients discontinuing denosumab, bone health optimization for orthopedic surgery, estrogen and testosterone in the management of osteoporosis, osteoporosis treatment in the very old, overview of rare bone diseases, treat-to-target for osteoporosis, and a progress report on global activities of Bone Health ECHO. There were two highly interactive faculty panel discussions - one with case presentations by attendees and another with open microphone for all topics of interest. Endocrinology fellows, selected from attendees of the Santa Fe Fellows Workshop on Metabolic Bone Diseases, held the two days preceding the SFBS, participated with presentations of oral abstracts. Ancillary events addressed modern approaches to menopause and bone health, case studies of management of patients at very high fracture risk, and management of patients with rare bone diseases, such as hypophosphatasia, fibrodysplasia ossificans progressiva, X-linked hypophosphatemia, and hypoparathyroidism. These proceedings of the SFBS present the clinical highlights of the plenary sessions and the discussions that followed.</p>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 1","pages":"101559"},"PeriodicalIF":1.7,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Approach to Identify Forearm "Slot Error". 一种前臂“槽位误差”识别方法。
IF 1.7 4区 医学
Journal of Clinical Densitometry Pub Date : 2024-12-27 DOI: 10.1016/j.jocd.2024.101557
G Gottinger, N Binkley, D Krueger
{"title":"An Approach to Identify Forearm \"Slot Error\".","authors":"G Gottinger, N Binkley, D Krueger","doi":"10.1016/j.jocd.2024.101557","DOIUrl":"https://doi.org/10.1016/j.jocd.2024.101557","url":null,"abstract":"","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 1","pages":"101557"},"PeriodicalIF":1.7,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of a high-impact exercise program on hip strength indices in a group of obese women after bariatric surgery. 高强度运动计划对减肥手术后肥胖妇女髋关节力量指数的影响。
IF 1.7 4区 医学
Journal of Clinical Densitometry Pub Date : 2024-12-24 DOI: 10.1016/j.jocd.2024.101556
Emne Hammoud, Christophe Jacob, Antonio Pinti, Nour Khalil, Zaher El Hage, Hechmi Toumi, Rawad El Hage
{"title":"Effect of a high-impact exercise program on hip strength indices in a group of obese women after bariatric surgery.","authors":"Emne Hammoud, Christophe Jacob, Antonio Pinti, Nour Khalil, Zaher El Hage, Hechmi Toumi, Rawad El Hage","doi":"10.1016/j.jocd.2024.101556","DOIUrl":"https://doi.org/10.1016/j.jocd.2024.101556","url":null,"abstract":"<p><p>The purpose of this study was to explore the influence of a 12-month high-impact physical training program (descending stairs) on bone health in a group of young obese women who had undergone bariatric surgery (type sleeve). Fifty-two premenopausal women with a body mass index (BMI) > 35 kg/m<sup>2</sup> (range: 35.06-60.97 kg/m<sup>2</sup>), aged 19-47 years old were included in this study. Patients were randomized to either exercise group (EG), control group (CG) or observational group (OG). 2 to 3 weeks post-bariatric surgery (BS), EG underwent a 12-month semi-supervised high impact (descending stairs) exercise program, CG performed a 12-month oriental dance activity while the third OG received only standard medical care. Patients were assessed before BS and 12 months post-BS for body composition, bone mineral density (BMD) and femoral neck geometry. Bone parameters were evaluated by DXA. At baseline, there were no significant differences among the three groups in the clinical characteristics and the bone variables. 12 months after the surgery, there were some group*time interactions. The 3 groups showed significantly lower whole body BMD (-1.8; -2.9; -4.2 % respectively for EG; CG and OG). The EG showed a significant increase of the femoral neck BMD (+1.4 %; p < 0.05), the femoral neck cross-sectional area (+4.6 %; p < 0.05), and the femoral neck cross-sectional moment of inertia (+15.7 %; p < 0.01) while all these values decreased significantly in the 2 other groups. The total hip BMD decreased in all groups, but the EG showed less significant total hip variation, and lumbar spine BMD decreased significantly only in the OG. This study mainly shows that the stair descent can be considered as an effective high-impact physical exercise for obese women who have undergone bariatric surgery. This kind of exercise has significant effects in maintaining or reducing the loss of BMD at the femoral neck and the total hip. Finally, since the EG group showed significant increases in femoral neck geometry variables, this study suggests that this kind of training could be efficient at reducing the hip fracture risk.</p>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 1","pages":"101556"},"PeriodicalIF":1.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of traditional Chinese medicine kidney-tonifying methods on osteoporosis or bone loss in HR+ breast cancer patients following endocrine therapy. 中药补肾法对内分泌治疗后HR+乳腺癌患者骨质疏松或骨质流失的影响。
IF 1.7 4区 医学
Journal of Clinical Densitometry Pub Date : 2024-12-22 DOI: 10.1016/j.jocd.2024.101558
Jie Luo, Peng Jiang, Liming Xu
{"title":"The impact of traditional Chinese medicine kidney-tonifying methods on osteoporosis or bone loss in HR+ breast cancer patients following endocrine therapy.","authors":"Jie Luo, Peng Jiang, Liming Xu","doi":"10.1016/j.jocd.2024.101558","DOIUrl":"https://doi.org/10.1016/j.jocd.2024.101558","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to systematically assess the therapeutic effects of Traditional Chinese Medicine (TCM) kidney-tonifying methods on osteoporosis in HR+ breast cancer patients after endocrine therapy, and to explore their clinical application value.</p><p><strong>Methods: </strong>This systematic review and meta-analysis adhered to the PRISMA guidelines and aimed to evaluate the impact of TCM kidney-tonifying methods on osteoporosis in HR+ breast cancer patients after endocrine therapy. Literature searches were conducted through October 2024 in databases including CBM, CNKI, Wanfang Data, PubMed, Web of Science, Cochrane Central, VIP, and renowned TCM databases such as TCM Online. Randomized controlled trials reporting lumbar spine bone density, femoral neck bone density, osteocalcin levels, pain VAS scores, and drug safety were included. The Cochrane tool was used for quality assessment, and meta-analysis was performed using RevMan 5.3 and Stata software.</p><p><strong>Results: </strong>This meta-analysis included 25 studies, covering 1795 patients. The combined results showed significant improvements in lumbar spine bone density (SMD = 0.98, 95 % CI: 0.52-1.44, P < 0.0001), femoral neck bone density (SMD = 0.73, 95 % CI: 0.35-1.10, P = 0.0001), and osteocalcin levels (SMD = 1.23, 95 % CI: 0.52-1.93, P = 0.0007) in patients treated with TCM kidney-tonifying methods compared to those in the control group. There was also a significant reduction in pain VAS scores (SMD = -1.14, 95 % CI:1.55 to -0.72, P < 0.00001). The safety data indicated no significant adverse reactions associated with the treatment.</p><p><strong>Conclusion: </strong>TCM kidney-tonifying methods can significantly improve osteoporosis symptoms post-endocrine therapy in HR+ breast cancer patients, enhance bone density, and effectively reduce pain, demonstrating good safety and potential clinical value. Future research should further validate these findings through large-scale, multi-center randomized controlled trials to optimize treatment strategies.</p>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 1","pages":"101558"},"PeriodicalIF":1.7,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bone health ECHO case report: High bone mass in a patient with chronic kidney disease. 骨健康ECHO病例报告:1例慢性肾病患者骨量增高。
IF 1.7 4区 医学
Journal of Clinical Densitometry Pub Date : 2024-12-18 DOI: 10.1016/j.jocd.2024.101554
Zhanna Belaya, Elena Przhiyalkovskaya, Elizaveta Mamedova, Sofia Gronskaia, Natalia Tarbaeva, Margarita Sharova, Sergey Popov, Michael Lewiecki
{"title":"Bone health ECHO case report: High bone mass in a patient with chronic kidney disease.","authors":"Zhanna Belaya, Elena Przhiyalkovskaya, Elizaveta Mamedova, Sofia Gronskaia, Natalia Tarbaeva, Margarita Sharova, Sergey Popov, Michael Lewiecki","doi":"10.1016/j.jocd.2024.101554","DOIUrl":"https://doi.org/10.1016/j.jocd.2024.101554","url":null,"abstract":"<p><p>Bone Health ECHO (Extension of Community Healthcare Outcomes) is a growing family of online educational programs. Its mission is to enhance delivery of best practice skeletal healthcare worldwide. Each program typically consists of a didactic lecture and discussion of clinical cases with diagnostic and treatment dilemmas. Here we present a Bone Health ECHO case of a 39-year-old man who has received hemodialysis for 12 years. This case is characterized by the development of chronic kidney disease - mineral and bone disorder (CKD-MBD) which was managed using conservative treatment to maintain phosphate and calcium levels within the reference range in spite of severe secondary hyperparathyroidism, after the patient declined parathyroidectomy. Although this patient had multiple vertebral fractures with height loss, his bone mineral density was higher than expected for his age and gradually increased over the period of observation. Whole-exome sequencing showed a heterozygous, likely pathogenic variant in LEMD3 gene (13 exon HG38, chr12:65246271dup, с.2682dup in a heterozygous state), which may explain the high bone mass phenotype. As a result of the ECHO presentation, we decided that successful treatment of CKD-MBD would be the most effective approach to managing his bone fragility. His high bone mass phenotype was most likely associated with LEMD3 gene variant. This patient does not require any specific anti-osteoporotic treatment at this time; however, he is likely to benefit from parathyroid surgery.</p>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 1","pages":"101554"},"PeriodicalIF":1.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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