Journal of Clinical Densitometry最新文献

{"title":"Real-world evaluation and management of osteoporosis in postmenopausal women following distal radius fracture","authors":"Byung Hun Oh,&nbsp;Jae Kwang Kim,&nbsp;Young Ho Shin","doi":"10.1016/j.jocd.2026.101691","DOIUrl":"10.1016/j.jocd.2026.101691","url":null,"abstract":"<div><div><em>Introduction:</em> This study aimed to evaluate the factors associated with the initiation and maintenance of osteoporosis evaluation and management in postmenopausal women following distal radius fracture (DRF).</div><div><em>Materials and methods</em>: We retrospectively reviewed 341 consecutive postmenopausal women who sustained a DRF after minor trauma between January 2018 and August 2021. Data on baseline characteristics, general medical condition (assessed using the American Society of Anesthesiologists classification system), dual-energy X-ray absorptiometry (DXA) results, and osteoporosis treatments before and up to two years following DRF were collected.</div><div><em>Results:</em> After excluding 36 patients who were receiving anti-osteoporosis medication at the time of DRF, 305 patients were recommended for DXA evaluation after DRF. Sixteen patients (5.2%) with normal DXA results were not prescribed medication. Fifty patients (16.4%) either declined DXA evaluation or refused to initiate anti-osteoporosis medications (refusal group), while 239 patients initiated anti-osteoporosis medication (initiation group). A significantly higher portion of patients in the initiation group underwent surgery for DRF compared with the refusal group (82.0% vs. 68.0%, <em>p</em> = 0.03). Among the 239 patients who initiated anti-osteoporosis treatment, 164 (68.6%) maintained medication for two years. In multivariable analysis, only a diagnosis of osteoporosis rather than osteopenia was significantly associated with medication maintenance (odds ratio 1.960; 95% confidence interval, 1.117–3.440, <em>p</em> = 0.02).</div><div><em>Conclusions:</em> This study found that postmenopausal women who received non-operative treatment or had osteopenia on DXA are less likely to initiate or maintain osteoporosis evaluation and management following DRF. Clinicians need to emphasize osteoporosis evaluation and treatment adherence, particularly in these patients following DRF.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 2","pages":"Article 101691"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenic obesity negatively affects composite indices of femoral neck strength in premenopausal women","authors":"Nour Khalil ,&nbsp;Rawad El Hage ,&nbsp;Emne Hammoud,&nbsp;Elie Maliha,&nbsp;Gisèle El Khoury,&nbsp;Zaher El Hage,&nbsp;Christophe Jacob","doi":"10.1016/j.jocd.2026.101667","DOIUrl":"10.1016/j.jocd.2026.101667","url":null,"abstract":"","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 2","pages":"Article 101667"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146015653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing bone health in elite female athletes: A study of aesthetic and non-aesthetic sports","authors":"Yuka Tsukahara ,&nbsp;Misora Oka ,&nbsp;Toshiharu Tsutsui ,&nbsp;Junna Mori ,&nbsp;Wataru Sakamaki ,&nbsp;Yuki Honma ,&nbsp;Akiko Hatsukari ,&nbsp;Erika Akiyama ,&nbsp;Suguru Torii","doi":"10.1016/j.jocd.2026.101690","DOIUrl":"10.1016/j.jocd.2026.101690","url":null,"abstract":"<div><div><em>Introduction:</em> Bone mineral density (BMD) and bone metabolism are crucial for athlete health but remain unexplored among aesthetic athletes. This study aimed to compare BMD and bone metabolism markers between aesthetic and non-aesthetic athletes and to identify factors influencing bone health.</div><div><em>Materials and Methods:</em> Female collegiate and high school athletes (<em>n</em> = 172) from aesthetic (<em>n</em> = 113) and non-aesthetic (<em>n</em> = 59) sports competing at a national level were enrolled. Total body BMD was measured using dual-energy X-ray absorptiometry, and bone biomarkers were assessed. Maturation status was calculated as chronological age minus age at menarche. Multiple regression analyses examined the effects of sport type and maturation on BMD and bone biomarkers.</div><div><em>Results:</em> Aesthetic athletes exhibited significantly lower total body BMD (Z-score: 1.03 ± 1.16) compared to non-aesthetic athletes (Z-score: 1.71 ± 1.25, <em>p</em> &lt; 0.01). Vitamin D levels were also significantly lower in aesthetic athletes (15.7 ± 5.6 ng/mL) compared to non-aesthetic athletes (28.1 ± 8.9 ng/mL, <em>p</em> &lt; 0.01). However, in adjusted models, aesthetic sport participation was not associated with BMD, whereas greater maturation was a significant positive predictor (β = 0.18, 95% CI: 0.08–0.27, <em>p</em> &lt; 0.001). Aesthetic sport participation was associated with altered bone resorption markers, including lower tartrate-resistant acid phosphatase type 5b and higher Type I collagen cross-linked N-telopeptide. Bone formation markers were not associated with sport type but showed significant negative associations with maturation.</div><div><em>Conclusion:</em> Maturation—reflecting age and earlier menarche—was the strongest predictor of BMD and bone metabolism, exerting greater influence than sport type. These findings highlight the importance of developmental stage in evaluating bone health among female athletes.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 2","pages":"Article 101690"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Osteoporosis prediction from frontal lumbar spine X-rays’ [Journal of clinical densitometry, volume 29 (2026), 101666]","authors":"Ryusei Inamori ,&nbsp;Tomoya Kobayashi ,&nbsp;Eichi Takaya ,&nbsp;Junya Iwazaki ,&nbsp;Carlos Makoto Miyauchi ,&nbsp;Saori Ikumi ,&nbsp;Yoshikazu Okamoto ,&nbsp;Cheng Wei Lin ,&nbsp;Sheng Che Hsiao ,&nbsp;Qingzong Tseng ,&nbsp;Shinya Sonobe","doi":"10.1016/j.jocd.2026.101671","DOIUrl":"10.1016/j.jocd.2026.101671","url":null,"abstract":"","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 2","pages":"Article 101671"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging diagnostic gaps in osteoporosis and sarcopenia in long-term care: Leveraging a mobile assessment unit for clinical trials and comprehensive musculoskeletal evaluations","authors":"Nami Safai Haeri ,&nbsp;Subashan Perera ,&nbsp;Susan L. Greenspan","doi":"10.1016/j.jocd.2025.101664","DOIUrl":"10.1016/j.jocd.2025.101664","url":null,"abstract":"<div><div><em>Background:</em> Osteoporosis and sarcopenia are prevalent in older adults, particularly in long-term care (LTC) settings, where logistical barriers often impede timely musculoskeletal assessments. Traditional mobile DXA services are limited and typically lack integrated evaluations of muscle health and functional performance. The present report shares our experience with an all-in-one mobile assessment unit designed to provide comprehensive musculoskeletal evaluations directly at LTC facilities.</div><div><em>Methods:</em> The mobile unit was deployed across five randomized controlled trials in over 30 LTC facilities from 2007 to 2025. It integrates multiple modalities to evaluate bone and muscle health. We report on feasibility, resource utilization, acceptability, and safety.</div><div><em>Results:</em> A total of 876 individuals were enrolled in the trials and underwent 3,623 assessments in the mobile unit, including screenings of non-enrolled individuals and repeated visits during 2–3 years of follow-up among enrolled participants. The mobile unit effectively conducted comprehensive assessments within 45 to 60 min per participant. No device-related adverse events occurred.</div><div><em>Conclusion:</em> This mobile assessment model offers a scalable solution to enhance musculoskeletal care access for older adults in LTC settings. Future directions include expanding its use to underserved populations and integrating telehealth capabilities to further improve care delivery.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101664"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between body mass index, bone mineral density and trabecular bone score in patients with Type 2 diabetes","authors":"Lili Zhuang ,&nbsp;Song Zou","doi":"10.1016/j.jocd.2025.101640","DOIUrl":"10.1016/j.jocd.2025.101640","url":null,"abstract":"<div><div><em>Objective:</em> To investigate the relationship between body mass index (BMI) and areal bone mineral density (BMD) as well as trabecular bone score (TBS) in adults with type 2 diabetes mellitus (T2DM) and to determine whether age or sex modifies these relationships.</div><div><em>Methods:</em> We retrospectively identified 762 community-dwelling adults aged ≥ 50 years (257 with T2DM and 505 non-diabetic controls) who underwent dual-energy X-ray absorptiometry at our centre between August 2023 and May 2024. Lumbar-spine and femoral-neck BMD as well as TBS were extracted. Associations were evaluated with Spearman’s ρ and multiple linear regression, adjusting for age and sex.</div><div><em>Results:</em> In men, BMI, BMD and TBS did not differ between diabetic and non-diabetic participants in any age stratum (all P &gt; 0.05). Women aged 50–60 y with T2DM exhibited higher LS-BMD but lower TBS than non-diabetic peers (both P &lt; 0.05), indicating early dissociation between density and micro-architecture. Correlation analysis shows a positive association between BMI and LS-BMD (ρ=0.286, <em>P</em>= 0.002). Multivariate linear regression confirmed that BMI was an independent positive predictor of LS-BMD (β = 0.276, <em>P</em> &lt; 0.001) and an independent negative predictor of TBS (β = −0.069, <em>P</em> = 0.043).</div><div><em>Conclusion:</em> In T2DM, higher BMI is independently associated with greater BMD but poorer trabecular micro-architecture. This paradox is most evident in post-menopausal women, underscoring TBS as an early warning tool when BMD remains normal.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101640"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145435654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring body composition ratios and their relation to cardiometabolic disease risk factors in adults with varying body mass index categories","authors":"Hannah E. Westerberg ,&nbsp;Madeline A. Czeck ,&nbsp;Donald R. Dengel ,&nbsp;Lisa S. Chow","doi":"10.1016/j.jocd.2025.101661","DOIUrl":"10.1016/j.jocd.2025.101661","url":null,"abstract":"<div><div><em>Introduction:</em> Muscle and bone are impacted by adiposity and metabolic dysfunction. To investigate their relationship, we assessed total and regional muscle-to-bone (MBR) and soft tissue-to-bone (SBR) ratios and their association with cardiometabolic risk factors in adults across body mass indexes (BMIs).</div><div><em>Methodology:</em> This study included 152 males (n=58; age 28.8±6.4 yrs) and females (n=94; age 28.1±6.8 yrs) with different BMIs. Dual X-ray absorptiometry provided lean mass, fat mass, and bone mineral content. ANCOVA with Bonferroni correction assessed ratio differences between BMIs while controlling for age. Linear regression assessed associations between the ratios with insulin, glucose, homeostatic model assessment of insulin resistance (HOMA-IR), triglycerides, total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein, TC:HDL ratio, and blood pressure while controlling for BMI and self-reported exercise status.</div><div><em>Results:</em> Males with obesity (O_M) had higher arm and leg, but not total MBR than males with healthy weight (HW_M). O_M had higher total, arm, and leg SBRs (all p&lt;0.001) than HW_M. Females with obesity (O_F) had higher total, arm, and leg MBRs and SBRs than healthy weight (HW_F) (all p&lt;0.01). Controlling for BMI and exercise status in females, total MBR and SBR positively associated with insulin (MBR: adjusted r²=0.24, p=0.02; SBR: adjusted r²=0.25, p=0.01) and HOMA-IR (MBR: adjusted r²=0.28, p=0.04; SBR: adjusted r²=0.30, p=0.01) while SBR associated with TC:HDL ratio (adjusted r²=0.19, p=0.03). No associations were found between the ratios with cardiometabolic outcomes in males.</div><div><em>Conclusions:</em> O_F had higher total and regional MBRs and SBRs than HW_F. O_M had higher regional MBRs and all SBRs than HW_M, but not total MBR. Total MBR and SBR associated positively with insulin and HOMA-IR in females, but not males. In females, SBR also positively associated with TC:HDL ratio. Although higher MBRs and SBRs may relate to higher cardiometabolic risk in females, further research is needed.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101661"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment trends after hip fracture of veterans with osteoporosis","authors":"Ashley McKenzie ,&nbsp;Alvin Lee Day","doi":"10.1016/j.jocd.2025.101656","DOIUrl":"10.1016/j.jocd.2025.101656","url":null,"abstract":"<div><div><em>Introduction:</em> Osteoporosis is the most common metabolic bone disease in the United States. It is often underdiagnosed and undertreated resulting in additional fragility fractures. Hip fractures specifically can lead to 8-36 % excess mortality at 1 year. It has been found that 80-95 % of patients in certain practice settings are discharged with insufficient antifracture treatment. We were interested in determining the frequency of transition from oral bisphosphonate to parenteral osteoporosis therapy following hospitalization for a hip fracture in veterans aged 65 and older.</div><div><em>Methods:</em> Utilizing the national Department of Veterans Affairs database, VA Informatics and Computing Infrastructure or VINCI, a cohort of patients aged 65 and older with a prior diagnosis of osteoporosis taking bisphosphonates who subsequently had a hip fracture was collected and analyzed. This created a cohort of 46,004 patients. This cohort was divided by gender and included 42,876 males and 3,128 females. The deidentified cohort records were reviewed to determine who received parenteral medications after the hip fracture.</div><div><em>Results:</em> Based on the analysis, there were 1,459 patients on parenteral medications in the cohort of 46,004 after hip fracture. This resulted in a percentage of 3.17 % overall. The percentage of women placed on a parenteral medication was 1.66 % and for men was 3.28 %. The most used medication was zoledronic acid (Zoledronic Acid) with 1,190 uses of the 1,459 (81.6 %).</div><div><em>Conclusion:</em> Hip fractures have a large impact on morbidity and mortality in the older population. Our study shows opportunity for increased utilization of parenteral therapies in patients who fractured on a background of oral bisphosphonate therapy. Delays may be the result of several issues including cost, recognition of fracture risk change, lack of communication, and comfort with therapies. The low percentage of parenteral medication use indicates some opportunity for more potent treatment. Future research directions could analyze civilian databases to get a more generalizable data set.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101656"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Bone Mass is Common and Associated with Delayed Estrogen Replacement Therapy in Adult Brazilian Women with Turner Syndrome","authors":"Carla Antoniana Ferreira de Almeida Vieira ,&nbsp;Eveline Gadelha Pereira Fontenele ,&nbsp;Danielle de Souza Bessa ,&nbsp;Fábia Karine de Moura Lopes ,&nbsp;Larissa Luna Queiroz ,&nbsp;Carlos Henrique Paiva Grangeiro ,&nbsp;Catarina Brasil D´alva ,&nbsp;Renan Magalhães Montenegro Junior ,&nbsp;Maria Elisabete Amaral de Moraes","doi":"10.1016/j.jocd.2025.101635","DOIUrl":"10.1016/j.jocd.2025.101635","url":null,"abstract":"<div><div><em>Introduction:</em> Turner syndrome is a rare chromosomal abnormality in females who typically present with short stature, hypogonadism and increased risk of osteoporosis. Areal bone densitometry (aBMD) usually underestimates bone mass in people with short stature and the bone mineral apparent density (BMAD) can be used as an adjustment for height. The study aimed to assess the frequency of low bone mass and associated factors in Brazilian women with TS at a referral center.</div><div><em>Methodology:</em> Cross-sectional dual-energy X-ray absorptiometry scans at the lumbar spine and femur were performed to assess bone mass. The association of aBMD, BMAD, age, height, history of fractures, karyotype, use of somatropin (rhGH) and estrogen replacement therapy (ERT) with low bone mass was tested and p-value &lt; 0.05 was considered statistically significant.</div><div><em>Results:</em> Forty-six patients with a mean age of 32 years and height (SDS) 145 cm (-2.89) were evaluated. Five (11%) had a history of fracture. Thirty-five (83%) patients had delayed puberty (&gt; 13 years), 4 (9%) had spontaneous menarche, 19 (41%) were treated with rhGH. Lumbar aBMD was positively correlated to height (p = 0.010). Low bone mass was more frequently detected with aBMD (49% lumbar spine and 48% femoral neck) than with BMAD (31% lumbar spine and 13% femoral neck) and was associated with estrogen status (p=0,002). All patients with delayed puberty and without ERT at the time of the study had low bone mass at the lumbar spine. In contrast, all patients with spontaneous menarche had normal bone mass at both sites. No significant correlation between treatment with rhGH or karyotype with low bone mass was observed.</div><div><em>Conclusions:</em> Low bone mass is a common finding in a cohort of Brazilian women with TS and is associated with delayed puberal induction or start of ERT. Our results highlight the importance of early diagnosis and prompt initiation of ERT to optimise bone mass acquisition.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101635"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145469077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Q-BONE system: A novel dual-energy X-ray diagnostic method for osteoporosis","authors":"Takahiro Kawamura ,&nbsp;Tomoyuki Takahashi ,&nbsp;Kayo Okano ,&nbsp;Masahiko Yamada ,&nbsp;Toshiko Iidaka ,&nbsp;Sakae Tanaka ,&nbsp;Noriko Yoshimura","doi":"10.1016/j.jocd.2025.101638","DOIUrl":"10.1016/j.jocd.2025.101638","url":null,"abstract":"<div><h3>Background</h3><div>Osteoporosis is a prevalent and growing public health issue, particularly in aging populations, due to its association with fragility fractures, reduced mobility, and increased healthcare burden. Dual-energy X-ray absorptiometry (DXA) remains the clinical gold standard for assessing bone mineral density (BMD), but it requires dedicated equipment. DXA is separately required from the radiography system for fracture diagnosis, making DXA difficult to access depending on the facility and region.</div></div><div><h3>Purpose</h3><div>To address these limitations, we developed the quantitative bone (Q-BONE) system, a novel diagnostic tool that updates existing radiography system to utilize dual energy in a single X-ray irradiation to produce BMD (Q-BONE score) and high-resolution X-ray images (Q-BONE images).</div></div><div><h3>Methods</h3><div>We evaluated the correlation between the Q-BONE score of Q-BONE system and the BMD of the DXA for the DXA measurement phantom and the 200 people, and the degree of agreement among them by Bland-Altman analysis. Further, fracture detectability was compared between Q-BONE images and radiographs using predefined radiological criteria.</div></div><div><h3>Results</h3><div>The correlation between bone mineral density and Q-BONE score for 200 individuals was as high as 0.91 with good linearity; however, these two values were statistically inconsistent mainly because of body fat percentage (<em>P</em> &lt; 0.05). Q-BONE images significantly improved visualization of cortical and trabecular bone structures (<em>P</em> &lt; 0.01) and improved detection of fractures and structural abnormalities compared with conventional radiographs.</div></div><div><h3>Conclusions</h3><div>The Q-BONE system has the potential that achieves comprehensive osteoporosis assessment by combining BMD measurement and fracture evaluation in a single efficient procedure. Its implementation could improve diagnostic efficiency and accessibility, particularly in settings where DXA is unavailable. Further technical improvement on body fat issues, and studies are warranted to assess its clinical utility across broader populations and skeletal sites.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101638"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145670612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}