Correlation of Lean Mass Measurements Between a Novel Whole-body X-ray Bone Densitometer (iNSiGHT C510) and Magnetic Resonance Imaging: A Single-center Comparative study

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry Pub Date : 2025-03-26 DOI:10.1016/j.jocd.2025.101585

Yong-Chan Ha , Shinjune Kim , Jun-Il Yoo

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引用次数: 0

Abstract

Background: Sarcopenia, the age-related loss of muscle mass, increases health risks in older adults. Accurate measurement of skeletal muscle mass is critical for diagnosis. While DEXA is widely used, its extended scan time limits clinical utility. This study evaluates the accuracy of lean mass measurements from the newly developed iNSiGHT C510 X-ray bone densitometer compared to MRI, the gold standard.

Methods: This single-center, open-label clinical trial included 20 adult participants (10 males, 10 females) aged 20–70 years. Participants underwent whole-body scans using the iNSiGHT C510 and MRI. Lean and fat mass measurements were obtained from both devices. Statistical analysis included Bland-Altman plots, intraclass correlation coefficients (ICC), and concordance correlation coefficients (CCC) to assess agreement between the two methods. Linear regression analysis was performed to derive conversion formulas between C510 and MRI measurements.

Results: The study found a very strong correlation between lean mass measurements from the iNSiGHT C510 and MRI, with correlation coefficients (r) of 0.961 for the right side, 0.967 for the left, and 0.963 for combined lean mass. ICC and CCC values for lean mass were also high, indicating strong agreement between the two methods. Fat mass measurements, though moderately correlated, showed larger discrepancies compared to lean mass. The iNSiGHT C510 significantly reduced measurement time by 50 % compared to conventional DEXA scans.

Conclusion: The iNSiGHT C510 demonstrated high accuracy in measuring lean mass compared to MRI, with the added benefit of shorter measurement time, making it a practical tool for sarcopenia diagnosis and monitoring in clinical settings. However, further research with larger sample sizes and long-term assessments is needed to validate its broader clinical utility.

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新型全身x线骨密度仪（iNSiGHT C510）与磁共振成像之间瘦质量测量的相关性：单中心比较研究

背景：骨骼肌减少症，与年龄相关的肌肉质量损失，增加了老年人的健康风险。准确测量骨骼肌质量对诊断至关重要。虽然DEXA被广泛使用，但其延长的扫描时间限制了临床应用。本研究评估了新开发的iNSiGHT C510 x射线骨密度仪与MRI（金标准）相比的瘦质量测量的准确性。方法：这项单中心、开放标签的临床试验包括20名年龄在20 - 70岁之间的成人受试者（10男10女）。参与者使用iNSiGHT C510和MRI进行全身扫描。从这两种设备中获得了瘦和脂肪质量测量值。统计分析包括Bland-Altman图、类内相关系数（ICC）和一致性相关系数（CCC）来评估两种方法之间的一致性。进行线性回归分析，得出C510与MRI测量值之间的转换公式。结果：研究发现iNSiGHT C510测量的瘦质量与MRI之间存在很强的相关性，右侧的相关系数(r)为0.961，左侧为0.967，综合瘦质量为0.963。瘦质量的ICC和CCC值也很高，表明两种方法之间的一致性很强。脂肪质量测量虽然有一定的相关性，但与瘦质量相比，差异更大。与传统的DEXA扫描相比，iNSiGHT C510显着减少了50%的测量时间。结论：与MRI相比，iNSiGHT C510在测量瘦质量方面具有较高的准确性，并且测量时间更短，使其成为临床诊断和监测肌肉减少症的实用工具。然而，需要更大样本量的进一步研究和长期评估来验证其更广泛的临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Densitometry 医学-内分泌学与代谢

CiteScore

4.90

自引率

8.00%

发文量

审稿时长

90 days

期刊介绍： The Journal is committed to serving ISCD''s mission - the education of heterogenous physician specialties and technologists who are involved in the clinical assessment of skeletal health. The focus of JCD is bone mass measurement, including epidemiology of bone mass, how drugs and diseases alter bone mass, new techniques and quality assurance in bone mass imaging technologies, and bone mass health/economics. Combining high quality research and review articles with sound, practice-oriented advice, JCD meets the diverse diagnostic and management needs of radiologists, endocrinologists, nephrologists, rheumatologists, gynecologists, family physicians, internists, and technologists whose patients require diagnostic clinical densitometry for therapeutic management.