Journal of Clinical Densitometry最新文献

{"title":"Identifying Key Genes and Their Associated Molecular Pathways in Lupus Nephritis-Osteoporosis: An In-Silico Analysis","authors":"Guangdi Zhang ,&nbsp;Bo Li ,&nbsp;Yun Xia","doi":"10.1016/j.jocd.2024.101524","DOIUrl":"10.1016/j.jocd.2024.101524","url":null,"abstract":"<div><p>Nephritis and osteoporosis are debilitating medical conditions that significantly impact human health and reduce quality of life. To develop potential therapeutic strategies for these disorders necessitates understanding the genetic and molecular mechanisms. Here, we employed bioinformatics techniques purposed to find key genes and associated pathways responsible for nephritis-osteoporosis comorbidity. Six microarray datasets of systemic lupus erythematosus (SLE) and osteoporosis were retrieved from the Gene Expression Omnibus (GEO) database. Post normalization of data sets LIMMA package was utilized for differential expression analysis, among the datasets 44 differentially expressed genes (DEGs) were identified. The identified 44 genes were further analyzed for gene ontology (GO) where it was found that these genes are involved in defense response, organism interactions, and response to external stimuli. In predicting the molecular function, they were involved in several biological processes including binding to lipopolysaccharides and having peptidase and hydrolase activities. Firstly, the identified genes were primarily associated with certain granules such as specific granules and secretory granules in the aspect of cellular components. Enrichment analysis pointed out the potential pathways linked to the immune system, neutrophil degranulation, innate immunity, and immune response to tuberculosis. To examine interactions among DEGs, a complex protein-protein interaction (PPI) network was built, resulting in the identification of seven hub genes, <em>CXCL8, ELANE, LCN2, MMP8, IFIT1, MX1,</em> and <em>ISG15</em>. The study suggests that these elucidated hub genes might have high potential to be exploited as promising biomarkers and therapeutic targets in nephritis-osteoporosis. Taken together, this study provided deeper insights into the genetic and molecular basis for the comorbidity of nephritis and osteoporosis.</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 4","pages":"Article 101524"},"PeriodicalIF":1.7,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142095760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone health ECHO case report: Orbital inflammation after zoledronate infusion","authors":"Danielle D'Annibale ,&nbsp;E. Michael Lewiecki ,&nbsp;Preethika Ekanayake","doi":"10.1016/j.jocd.2024.101519","DOIUrl":"10.1016/j.jocd.2024.101519","url":null,"abstract":"<div><p>Prior to the initiation of intravenous bisphosphonate therapy for osteoporosis, the impact on ocular health is not routinely discussed with patients. This is due to the scarcity of data on the association between bisphosphonates and ocular side effects, resulting in lack of provider awareness to effectively counsel patients. Furthermore, there is little consensus among clinicians on the safety of re-challenging with intravenous bisphosphonate treatment following ocular complications. This is a case report of a patient who developed orbital inflammation four days after receiving a zoledronate infusion. This case was discussed amongst health care providers and osteoporosis experts during a meeting of Bone Health Extension for Community Healthcare Outcomes (ECHO) virtual platform, which was established in 2015.</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 4","pages":"Article 101519"},"PeriodicalIF":1.7,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Team sports practice and bone health: A systematic review and meta- analysis","authors":"Hassane Zouhal ,&nbsp;Abdel-Jalil Berro ,&nbsp;Elie Maliha ,&nbsp;Nour Khalil ,&nbsp;Gisèle El Khoury ,&nbsp;Ayyappan Jayavel ,&nbsp;Fatiha Laziri ,&nbsp;Ayoub Saeidi ,&nbsp;Ismail Laher ,&nbsp;Rawad El Hage","doi":"10.1016/j.jocd.2024.101508","DOIUrl":"10.1016/j.jocd.2024.101508","url":null,"abstract":"<div><p>The primary aim of this study was to explore the effects of team sports practice on bone health indices in adults engaged in team sports. The secondary aim was to investigate the osteogenic effects of each type of team sport. This systematic literature search was conducted using common electronic databases from inception in June 2023, using key terms (and synonyms searched for by the MeSH database) that were combined using the operators “AND”, “OR”, “NOT”: (``men'' OR ``man'' OR ``women'' OR ``woman'') AND (``bone mineral density'' OR ``BMD'' OR ``bone mineral content'' OR ``BMC'' OR ``peak bone mass'' OR ``mechanical loading'' OR ``osteoporosis'' OR ``bone geometry'' OR ``bone resistance'') AND (``team sport'' OR ``sport'' OR rugby OR basketball OR volleyball OR handball OR soccer OR football OR ``players''). After screening, 16 studies were included in the final analysis (5 continents, 2740 participants). The training duration lasted 1 to 13 years. Team sport training had a moderate impact on whole body bone mineral density (WB BMD) (1.07 SMD; 95 % [0.77, 1.37], <em>p</em> &lt; 0.00) but a more significant impact on whole body bone mineral content (WB BMC) (1.3 SMD; 95 % [0.81, 1.79], <em>p</em> &lt; 0.00). Subgroup analyses indicated that rugby training had a moderate but non-significant impact on WB BMD (1.19 SMD; 95 % [−0.13, 2.52], <em>p</em> = 0.08) but a greater impact on WB BMC (2.12 SMD; 95 % [0.84, 3.39], <em>p</em> &lt; 0.00); basketball training had a moderate but significant impact on WB BMD (1 SMD; 95 % [0.35, 1.64], <em>p</em> &lt; 0.00) and a trivial non-significant impact on WB BMC (0.18 SMD; 95 % [−1.09, 1.46], <em>p</em> = 0.78); volleyball training had a moderate but non-significant impact on WB BMD (0.63 SMD; 95 % [−0.22, 1.49], <em>p</em> = 0.15) and a significant impact on WB BMC (2.39 SMD; 95 % [1.45, 3.33], <em>p</em> &lt; 0.00). Handball training produced a moderate significant impact on WB BMD (1.02 SMD; 95 % [0.33, 1.71], <em>p</em> &lt; 0.00) and WB BMC (0.97 SMD; 95 % [0.47, 1.48], <em>p</em> &lt; 0.00), and soccer training led to moderate but significant effects on WB BMD (1.16 SMD; 95 % [0.88, 1.44], <em>p</em> &lt; 0.00) and a large effect on WB BMC (1.34 SMD; 95 % [0.92, 1.77], <em>p</em> &lt; 0.00). Rugby training was associated with a higher WB BMC compared to basketball training (<em>p</em> = 0.03). Our systematic review and meta-analysis suggests that team sports, such as rugby, basketball, volleyball, handball and soccer have moderate to large effects on WB BMD and WB BMC. Specifically, our findings indicate that handball and soccer enhance WB BMD and WB BMC, whereas rugby only increases WB BMC. There is currently insufficient evidence indicating the superiority of any type of sport training that improves bone health in adults.</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 4","pages":"Article 101508"},"PeriodicalIF":1.7,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosing (severe) osteoporosis by Hologic vs. Lunar measurements: A single-center retrospective study","authors":"Pelin Analay ,&nbsp;Murat Kara ,&nbsp;Ahmet Sertçelik ,&nbsp;Kübranur Demirel ,&nbsp;Berkay Yalçınkaya ,&nbsp;Bayram Kaymak ,&nbsp;Banu Çakır ,&nbsp;Levent Özçakar","doi":"10.1016/j.jocd.2024.101509","DOIUrl":"10.1016/j.jocd.2024.101509","url":null,"abstract":"<div><p><em>Introduction:</em> Although different dual-energy X-ray absorptiometry (DXA) scanners provide different bone mineral density (BMD) values, there is not a gold standard DXA scanner. <em>T</em>-score is used to facilitate the interpretation of BMD, and osteoporosis (OP) is diagnosed based on <em>T</em>-scores. In this retrospective study, we aimed to evaluate the BMD and <em>T</em>-score differences between Lunar Prodigy and Hologic Horizon DXA scanners.</p><p><em>Methodology:</em> Data were collected for patients with previous BMD measurement on Lunar Prodigy and Hologic Horizon DXA scanners within one year in the same medical center.</p><p><em>Results:</em> In a total of 55 patients, BMD values of femoral neck/total, and lumbar vertebrae were all lower at Hologic than Lunar (all <em>p</em> &lt; 0.01). The mean <em>T</em>-score difference at the lumbar spine was 0.74 ± 0.42 (<em>p</em> &lt; 0.001). Of the 49 patients diagnosed as OP (<em>T</em>-score ≤−2.5) with the Hologic, the diagnoses were changed for 25 individuals (51.0 %) with Lunar (<em>p</em> &lt; 0.001). Herewith, although the diagnoses of OP did not change by the repeat technique in other 24 patients (49 %), 13 of them (26.5 %) were categorized as having “high fracture risk” instead of “very high fracture risk” group (i.e., <em>T</em>-score &lt;−3.0). We observed moderate-to-good reliabilities (with an intraclass correlation coefficient [ICC] of 0.633–0.878 and 0.733–0.842 for BMD and <em>T</em>-scores, respectively) between measurements with the Lunar and Hologic scanners. Except for one measurement in L3, L4, L1–4 vertebrae, the Bland–Altman plot did not reveal any consistent bias between the measurements of the Lunar and Hologic scanners.</p><p><em>Conclusions:</em> The consistency between different DXA scanners (especially for Hologic vs. Lunar) is important for proper management, especially in patients with low <em>T</em>-scores and OP.</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 4","pages":"Article 101509"},"PeriodicalIF":1.7,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141710530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between bony changes of the mandibular condyle and eichner index","authors":"Sedef Kotanlı ,&nbsp;Nurbanu Uluısık ,&nbsp;Mehmet Oguzhan Ergin","doi":"10.1016/j.jocd.2024.101507","DOIUrl":"10.1016/j.jocd.2024.101507","url":null,"abstract":"<div><p><em>Introduction:</em> The aim of this study was to evaluate whether degenerative bone changes in the mandibular condyle on cone beam computed tomography images are associated with the Eichner index.</p><p><em>Methodology:</em> 336 cone beam computed tomography images condyle images of 168 patients were analyzed for degenerative bone changes. These changes were named as condyle flattening, osteophytes, erosions, subchondral sclerosis, generalized sclerosis and subchondral cysts. The edentulous status of the patients was classified as group A-B-C and subtypes according to the Eichner index. Categorical variables were evaluated with chi-square test and p &lt; 0.05 was considered statistically significant.</p><p><em>Results:</em> According to the results of the study, the most common degenerative condyle change was flattening of the condyle. Among the Eichner index groups, the most common group was A and the least common group was C. Condyle changes on the right and left sides were most commonly observed in group A patients. The statistically significant majority of patients with right-sided condyle flattening and erosion were in group C. No significant difference was found between all other condyle changes and Eichner index groups. There was no significant relationship between Eichner index and gender.</p><p><em>Conclusion:</em> Degenerative bone changes (flattening and erosion of the condyle) in the condyle region were more common in group C patients with more tooth loss. There is a significant relationship between condyle changes and posterior toothlessness.</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 4","pages":"Article 101507"},"PeriodicalIF":1.7,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1094695024000428/pdfft?md5=9e4ed6e7341ac7f5334ce35e41c7576c&pid=1-s2.0-S1094695024000428-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141614273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of bone mass accrual in transgender and gender diverse youth undergoing pubertal suppression therapy","authors":"Samantha Roberge ,&nbsp;Taylor Roberge ,&nbsp;Sarah Corathers ,&nbsp;Nat Nasomyont","doi":"10.1016/j.jocd.2024.101505","DOIUrl":"10.1016/j.jocd.2024.101505","url":null,"abstract":"<div><p><em>Introduction/Background:</em> Gender-affirming care for gender diverse and transgender (GDTG) youth includes puberty suppression with gonadotropin-releasing hormone agonists (GnRHa). Puberty is a critical period of bone mass accrual, and pubertal suppression may impact bone health. Previous studies have shown a decrease in areal bone mineral density (aBMD) Z-score while on puberty suppression. However, the rate of bone mass accrual and its determinants during GnRHa therapy are not known.</p><p><em>Methodology:</em> This is a retrospective chart review of GDTG youth with aBMD assessment within six months of starting GnRHa monotherapy at Cincinnati Children's Hospital Medical Center between 01/2011 and 12/2022. In individuals with follow-up aBMD assessment, we calculated their aBMD velocity and generated Z-scores using reference data from the Bone Mineral Density in Childhood Study. The determinants of baseline height-adjusted aBMD and aBMD velocity Z-scores were assessed with multiple linear regression models.</p><p><em>Results:</em> Thirty-six participants (36% assigned female at birth (AFAB), mean age at first aBMD assessment 12 ± 1.1 years) had baseline height-adjusted aBMD Z-score of -0.053 ± 0.79. Among 16 participants with follow-up aBMD assessment, the mean aBMD velocity Z-score was -0.42 ± 1.13 (-0.27 ± 0.79 in AFAB vs -0.52 ± 1.32 in assigned male at birth, <em>p</em> = 0.965). Baseline aBMD Z-scores significantly correlated with age at the first aBMD assessment (adjusted R² 0.124, <em>p</em> = 0.02) with combined modeling including age at first aBMD assessment and BMI Z-score being most significant (adjusted R² 0.21, <em>p</em> = 0.008). Only BMI Z-scores were positively associated with the aBMD-velocity Z-scores (adjusted R² 0.255, <em>p</em> = 0.046).</p><p><em>Conclusions:</em> GDTG youth undergoing GnRHa therapy appeared to have below-average aBMD velocity Z-scores. A lower BMI Z-score was a determinant of lower baseline height-adjusted aBMD and aBMD velocity Z-scores. Building on previous studies, our study highlights aBMD velocity as a novel technique for bone health surveillance in GDTG youth.</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 3","pages":"Article 101505"},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141391776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sprinting performance correlates with composite indices of femoral neck strength in young men","authors":"Lara Chatrieh,&nbsp;Antonio Pinti,&nbsp;Rawad El Hage","doi":"10.1016/j.jocd.2024.101506","DOIUrl":"10.1016/j.jocd.2024.101506","url":null,"abstract":"","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 3","pages":"Article 101506"},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of volumetric bone mineral density measurement in weight bearing, cone beam computed tomography","authors":"Tadiwa H. Waungana ,&nbsp;Keven Qiu ,&nbsp;Justin J. Tse ,&nbsp;Donald D. Anderson ,&nbsp;Carolyn A. Emery ,&nbsp;Steven K. Boyd ,&nbsp;Sarah L. Manske","doi":"10.1016/j.jocd.2024.101504","DOIUrl":"10.1016/j.jocd.2024.101504","url":null,"abstract":"<div><p><em>Background:</em> Weight bearing computed tomography (WBCT) utilizes cone beam CT technology to provide assessments of lower limb joint structures while they are functionally loaded. Grey-scale values indicative of X-ray attenuation that are output from cone beam CT are challenging to calibrate, and their use for bone mineral density (BMD) measurement remains debatable. To determine whether WBCT can be reliably used for cortical and trabecular BMD assessment, we sought to establish the accuracy of BMD measurements at the knee using modern WBCT by comparing them to measurements from conventional CT.</p><p><em>Methods:</em> A hydroxyapatite phantom with three inserts of varying densities was used to systematically quantify signal uniformity and BMD accuracy across the acquisition volume. We evaluated BMD <em>in vivo</em> (n = 5, female) using synchronous and asynchronous calibration techniques in WBCT and CT. To account for variation in attenuation along the height (<em>z</em>-axis) of acquisition volumes, we tested a height-dependent calibration approach for both WBCT and CT images.</p><p><em>Results:</em> Phantom BMD measurement error in WBCT was as high as 15.3% and consistently larger than CT (up to 5.6%). Phantom BMD measures made under synchronous conditions in WBCT improved measurement accuracy by up to 3% but introduced more variability in measured BMD. We found strong correlations (R = 0.96) as well as wide limits of agreement (-324 mgHA/cm³ to 183 mgHA/cm³) from Bland-Altman analysis between WBCT and CT measures <em>in vivo</em> that were not improved by height-dependent calibration.</p><p><em>Conclusion:</em> Whilst BMD accuracy from WBCT was found to be dependent on apparent density, accuracy was independent of the calibration technique (synchronous or asynchronous) and the location of the measurement site within the field of view. Overall, we found strong correlations between BMD measures from WBCT and CT and <em>in vivo</em> measures to be more accurate in trabecular bone regions. Importantly, WBCT can be used to distinguish between anatomically relevant differences in BMD, however future work is necessary to determine the repeatability and sensitivity of BMD measures in WBCT.</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 3","pages":"Article 101504"},"PeriodicalIF":2.5,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1094695024000398/pdfft?md5=265fd47b988c7c6381cc0b185da96bd5&pid=1-s2.0-S1094695024000398-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141414832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of Tai Chi Rouli ball exercise on bone mineral content and bone metabolism indicators in perimenopausal women","authors":"Aili Xin ,&nbsp;Liumei Guo","doi":"10.1016/j.jocd.2024.101503","DOIUrl":"10.1016/j.jocd.2024.101503","url":null,"abstract":"<div><p>Background Perimenopause is associated with a decline in estrogen levels, leading to decreased bone mineral density (BMD) and altered bone metabolism, increasing the risk of osteoporosis. Tai Chi Rouli Ball, a traditional Chinese sport, is thought to have beneficial effects on physical health, but its impact on bone health in perimenopausal women is not well understood.</p><p>Methods This study involved a randomized controlled trial with 52 perimenopausal women aged 45–55 years from community senior centers. Participants were divided into two groups: the Tai Chi Rouli Ball group and the control group. Baseline assessments of bone density, bone mineral content (BMC), and bone metabolism markers, including estrogen levels, were conducted. The Tai Chi Rouli Ball group underwent regular training for a specific period, while the control group did not receive any intervention. Post-experiment assessments were then compared to the baseline.</p><p>Results Post-intervention, the Tai Chi Rouli Ball group showed a significant increase in spine bone density and BMC in various body parts, including the whole body, trunk/torso, and spine, compared to the control group. Bone metabolism indicators also improved, with increased levels of estrogen and a decrease in follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Calcium levels showed a significant increase, while other markers like alkaline phosphatase (ALP), phosphorus (P), and magnesium (Mg) had non-significant changes.</p><p>Conclusions Tai Chi Rouli Ball exercise may positively influence bone health by improving bone density, BMC, and altering bone metabolism markers in perimenopausal women. These findings suggest that Tai Chi Rouli Ball could be a viable non-pharmacological approach to prevent osteoporosis in this demographic.</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 3","pages":"Article 101503"},"PeriodicalIF":2.5,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141028267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pheochromocytoma or paraganglioma on bone metabolism: A systemic review and meta-analysis","authors":"Deep Dutta ,&nbsp;Lakshmi Nagendra ,&nbsp;Manju Chandran ,&nbsp;Meha Sharma ,&nbsp;Saptarshi Bhattacharya ,&nbsp;Satinath Mukhopadhyay","doi":"10.1016/j.jocd.2024.101501","DOIUrl":"10.1016/j.jocd.2024.101501","url":null,"abstract":"<div><p><em>Introduction:</em> Preclinical and animal studies have suggested that excess catecholamines can lead to bone mineral loss. However, to date, no systematic review is available that has analyzed the impact of catecholamine excess in the context of pheochromocytoma/paraganglioma (PPGL) on bone metabolism. We conducted this meta-analysis to address this knowledge gap.</p><p><em>Methods:</em> Electronic databases were searched for studies evaluating bone metabolism, including assessments of bone mineral density (BMD), quantitative computed tomography (qCT), trabecular bone score (TBS), or bone turnover markers in patients with PPGL. These markers included those of bone resorption, such as tartrate-resistant acid phosphatase 5b (TRACP-5b) and cross-linked C-telopeptide of type I collagen (CTx), as well as markers of bone formation, such as bone-specific alkaline phosphatase (BS ALP).</p><p><em>Results:</em> Out of the initially screened 1614 articles, data from six studies published in four different patient cohorts with PPGL that met all criteria were analysed. Individuals with PPGL had significantly lower TBS [Mean Difference (MD) -0.04 (95% CI: -0.05–-0.03); <em>p</em> &lt; 0.00001; I2 = 0%], higher serum CTx [MD 0.13 ng/ml (95% CI: 0.08–0.17); <em>p</em> &lt; 0.00001; I2 = 0%], and higher BS-ALP [MD 1.47 U/L (95% CI: 0.30–2.64); <em>p</em> = 0.01; I2 = 1%]. TBS at 4-7 months post-surgery was significantly higher compared to baseline [MD 0.05 (95% CI: 0.02–0.07); <em>p</em> &lt; 0.0001]. A decrease in CTx has been documented post-surgery.</p><p><em>Conclusion:</em> Bone health deterioration is a major concern in patients with PPGL. In addition to providing a definitive cure for catecholamine excess, monitoring and treating osteoporosis is essential for individuals with secondary osteoporosis due to PPGL. Long-term studies on bone health outcomes in PPGL are warranted</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 3","pages":"Article 101501"},"PeriodicalIF":2.5,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141046083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}