Journal of Clinical Densitometry最新文献

{"title":"Effects of two types of resistance training modalities (hypertrophy vs. contrast training) on bone parameters in a group of healthy elderly women","authors":"Obaida Abdul-Al ,&nbsp;Gautier Zunquin ,&nbsp;Rawad El Hage","doi":"10.1016/j.jocd.2024.101521","DOIUrl":"10.1016/j.jocd.2024.101521","url":null,"abstract":"<div><p>The aim of the present study was to explore the effects of two types of resistance training modalities (hypertrophy training vs. contrast training) on bone health parameters in a group of healthy elderly women. Forty-nine healthy elderly women whose ages range between 60 and 70 years were included in this study. The study population was randomly divided into three groups: hypertrophy training group (HTG; n=16), contrast training group (CTG; n=16) and control group (CG; n=17). Bone mineral density (BMD) values at the whole body (WB), lumbar spine (L1-L4), total hip (TH) and femoral neck (FN) were measured by DXA before and after 12 months of resistance training. Composite indices of femoral neck strength were calculated. WB BMD, L1-L4 BMD, TH BMD and FN BMD increased in the contrast training group. WB BMD and L1-L4 BMD increased in the hypertrophy training group, while TH BMD and FN BMD remained unchanged. Significant decreases in WB BMD, L1-L4 BMD, TH BMD and FN BMD were observed in the control group. The contrast training group showed the highest improvements in BMD values compared to the two other groups. Both experimental groups (HTG and CTG) showed similar significant improvements in composite indices of femoral neck strength and muscular strength. In conclusion, contrast training and hypertrophy training can stimulate bone gain at clinically important sites of osteoporotic fractures in elderly women.</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 4","pages":"Article 101521"},"PeriodicalIF":1.7,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142049607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Mineral Density Monitoring in Contiguous versus Non-Contiguous Lumbar Vertebrae: The Manitoba BMD Registry","authors":"Auryan Szalat ,&nbsp;Harold Rosen ,&nbsp;William D. Leslie","doi":"10.1016/j.jocd.2024.101520","DOIUrl":"10.1016/j.jocd.2024.101520","url":null,"abstract":"<div><p><em>Introduction:</em> Only change in bone mineral density (BMD) on repeat DXA that exceeds the 95% least significant change (LSC) should be considered clinically meaningful. Frequently lumbar spine DXA must be reported after omitting vertebrae with localized structural artifact, which reduces measurement precision. Previous reports have raised concerns of higher least significant change (LSC) when spine BMD is based on non-contiguous rather than contiguous vertebrae. The current study was performed to compare lumbar spine LSC and BMD response to intervening anti-osteoporosis medication use from non-contiguous versus contiguous vertebrae.</p><p><em>Methodology:</em> LSCs for lumbar spine DXA based on L1-L4 and all combinations of non-contiguous and contiguous vertebrae were calculated using 879 scan-pairs from the Manitoba BMD Program. We compared BMD change from these regions, overall and in relation to intervening anti-osteoporosis medication use, in 11,722 patients who had 2 DXA examinations.</p><p><em>Results:</em> LSCs were slightly greater when calculated from combinations of fewer than 4 vertebrae, but there was no meaningful difference between contiguous versus non-contiguous vertebrae. There were consistently high correlations between lumbar spine BMD change from L1-L4 and all combinations of continuous and non-contiguous vertebrae (all Pearson r≥ 0.9, p&lt;0.001). Percentage changes in spine BMD and the fraction with treatment-concordant change exceeding the LSC were similar using contiguous or non-contiguous vertebrae.</p><p><em>Conclusions:</em> Lumbar spine BMD change can be assessed from 2 or 3 non-contiguous vertebrae when clinically necessary, and precision in such cases is similar to using contiguous vertebrae. Non-contiguous vertebrae can detect treatment-concordant changes similar in spine BMD to contiguous vertebrae.</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 4","pages":"Article 101520"},"PeriodicalIF":1.7,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142049606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Key Genes and Their Associated Molecular Pathways in Lupus Nephritis-Osteoporosis: An In-Silico Analysis","authors":"Guangdi Zhang ,&nbsp;Bo Li ,&nbsp;Yun Xia","doi":"10.1016/j.jocd.2024.101524","DOIUrl":"10.1016/j.jocd.2024.101524","url":null,"abstract":"<div><p>Nephritis and osteoporosis are debilitating medical conditions that significantly impact human health and reduce quality of life. To develop potential therapeutic strategies for these disorders necessitates understanding the genetic and molecular mechanisms. Here, we employed bioinformatics techniques purposed to find key genes and associated pathways responsible for nephritis-osteoporosis comorbidity. Six microarray datasets of systemic lupus erythematosus (SLE) and osteoporosis were retrieved from the Gene Expression Omnibus (GEO) database. Post normalization of data sets LIMMA package was utilized for differential expression analysis, among the datasets 44 differentially expressed genes (DEGs) were identified. The identified 44 genes were further analyzed for gene ontology (GO) where it was found that these genes are involved in defense response, organism interactions, and response to external stimuli. In predicting the molecular function, they were involved in several biological processes including binding to lipopolysaccharides and having peptidase and hydrolase activities. Firstly, the identified genes were primarily associated with certain granules such as specific granules and secretory granules in the aspect of cellular components. Enrichment analysis pointed out the potential pathways linked to the immune system, neutrophil degranulation, innate immunity, and immune response to tuberculosis. To examine interactions among DEGs, a complex protein-protein interaction (PPI) network was built, resulting in the identification of seven hub genes, <em>CXCL8, ELANE, LCN2, MMP8, IFIT1, MX1,</em> and <em>ISG15</em>. The study suggests that these elucidated hub genes might have high potential to be exploited as promising biomarkers and therapeutic targets in nephritis-osteoporosis. Taken together, this study provided deeper insights into the genetic and molecular basis for the comorbidity of nephritis and osteoporosis.</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 4","pages":"Article 101524"},"PeriodicalIF":1.7,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142095760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone health ECHO case report: Orbital inflammation after zoledronate infusion","authors":"Danielle D'Annibale ,&nbsp;E. Michael Lewiecki ,&nbsp;Preethika Ekanayake","doi":"10.1016/j.jocd.2024.101519","DOIUrl":"10.1016/j.jocd.2024.101519","url":null,"abstract":"<div><p>Prior to the initiation of intravenous bisphosphonate therapy for osteoporosis, the impact on ocular health is not routinely discussed with patients. This is due to the scarcity of data on the association between bisphosphonates and ocular side effects, resulting in lack of provider awareness to effectively counsel patients. Furthermore, there is little consensus among clinicians on the safety of re-challenging with intravenous bisphosphonate treatment following ocular complications. This is a case report of a patient who developed orbital inflammation four days after receiving a zoledronate infusion. This case was discussed amongst health care providers and osteoporosis experts during a meeting of Bone Health Extension for Community Healthcare Outcomes (ECHO) virtual platform, which was established in 2015.</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 4","pages":"Article 101519"},"PeriodicalIF":1.7,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Team sports practice and bone health: A systematic review and meta- analysis","authors":"Hassane Zouhal ,&nbsp;Abdel-Jalil Berro ,&nbsp;Elie Maliha ,&nbsp;Nour Khalil ,&nbsp;Gisèle El Khoury ,&nbsp;Ayyappan Jayavel ,&nbsp;Fatiha Laziri ,&nbsp;Ayoub Saeidi ,&nbsp;Ismail Laher ,&nbsp;Rawad El Hage","doi":"10.1016/j.jocd.2024.101508","DOIUrl":"10.1016/j.jocd.2024.101508","url":null,"abstract":"<div><p>The primary aim of this study was to explore the effects of team sports practice on bone health indices in adults engaged in team sports. The secondary aim was to investigate the osteogenic effects of each type of team sport. This systematic literature search was conducted using common electronic databases from inception in June 2023, using key terms (and synonyms searched for by the MeSH database) that were combined using the operators “AND”, “OR”, “NOT”: (``men'' OR ``man'' OR ``women'' OR ``woman'') AND (``bone mineral density'' OR ``BMD'' OR ``bone mineral content'' OR ``BMC'' OR ``peak bone mass'' OR ``mechanical loading'' OR ``osteoporosis'' OR ``bone geometry'' OR ``bone resistance'') AND (``team sport'' OR ``sport'' OR rugby OR basketball OR volleyball OR handball OR soccer OR football OR ``players''). After screening, 16 studies were included in the final analysis (5 continents, 2740 participants). The training duration lasted 1 to 13 years. Team sport training had a moderate impact on whole body bone mineral density (WB BMD) (1.07 SMD; 95 % [0.77, 1.37], <em>p</em> &lt; 0.00) but a more significant impact on whole body bone mineral content (WB BMC) (1.3 SMD; 95 % [0.81, 1.79], <em>p</em> &lt; 0.00). Subgroup analyses indicated that rugby training had a moderate but non-significant impact on WB BMD (1.19 SMD; 95 % [−0.13, 2.52], <em>p</em> = 0.08) but a greater impact on WB BMC (2.12 SMD; 95 % [0.84, 3.39], <em>p</em> &lt; 0.00); basketball training had a moderate but significant impact on WB BMD (1 SMD; 95 % [0.35, 1.64], <em>p</em> &lt; 0.00) and a trivial non-significant impact on WB BMC (0.18 SMD; 95 % [−1.09, 1.46], <em>p</em> = 0.78); volleyball training had a moderate but non-significant impact on WB BMD (0.63 SMD; 95 % [−0.22, 1.49], <em>p</em> = 0.15) and a significant impact on WB BMC (2.39 SMD; 95 % [1.45, 3.33], <em>p</em> &lt; 0.00). Handball training produced a moderate significant impact on WB BMD (1.02 SMD; 95 % [0.33, 1.71], <em>p</em> &lt; 0.00) and WB BMC (0.97 SMD; 95 % [0.47, 1.48], <em>p</em> &lt; 0.00), and soccer training led to moderate but significant effects on WB BMD (1.16 SMD; 95 % [0.88, 1.44], <em>p</em> &lt; 0.00) and a large effect on WB BMC (1.34 SMD; 95 % [0.92, 1.77], <em>p</em> &lt; 0.00). Rugby training was associated with a higher WB BMC compared to basketball training (<em>p</em> = 0.03). Our systematic review and meta-analysis suggests that team sports, such as rugby, basketball, volleyball, handball and soccer have moderate to large effects on WB BMD and WB BMC. Specifically, our findings indicate that handball and soccer enhance WB BMD and WB BMC, whereas rugby only increases WB BMC. There is currently insufficient evidence indicating the superiority of any type of sport training that improves bone health in adults.</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 4","pages":"Article 101508"},"PeriodicalIF":1.7,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosing (severe) osteoporosis by Hologic vs. Lunar measurements: A single-center retrospective study","authors":"Pelin Analay ,&nbsp;Murat Kara ,&nbsp;Ahmet Sertçelik ,&nbsp;Kübranur Demirel ,&nbsp;Berkay Yalçınkaya ,&nbsp;Bayram Kaymak ,&nbsp;Banu Çakır ,&nbsp;Levent Özçakar","doi":"10.1016/j.jocd.2024.101509","DOIUrl":"10.1016/j.jocd.2024.101509","url":null,"abstract":"<div><p><em>Introduction:</em> Although different dual-energy X-ray absorptiometry (DXA) scanners provide different bone mineral density (BMD) values, there is not a gold standard DXA scanner. <em>T</em>-score is used to facilitate the interpretation of BMD, and osteoporosis (OP) is diagnosed based on <em>T</em>-scores. In this retrospective study, we aimed to evaluate the BMD and <em>T</em>-score differences between Lunar Prodigy and Hologic Horizon DXA scanners.</p><p><em>Methodology:</em> Data were collected for patients with previous BMD measurement on Lunar Prodigy and Hologic Horizon DXA scanners within one year in the same medical center.</p><p><em>Results:</em> In a total of 55 patients, BMD values of femoral neck/total, and lumbar vertebrae were all lower at Hologic than Lunar (all <em>p</em> &lt; 0.01). The mean <em>T</em>-score difference at the lumbar spine was 0.74 ± 0.42 (<em>p</em> &lt; 0.001). Of the 49 patients diagnosed as OP (<em>T</em>-score ≤−2.5) with the Hologic, the diagnoses were changed for 25 individuals (51.0 %) with Lunar (<em>p</em> &lt; 0.001). Herewith, although the diagnoses of OP did not change by the repeat technique in other 24 patients (49 %), 13 of them (26.5 %) were categorized as having “high fracture risk” instead of “very high fracture risk” group (i.e., <em>T</em>-score &lt;−3.0). We observed moderate-to-good reliabilities (with an intraclass correlation coefficient [ICC] of 0.633–0.878 and 0.733–0.842 for BMD and <em>T</em>-scores, respectively) between measurements with the Lunar and Hologic scanners. Except for one measurement in L3, L4, L1–4 vertebrae, the Bland–Altman plot did not reveal any consistent bias between the measurements of the Lunar and Hologic scanners.</p><p><em>Conclusions:</em> The consistency between different DXA scanners (especially for Hologic vs. Lunar) is important for proper management, especially in patients with low <em>T</em>-scores and OP.</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 4","pages":"Article 101509"},"PeriodicalIF":1.7,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141710530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between bony changes of the mandibular condyle and eichner index","authors":"Sedef Kotanlı ,&nbsp;Nurbanu Uluısık ,&nbsp;Mehmet Oguzhan Ergin","doi":"10.1016/j.jocd.2024.101507","DOIUrl":"10.1016/j.jocd.2024.101507","url":null,"abstract":"<div><p><em>Introduction:</em> The aim of this study was to evaluate whether degenerative bone changes in the mandibular condyle on cone beam computed tomography images are associated with the Eichner index.</p><p><em>Methodology:</em> 336 cone beam computed tomography images condyle images of 168 patients were analyzed for degenerative bone changes. These changes were named as condyle flattening, osteophytes, erosions, subchondral sclerosis, generalized sclerosis and subchondral cysts. The edentulous status of the patients was classified as group A-B-C and subtypes according to the Eichner index. Categorical variables were evaluated with chi-square test and p &lt; 0.05 was considered statistically significant.</p><p><em>Results:</em> According to the results of the study, the most common degenerative condyle change was flattening of the condyle. Among the Eichner index groups, the most common group was A and the least common group was C. Condyle changes on the right and left sides were most commonly observed in group A patients. The statistically significant majority of patients with right-sided condyle flattening and erosion were in group C. No significant difference was found between all other condyle changes and Eichner index groups. There was no significant relationship between Eichner index and gender.</p><p><em>Conclusion:</em> Degenerative bone changes (flattening and erosion of the condyle) in the condyle region were more common in group C patients with more tooth loss. There is a significant relationship between condyle changes and posterior toothlessness.</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 4","pages":"Article 101507"},"PeriodicalIF":1.7,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1094695024000428/pdfft?md5=9e4ed6e7341ac7f5334ce35e41c7576c&pid=1-s2.0-S1094695024000428-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141614273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of bone mass accrual in transgender and gender diverse youth undergoing pubertal suppression therapy","authors":"Samantha Roberge ,&nbsp;Taylor Roberge ,&nbsp;Sarah Corathers ,&nbsp;Nat Nasomyont","doi":"10.1016/j.jocd.2024.101505","DOIUrl":"10.1016/j.jocd.2024.101505","url":null,"abstract":"<div><p><em>Introduction/Background:</em> Gender-affirming care for gender diverse and transgender (GDTG) youth includes puberty suppression with gonadotropin-releasing hormone agonists (GnRHa). Puberty is a critical period of bone mass accrual, and pubertal suppression may impact bone health. Previous studies have shown a decrease in areal bone mineral density (aBMD) Z-score while on puberty suppression. However, the rate of bone mass accrual and its determinants during GnRHa therapy are not known.</p><p><em>Methodology:</em> This is a retrospective chart review of GDTG youth with aBMD assessment within six months of starting GnRHa monotherapy at Cincinnati Children's Hospital Medical Center between 01/2011 and 12/2022. In individuals with follow-up aBMD assessment, we calculated their aBMD velocity and generated Z-scores using reference data from the Bone Mineral Density in Childhood Study. The determinants of baseline height-adjusted aBMD and aBMD velocity Z-scores were assessed with multiple linear regression models.</p><p><em>Results:</em> Thirty-six participants (36% assigned female at birth (AFAB), mean age at first aBMD assessment 12 ± 1.1 years) had baseline height-adjusted aBMD Z-score of -0.053 ± 0.79. Among 16 participants with follow-up aBMD assessment, the mean aBMD velocity Z-score was -0.42 ± 1.13 (-0.27 ± 0.79 in AFAB vs -0.52 ± 1.32 in assigned male at birth, <em>p</em> = 0.965). Baseline aBMD Z-scores significantly correlated with age at the first aBMD assessment (adjusted R² 0.124, <em>p</em> = 0.02) with combined modeling including age at first aBMD assessment and BMI Z-score being most significant (adjusted R² 0.21, <em>p</em> = 0.008). Only BMI Z-scores were positively associated with the aBMD-velocity Z-scores (adjusted R² 0.255, <em>p</em> = 0.046).</p><p><em>Conclusions:</em> GDTG youth undergoing GnRHa therapy appeared to have below-average aBMD velocity Z-scores. A lower BMI Z-score was a determinant of lower baseline height-adjusted aBMD and aBMD velocity Z-scores. Building on previous studies, our study highlights aBMD velocity as a novel technique for bone health surveillance in GDTG youth.</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 3","pages":"Article 101505"},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141391776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sprinting performance correlates with composite indices of femoral neck strength in young men","authors":"Lara Chatrieh,&nbsp;Antonio Pinti,&nbsp;Rawad El Hage","doi":"10.1016/j.jocd.2024.101506","DOIUrl":"10.1016/j.jocd.2024.101506","url":null,"abstract":"","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 3","pages":"Article 101506"},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of volumetric bone mineral density measurement in weight bearing, cone beam computed tomography","authors":"Tadiwa H. Waungana ,&nbsp;Keven Qiu ,&nbsp;Justin J. Tse ,&nbsp;Donald D. Anderson ,&nbsp;Carolyn A. Emery ,&nbsp;Steven K. Boyd ,&nbsp;Sarah L. Manske","doi":"10.1016/j.jocd.2024.101504","DOIUrl":"10.1016/j.jocd.2024.101504","url":null,"abstract":"<div><p><em>Background:</em> Weight bearing computed tomography (WBCT) utilizes cone beam CT technology to provide assessments of lower limb joint structures while they are functionally loaded. Grey-scale values indicative of X-ray attenuation that are output from cone beam CT are challenging to calibrate, and their use for bone mineral density (BMD) measurement remains debatable. To determine whether WBCT can be reliably used for cortical and trabecular BMD assessment, we sought to establish the accuracy of BMD measurements at the knee using modern WBCT by comparing them to measurements from conventional CT.</p><p><em>Methods:</em> A hydroxyapatite phantom with three inserts of varying densities was used to systematically quantify signal uniformity and BMD accuracy across the acquisition volume. We evaluated BMD <em>in vivo</em> (n = 5, female) using synchronous and asynchronous calibration techniques in WBCT and CT. To account for variation in attenuation along the height (<em>z</em>-axis) of acquisition volumes, we tested a height-dependent calibration approach for both WBCT and CT images.</p><p><em>Results:</em> Phantom BMD measurement error in WBCT was as high as 15.3% and consistently larger than CT (up to 5.6%). Phantom BMD measures made under synchronous conditions in WBCT improved measurement accuracy by up to 3% but introduced more variability in measured BMD. We found strong correlations (R = 0.96) as well as wide limits of agreement (-324 mgHA/cm³ to 183 mgHA/cm³) from Bland-Altman analysis between WBCT and CT measures <em>in vivo</em> that were not improved by height-dependent calibration.</p><p><em>Conclusion:</em> Whilst BMD accuracy from WBCT was found to be dependent on apparent density, accuracy was independent of the calibration technique (synchronous or asynchronous) and the location of the measurement site within the field of view. Overall, we found strong correlations between BMD measures from WBCT and CT and <em>in vivo</em> measures to be more accurate in trabecular bone regions. Importantly, WBCT can be used to distinguish between anatomically relevant differences in BMD, however future work is necessary to determine the repeatability and sensitivity of BMD measures in WBCT.</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 3","pages":"Article 101504"},"PeriodicalIF":2.5,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1094695024000398/pdfft?md5=265fd47b988c7c6381cc0b185da96bd5&pid=1-s2.0-S1094695024000398-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141414832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}