Canadian adult reference data for body composition, trabecular bone score and advanced hip analysis using DXA

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry Pub Date : 2024-10-16 DOI:10.1016/j.jocd.2024.101535

Lauren A. Burt , Liam T. Pond , Annabel R. Bugbird , David A. Hanley , Steven K. Boyd

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引用次数: 0

Abstract

DXA-derived reference data for visceral adipose tissue (VAT) and advanced hip analysis (AHA) parameters spanning the entire adult lifespan are limited. The purpose of this study was to develop age-, site- and sex-specific reference data for dual X-ray absorptiometry (DXA) -derived body composition, trabecular bone score (TBS) and advanced hip analysis (AHA) parameters across the adult lifespan. Adults (N = 908; female: 561 and male: 347) from Calgary and the surrounding area over the age of 20 years participated in this study. Participants received DXA scans of their hip (total hip [TH] and femoral neck [FN]), lumbar spine [LS], forearm [33 % site] and total body (iDXA, GE Lunar, GE Healthcare). Areal bone mineral density (aBMD, g/cm²) was captured at all sites, and body composition variables, including lean mass, fat mass and percent fat, were analyzed from the total body scan. VAT mass was assessed from total body DXA scans. Advanced hip analysis (AHA) was performed on hip scans and trabecular bone score (TBS) on the LS scans to assess bone quality. Site- and sex-specific centile curves and tables were generated using the Generalized Additive Models for Location, Scale, and Shape (GAMLSS) method. Clinicians and researchers can use these Canadian reference data as a tool to assess body composition, TBS and AHA parameters across the adult lifespan.

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使用 DXA 进行身体成分、骨小梁评分和高级髋关节分析的加拿大成人参考数据。

由 DXA 得出的内脏脂肪组织（VAT）和高级髋关节分析（AHA）参数的参考数据在整个成人生命周期中都很有限。本研究的目的是为双 X 射线吸收测定法（DXA）得出的身体成分、骨小梁评分（TBS）和高级髋关节分析（AHA）参数开发针对不同年龄、部位和性别的参考数据。卡尔加里及周边地区 20 岁以上的成年人（N = 908；女性：561；男性：347）参加了这项研究。参与者接受了髋部（全髋[TH]和股骨颈[FN]）、腰椎[LS]、前臂[33%部位]和全身（iDXA，GE Lunar，GE Healthcare）的 DXA 扫描。在所有部位采集骨矿物质密度（aBMD，克/平方厘米），并通过全身扫描分析身体成分变量，包括瘦体重、脂肪量和脂肪百分比。全身 DXA 扫描评估了增值肌肉质量。对髋部扫描进行高级髋部分析（AHA），对LS扫描进行骨小梁评分（TBS），以评估骨质情况。使用位置、尺度和形状的广义相加模型（GAMLSS）方法生成了特定部位和性别的百分位曲线和表格。临床医生和研究人员可以使用这些加拿大参考数据作为工具，评估成年人整个生命周期的身体成分、TBS 和 AHA 参数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Densitometry 医学-内分泌学与代谢

CiteScore

4.90

自引率

8.00%

发文量

审稿时长

90 days

期刊介绍： The Journal is committed to serving ISCD''s mission - the education of heterogenous physician specialties and technologists who are involved in the clinical assessment of skeletal health. The focus of JCD is bone mass measurement, including epidemiology of bone mass, how drugs and diseases alter bone mass, new techniques and quality assurance in bone mass imaging technologies, and bone mass health/economics. Combining high quality research and review articles with sound, practice-oriented advice, JCD meets the diverse diagnostic and management needs of radiologists, endocrinologists, nephrologists, rheumatologists, gynecologists, family physicians, internists, and technologists whose patients require diagnostic clinical densitometry for therapeutic management.