Journal of Clinical Sleep Medicine最新文献

{"title":"Refining adherence assessment in oral appliance therapy for obstructive sleep apnea.","authors":"Nashmia Faraz, Haider Imran, Abdul Basit","doi":"10.1007/s44470-026-00176-7","DOIUrl":"10.1007/s44470-026-00176-7","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep homeostasis in OSA: a complementary neurophysiological outcome measure.","authors":"Sasikanth Gorantla, Katyayini Aribindi, Vishesh K Kapur","doi":"10.1007/s44470-026-00174-9","DOIUrl":"10.1007/s44470-026-00174-9","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological considerations in assessing diagnostic accuracy of home sleep apnea tests in children.","authors":"Anmol Devi","doi":"10.1007/s44470-026-00185-6","DOIUrl":"10.1007/s44470-026-00185-6","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13553998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing multicomponent chronotherapeutic interventions for emerging adults with delayed sleep timing.","authors":"Delainey L Wescott, Alison M Klevens, Maddison L Taylor, Kathryn A Roecklein, Brant P Hasler","doi":"10.1007/s44470-026-00171-y","DOIUrl":"10.1007/s44470-026-00171-y","url":null,"abstract":"<p><p>Emerging adulthood (ages 18-25) is the developmental peak for delayed sleep and circadian timing and a period of risk for psychopathology. The current study compared two chronotherapeutic interventions targeting delayed sleep timing in emerging adults with no-to-moderate depression. Study 1 (N = 21, ages 18-22, 43% women) was a 2-week morning bright light therapy intervention. Study 2 (N = 15, ages 18-25, 86% women) supplemented 2 weeks of morning bright light therapy with a personalized sleep-wake timing advance and blue-light blocking glasses for 2 h prior to bedtime. After 2 weeks, circadian phase (B = 0.1; SE = 0.1; p = 0.46) and depression symptoms (B = -0.2; SE = 0.1; p = 0.05) did not significantly change in Study 1. In contrast, circadian phase advanced by ~35 min (B = -0.4; SE = 0.2; p = 0.03) and depression symptoms decreased (B = -1.2; SE = 0.3; p < 0.001) in Study 2. Future work in larger, randomized controlled trials with rigorous adherence monitoring is needed to confirm the effectiveness of these interventions.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-varying restless legs syndrome and risk of incident perinatal depression.","authors":"Kazuhide Tezuka, Yuka Ito, Natsu Sasaki, Daisuke Nishi","doi":"10.1007/s44470-026-00168-7","DOIUrl":"10.1007/s44470-026-00168-7","url":null,"abstract":"<p><strong>Purpose: </strong>Previous studies have reported associations between restless legs syndrome (RLS) and perinatal depressive symptoms. However, no study has used diagnostic instruments to examine changes in RLS status during pregnancy in relation to the incidence of perinatal depression. This study aimed to investigate whether time-varying RLS status is associated with an increased risk of incident perinatal depression.</p><p><strong>Methods: </strong>This prospective cohort study analyzed data from 2435 Japanese pregnant women in the control group of a randomized controlled trial on perinatal depression. Time-varying RLS status was assessed using data obtained in the second and third trimesters with the short form of the Cambridge-Hopkins diagnostic questionnaire. Incident major depressive episodes and depressive symptoms from the second trimester to 3 months postpartum were assessed using the self-administered World Health Organization Composite International Diagnostic Interview 3.0 and the Edinburgh Postnatal Depression Scale (EPDS), respectively. Associations were examined using Cox proportional hazards models with time-varying covariates.</p><p><strong>Results: </strong>The prevalence of RLS was 40 (1.6%) in the second trimester and 60 (3.5%) in the third trimester. During a mean follow-up of 6.5 months (SD, 3.2), 69 participants developed perinatal depression. Time-varying RLS status was significantly associated with an increased risk of incident perinatal depression (hazard ratio [HR], 3.04; 95% CI, 1.22-7.58) and depressive symptoms (EPDS ≥ 13; HR, 2.12; 95% CI, 1.28-3.51). These associations remained robust after adjustment for potential confounders.</p><p><strong>Conclusion: </strong>RLS, modeled as a time-varying condition, was associated with an increased risk of incident perinatal depression, suggesting the importance of screening for RLS during pregnancy for the prevention of perinatal depression.</p><p><strong>Current knowledge/study rationale: </strong>RLS is common during pregnancy and has been linked to depressive symptoms, possibly through shared pathophysiological mechanisms such as sleep disturbances and iron deficiency; however, longitudinal evidence using diagnostic instruments remains limited. This study examined whether time-varying RLS status is associated with incident perinatal depression.</p><p><strong>Study impact: </strong>Pregnant women with RLS, particularly in the third trimester, had an increased risk of perinatal depression, suggesting the clinical importance of routine RLS screening to support timely treatment and potentially prevent perinatal depression. Increased awareness of RLS among pregnant women and healthcare providers may promote early identification of individuals at higher risk. However, whether RLS treatment can reduce perinatal depression risk requires further investigation.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygen overshoot burden of central sleep apnea and its association with cardiovascular outcomes.","authors":"Ali Azarbarzin, Scott McKane, Katie L Stone, Robin Germany, Susan Redline, Atul Malhotra","doi":"10.1007/s44470-026-00161-0","DOIUrl":"10.1007/s44470-026-00161-0","url":null,"abstract":"<p><strong>Purpose: </strong>The role of oxidative stress in central sleep apnea (CSA) remains unknown. We examined whether \"oxygen overshoot burden\"-a measure of cumulative oxygen saturation levels above baseline-is associated with major adverse cardiovascular events (MACE) in CSA.</p><p><strong>Methods: </strong>We analyzed 7530 participants from the Sleep Heart Health Study (SHHS; age 64 years; 47.0% male) and the Osteoporotic Fractures in Men Study (MrOS; age 76 years; 100% male). Oxygen overshoot burden was defined as the area under the SpO₂ curve above a stable sleep baseline (wakefulness baseline was also considered). In primary analysis, oxygen overshoot burden was modeled continuously. In secondary analyses, participants were classified as having CSA, obstructive sleep apnea (OSA), or no sleep apnea, and stratified by high (≥ median) versus low oxygen overshoot burden. Cox models adjusted for covariates were used to estimate hazard ratios (HRs) for MACE.</p><p><strong>Results: </strong>Over a follow-up of 8.92 years, 2258 MACE events occurred. Oxygen overshoot burden (continuous) was associated with increased MACE risk, with stronger associations among individuals with any central apneas (p = 0.003 and p = 0.02 for sleep and wakefulness baselines, respectively). In secondary analyses, participants with CSA and high oxygen overshoot burden had higher MACE incidence (54.6%) than controls (25.6%; HR 1.45 [95%CI = 1.16,1.82]; p = 0.001). In contrast, CSA with low oxygen overshoot burden and OSA with high or low oxygen overshoot burden showed MACE risk comparable to controls. Results were robust to adjustment for AHI, central apnea index, loop gain, and hypoxic burden.</p><p><strong>Conclusions: </strong>Oxygen overshoot burden in CSA is independently associated with increased MACE risk and may improve risk stratification in sleep-disordered breathing. These findings require validation in larger, more diverse populations given sample limitations and potential pulse oximetry bias across skin pigmentation.</p><p><strong>Current knowledge/study rationale: </strong>Oxidative stress may contribute to cardiovascular risk in central sleep apnea (CSA), but the clinical significance of post-apneic oxygen overshoot is unknown. We examined whether oxygen overshoot burden, representing cumulative oxygen saturation above baseline, is associated with major adverse cardiovascular events (MACE).</p><p><strong>Study impact: </strong>Greater oxygen overshoot burden was associated with increased cardiovascular risk in individuals with central sleep apnea but not in those with obstructive sleep apnea. These findings identify a potential high-risk central sleep apnea phenotype and suggest that oxygen overshoot burden may improve cardiovascular risk stratification and inform future mechanistic and interventional studies.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional sleep health and serious cognitive difficulty among US adolescents.","authors":"Adam P Knowlden","doi":"10.1007/s44470-026-00155-y","DOIUrl":"10.1007/s44470-026-00155-y","url":null,"abstract":"<p><strong>Purpose: </strong>This study examined associations among concussion history, multidimensional sleep health, physical activity, and serious cognitive difficulty in a nationally representative sample of US adolescents.</p><p><strong>Methods: </strong>Cross-sectional data from adolescents aged 12-17 years participating in the 2022-2024 National Survey of Children's Health were analyzed. Sequential multivariable models accounting for complex sampling examined associations among concussion history, short sleep duration, bedtime inconsistency, sports participation, physical activity, and serious cognitive difficulty. Sensitivity analyses evaluated alternative bedtime consistency operationalizations and interaction effects.</p><p><strong>Results: </strong>In fully adjusted models, concussion history (aOR = 2.07, 95% CI = 1.72-2.48), short sleep duration (aOR = 1.27, 95% CI = 1.11-1.46), bedtime inconsistency (aOR = 1.42, 95% CI = 1.22-1.65), no sports participation (aOR = 2.05, 95% CI = 1.81-2.33), insufficient physical activity (aOR = 1.32, 95% CI = 1.09-1.58), greater ACE burden, and lower caregiver capacity (aOR = 2.04, 95% CI = 1.80-2.31) were associated with greater odds of serious cognitive difficulty. Exploratory analyses identified a statistically significant short sleep × bedtime inconsistency interaction (Wald F = 4.35, p = .037), whereas concussion-related interaction terms were not statistically significant. Adjusted predicted probabilities demonstrated substantial cumulative neurobehavioral vulnerability across multidimensional sleep health and concussion-risk profiles.</p><p><strong>Conclusion: </strong>Insufficient sleep duration and bedtime inconsistency were independently associated with serious cognitive difficulty among US adolescents. Findings support consideration of both sleep duration and sleep regularity in adolescent neurobehavioral health promotion efforts.</p><p><strong>Current knowledge/study rationale: </strong>Concussion history and insufficient sleep have independently been associated with poorer neurobehavioral functioning among adolescents. However, fewer nationally representative studies have examined multidimensional sleep health constructs, including bedtime consistency, in relation to serious cognitive difficulty.</p><p><strong>Study impact: </strong>Short sleep duration and bedtime inconsistency were associated with greater odds of serious cognitive difficulty among US adolescents. Findings support multidimensional sleep health frameworks emphasizing the combined importance of sleep duration and bedtime consistency for adolescent cognitive functioning.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insomnia disorder at 6 weeks postpartum: a prospective study.","authors":"Moe Takenoshita, Arash Jalali-Sohi, Nathan Z Hidajat, Guillermina Michel, Nan Guo, Rachel Manber, Deirdre J Lyell, Fiona Barwick, Arden M Morris, Heather Moody, Rania Elkhateb, Jill Mhyre, David Cella, Sara Shaunfield, Sean Mackey, Lu Tian, Suzan L Carmichael, Danielle M Panelli, Xiaodan Tang, Pervez Sultan","doi":"10.1007/s44470-026-00150-3","DOIUrl":"10.1007/s44470-026-00150-3","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;To estimate the prevalence of insomnia disorder and insomnia symptoms, explore risk factors for insomnia disorder, and characterize sleep at 6 weeks postpartum.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Following IRB approval, adults who delivered a live infant at two academic US hospitals were prospectively recruited with a pre-specified cross-sectional analysis planned at 6 weeks postpartum, evaluating new sleep disturbance (SD) and sleep-related impairment (SRI) surveys. Participants were invited to complete surveys (Bergen Insomnia Scale (BIS), PROMIS SD, and SRI), and a structured clinical interview for sleep disorders (SCISD-R, the diagnostic standard), at 6 weeks postpartum, until 150 interviews were completed. Demographic and clinical variables were collected. Primary outcome was prevalence of insomnia disorder by SCISD-R; secondary outcomes were sleep characteristics and survey scores, clinical and sociodemographic factors associated with insomnia disorder, and exploratory evaluation of the diagnostic accuracy of BIS, PROMIS SD, and SRI for insomnia disorder identified by SCISD-R. Associations were assessed using univariate odds ratios and 95% confidence intervals, and receiver operating characteristic (ROC) curve was used to evaluate diagnostic accuracy of the surveys.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Of the 188 patients who accepted interview invitations, 150 completed interviews (79.8%) at 44 ± 7 days postpartum, mean age 33 ± 5 years. Insomnia symptoms were reported in 38 (25.3%) patients and 20 (13%) met diagnostic criteria for insomnia disorder. Only 2 had received clinical evaluation. Among 144 respondents, median BIS, PROMIS SD, and SRI T scores were 20 [IQR 14-27], 51 [IQR 45-56], and 57 [IQR 50-62] respectively, indicating normal SD and mild SRI in most patients. Fifty-one percent reported low or very low sleep satisfaction. Seventy percent reported sleeping ≤ 6 h. No statistically significant factors associated with insomnia disorder were identified, likely reflecting insufficient power rather than a true null finding. ROC curve analysis of BIS, PROMIS SD, and SRI in identifying insomnia disorder yielded area under the curve values of 0.73, 0.85, and 0.70 respectively.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The prevalence of insomnia disorder at 6 weeks postpartum was 13%, with most cases clinically undiagnosed. Improved screening strategies are needed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Current knowledge/study rationale: &lt;/strong&gt;Insomnia disorder is the most common sleep disorder in the postpartum period and accounts for up to 68% of sleep disorders; however, prevalence estimates of insomnia disorder in the first year after delivery vary widely. We aimed to estimate the prevalence of insomnia disorder and insomnia symptoms, explore risk factors associated with insomnia disorder, and characterize sleep at 6 weeks postpartum.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study impact: &lt;/strong&gt;The prevalence of insomnia disorder at 6 weeks postpartum was 13%, with ","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of tirzepatide with changes in OSA-related measures based on baseline characteristics - post hoc analyses of SURMOUNT-OSA.","authors":"Beverly Falcon, Cathy Chang Xie, Susan Redline, Ronald Grunstein, Christopher D Turnbull, David M Rapoport, Hui Wang, Sujatro Chakladar, Georgios K Dimitriadis, Eva Lau, Jo Bednarik, Birong Liao, Atul Malhotra","doi":"10.1007/s44470-026-00162-z","DOIUrl":"10.1007/s44470-026-00162-z","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive collapse of the upper airway during sleep. Given that excess adiposity is a known risk factor for OSA, we aimed to descriptively assess the association of tirzepatide, a GIP/GLP-1 receptor agonist, with changes in AHI, hypoxic burden, body weight, and blood pressure in different patient populations based on baseline characteristics such as age, sex, BMI, AHI, and neck circumference.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;These post hoc analyses examined data from two Phase 3 randomized, double-blind studies evaluating maximum tolerated dose (MTD) tirzepatide (10 mg or 15 mg) compared with placebo in adults with moderate-to-severe OSA (AHI ≥ 15 events/h) and obesity (BMI ≥ 30 kg/m&lt;sup&gt;2&lt;/sup&gt;) over a 52-week period. Baseline subgroup analyses were conducted in participants with non-missing relevant baseline measurements.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Generally, participants treated with tirzepatide showed greater improvements in OSA outcomes compared with placebo, regardless of baseline subgroup. Participants treated with tirzepatide experienced reductions in AHI across subgroups, regardless of baseline age (-27.7 to -34.1 events/h), sex (-19.8 to -32.6 events/h), AHI severity (-12.1 to -52.2 events/h), BMI (-25.2 to -34.4 events/h), and neck circumference (-23.9 to -30.8 events/h). Additionally, improvements were observed in body weight, systolic blood pressure, and sleep apnea-specific hypoxic burden across baseline subgroups. Overall, most participants experienced an improvement in AHI severity category with tirzepatide treatment (68% to 79%), while the majority in the placebo group saw no clinically relevant change (64% to 70%).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;In these descriptive, hypothesis-generating, post hoc analyses, tirzepatide treatment was associated with improvements in multiple measures in participants with moderate-to-severe OSA and obesity. These improvements were observed across both studies, regardless of baseline age, sex, AHI severity, BMI, or neck circumference.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical trial registration: &lt;/strong&gt;SURMOUNT-OSA program (NCT05412004).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Current knowledge/study rationale: &lt;/strong&gt;Tirzepatide has been associated with clinically relevant improvements in OSA-related measures, body weight, and systolic blood pressure among individuals with moderate-to-severe OSA and obesity. These post hoc analyses aimed to assess whether there were variations in improvements based on baseline age, sex, AHI severity, BMI, or neck circumference.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study impact: &lt;/strong&gt;In general, tirzepatide treatment was associated with improvement in OSA outcomes across both studies, regardless of baseline age, sex, AHI severity, BMI, or neck circumference, with some observed differences among some baseline characteristics. This research may help us better understand the relationship between baseline characteristics a","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartwatch-based detection of moderate-to-severe and high-risk obstructive sleep apnea.","authors":"Arash Alavi, Elaine Costa, Monica M S Matsumoto, Nicole Odenwald, Nadia Elkarra, Yifei Ma, Pahnwat Tonya Taweesedt, Makoto Kawai, Clete Kushida, Robson Capasso","doi":"10.1007/s44470-026-00159-8","DOIUrl":"10.1007/s44470-026-00159-8","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;Obstructive sleep apnea (OSA) is a prevalent condition associated with long-term consequences, such as cardiovascular and neurocognitive diseases, yet many cases remain undiagnosed and therefore untreated due to the cost and limited access to traditional in-lab overnight polysomnography (PSG). The ubiquity of consumer wearable technology offers a practical way to mitigate these limitations, enabling more accessible, large-scale screening. However, the clinical validity of these devices requires further testing.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In this novel prospective study, we rigorously evaluated the diagnostic performance of the Samsung Galaxy Watch for detecting moderate-to-severe OSA (apnea-hypopnea index, AHI ≥ 15 events/h) compared to in-lab PSG using the AHI, and \"high-risk\" OSA subjects using the PSG-derived hypoxic burden (HB) criteria. We enrolled 152 adults aged 22 years or older with a prior diagnosis of moderate-to-severe OSA or a high pre-test likelihood of having it (STOP-Bang score ≥ 3), who wore the smartwatch during two in-lab PSG nights (147 completed both nights; total 1,850 h of in-lab PSG sleep): an initial in-lab PSG night, followed by ≥ 3 watch-only at-home nights, and then a second in-lab PSG night. In addition to AHI, we evaluated Galaxy Watch performance across PSG-derived HB-defined risk strata (low- vs. high-risk OSA) as HB integrates the depth, duration, and frequency of oxygen desaturations and has been shown to better reflect cardiometabolic risk and disease severity than AHI.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In our cohort, the Galaxy Watch achieved an area under the receiver operating characteristic (AUROC) curve of 0.94 (95% CI 0.889-0.980) for detecting moderate-to-severe OSA. With the default estimated AHI (eAHI) threshold of 15, the device yielded a sensitivity of 94.1% (95% CI 84.1-98%) and a specificity of 66.7% (95% CI 51-79.4%), while with the cohort-optimized eAHI threshold of 25.95, sensitivity was 82.4% (95% CI 69.7-90.4%) and specificity was 94.9% (95% CI 83.1-98.6%). Notably, within the HB defined high-risk OSA group, the Galaxy Watch achieved 100% sensitivity and 100% specificity using the default threshold, indicating robust discrimination between HB-defined low- and high-risk OSA categories.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Overall, these findings highlight the substantial potential of consumer-grade wearables to accurately detect moderate-to-severe sleep apnea using both AHI- and HB-defined risk strata across controlled and real-world settings.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Registration: &lt;/strong&gt;ClinicalTrials.gov ID: NCT06603441; First posted: 2024-09-19.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Current knowledge/study rationale: &lt;/strong&gt;Obstructive sleep apnea (OSA) remains substantially underdiagnosed because definitive testing with polysomnography (PSG) is resource-intensive and not readily accessible to all patients. Although consumer smartwatches offer a promising approach for large-scale OSA screenin","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13522277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}