Journal of Clinical Sleep Medicine最新文献_第10页

Loop gain and central chemosensitivity assessment as a valuable tool in guiding treatment decisions for central sleep apnea in children. 环路增益和中枢化学敏感性评估作为指导儿童中枢睡眠呼吸暂停治疗决策的有价值工具。

IF 3.5 3区医学

Journal of Clinical Sleep Medicine Pub Date : 2024-12-31 DOI: 10.5664/jcsm.11538

Plamen Bokov, Benjamin Dudoignon, Christophe Delclaux

引用次数: 0

Z hypnotics in the management of narcolepsy: a case series. Z催眠在治疗发作性睡病中的应用：一个病例系列。

IF 3.5 3区医学

Journal of Clinical Sleep Medicine Pub Date : 2024-12-30 DOI: 10.5664/jcsm.11546

Amer Aboukasm, Anthony N Reffi, Christopher L Drake

引用次数: 0

Families of adults with idiopathic hypersomnia and narcolepsy: psychosocial impact and contribution to symptom management. 特发性嗜睡和发作性睡的成人家庭：社会心理影响和对症状管理的贡献。

IF 3.5 3区医学

Journal of Clinical Sleep Medicine Pub Date : 2024-12-30 DOI: 10.5664/jcsm.11526

Jennifer M Mundt, Rachel-Clair Franklin, Matthew Horsnell, Victoria Garza

{"title":"Families of adults with idiopathic hypersomnia and narcolepsy: psychosocial impact and contribution to symptom management.","authors":"Jennifer M Mundt, Rachel-Clair Franklin, Matthew Horsnell, Victoria Garza","doi":"10.5664/jcsm.11526","DOIUrl":"https://doi.org/10.5664/jcsm.11526","url":null,"abstract":"Study objectives: This study examined the impact of central disorders of hypersomnolence (CDH) on family members of adult patients, the ways family members assist with managing CDH, and family members' utilization and satisfaction with information and support.Methods: Participants were adults (N=100) with an adult family member diagnosed with idiopathic hypersomnia or narcolepsy. They completed a survey which included the Family Reported Outcome Measure (FROM-16), checklists, satisfaction ratings, and open-response questions.Results: The FROM-16 sample mean (14.2, SD=6.8) corresponded to a moderate effect on quality of life. Compared to parents, partners reported a higher impact on the Personal and Social Life domain (p=.04, d=.44). The most frequently endorsed sources of support were family (60.0%) and friends (50.0%), whereas information was most commonly obtained from hypersomnia organizations (69.0%) and medical professionals (61.0%). Only 8.0% of participants were satisfied with support, and 9.0% were satisfied with information. Participants endorsed assisting with managing CDH, such as picking up prescriptions (61.0%), attending medical visits (50.0%), reminding to take medication (48.0%), and coordinating medical care (39.0%). Qualitative data indicated that relationships underwent a transformation from conflict and confusion (pre-diagnosis) to clarity (post-diagnosis), followed by adjusting expectations. Caregiving strain, effects on shared activities, and negative psychosocial impacts on family also emerged as themes.Conclusions: Family members play an important role in supporting adults with CDH in many ways, including tasks related to managing CDH. Family members experience many psychosocial impacts from CDH, and data from this study indicate unmet needs for support.","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

REM sleep atonia in patients with pediatric acute-onset neuropsychiatric syndrome (PANS): implications for pathophysiology. 小儿急性发作性神经精神综合征（PANS）患者的快速眼动睡眠弛缓：病理生理学意义

IF 3.5 3区医学

Journal of Clinical Sleep Medicine Pub Date : 2024-12-30 DOI: 10.5664/jcsm.11544

Patrizia Congiu, Antonella Gagliano, Sara Carucci, Giuseppe Lanza, Raffaele Ferri, Monica Puligheddu

{"title":"REM sleep atonia in patients with pediatric acute-onset neuropsychiatric syndrome (PANS): implications for pathophysiology.","authors":"Patrizia Congiu, Antonella Gagliano, Sara Carucci, Giuseppe Lanza, Raffaele Ferri, Monica Puligheddu","doi":"10.5664/jcsm.11544","DOIUrl":"https://doi.org/10.5664/jcsm.11544","url":null,"abstract":"Study objectives: Sleep disorders and/or disordered sleep represent common clinical presentations of pediatric acute-onset neuropsychiatric syndrome (PANS), occurring in up to 80% of affected children, with REM sleep motor disinhibition being a prevalent feature. To date, limited polysomnographic (PSG) studies have been conducted. Therefore, the objective of this study was to evaluate the PSG characteristics of a cohort of children with PANS, focusing particularly on REM sleep without atonia (RSWA) as assessed by the REM atonia index (RAI), and to compare these characteristics with those of a control group.Methods: Sixty-nine patients diagnosed with PANS were consecutively recruited who underwent comprehensive PSG examinations following standard criteria. Chin muscle tone during REM sleep was evaluated using RAI. Forty-four healthy subjects, matched for age and sex, were used as controls.Results: RAI was significantly lower in patients compared to controls. In controls, RAI showed a significant progressive increase with age from preschool to adolescence. Conversely, this age-related trend was absent in patients, with no significant correlation between RAI and age, with a random distribution of values. Only one control subject (1/43) but 25 patients (25/57) exhibited a RAI below the lower limit of the predicted range obtained from controls.Conclusions: Our findings underscore the significance of REM sleep abnormalities in children with PANS. The substantial reduction in RAI and the lack of correlation between RAI and age observed in patients suggest a potential pathological mechanism leading to dysfunction in brainstem structures regulating REM sleep atonia in this population.","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adherence to positive airway pressure therapy in patients with Down syndrome: assessing cloud based monitoring data. 唐氏综合征患者坚持气道正压治疗：评估基于云的监测数据。

IF 3.5 3区医学

Journal of Clinical Sleep Medicine Pub Date : 2024-12-30 DOI: 10.5664/jcsm.11520

Rakesh Bhattacharjee, Megan Warner, Brandon Nokes, Jeremy S Landeo Gutierrez, Zihan Chen, Milan D Amin, Atul Malhotra

{"title":"Adherence to positive airway pressure therapy in patients with Down syndrome: assessing cloud based monitoring data.","authors":"Rakesh Bhattacharjee, Megan Warner, Brandon Nokes, Jeremy S Landeo Gutierrez, Zihan Chen, Milan D Amin, Atul Malhotra","doi":"10.5664/jcsm.11520","DOIUrl":"10.5664/jcsm.11520","url":null,"abstract":"Study objectives: Obstructive sleep apnea (OSA) is common in Down syndrome (DS) with many patients prescribed positive airway pressure (PAP) therapy. This study evaluates PAP adherence and identifies factors influencing adherence.Methods: Retrospective analysis of electronic health records and cloud-based PAP therapy data from DS patients at Rady Children's Hospital, San Diego, CA. Cloud data were evaluated cross-sectionally at 30- and 90-nights post-clinic visit and longitudinally in patients with ≥2 90-night data downloads. Outcomes included compliance (percentage of nights with ≥4 hours of use) and usage (percentage of nights with any PAP usage). The impact of demographic and PAP therapy factors (e.g., mask leak) on these outcomes was also assessed.Results: 47 patients with DS with cloud-based PAP therapy data over a 90-night period and 46 over a 30-night period were analyzed. The mean age was 17.7±4.6 years (21 females). Median compliance was significantly higher at 30 nights (56.7%, IQR:0.0,90.8%) than at 90 nights (34.4%, IQR:0.0,86.7%) (p<0.05). Median usage did not differ between the 30-night and 90-night periods. Demographic characteristics and PAP therapy parameters were not associated with compliance or usage. Among the longitudinal cohort (n=32), median compliance was 69.7% (IQR:19.2,90.0%) and median usage was 78.2% (IQR:45.2,95.7%). Compared to an age- and sex-matched cohort without DS, patients with DS demonstrated higher PAP compliance (p<0.05).Conclusions: Cross-sectional and longitudinal analyses reveal that many DS patients successfully adhere to PAP therapy, challenging the misconception that they struggle with adherence and proving they may be as successful, if not more, than non-DS patients.","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of WatchPAT to polysomnography measurement of apnea-hypopnea index and obstructive sleep apnea severity in adolescents with overweight and obesity. WatchPAT与多导睡眠描记术测量超重和肥胖青少年呼吸暂停低通气指数和阻塞性睡眠呼吸暂停严重程度的比较。

IF 3.5 3区医学

Journal of Clinical Sleep Medicine Pub Date : 2024-12-30 DOI: 10.5664/jcsm.11530

Mia L Dobbin, Angel Bernard, Laura Pyle, Norman Friedman, Melanie G Cree, Stephen M M Hawkins, Stacey L Simon

{"title":"Comparison of WatchPAT to polysomnography measurement of apnea-hypopnea index and obstructive sleep apnea severity in adolescents with overweight and obesity.","authors":"Mia L Dobbin, Angel Bernard, Laura Pyle, Norman Friedman, Melanie G Cree, Stephen M M Hawkins, Stacey L Simon","doi":"10.5664/jcsm.11530","DOIUrl":"https://doi.org/10.5664/jcsm.11530","url":null,"abstract":"Study objectives: The prevalence of obstructive sleep apnea (OSA) increases dramatically in adolescents with overweight or obesity. The gold standard for diagnosis of OSA is in-laboratory polysomnography (PSG). However, access to PSG can be challenging, necessitating development of alternative devices. This study aimed to compare the accuracy of WatchPAT, a device that indirectly detects apnea and hypopnea events through peripheral arterial tonometry, to PSG in adolescents with overweight and obesity.Methods: 38 participants (15.5±1.6 years; 76% female; 40% Hispanic/Latino; BMI 97.7±2.0 percentile) were analyzed. Correlation, agreement, sensitivity, specificity, and concordance between WatchPAT with PSG-derived measures of apnea-hypopnea index (AHI) and OSA severity were conducted. A subset (n=21) underwent subjective assessment of nasal flow sensor reliability and video characteristics to evaluate possible underestimation of PSG-assessed AHI.Results: Mean bias between WatchPAT- and PSG-derived AHI was 16.9±13.4 events/hour (95% CI 12.5-21.3). WatchPAT overestimated OSA severity compared to PSG in 89% of participants. Sensitivity was 62-100% and specificity was 5.5-32% across all OSA severity levels. Of the subset with subjective assessment of PSG data, 38% had nasal flow sensor reliability <75%, 14% had underestimated AHI, and 28% had probably underestimated AHI. However, these characteristics did not fully explain the discrepancy between WatchPAT and PSG measurements.Conclusions: The WatchPAT device showed a significant discrepancy compared to the gold-standard PSG in measurement of AHI and accuracy of OSA severity in adolescents with overweight or obesity. Future research is needed to understand pathophysiological differences to enhance assessment of OSA in this high-risk population.","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Palatal plates for treating infants with Robin sequence. 用Robin序列治疗婴儿腭板。

IF 3.5 3区医学

Journal of Clinical Sleep Medicine Pub Date : 2024-12-23 DOI: 10.5664/jcsm.11480

Christian F Poets, Maite Aretxabaleta, Christina Weismann, Mirja Quante, Cornelia Wiechers, Bernd Koos

引用次数: 0

Enhancing Mendelian randomization in sleep research: methodological considerations. 加强睡眠研究中的孟德尔随机化：方法学考虑。

IF 3.5 3区医学

Journal of Clinical Sleep Medicine Pub Date : 2024-12-23 DOI: 10.5664/jcsm.11542

Ahmed S BaHammam

引用次数: 0

Stanford orthodontic airway plate treatment program for neonates with Pierre Robin sequence in the United States: non-surgical alternative to neonatal mandibular distraction osteogenesis. 美国Pierre Robin序列新生儿Stanford正畸气道板治疗方案：新生儿下颌牵张成骨的非手术替代方案。

IF 3.5 3区医学

Journal of Clinical Sleep Medicine Pub Date : 2024-12-20 DOI: 10.5664/jcsm.11516

HyeRan Choo

引用次数: 0

Cost-utility analysis of a tiered diagnostic approach combining a screening model and polysomnography in pediatric obstructive sleep apnea. 结合筛查模式和多导睡眠监测仪对小儿阻塞性睡眠呼吸暂停的分级诊断方法的成本效用分析。

IF 3.5 3区医学

Journal of Clinical Sleep Medicine Pub Date : 2024-12-13 DOI: 10.5664/jcsm.11518

Shenglong Xu, Yanru Li, Demin Han

{"title":"Cost-utility analysis of a tiered diagnostic approach combining a screening model and polysomnography in pediatric obstructive sleep apnea.","authors":"Shenglong Xu, Yanru Li, Demin Han","doi":"10.5664/jcsm.11518","DOIUrl":"https://doi.org/10.5664/jcsm.11518","url":null,"abstract":"Study objectives: Obstructive sleep apnea (OSA) is a common disorder in the pediatric population, primarily diagnosed through polysomnography (PSG). However, PSG can be expensive and is often limited in availability. This study aimed to develop a cost-effective diagnostic strategy by integrating a screening model with PSG.Methods: A retrospective analysis was conducted on children suspected of OSA. Screening models were initially constructed with machine learning techniques. Cost-utility analyses compared three diagnostic strategies: (1) PSG alone, (2) the screening model alone, and (3) the screening model-PSG combined, in the discovery and validation cohorts. Cost-utility was measured using the incremental net monetary benefit (INMB).Results: 690 children were included. The logistic regression model using age, tonsil scale, OSA-18 questions 1 and 2, and oxygen desaturation index 3% predicted OSA with an area under the curve of 0.91. In the cost-utility analysis, the \"PSG alone\" strategy, as the baseline, was the most beneficial (utility 0.9557) at Chinese Yuan (CNY) 4523.98. The \"screening model alone\" had 91.6% sensitivity and 59.3% specificity, offering lesser value (utility 0.9337) at CNY 6071.51 (INMB CNY -3966.43) when compared to \"PSG alone\". The \"screening model-PSG combined\" strategy increased sensitivity to 100%, specificity to 99.2%, and utility to 0.9554 at CNY 4463.36, establishing it as the most cost-effective option with an INMB of CNY 34.22. One-way sensitivity analyses and adaptation to US cost parameters confirmed the robustness of these results.Conclusions: Using the screening model as a triage tool for PSG enhances the cost-effectiveness of pediatric OSA management.","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0