Journal of Clinical Sleep Medicine最新文献

{"title":"Reply to \"The question of whether narcolepsy increases mortality should be answered based on reliable studies\".","authors":"Amir Sharafkhaneh, Ahmed S BaHammam, Yves Dauvilliers, Mehnaz Azarian, Michael Thorpy, Fang Han, Gulcin Benbir Senel, Murat Aksu, Javad Razjouyan","doi":"10.1007/s44470-026-00121-8","DOIUrl":"10.1007/s44470-026-00121-8","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13350561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"Veteran status as an underappreciated confound in narcolepsy mortality\".","authors":"Amir Sharafkhaneh, Yves Dauvilliers, Ahmed S BaHammam, Mehnaz Azarian, Michael Thorpy, Fang Han, Gulcin Benbir Senel, Murat Aksu, Javad Razjouyan","doi":"10.1007/s44470-026-00124-5","DOIUrl":"10.1007/s44470-026-00124-5","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13350607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bringing cognitive behavioral therapy for nightmares to patients with trauma: increasing access and feasibility via primary and acute care.","authors":"Anthony N Reffi, Jennifer Peltzer-Jones, David A Moore, Jeffrey L Johnson, Christopher L Drake","doi":"10.1007/s44470-026-00108-5","DOIUrl":"10.1007/s44470-026-00108-5","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13341974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148406693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression of mild sleep-disordered breathing in children managed with watchful waiting.","authors":"Erin M Kirkham, Stacey Ishman, Susan Garetz, Cristina M Baldassari, Ron B Mitchell, Christopher Liu, Ignacio E Tapia, Lisa M Elden, Fauziya Hassan, Sally Ibrahim, Kristie Ross, Mengqi Cen, Rui Wang, Susan Redline, Ronald D Chervin","doi":"10.1007/s44470-026-00082-y","DOIUrl":"10.1007/s44470-026-00082-y","url":null,"abstract":"<p><strong>Purpose: </strong>To identify clinical characteristics that may be associated with persistence or progression of mild sleep-disordered breathing (SDB) in children who are observed without surgery.</p><p><strong>Methods: </strong>This is a secondary analysis of the control arm of the Pediatric Adenotonsillectomy Trial for Snoring (PATS), which randomized 458 children aged 3.0 to 12.9 years with mild SDB (snoring with obstructive apnea-hypopnea index [oAHI] < 3 events/hour) to early adenotonsillectomy (eAT) versus watchful waiting with supportive care (WWSC). Participants were assessed at baseline and 12 months with the Pediatric Sleep Questionnaire-Sleep-Related Breathing Disorder (PSQ-SRBD) scale and polysomnography (PSG). We tested for factors predictive of either (1) PSG progression defined by a 12-month oAHI ≥ 3 or (2) symptom persistence or progression defined by a 12-month PSQ-SRBD score ≥ 0.33.</p><p><strong>Results: </strong>A total of 234 participants were observed (mean age 6.2 years, 111 [47%] female, 65 [28%] Black or African American, 37 [16%] Hispanic). Overall, only 13% (n = 20/150) progressed to an oAHI ≥ 3 on repeat PSG, whereas over half (n = 110/192, 57%) had symptom persistence/progression. Of the children with persistent or progressive symptoms, 18% (n = 16/103) progressed to oAHI ≥ 3. In unadjusted analyses, PSG progression was associated with Black race (OR 2.71, 95% CI 1.03-7.17) and higher baseline PSQ-SRBD (OR 1.74, 95% CI 1.03-3.08). Symptom persistence/progression was predicted by asthma (OR 2.70 [95% CI 1.29, 6.01]), ADHD (OR 3.73 [95% CI 1.13, 16.88]), and tobacco smoke exposure (OR 2.41 [95% CI 1.08-5.82]), while children with larger tonsils (grade III-IV) had lower odds of progression (OR 0.42 [95% CI 0.22-0.78]).</p><p><strong>Conclusions: </strong>A high symptom burden is common after a year of WWSC for mild SDB, but only a minority of children progressed on PSG. Black race and several clinical characteristics and symptom scores were associated with higher likelihood of progression.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT0256204.</p><p><strong>Current knowledge/study rationale: </strong>Can clinical information predict persistence or progression of mild sleep-disordered breathing in children who are observed for 1 year without adenotonsillectomy?</p><p><strong>Study impact: </strong>Polysomnographic progression to obstructive sleep apnea occurs in a minority (13%) of those observed while symptom persistence or progression is more common (57%). Children who are Black or who have asthma, attention-deficit hyperactivity disorder, environmental tobacco exposure, and a high symptom burden could be considered stronger candidates than their peers for earlier adenotonsillectomy for symptomatic mild sleep-disordered breathing.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13341984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148406687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lose sleep, lose score? Interpreting computerized neurocognitive testing after concussion.","authors":"Amir Sharafkhaneh, J Kent Werner, Ahmed BaHammam","doi":"10.1007/s44470-026-00107-6","DOIUrl":"10.1007/s44470-026-00107-6","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13341979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148406724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between sleep inertia and cognitive performance among older adults in the Wisconsin Sleep Cohort study.","authors":"Jessica J Love, Jesse D Cook, Erika W Hagen, Amanda Rasmunon, Laurel A Ravelo, Mari Palta, Paul E Peppard, David T Plante","doi":"10.1007/s44470-026-00133-4","DOIUrl":"10.1007/s44470-026-00133-4","url":null,"abstract":"<p><strong>Purpose: </strong>Since sleep inertia and hypersomnolence, broadly, have not been adequately studied in the context of neurocognitive performance, this investigation examined associations between sleep inertia severity, other measures of hypersomnolence, and outcomes from a standardized, cognitive testing battery in a well-characterized community-based sample of older adults.</p><p><strong>Methods: </strong>Wisconsin Sleep Cohort participants completed the Sleep Inertia Questionnaire (SIQ), Epworth Sleepiness Scale (ESS), Hypersomnia Severity Index (HSI) and six widely used cognitive tests. Linear regression examined relationships between hypersomnolence measures (SIQ, ESS, and HSI) and cognitive outcomes. Secondary analyses assessed relationships between SIQ subscales (physiological, cognitive, emotional, and responses) and cognitive outcomes. Adjusted models included covariates capturing demographic, psychosocial, sleep, and testing characteristics.</p><p><strong>Results: </strong>The sample (N = 461) was predominantly non-Hispanic white older adults (average age = 73.84 ± 6.66 years), with majority being male (55.8%). In unadjusted analyses, SIQ total score was associated with Grooved Pegboard (GPB), Trail Making Test-Part B (TMT-B), and Symbol Digits Modalities Test, while neither ESS nor HSI was associated with cognitive outcomes. Significant associations between SIQ and GPB and TMT-B remained in fully adjusted analyses. Physiological, cognitive, and emotional SIQ subscales were also associated with cognitive tests, particularly GPB and TMT-B.</p><p><strong>Conclusions: </strong>This study suggests that sleep inertia may be an important, specific symptom that is associated with cognitive performance in older adults. Future research is indicated to clarify the role of sleep inertia in aging, while exploring its potential value as a risk factor for cognitive impairment and target for intervention to support cognitive health.</p><p><strong>Current study/study rationale: </strong>Sleep inertia is a common sleep-related symptom, yet it remains insufficiently studied, particularly regarding neurocognitive performance. The Sleep Inertia Questionnaire (SIQ) is a validated measure of sleep inertia, but has not been studied in older populations at risk for cognitive impairment. Clarifying relationships between SIQ scores and neurocognitive outcomes may identify those at greater risk for cognitive impairment.</p><p><strong>Study impact: </strong>Sleep inertia is a common sleep-related symptom, yet it remains insufficiently studied, particularly regarding neurocognitive performance. The Sleep Inertia Questionnaire (SIQ) is a validated measure of sleep inertia, but has not been studied in older populations at risk for cognitive impairment. Clarifying relationships between SIQ scores and neurocognitive outcomes may identify those at greater risk for cognitive impairment.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13337965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148399703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence regarding \"Obstructive sleep apnea and primary snoring in children are associated with oropharyngeal dysbiosis and a mild compositional imbalance in the gastrointestinal tract\".","authors":"Hyun Jin Min","doi":"10.1007/s44470-026-00112-9","DOIUrl":"10.1007/s44470-026-00112-9","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13328611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148377478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes mellitus is associated with increased prevalence and severity of COMISA: evidence from the nationwide TURKAPNE cohort.","authors":"Canan Gündüz Gürkan, Aylin Pihtili, Esen Kiyan, Mehmet Sezai Tasbakan, Özen K Basoglu, Semih Arbatli, Senay Aydin, Aykut Cilli, Neşe Dursunoglu, Burcu Baran, Yüksel Peker","doi":"10.1007/s44470-026-00109-4","DOIUrl":"10.1007/s44470-026-00109-4","url":null,"abstract":"<p><strong>Background: </strong>Comorbid insomnia and obstructive sleep apnea (COMISA) is increasingly recognized as a clinically important sleep disorder phenotype with potential cardiometabolic consequences. However, its association with diabetes mellitus (DM) remains insufficiently characterized.</p><p><strong>Methods: </strong>This cross-sectional analysis included 12,715 adults with suspected obstructive sleep apnea (OSA) from the nationwide multicenter TURKAPNE cohort who underwent full-night polysomnography. Insomnia symptoms were assessed using standardized questionnaire items, and OSA was defined as apnea-hypopnea index (AHI) ≥ 5 events/hour. COMISA was defined as the coexistence of insomnia symptoms and OSA. DM was identified based on self-reported physician diagnosis or use of antidiabetic medications. Multivariable logistic regression was performed to evaluate independent variables associated with COMISA.</p><p><strong>Results: </strong>COMISA was present in 3,275 patients (25.7%). DM was significantly more prevalent among patients with COMISA compared with those without COMISA (22.8% vs. 15.4%, p < 0.001). Overall, COMISA was observed in 33.9% of diabetic individuals and 24.1% of non-diabetic individuals. In multivariable analysis adjusted for age, sex, body-mass-index, smoking status, education level, and comorbidities, DM remained independently associated with COMISA (adjusted OR 1.17; 95% CI 1.05-1.31; p = 0.006). Among COMISA patients, those with DM exhibited greater sleep fragmentation and more severe sleep-disordered breathing, including higher AHI (30.0 vs. 24.0 events/h) and oxygen desaturation index (26.0 vs. 20.0 events/h) (p < 0.001).</p><p><strong>Conclusions: </strong>DM is independently associated with COMISA and with more severe sleep and respiratory disturbances within this phenotype. These findings highlight the need for integrated screening of sleep disorders in individuals with DM.</p><p><strong>Trial registration: </strong>ClinicalTrials gov (NCT02784977).</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13328692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon-like peptide receptor agonists (GLP-1RAs) as cardiovascular risk modifiers in obstructive sleep apnea and obesity: a real-world study.","authors":"Jaeun Ahn, Junmin Song, Kyle Admire, Yu Chang, Kuan-Yu Chi, Nathaniel T Gordon, Joshua M Sill","doi":"10.1007/s44470-026-00110-x","DOIUrl":"10.1007/s44470-026-00110-x","url":null,"abstract":"<p><strong>Introduction: </strong>Obstructive sleep apnea (OSA) is a well-established risk factor for cardiovascular disease. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have demonstrated potential in reducing cardiovascular risk and improving OSA severity. However, a significant knowledge gap remains regarding the impact of GLP-1RAs on cardiovascular events in OSA patients.</p><p><strong>Methods: </strong>We examined patients with a BMI over 30 diagnosed with OSA between January 2010 and November 2021 without a previous diagnosis of heart failure, pulmonary hypertension, or myocardial infarction. Two cohorts were created: those prescribed GLP-1RAs within 1 year of their OSA diagnosis and patients who were never prescribed GLP-1RAs. Propensity score matching was performed using TriNetX software with greedy nearest neighbor methodology. Cox proportional hazards analyses were conducted over a 3-year follow-up period. The primary outcome was newly diagnosed heart failure. Secondary outcomes included pulmonary hypertension, death from all causes, ischemic stroke, and acute myocardial infarction (AMI).</p><p><strong>Results: </strong>We included 18,774 patients in the GLP-1RA cohort and 847,137 patients in the non-GLP-1RA cohort. Propensity score matching resulted in 18,523 patients remaining in each cohort, which were well-matched in demographics, comorbidities, medications, BMI, and HbA1c. After 3 years, the GLP-1RA cohort had a significantly lower risk of newly developed heart failure (HR, 0.76; 95% CI, 0.71-0.82), pulmonary hypertension (HR, 0.67; 95% CI, 0.59-0.75), AMI (HR, 0.76; 95% CI, 0.67-0.86), and death from all causes (HR, 0.57; 95% CI, 0.51-0.63).</p><p><strong>Conclusion: </strong>GLP-1RAs were associated with reduced risks of heart failure, pulmonary hypertension, AMI, and death from all causes in obese OSA patients. Prospective studies are needed for validation. GLP-1 receptor agonists (GLP-1RAs) have shown promising potential in reducing cardiovascular risk and alleviating the severity of obstructive sleep apnea (OSA), a well-known risk factor for cardiovascular disease. However, a significant knowledge gap remains regarding the impact of GLP-1RAs on cardiovascular events specifically in patients with OSA. With 3 years of follow-up, the GLP-1RAs reduced newly developed heart failure by 24%, pulmonary hypertension by 33%, acute myocardial infarction by 24%, and death by 43%, with notable early separation in heart failure and all-cause mortality. This finding supports the potential for broader use of GLP-1RAs in this population, not only to improve OSA severity, but also to reduce cardiovascular risk.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13323676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dr. AI says you have sleep apnea: measuring the accuracy of patient-facing AI in sleep medicine.","authors":"Christine H J Won","doi":"10.1007/s44470-026-00119-2","DOIUrl":"10.1007/s44470-026-00119-2","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13323409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}