Journal of Clinical Sleep Medicine最新文献

{"title":"Correction: Increasing reports and shifting categorical trends in adverse events for oral appliances.","authors":"Aaron Glick, Sue Ellen Richardson","doi":"10.1007/s44470-026-00200-w","DOIUrl":"10.1007/s44470-026-00200-w","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social jetlag in a longitudinal Chinese wearable cohort: weekly variation, solar-time mismatch, and sleep-activity associations.","authors":"Xinyu Fu, Kaiyan Ma, Min Yu, Yuhan Xu, Yuke Chen, Zhili Huang, Xuemei Gao","doi":"10.1007/s44470-026-00209-1","DOIUrl":"10.1007/s44470-026-00209-1","url":null,"abstract":"<p><strong>Purpose: </strong>To examine how sleep-corrected social jetlag (SJLsc) varied with work-rest schedules and solar time zone and how it was associated with sleep, physical activity, and nocturnal heart rate variability (HRV).</p><p><strong>Methods: </strong>Wearable-device and questionnaire data from 63,752 adults contributing 2,037,507 person-weeks were analyzed. SJLsc was the difference in sleep midpoint between workdays and free days, corrected for sleep debt. High SJL was SJLsc > 1 h. Weeks were classified as normal, extended-rest (statutory holidays added), or extended-work (weekend days reassigned as workdays). Provinces were grouped as east, central, or west by solar time offset, the gap between local solar time and China Standard Time. Generalized linear mixed models tested week type and solar offset. Within-person centering was used to separate between- from within-person associations.</p><p><strong>Results: </strong>Median SJLsc was 0.70 h. High SJL was more common by week than by person (25.02% of person-weeks vs 20.25% of participants). High SJL was less likely during extended-rest (OR = 0.844, 95% CI 0.830-0.859) and extended-work weeks (OR = 0.776, 95% CI 0.758-0.794), while short-sleep odds were higher in both. Locations farther west were associated with later sleep and greater SJLsc. Adverse associations of SJL with sleep and physical activity were stronger between people than within people, whereas HRV showed no robust association.</p><p><strong>Conclusion: </strong>Associations of social jetlag with sleep and physical activity were driven mainly by between-person differences. Lower social jetlag during extended-rest and extended-work weeks coexisted with higher odds of short sleep, suggesting that social jetlag should be interpreted alongside sleep duration and schedule context.</p><p><strong>Current study/study rationale: </strong>Social jetlag has been linked to adverse sleep and health outcomes, but prior studies have relied largely on cross-sectional or questionnaire-based measures. Large longitudinal wearable data can test how social jetlag varies across real-world schedules and examine associations between social jetlag and sleep, physical activity, and HRV, with stable person-level differences or week-to-week change clearly defined.</p><p><strong>Study impact: </strong>In 63,752 Chinese adults, high social jetlag was more common at the week level than at the person level, and lower social jetlag during altered schedules did not necessarily indicate longer or more continuous sleep. Adverse associations with sleep and physical activity were driven mainly by between-person differences, supporting trait-state decomposition in clinical sleep research.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom improvement with dosing above 9 g of low-sodium oxybate: effectiveness and safety in participants with narcolepsy in the DUET study.","authors":"Jerald H Simmons, Logan D Schneider, Chad M Ruoff, David T Plante, Deborah A Nichols, Teresa L Steininger, Marisa Whalen, M Todd Kirby, Jing Dai, Alyssa Cairns, Richard K Bogan","doi":"10.1007/s44470-026-00193-6","DOIUrl":"10.1007/s44470-026-00193-6","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;Evaluate effectiveness/safety of low-sodium oxybate (LXB; Xywav&lt;sup&gt;®&lt;/sup&gt;) dosages &gt; 9 g/night in participants with narcolepsy (type 1 [NT1] or 2 [NT2]).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Jazz DUET (prospective, multiple-cohort, open-label study [NCT05875974]) included screening, 9-day baseline (LXB 9 g/night [\"LXB 9 g BL\"]), 2-8-week titration, 2-week stable-dose, 9-day end-of-treatment (LXB &gt; 9 g- ≤ 12 g [\"optimized LXB &gt; 9 g EOT\"]; twice-nightly, first/second max doses = 7.5/4.5 g), and 2-week follow-up. Endpoints included Epworth Sleepiness Scale (ESS), Narcolepsy Severity Scale-clinical trials version (NSS-CT), Patient Global Impression of Severity (PGI-S) and Change (PGI-C), and polysomnography (PSG)-measured respiratory assessments.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Forty-eight participants took LXB &gt; 9 g/night (mean ± SD age: 39.2 ± 10.9 years; 62.5% female); 44 (NT1, n = 28; NT2, n = 16) completed the study. Mean ± SD stable-LXB dosage (n = 45) was 11.1 ± 1.0 g/night (most common [43.8%], 12 g/night). From LXB 9 g BL to optimized LXB &gt; 9 g EOT, mean ± SE ESS scores (11.4 ± 0.8 to 8.3 ± 0.9), NSS-CT (NT1) scores (17.3 ± 2.2 to 9.4 ± 2.1), and NSS-2-CT (NT2) scores (9.7 ± 1.7 to 4.3 ± 1.6) improved. Fewer participants rated their disease as severe (61.4% to 29.5%), and most (92.3%) reported their disease improved. AHI (1.8 ± 0.4 to 1.6 ± 0.3), CAI (0.01 ± 0.01 to 0.01 ± 0.00), and mean SpO&lt;sub&gt;2&lt;/sub&gt; (95.8 ± 0.2 to 95.8 ± 0.1) remained stable. Common TEAEs included nausea (12.5%), vomiting (12.5%), and headache (10.4%).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Participants taking LXB &gt; 9 g/night experienced further improvements in narcolepsy symptoms versus 9 g/night, suggesting some patients may require higher dosages for optimal benefit. No changes in mean respiratory PSG measures were observed. TEAEs align with the known safety profile. Findings support individualized clinical decision-making with higher LXB dosages.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical trial registration: &lt;/strong&gt;Trial name: A Study to Investigate the Effect of XYWAV on Sleepiness, Polysomnography, and Functional Outcomes in Participants With Idiopathic Hypersomnia or Narcolepsy; URL: https://clinicaltrials.gov/study/NCT05875974 ; ID number: NCT05875974.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Current knowledge/study rationale: &lt;/strong&gt;Narcolepsy is a heterogeneous disorder requiring individualized treatment strategies to optimize symptom management. This study fills a critical knowledge gap by evaluating effectiveness and safety of low-sodium oxybate (LXB) dosing regimens higher (&gt; 9-12 g/night) than the recommended dosage (6-9 g/night).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study impact: &lt;/strong&gt;Participants with narcolepsy taking LXB &gt; 9 g/night experienced further overall symptom benefit compared with 9 g/night at baseline, suggesting some patients may require higher dosages to achieve optimal therapeutic benefit. The safety profile, including respiratory safety parameters, was comparable to that observ","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond hours per night: rethinking oral appliance adherence in OSA.","authors":"Joseph Russo, Vinita Vidya, Robert Stansbury","doi":"10.1007/s44470-026-00207-3","DOIUrl":"10.1007/s44470-026-00207-3","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"Central hypopnea classification: bridging the gap between event identification and clinical utility\".","authors":"Anjali P Ahn, Atul Malhotra","doi":"10.1007/s44470-026-00211-7","DOIUrl":"10.1007/s44470-026-00211-7","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"Methodological caveats in interpreting slow-wave slope as a marker of synaptic homeostasis in OSA\".","authors":"Rama Maganti, Jun Wang, Scott Hetzel","doi":"10.1007/s44470-026-00203-7","DOIUrl":"10.1007/s44470-026-00203-7","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"Methodological considerations in assessing diagnostic accuracy of home sleep apnea tests in children\".","authors":"Ann M Murray, Timothy I Morgenthaler, Allison LeMahieu, Julie M Baughn","doi":"10.1007/s44470-026-00208-2","DOIUrl":"10.1007/s44470-026-00208-2","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13658711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep does not occur in isolation: contextualizing adolescent sleep disparities.","authors":"BreAnne Young, Azizi Seixas, Girardin Jean-Louis","doi":"10.1007/s44470-026-00201-9","DOIUrl":"10.1007/s44470-026-00201-9","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13658704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From shifting the clock to sustaining alignment: toward precision chronotherapy for emerging adults with delayed sleep timing.","authors":"Nining Maizura, Altha Nurzafira Melin Pisyam, Herra Aprillia Sabrina, Arbin Janu Setiyowati, Nugraheni Warih Utami, Irene Maya Simon, Widya Multisari","doi":"10.1007/s44470-026-00194-5","DOIUrl":"10.1007/s44470-026-00194-5","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13652990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond sleep symptoms: why functional trajectories matter in Parkinson's disease.","authors":"Maghfirotul Lathifah","doi":"10.1007/s44470-026-00205-5","DOIUrl":"10.1007/s44470-026-00205-5","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"22 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}