Journal of Clinical Sleep Medicine最新文献

{"title":"The complexity of employing \"optimal AHI/RDI cutoffs\" in assessing the performance of OSA-detecting wearables.","authors":"Ambrose A Chiang, Steven Holfinger, Sharon Schutte-Rodin","doi":"10.5664/jcsm.11508","DOIUrl":"10.5664/jcsm.11508","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"741-742"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lateral epiglottic collapse in obstructive sleep apnea is associated with laterally directed pharyngeal collapse.","authors":"Tsai-Yu Wang, Phillip Huyett, Hyungchae Yang, Jeffrey Sumner, Atqiya Aishah, Laura Gell, Ali Azarbarzin, Ludovico Messineo, Gonzalo Labarca, David White, Scott Sands, Andrew Wellman, Daniel Vena","doi":"10.5664/jcsm.11478","DOIUrl":"10.5664/jcsm.11478","url":null,"abstract":"<p><strong>Study objectives: </strong>Epiglottic collapse can obstruct the airway in patients with obstructive sleep apnea in an anteroposterior or lateral direction. The present study investigates the concept that lateral or concentric pharyngeal collapse patterns may remodel the epiglottis and predispose it to lateral collapse. To do so, we hypothesized that the presence of-any form of laterally directed pharyngeal collapse, eg, oropharyngeal lateral wall collapse or complete concentric collapse of the soft palate, is associated with increased odds for having concurrent lateral epiglottic collapse (E-lat).</p><p><strong>Methods: </strong>We analyzed 582 patients with obstructive sleep apnea from our drug-induced sleep endoscopy cohort. Site of collapse was scored by a single scorer using the VOTE criteria, with patients with epiglottic collapse reviewed by 2 additional independent scorers. Logistic regression evaluated the association between presence of laterally directed pharyngeal collapse and the presence of E-lat.</p><p><strong>Results: </strong>The overall prevalence of E-lat was 2.6% (n = 15). The presence of any form of laterally directed pharyngeal collapse was associated with 4-fold increased odds (4.4 [1.5-12.6], <i>P</i> = .006) of having concurrent E-lat. Further, the specific presence of either complete oropharyngeal lateral wall collapse or complete concentric collapse of the soft palate was associated with an odds ratio of 3.4 [1.2-9.6] and 8.6 [2.2-33.5], respectively, of having concurrent E-lat.</p><p><strong>Conclusions: </strong>Greater prevalence of severe laterally directed pharyngeal collapse, in the form of either complete concentric collapse of the soft palate or oropharyngeal lateral wall collapse in patients with E-lat supports the concept that laterally and concentric pharyngeal collapse patterns may shape the epiglottis and thereby contribute to the pathogenesis of E-lat.</p><p><strong>Citation: </strong>Wang T-Y, Huyett P, Yang H, et al. Lateral epiglottic collapse in obstructive sleep apnea is associated with laterally directed pharyngeal collapse. <i>J Clin Sleep Med</i>. 2025;21(4):649-654.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"649-654"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asian adult sleep medicine fellowship training curriculum: one curriculum, many contexts.","authors":"Ahmed S BaHammam, Mohammed A Al-Abri, Khaled Al Oweidat, Babak Amra, Joey W Y Chan, Naricha Chirakalwasan, Hamza Dhafar, Rodolfo V Dizon, Ravi Gupta, Sy Duong-Quy, Fang Han, Seung Bong Hong, Ahmad I Ismail, Haitham Jahrami, Mouhamad Ghyath Jamil, Ki-Young Jung, Hiroshi Kadotani, Leong Chai Leow, Pei-Lin Lee, Fadi Munshi, Rimawati Tedjasukmana, Yun Kwok Wing, Yuichi Inoue","doi":"10.5664/jcsm.11484","DOIUrl":"10.5664/jcsm.11484","url":null,"abstract":"<p><strong>Study objectives: </strong>To develop a comprehensive Asian adult sleep medicine fellowship training curriculum to address the significant disparities in sleep medicine training across Asia, guided by the principle of \"One Curriculum, Many Contexts,\" providing a standardized yet adaptable framework for sleep medicine education across the diverse health care landscapes of Asian countries.</p><p><strong>Methods: </strong>The curriculum development process involved a gap analysis, comprehensive literature review, and expert consensus through a modified RAND/UCLA appropriateness method/Delphi survey.</p><p><strong>Results: </strong>The curriculum offers 2 flexible tracks: a 1-year program (Track A) and a 2-year program (Track B), accommodating varied educational pathways and health care system structures across Asia. Key features of the curriculum include detailed learning outcomes, competency-based educational content, and recommendations for teaching and learning activities. The assessment strategy incorporates summative and formative methods, with standard setting and program evaluation guidelines. The curriculum also provides recommendations for program accreditation, fellow-faculty ratios, and funding considerations.</p><p><strong>Conclusions: </strong>The Asian adult sleep medicine fellowship training curriculum provides a standardized yet adaptable framework for sleep medicine education across diverse Asian health care landscapes. By emphasizing flexibility and customization while maintaining high training standards, the curriculum aims to bridge the gap in sleep medicine training across Asia, ultimately improving the quality of sleep health care and patient outcomes throughout the region.</p><p><strong>Citation: </strong>BaHammam AS, Al-Abri MA, Al Oweidat K, et al. Asian adult sleep medicine fellowship training curriculum: one curriculum, many contexts. <i>J Clin Sleep Med</i>. 2025;21(4):627-638.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"627-638"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Mendelian randomization in sleep research: methodological considerations.","authors":"Ahmed S BaHammam","doi":"10.5664/jcsm.11542","DOIUrl":"10.5664/jcsm.11542","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"739-740"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Images: Combined positive air way pressure and atomoxetine-oxybutynin for the treatment of severe obstructive sleep apnea.","authors":"Jonathan Mitton, Muhammad E Khan, Daniel Combs, Sairam Parthasarathy, Saif Mashaqi","doi":"10.5664/jcsm.11496","DOIUrl":"10.5664/jcsm.11496","url":null,"abstract":"<p><p>Obstructive sleep apnea is one of the most common sleep disorders. Positive airway pressure therapy is considered the gold standard for treating obstructive sleep apnea. Yet, optimal therapy might not be achieved in some cases of severe obstructive sleep apnea, despite using maximum settings. In this case report, we describe the successful combination of positive airway pressure therapy and atomoxetine-oxybutynin in reducing the apnea-hypopnea index from the severe range to the mild to moderate range. This was also associated with significant improvement in several symptoms including excessive daytime sleepiness and drowsiness while driving.</p><p><strong>Citation: </strong>Mitton J, Khan ME, Combs D, Parthasarathy S, Mashaqi S. Images: combined positive air way pressure and atomoxetine-oxybutynin for the treatment of severe obstructive sleep apnea. <i>J Clin Sleep Med</i>. 2025;21(4):743-746.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"743-746"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noncontact respiratory monitoring during sleep: comparison of the touchless flow signal with respiratory inductance plethysmography flow (RIP_flow) signal to assess respiratory events.","authors":"Paul S Addison, Lara Brewer, Krishna M Sundar, Robert Farney, Philip Smit, Andre Antunes, Dean Montgomery","doi":"10.5664/jcsm.11486","DOIUrl":"10.5664/jcsm.11486","url":null,"abstract":"<p><strong>Study objectives: </strong>A nonintrusive sleep monitoring technology based on the data from a commercially available depth sensing camera has been utilized for respiratory monitoring and shown to have good performance in assessing respiratory rates across a range of rates. This noncontact or <i>touchless</i>, technology allows continuous respiratory monitoring without attaching probes to the patient. We have noticed a strikingly similar morphology between the noncontact flow signal (NCM_flow) and the flow signal derived using the chest and abdomen respiratory inductance plethysmography (RIP_flow) bands. Here we report on a quantitative assessment of the morphological similarity between the two signals for a cohort of patients undergoing polysomnography.</p><p><strong>Methods: </strong>We collected depth data from 25 sleep patients undergoing attended polysomnography. Correlation and mutual trending were assessed between the NCM_flow and RIP_flow signals in individuals undergoing diagnostic and split night polysomnography using Pearson correlation and concordance between the NCM_flow and RIP_flow signals.</p><p><strong>Results: </strong>Strong correlation was observed across all patients between the NCM_flow and RIP_flow signals (range: 0.78-0.98, mean: 0.89 ± 0.06). Similarly, high values of concordance were achieved between the NCM_flow and RIP_flow signals (range: 0.85-1.0, mean: 0.96 ± 0.04).</p><p><strong>Conclusions: </strong>The high values of correlation and concordances confirm that the NCM_flow signal can potentially be used as a surrogate for RIP_flow signal during sleep. Our findings strongly support the potential for noncontact continuous monitoring of respiratory disturbances during sleep.</p><p><strong>Citation: </strong>Addison PS, Brewer L, Sundar KM, et al. Noncontact respiratory monitoring during sleep: comparison of the touchless flow signal with respiratory inductance plethysmography flow (RIP_flow) signal to assess respiratory events. <i>J Clin Sleep Med</i>. 2025;21(4):713-721.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":"21 4","pages":"713-721"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Families of adults with idiopathic hypersomnia and narcolepsy: psychosocial impact and contribution to symptom management.","authors":"Jennifer M Mundt, Rachel-Clair Franklin, Matthew Horsnell, Victoria Garza","doi":"10.5664/jcsm.11526","DOIUrl":"10.5664/jcsm.11526","url":null,"abstract":"<p><strong>Study objectives: </strong>This study examined the impact of central disorders of hypersomnolence (CDH) on family members of adult patients, the ways family members assist with managing CDH, and family members' utilization and satisfaction with information and support.</p><p><strong>Methods: </strong>Participants were adults (n = 100) with an adult family member diagnosed with idiopathic hypersomnia or narcolepsy. They completed a survey which included the Family Reported Outcome Measure, checklists, satisfaction ratings, and open-response questions.</p><p><strong>Results: </strong>The Family Reported Outcome Measure sample mean (14.2, standard deviation = 6.8) corresponded to a moderate effect on quality of life. Compared to parents, partners reported a higher impact on the personal and social life domain (<i>P</i> = .04, d = .44). The most frequently endorsed sources of support were family (60.0%) and friends (50.0%), whereas information was most commonly obtained from hypersomnia organizations (69.0%) and medical professionals (61.0%). Only 8.0% of participants were satisfied with support, and 9.0% were satisfied with information. Participants endorsed assisting with managing CDH, such as picking up prescriptions (61.0%), attending medical visits (50.0%), reminding to take medication (48.0%), and coordinating medical care (39.0%). Qualitative data indicated that relationships underwent a transformation from conflict and confusion (prediagnosis) to clarity (postdiagnosis), followed by adjusting expectations. Caregiving strain, effects on shared activities, and negative psychosocial impacts on family also emerged as themes.</p><p><strong>Conclusions: </strong>Family members play an important role in supporting adults with CDH in many ways, including tasks related to managing CDH. Family members experience many psychosocial impacts from CDH, and data from this study indicate unmet needs for support.</p><p><strong>Citation: </strong>Mundt JM, Franklin R-C, Horsnell M, Garza V. Families of adults with idiopathic hypersomnia and narcolepsy: psychosocial impact and contribution to symptom management. <i>J Clin Sleep Med</i>. 2025;21(4):683-694.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"683-694"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A strategic approach of the management of sleep-disordered breathing in multiple system atrophy.","authors":"Anaïs Laga, Fré Bauters, Katrien Hertegonne, Peter Tomassen, Patrick Santens, Chloé Kastoer","doi":"10.5664/jcsm.11472","DOIUrl":"10.5664/jcsm.11472","url":null,"abstract":"<p><strong>Study objectives: </strong>Multiple system atrophy (MSA) is a rare neurodegenerative disorder characterized by autonomic dysfunction associated with a combination of cerebellar, parkinsonian, or pyramidal signs. Sleep-disordered breathing such as stridor, obstructive sleep apnea, and central sleep apnea is common in MSA and can impact survival. Several studies have evaluated treatment modalities. However, the optimal strategy often remains unclear in these patients. This review aims to provide an overview of the current evidence on treatment of sleep-disordered breathing in MSA.</p><p><strong>Methods: </strong>Systematic review of the current literature through combined keyword search in PubMed, Embase, the Cochrane Library, and cited references: \"multiple system atrophy,\" \"stridor,\" \"sleep apnea syndrome,\" \"sleep-disordered breathing,\" \"Shy Drager syndrome.\"</p><p><strong>Results: </strong>Twenty-nine papers were included, with a total of 681 patients with MSA and sleep-disordered breathing. Treatment modalities are: continuous positive airway pressure, tracheostomy, tracheostomy-invasive ventilation, noninvasive positive pressure ventilation, adaptive servoventilation, vocal cord surgery, botulinum toxin injections, oral appliance therapy, cervical spinal cord stimulation, selective serotonin reuptake inhibitors.</p><p><strong>Conclusions: </strong>Conflicting results on survival are found for continuous positive airway pressure therapy. Tracheostomy has a proven survival benefit. Most beneficial outcomes are seen with tracheostomy-invasive ventilation. Continuous positive airway pressure, other types of positive airway pressure therapy and tracheostomy can adequately control symptoms of obstructive sleep apnea. However, continuous positive airway pressure may exacerbate central sleep apnea. There was a lack of sufficient data regarding servoventilation or noninvasive positive pressure ventilation. Some patients exhibit a floppy epiglottis and require a different approach. In conclusion, due to the complex characteristics of sleep-disordered breathing in MSA, an individualized and multidisciplinary approach is mandatory.</p><p><strong>Citation: </strong>Laga A, Bauters F, Hertegonne K, Tomassen P, Santens P, Kastoer C. A strategic approach of the management of sleep-disordered breathing in multiple system atrophy. <i>J Clin Sleep Med.</i> 2025;21(4):703-711.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"703-711"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adults with Down syndrome and obstructive sleep apnea treated with hypoglossal nerve stimulation.","authors":"Phillip Huyett, Stephanie L Santoro, Nicolas M Oreskovic, Brian G Skotko","doi":"10.5664/jcsm.11452","DOIUrl":"10.5664/jcsm.11452","url":null,"abstract":"<p><strong>Study objectives: </strong>We aimed to examine the feasibility, adherence to therapy, and efficacy of hypoglossal nerve stimulation in adults with Down syndrome and obstructive sleep apnea.</p><p><strong>Methods: </strong>Adults patients with Down syndrome who met criteria for hypoglossal nerve stimulation were prospectively enrolled. Objective adherence was extracted from a cloud-based compliance database. Preoperative sleep studies were compared to follow-up testing performed no sooner than 3 months after device activation.</p><p><strong>Results: </strong>Eleven adults with Down syndrome underwent implantation of hypoglossal nerve stimulation between May 2021 and July 2024. Median age was 27 years (interquartile range 26, 33), body mass index 28.5 kg/m² (26.5, 32.4), 27% were female, and patients had severe obstructive sleep apnea (apnea-hypopnea index 40 events/h, 28.4, 42.9). All patients were successfully implanted on an outpatient basis with no postoperative complications or readmissions and activated on schedule at 1 month after surgery. Adherence data show nightly usage longer than 4 hours was 100% and 96% of nights and a median of 9.2 and 8.5 hours/night in the first 30 and 90 days, respectively. Seven patients have undergone follow-up testing and the median entire-night apnea-hypopnea index was reduced by 76%. All patients experienced a > 50% decrease in apnea-hypopnea index and to less than 15 events/h. Median time spent below 88% improved from 2.0% (0.3, 5.0) to 0.2% (0, 0.6), and oxygenation nadir improved from 79.0% (75.5, 85) to 88.0% (86.5, 91).</p><p><strong>Conclusions: </strong>In this small initial cohort, hypoglossal nerve stimulation appears to be a safe, well-tolerated, and efficacious treatment option for adults with Down syndrome with moderate-to-severe obstructive sleep apnea and positive airway pressure therapy intolerance.</p><p><strong>Citation: </strong>Huyett P, Santoro SL, Oreskovic NM, Skotko BG. Adults with Down syndrome and obstructive sleep apnea treated with hypoglossal nerve stimulation. <i>J Clin Sleep Med.</i> 2025;21(4):619-625.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"619-625"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to positive airway pressure therapy in patients with Down syndrome: assessing cloud-based monitoring data.","authors":"Rakesh Bhattacharjee, Megan Warner, Brandon Nokes, Jeremy S Landeo Gutierrez, Zihan Chen, Milan D Amin, Atul Malhotra","doi":"10.5664/jcsm.11520","DOIUrl":"10.5664/jcsm.11520","url":null,"abstract":"<p><strong>Study objectives: </strong>Obstructive sleep apnea is common in Down syndrome (DS) with many patients prescribed positive airway pressure (PAP) therapy. This study evaluates PAP adherence and identifies factors influencing adherence.</p><p><strong>Methods: </strong>Retrospective analysis of electronic health records and cloud-based PAP therapy data from patients with DS at Rady Children's Hospital, San Diego, CA. Cloud data were evaluated cross-sectionally at 30- and 90-night post-clinic visit and longitudinally in patients with ≥ 2 90-night data downloads. Outcomes included adherence (percentage of nights with ≥ 4 hours of use) and usage (percentage of nights with any PAP usage). The impact of demographic and PAP therapy factors (eg, mask leak) on these outcomes was also assessed.</p><p><strong>Results: </strong>Forty-seven patients with DS with cloud-based PAP therapy data over a 90-night period and 46 over a 30-night period were analyzed. The mean age was 17.7 ± 4.6 years (21 females). Median adherence was significantly higher at 30 nights (56.7%, interquartile range: 0.0, 90.8%) than at 90 nights (34.4%, interquartile range: 0.0, 86.7%) (<i>P</i> < .05). Median usage did not differ between the 30-night and 90-night periods. Demographic characteristics and PAP therapy parameters were not associated with adherence or usage. Among the longitudinal cohort (n = 32), median adherence was 69.7% (interquartile range: 19.2, 90.0%), and median usage was 78.2% (interquartile range: 45.2, 95.7%). Compared to an age- and sex-matched cohort without DS, patients with DS demonstrated higher PAP adherence (<i>P</i> < .05).</p><p><strong>Conclusions: </strong>Cross-sectional and longitudinal analyses reveal that many patients with DS successfully adhere to PAP therapy, challenging the misconception that they struggle with adherence and proving they may be as successful, if not more, than non-DS patients.</p><p><strong>Citation: </strong>Bhattacharjee R, Warner M, Nokes B, et al. Adherence to positive airway pressure therapy in patients with Down syndrome: assessing cloud-based monitoring data. <i>J Clin Sleep Med</i>. 2025;21(4):675-681.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"675-681"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}