Polysomnographic findings of multiple system atrophy: evidence from case-control studies.

IF 2.9 3区医学 Q1 CLINICAL NEUROLOGY

Journal of Clinical Sleep Medicine Pub Date : 2025-07-01 DOI:10.5664/jcsm.11758

Meiou Wang, Ye Zhang, Rong Ren, Jiaxue Huang, Xujun Feng, Michael V Vitiello, Larry D Sanford, Xiangdong Tang

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引用次数: 0

Abstract

Study objectives: This study examines the polysomnographic (PSG) differences between multiple system atrophy (MSA) patients and healthy controls.

Methods: An electronic literature search was performed in MEDLINE, EMBASE, All EBM databases and the Web of Science database from inception to August 2024.

Results: Meta-analysis found significant reductions in percent rapid eye movement (REM) sleep, sleep efficiency, and total sleep time, and increases in the apnea-hypopnea index, percent N1, periodic limb movement index and sleep latency in MSA patients compared with healthy controls.

Conclusions: Our meta-analysis found PSG abnormalities in MSA patients compared with controls. Future studies should include methodological considerations (i.e., REM sleep without atonia criteria) to evaluate the contributions of potential heterogeneous factors (i.e., disease duration, presence of stridor, comorbidity of rapid eye movement (REM) sleep behavior disorder) to PSG changes in MSA.

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多系统萎缩的多导睡眠图发现：来自病例对照研究的证据。

研究目的：本研究探讨多系统萎缩（MSA）患者与健康对照者的多导睡眠图（PSG）差异。方法：检索MEDLINE、EMBASE、All EBM数据库和Web of Science数据库自成立至2024年8月的电子文献。结果：荟萃分析发现，与健康对照组相比，MSA患者的快速眼动睡眠（REM）百分比、睡眠效率和总睡眠时间显著减少，呼吸暂停低通气指数、N1百分比、周期性肢体运动指数和睡眠潜伏期增加。结论：我们的荟萃分析发现，与对照组相比，MSA患者PSG异常。未来的研究应包括方法学考虑（即，无弛缓标准的快速眼动睡眠），以评估潜在的异质性因素（即，疾病持续时间、喘鸣的存在、快速眼动（REM）睡眠行为障碍的合并症）对MSA中PSG变化的贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Sleep Medicine CLINICAL NEUROLOGY-

CiteScore

6.20

自引率

7.00%

发文量

321

审稿时长

1 months

期刊介绍： Journal of Clinical Sleep Medicine focuses on clinical sleep medicine. Its emphasis is publication of papers with direct applicability and/or relevance to the clinical practice of sleep medicine. This includes clinical trials, clinical reviews, clinical commentary and debate, medical economic/practice perspectives, case series and novel/interesting case reports. In addition, the journal will publish proceedings from conferences, workshops and symposia sponsored by the American Academy of Sleep Medicine or other organizations related to improving the practice of sleep medicine.