Mustafa Jaafar, Aaryan Godhamgaonkar, Senan Alsanjari, Majd Protty
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引用次数: 0
Abstract
Study objectives: Obstructive sleep apnea (OSA) is a prevalent condition associated with cardiovascular morbidity. Cardiac magnetic resonance imaging (CMR) provides a noninvasive modality for detecting subclinical cardiac changes in OSA, however its role in OSA diagnosis and management remains underexplored.
Methods: We conducted a systematic scoping review to evaluate the utility of CMR in assessing cardiac remodeling and cardiovascular risk in patients with OSA. Following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, 6 databases (PubMed, Scopus, EMBASE, Google Scholar, Web of Science, and the Cochrane Library) were searched for studies on CMR use in OSA. A total of 21 studies met the inclusion criteria, providing data on left ventricular hypertrophy, myocardial fibrosis, right ventricular function, and pulmonary hypertension.
Results: The majority of studies indicated a significant correlation between OSA severity and adverse cardiac outcomes, including left ventricular hypertrophy, myocardial fibrosis, and right ventricular dysfunction. CMR demonstrated superior sensitivity in detecting these changes compared to other imaging modalities. Continuous positive airway pressure therapy was found to reduce left ventricular mass and improve right ventricular function in several studies, and showing the potential reversibility of OSA-related cardiac remodeling.
Conclusions: CMR is a valuable tool in identifying early cardiovascular changes in patients with OSA, with implications for earlier intervention and improved management of cardiovascular risk. Further research is warranted to standardize CMR protocols and explore long-term outcomes of CMR-guided interventions in OSA management.
Citation: Jaafar M, Godhamgaonkar A, Alsanjari S, Protty M. The role of cardiac magnetic resonance imaging in obstructive sleep apnea: a systematic scoping review. J Clin Sleep Med. 2025;21(9):1627-1638.
研究目的：阻塞性睡眠呼吸暂停（OSA）是一种与心血管疾病相关的普遍疾病。心脏磁共振成像（CMR）为检测OSA患者的亚临床心脏变化提供了一种无创的方法，但其在OSA诊断和治疗中的作用尚不明确。方法：我们进行了一项系统的范围综述，以评估CMR在评估OSA患者心脏重构和心血管风险方面的效用。按照PRISMA指南，检索了6个数据库（PubMed、Scopus、EMBASE、谷歌Scholar、Web of Science和Cochrane Library），寻找CMR在OSA中的应用研究。共有21项研究符合纳入标准，提供了左心室肥厚（LVH）、心肌纤维化、右心室功能和肺动脉高压的数据。结果：大多数研究表明，OSA严重程度与LVH、心肌纤维化和右室功能障碍等不良心脏结局之间存在显著相关性。与其他成像方式相比，CMR在检测这些变化方面表现出更高的灵敏度。多项研究发现，持续气道正压治疗可减少左心室质量，改善右心室功能，并显示osa相关心脏重构的潜在可逆性。结论：CMR是识别OSA患者早期心血管变化的有价值的工具，对早期干预和改善心血管风险管理具有重要意义。需要进一步的研究来标准化CMR方案，并探索CMR引导干预在OSA管理中的长期效果。
期刊介绍：
Journal of Clinical Sleep Medicine focuses on clinical sleep medicine. Its emphasis is publication of papers with direct applicability and/or relevance to the clinical practice of sleep medicine. This includes clinical trials, clinical reviews, clinical commentary and debate, medical economic/practice perspectives, case series and novel/interesting case reports. In addition, the journal will publish proceedings from conferences, workshops and symposia sponsored by the American Academy of Sleep Medicine or other organizations related to improving the practice of sleep medicine.
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