Journal of Clinical Sleep Medicine最新文献

{"title":"Nocturnal sleep stage stability features in unexplained hypersomnolence.","authors":"Jesse D Cook, Meredith E Rumble, Ana Maria Vascan, Kieulinh M Tran, Michael L Prairie, Jessica Love, David T Plante","doi":"10.5664/jcsm.11808","DOIUrl":"https://doi.org/10.5664/jcsm.11808","url":null,"abstract":"<p><strong>Study objectives: </strong>Evaluate nocturnal polysomnography (PSG) sleep stage stability (SSS) features in an adult, sample of hypersomnolence disorder (HD) clinical patients against healthy sleeper controls (HSC). Explore differences in SSS features across HD who displayed objective criteria for idiopathic hypersomnia (HD/IH+) and those who did not (HD/IH-).</p><p><strong>Methods: </strong>Sixty unmedicated HD clinical patients (average age = 28.6±8.6 years; percentage female = 78.3%) and 29 HSC underwent <i>ad libitum</i> nocturnal PSG and daytime multiple sleep latency testing. SSS features included number of stage bouts, median stage bout duration, number of transitions between stages, and survival analysis of stage bouts. Regression and cox proportional hazards models compared HD against HSC. ANCOVA, log-rank tests, and pairwise comparisons explored differences between HSC, HD/IH+ (n=14), and HD/IH-. All analyses accounted for age, sex, body mass index, and depressive symptom severity.</p><p><strong>Results: </strong>HD displayed longer N2 bouts (<i>p</i>=0.02) and increased survival of N2 (<i>p</i><0.0001) and REM (<i>p</i><0.0001) bouts, relative to HSC, with fewer N3 bouts (<i>p</i>=0.02) that were comparable in duration and survival. Many phenotypic similarities were observed between HD/IH+ and HD/IH-, though HD/IH+ displayed significantly increased N2 survival (<i>p</i>=0.03), longer sleep duration (<i>p</i>=0.004), and greater sleep continuity (<i>p</i>=0.003).</p><p><strong>Conclusions: </strong>Our findings demonstrate enhanced N2 and REM stability in adult clinical patients with unexplained hypersomnolence. Follow-up studies are necessary to determine the role of distinct SSS features as valid, reliable and specific signatures of unexplained hypersomnolence. These results may also be useful for future nosological frameworks that consider unexplained hypersomnolence along a continuum of severity that includes both HD and IH.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current knowledge on the pathophysiology of idiopathic hypersomnia and potential mechanisms of action for low-sodium oxybate treatment.","authors":"Logan D Schneider, Alyssa Cairns, Chad Ruoff, Richard K Bogan","doi":"10.5664/jcsm.11566","DOIUrl":"10.5664/jcsm.11566","url":null,"abstract":"<p><strong>Study objectives: </strong>We sought to elucidate hypotheses for the pathophysiology of idiopathic hypersomnia and discuss the mechanisms by which low-sodium oxybate (LXB) improves idiopathic hypersomnia symptoms.</p><p><strong>Methods: </strong>Published literature on idiopathic hypersomnia sleep abnormalities, symptoms, treatments, and underlying pathophysiology was reviewed.</p><p><strong>Results: </strong>Patients with idiopathic hypersomnia often show sleep architecture alterations, such as increased sleep efficiency and reduced slow-wave sleep, although the literature lacks consensus. The current understanding of pathophysiologic changes in idiopathic hypersomnia is sparse, but several hypotheses have been posited to explain specific symptoms. Long biological sleep clock, hypofunction of default mode network, dysregulated gamma-aminobutyric acid signaling, inflammation, reduced physical activity, and immunologic abnormalities have been linked, to varying degrees, with the hallmark symptoms of idiopathic hypersomnia (excessive daytime sleepiness, sleep inertia, brain fog, dysautonomia). Treatment mechanisms may help elucidate pathophysiologic mechanisms. LXB effectively addresses idiopathic hypersomnia symptoms and is the only US-approved therapy for this indication. Oxybate, the active moiety in LXB, acts dose-dependently on gamma-aminobutyric acid and gamma-hydroxybutyrate receptors, inhibits dopamine and noradrenaline signaling, and improves sleep architecture in people with narcolepsy. The effectiveness of LXB, a sleep-inducing treatment, on idiopathic hypersomnia symptoms suggests altered sleep architecture may contribute to this disorder.</p><p><strong>Conclusions: </strong>Idiopathic hypersomnia, a sleep disorder with potentially debilitating symptoms, remains understudied. The underlying pathophysiology of idiopathic hypersomnia needs defining; insights can be gleaned from contextualizing current knowledge about mechanisms of effective treatments, such as LXB.</p><p><strong>Citation: </strong>Schneider LD, Cairns A, Ruoff C, Bogan RK. Current knowledge on the pathophysiology of idiopathic hypersomnia and potential mechanisms of action for low-sodium oxybate treatment. <i>J Clin Sleep Med.</i> 2025;21(7):1245-1260.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1245-1260"},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The future of the sleep field using large language models in mental health care.","authors":"Maria Cecilia Lopes","doi":"10.5664/jcsm.11766","DOIUrl":"10.5664/jcsm.11766","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1151-1152"},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health advisory: infant sleep safety in childcare settings.","authors":"Amy Licis, Jocelyn Y Cheng, Tammy Wong, Muhammad Adeel Rishi","doi":"10.5664/jcsm.11724","DOIUrl":"10.5664/jcsm.11724","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1323"},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consumer sleep technologies that self-screen or self-assess risk for OSA: is subclinical OSA (SCOSA) coming to our clinics?","authors":"Sharon Schutte-Rodin, Steven Holfinger, Ambrose A Chiang, Anuja Bandyopadhyay","doi":"10.5664/jcsm.11738","DOIUrl":"10.5664/jcsm.11738","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1325-1326"},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral appliance therapy is highly efficacious at reducing sleep apnea-specific hypoxic burden, a metric predictive of cardiovascular morbidity and mortality.","authors":"Erin V Mosca, Joshua Grosse, John E Remmers","doi":"10.5664/jcsm.11622","DOIUrl":"10.5664/jcsm.11622","url":null,"abstract":"<p><strong>Study objectives: </strong>A surrogate metric of obstructive sleep apnea (OSA), sleep apnea-specific hypoxic burden (SASHB), predicts adverse health outcomes associated with the disease and may be useful in assessing therapeutic success. The purpose of this study was to compare outcomes of mandibular protruding oral appliance therapy using apnea-hypopnea index and SASHB in a population with a spectrum of OSA severity.</p><p><strong>Methods: </strong>Individuals with mild, moderate, or severe OSA (n = 152) were treated with mandibular protruding oral appliance therapy in a prospective observational study. Two-night home sleep apnea tests were used to determine baseline and outcome values of apnea-hypopnea index and SASHB.</p><p><strong>Results: </strong>Mean baseline SASHB differed by OSA severity strata, with 0%, 19%, and 94% percent of study participants with mild, moderate, and severe OSA, respectively, having values greater than 60%min/h. At outcome, these values were reduced to 0%, 0%, and 15%, respectively. For the entire population, therapeutic efficacy was 78% using apnea-hypopnea index < 10 events/h as a response criterion and 95% using SASHB < 60%min/h as the criterion.</p><p><strong>Conclusions: </strong>Using a risk-predictive outcome surrogate to assess the efficacy of oral appliance therapy yields a substantially higher estimate of therapeutic efficacy of oral appliance therapy, particularly in patients with severe OSA.</p><p><strong>Clinical trial registration: </strong>Registry: ClinicalTrials.gov; Name: Feasibility and Predictive Accuracy of an In-Home Computer Controlled Mandibular Positioner in Identifying Favorable Candidates for Oral Appliance Therapy; URL: https://clinicaltrials.gov/study/NCT03011762; Identifier: NCT03011762; Registry: ClinicalTrials.gov; Name: Predictive Accuracy of MATRx Plus in Identifying Favorable Candidates for Oral Appliance Therapy; URL: https://clinicaltrials.gov/study/NCT03217383; Identifier: NCT03217383; Registry: ClinicalTrials.gov; Name: Validation of a Simplified MATRx Plus; URL: https://clinicaltrials.gov/study/NCT03812692; Identifier: NCT03812692.</p><p><strong>Citation: </strong>Mosca EV, Grosse J, Remmers JE. Oral appliance therapy is highly efficacious at reducing sleep apnea-specific hypoxic burden, a metric predictive of cardiovascular morbidity and mortality. <i>J Clin Sleep Med.</i> 2025;21(7):1185-1190.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1185-1190"},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging digital therapeutics to improve physician sleep: a pilot implementation study.","authors":"Elizabeth Benge, Julie C Lauffenburger, Michelle Reid, Rebecca Rottapel, Darshan Mehta, Suzanne M Bertisch","doi":"10.5664/jcsm.11666","DOIUrl":"10.5664/jcsm.11666","url":null,"abstract":"<p><p>Given the high prevalence of physician burnout, strategies are needed to improve physician mental health and well-being. As sleep disturbance predicts burnout, there is a need to evaluate evidence-based, potentially scalable treatments that target physician sleep and sleep-related health. This pilot implementation study enrolled physicians and gave them access to the Sleep Healthy Using the Internet, a 6-session self-guided cognitive behavioral therapy for insomnia treatment program. Among 34 consented physicians, 44.1% engaged at least once with the platform. Among those, 23.5% completed all 6 sessions. Among the 8 completers, the program's session length, time requirements, and ease of access received high satisfaction ratings, and 75% reported they would recommend the program to other clinicians. In exploring effectiveness, Sleep Healthy Using the Internet was associated with reductions in insomnia severity, sleep disturbance, and sleep-related impairment postintervention. This pilot study demonstrates the promise of an evidence-based, web-based cognitive behavioral therapy for insomnia program for improving insomnia among physicians.</p><p><strong>Clinical trial registration: </strong>Registry: ClinicalTrials.gov; Identifier: NCT05289596.</p><p><strong>Citation: </strong>Benge E, Lauffenburger JC, Reid M, Rottapel R, Mehta D, Bertisch SM. Leveraging digital therapeutics to improve physician sleep: a pilot implementation study. <i>J Clin Sleep Med</i>. 2025;21(7):1297-1299.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1297-1299"},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of sleep-disordered breathing with anemia and microcytosis in premenopausal females: the Nagahama study.","authors":"Kimihiko Murase, Takeshi Matsumoto, Yasuharu Tabara, Miho Egawa, Takuma Minami, Osamu Kanai, Naomi Takahashi, Satoshi Hamada, Hironobu Sunadome, Jumpei Togawa, Takuma Ohsuga, Tomoko Wakamura, Naoko Komenami, Kazuya Setoh, Takahisa Kawaguchi, Takeo Nakayama, Susumu Sato, Masaki Mandai, Toyohiro Hirai, Fumihiko Matsuda, Kazuo Chin","doi":"10.5664/jcsm.11618","DOIUrl":"10.5664/jcsm.11618","url":null,"abstract":"<p><strong>Study objectives: </strong>While nocturnal hypoxia caused by sleep-disordered breathing (SDB) can result in polycythemia, the association between erythrocyte values and SDB may vary by sex and menopausal status. This study aimed to evaluate the correlation of erythrocyte variables with SDB in a large cohort categorized by sex and menopausal status from the general population.</p><p><strong>Methods: </strong>Sleep duration and SDB were assessed in community residents using a wearable actigraph and pulse oximeter. The actigraph-adjusted 3% oxygen saturation index was calculated by correcting the time measured by the pulse oximeter for sleep duration computed by the actigraph. SDB severity was defined by actigraph-adjusted 3% oxygen saturation index as normal (< 5 events/h), mild (5 to < 15 events/h), and moderate to severe (≥ 15 events/h).</p><p><strong>Results: </strong>Data were obtained from 6,836 participants (premenopausal females, 1,580; postmenopausal females, 3,058; and males, 2,198). Multivariate analysis revealed that actigraph-adjusted 3% oxygen saturation index was negatively correlated with hemoglobin level in premenopausal females (β = -0.13, <i>P</i> < .01), but no significant correlations were found in postmenopausal females and males. In addition, the presence of SDB was a risk factor for microcytic anemia (hemoglobin < 12 g/dL and mean corpuscular volume < 80 fL) in premenopausal females (odds ratio and 95% confidence interval: mild SDB, 1.93 [1.31-2.84], <i>P</i> < .01; moderate to severe SDB, 9.02 [3.02-26.88], <i>P</i> < .01).</p><p><strong>Conclusions: </strong>SDB was associated with microcytic anemia in premenopausal females. When SDB is diagnosed in a premenopausal female, we may need to evaluate her erythrocytic parameters.</p><p><strong>Citation: </strong>Murase K, Matsumoto T, Tabara Y, et al. Correlation of sleep-disordered breathing with anemia and microcytosis in premenopausal females: the Nagahama study. <i>J Clin Sleep Med</i>. 2025;21(7):1155-1164.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1155-1164"},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and predictors of obstructive sleep apnea in collegiate football players.","authors":"S Raj J Trikha, Richard Raab, Terry DeZeeuw, Steven Moore, Mark Neagle, Mark Petrun, Josiane L Broussard","doi":"10.5664/jcsm.11646","DOIUrl":"10.5664/jcsm.11646","url":null,"abstract":"<p><strong>Study objectives: </strong>Football players are a unique population that present with obstructive sleep apnea (OSA) at rates higher than the general population, likely due to high body mass indices and large neck circumferences. However, few studies have studied the prevalence of OSA in young, collegiate football players. We therefore examined the prevalence of OSA, as well as assessed a simple screening tool to identify OSA risk, in collegiate football players.</p><p><strong>Methods: </strong>Participants from the Colorado State University football team completed anatomical evaluations and in-depth health history and sleep questionnaires and wore a WatchPAT 300 device for 3 consecutive nights for in-home estimations of apnea-hypopnea index and blood oxygen saturation.</p><p><strong>Results: </strong>Fifty-eight young, healthy males completed the study (body mass index: 29.2 ± 4.2 kg/m²; mean ± standard deviation). Thirty-five percent of study participants (n = 18) had mild-to-moderate OSA, and a significantly higher body mass index as compared to no OSA (<i>P</i> = .03). In addition, participants with mild-to-moderate OSA scored significantly higher on the STOP-Bang questionnaire as compared to participants with no OSA (<i>P</i> < .01). The corresponding sensitivity and specificity for the STOP-Bang was 83% and 41%, respectively. When overnight oxygen saturation < 94% was added to the STOP-Bang assessment, the corresponding sensitivity and specificity was 61% and 79%, respectively.</p><p><strong>Conclusions: </strong>Collegiate football players present with OSA at a higher rate than the general population. Incorporating overnight oxygen saturation into the STOP-Bang questionnaire may increase the specificity for detecting OSA and should be included when assessing OSA in this population.</p><p><strong>Citation: </strong>Trikha SRJ, Raab R, DeZeeuw T, et al. Prevalence and predictors of obstructive sleep apnea in collegiate football players. <i>J Clin Sleep Med</i>. 2025;21(7):1233-1243.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1233-1243"},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A minimal clinically important difference for the sleep inertia visual analog scale in idiopathic hypersomnia.","authors":"Richard K Bogan, Douglas S Fuller, Marisa Whalen, Cristina Casstevens, Logan D Schneider","doi":"10.5664/jcsm.11662","DOIUrl":"10.5664/jcsm.11662","url":null,"abstract":"<p><strong>Study objectives: </strong>Measurement tools for sleep inertia, a common and important idiopathic hypersomnia symptom, are limited. For individuals with idiopathic hypersomnia, this post hoc analysis proposes a minimal clinically important difference (MCID) for the Sleep Inertia Visual Analog Scale (SI-VAS), which assesses difficulty waking up.</p><p><strong>Methods: </strong>Data from the pivotal phase 3, double-blind, placebo-controlled, randomized withdrawal study (NCT03533114) of low-sodium oxybate in adults with idiopathic hypersomnia were used to estimate an SI-VAS MCID anchored to the Patient Global Impression of Change, Idiopathic Hypersomnia Severity Scale, and Functional Outcomes of Sleep Questionnaire.</p><p><strong>Results: </strong>Of 109 participants included, the majority female (69.7%) and White (81.7%), most were at least moderately ill (95%) per baseline Clinical Global Impression of Severity. SI-VAS score changes were strongly associated with Patient Global Impression of Change levels (Kruskal-Wallis test statistic, 110.2; <i>P</i> < .0001). Estimated mean (standard error) difference in SI-VAS scores between consecutive Patient Global Impression of Change levels was 10.9 (0.8) mm, suggesting an MCID estimate of 10-12 mm. SI-VAS was also highly correlated with Idiopathic Hypersomnia Severity Scale (Pearson <i>r</i>, 0.79; <i>P</i> < .0001) and Functional Outcomes of Sleep Questionnaire (Pearson <i>r</i>, -0.74; <i>P</i> < .0001). Mean (standard error) SI-VAS change per 4-unit Idiopathic Hypersomnia Severity Scale change (MCID) was 6.0 (0.3) mm and per 2-unit Functional Outcomes of Sleep Questionnaire change (cutpoint) was 8.5 (0.5) mm.</p><p><strong>Conclusions: </strong>Establishing an MCID strengthens the SI-VAS value, adds context for findings related to sleep inertia in individuals with idiopathic hypersomnia from the phase 3 study, and aids clinicians in identifying clinically meaningful changes in sleep inertia to improve patient outcomes.</p><p><strong>Clinical trial registration: </strong>Registry: ClinicalTrials.gov; Name: A Multicenter Study of the Efficacy and Safety of JZP-258 in the Treatment of Idiopathic Hypersomnia (IH) With an Open-label Safety Extension; URL: https://www.clinicaltrials.gov/study/NCT03533114; Identifier: NCT03533114.</p><p><strong>Citation: </strong>Bogan RK, Fuller DS, Whalen M, Casstevens C, Schneider LD. A minimal clinically important difference for the sleep inertia visual analog scale in idiopathic hypersomnia. <i>J Clin Sleep Med.</i> 2025;21(7):1209-1216.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1209-1216"},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}