Journal of Clinical Sleep Medicine最新文献

{"title":"Classifying the types of therapeutic sleep studies.","authors":"Thomas M Kaffenberger, Ryan J Soose, Patrick J Strollo, Maurits Boon, Colin Huntley","doi":"10.5664/jcsm.11688","DOIUrl":"https://doi.org/10.5664/jcsm.11688","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of sleep-disordered breathing in opioid users with adaptive servo-ventilation: a subgroup analysis of the European READ-ASV registry.","authors":"Jean-Louis Pepin, Adam V Benjafield, Oliver Munt, Holger Woehrle, Raphael Heinzer, Michael Arzt","doi":"10.5664/jcsm.11652","DOIUrl":"https://doi.org/10.5664/jcsm.11652","url":null,"abstract":"<p><strong>Study objectives: </strong>Central sleep-disordered breathing (SDB) is associated with negative health outcomes. Intake of opioids influences stability of breathing and can cause central apneas. Screening for and treatment of SDB is recommended in opioid users. This sub-analysis of the READ-ASV registry investigated the effects of adaptive servo-ventilation therapy (ASV) on SDB symptoms in opioid users.</p><p><strong>Methods: </strong>Patients initiated on ASV who reported intake of opioids at baseline were included in this analysis of real-world registry data. Patients were prospectively followed up for 12 months. Disease-specific quality of life was assessed with the Functional Outcomes of Sleep questionnaire (FOSQ). Sleepiness was measured with the Epworth Sleepiness Scale (ESS). Symptomatic patients were defined as having a FOSQ score <17.9 and an ESS score of >10.</p><p><strong>Results: </strong>86 patients who reported opioid use were included. The population had severe SDB (median AHI 55/h), the majority (n=75 [87%]) had comorbidities, and 81.6% (40/49 with follow-up available questionnaires) were symptomatic at baseline. ASV effectively treated SDB (residual median AHI from device data [AHIflow] 1.5/h). The FOSQ (+1.4 points; p=0.003) and ESS (-3 points; p=0.029) scores improved significantly at follow-up compared with baseline, and improvements in disease-specific quality of life were more pronounced in symptomatic patients.</p><p><strong>Conclusions: </strong>ASV treatment of central breathing disorders in opioid users resolved SDB and was associated with significant improvements in disease-specific quality of life and sleepiness. ASV treatment may therefore be an actionable intervention to counteract the negative effects of opioids on SDB and quality of life.</p><p><strong>Clinical trial registration: </strong>Registry: ClinicalTrials.gov; Identifier: NCT03032029.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and predictors of obstructive sleep apnea in collegiate football players.","authors":"S Raj J Trikha, Richard Raab, Terry DeZeeuw, Steven Moore, Mark Neagle, Mark Petrun, Josiane L Broussard","doi":"10.5664/jcsm.11646","DOIUrl":"https://doi.org/10.5664/jcsm.11646","url":null,"abstract":"<p><strong>Study objectives: </strong>Football players are a unique population that present with OSA at rates higher than the general population, likely due to high body mass indices and large neck circumferences. However, few studies have studied the prevalence of OSA in young, collegiate football players. We therefore examined the prevalence of OSA, as well as assessed a simple screening tool to identify OSA risk, in collegiate football players.</p><p><strong>Methods: </strong>Participants from the Colorado State University football team completed anatomical evaluations and in-depth health history and sleep questionnaires and wore a WatchPAT 300 device for 3 consecutive nights for in-home estimations of apnea hypopnea index (AHI) and blood oxygen saturation.</p><p><strong>Results: </strong>Fifty-eight young, healthy men completed the study (BMI: 29.2 ± 4.2 kg/m²; mean ± SD). Thirty-five percent of study participants (n=18) had mild-to-moderate OSA, and a significantly higher BMI as compared to no OSA (p=0.03). In addition, participants with mild-to-moderate OSA scored significantly higher on the STOP-Bang questionnaire as compared to participants with no OSA (p<0.01). The corresponding sensitivity and specificity for the STOP-Bang was 83% and 41%, respectively. When overnight oxygen saturation <94% was added to the STOP-Bang assessment, the corresponding sensitivity and specificity was 61% and 79%, respectively.</p><p><strong>Conclusions: </strong>Collegiate football players present with OSA at a higher rate than the general population. Incorporating overnight oxygen saturation into the STOP-Bang questionnaire may increase the specificity for detecting OSA and should be included when assessing OSA in this population.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A minimal clinically important difference for the sleep inertia visual analog scale in idiopathic hypersomnia.","authors":"Richard K Bogan, Douglas S Fuller, Marisa Whalen, Cristina Casstevens, Logan D Schneider","doi":"10.5664/jcsm.11662","DOIUrl":"https://doi.org/10.5664/jcsm.11662","url":null,"abstract":"<p><strong>Study objectives: </strong>Measurement tools for sleep inertia, a common and important idiopathic hypersomnia symptom, are limited. For individuals with idiopathic hypersomnia, this post hoc analysis proposes a minimal clinically important difference (MCID) for the Sleep Inertia Visual Analog Scale (SI-VAS), which assesses difficulty waking up.</p><p><strong>Methods: </strong>Data from the pivotal phase 3, double-blind, placebo-controlled, randomized withdrawal study (NCT03533114) of low-sodium oxybate in adults with idiopathic hypersomnia were used to estimate an SI-VAS MCID anchored to the Patient Global Impression of Change (PGIc), Idiopathic Hypersomnia Severity Scale (IHSS), and Functional Outcomes of Sleep Questionnaire (FOSQ-10).</p><p><strong>Results: </strong>Of 109 participants included, majority female (69.7%) and White (81.7%), most were at least moderately ill (95%) per baseline Clinical Global Impression of Severity. SI-VAS score changes were strongly associated with PGIc levels (Kruskal-Wallis test statistic, 110.2; <i>P</i><0.0001). Estimated mean (SE) difference in SI-VAS scores between consecutive PGIc levels was 10.9 (0.8) mm, suggesting an MCID estimate of 10-12 mm. SI-VAS was also highly correlated with IHSS (Pearson <i>r,</i> 0.79; <i>P</i><0.0001) and FOSQ-10 (Pearson <i>r,</i> -0.74; <i>P</i><0.0001). Mean (SE) SI-VAS change per 4-unit IHSS change (MCID) was 6.0 (0.3) mm and per 2-unit FOSQ-10 change (cutpoint) was 8.5 (0.5) mm.</p><p><strong>Conclusions: </strong>Establishing an MCID strengthens the SI-VAS value, adds context for findings related to sleep inertia in individuals with idiopathic hypersomnia from the phase 3 study, and aids clinicians in identifying clinically meaningful changes in sleep inertia to improve patient outcomes.</p><p><strong>Clinical trial registration: </strong>Registry: ClinicalTrials.gov; Identifier: NCT03533114; Name: A Multicenter Study of the Efficacy and Safety of JZP-258 in the Treatment of Idiopathic Hypersomnia (IH) With an Open-label Safety Extension; URL: https://www.clinicaltrials.gov/study/NCT03533114.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective daytime sleepiness, not sleep quality or hypoxia, predicts sleep-dependent memory consolidation in a cohort of older adults.","authors":"Christian D Harding, Breanna M Holloway, Pamela N DeYoung, Crystal Kwan, Ina Djonlagic, Sonia Ancoli-Israel, Sarah J Banks, Atul Malhotra","doi":"10.5664/jcsm.11648","DOIUrl":"10.5664/jcsm.11648","url":null,"abstract":"<p><strong>Study objectives: </strong>Aging markedly increases the risk of both Alzheimer's disease (AD) and obstructive sleep apnea (OSA). Memory deficits, an early indicator of AD, can be reduced in middle-aged OSA sufferers through treatment, with positive-airway pressure being the first line treatment standard. Here, we utilize natural variation in the OSA severity of an older-aged cohort to investigate whether hypoxia or sleep quality predict sleep-dependent memory consolidation (SDMC).</p><p><strong>Methods: </strong>Participants aged 65-85 years not currently receiving OSA treatment were recruited from the San Diego community via advertisement and referrals from other sleep studies. Participants undertook a computerized neurocognitive battery and overnight polysomnography. SDMC was measured using a word-pair associates task. Two linear regression analyses assessed associations between 1) SDMC and hypoxia metrics and 2) SDMC and sleep quality metrics.</p><p><strong>Results: </strong>The study included 67 participants (36 women, 31 men) most of whom presented with moderate or severe OSA. No significant associations were present in the hypoxia model. A negative association between Epworth Sleepiness Scale (ESS) score and SDMC was the only significant relationship in the sleep quality model. There was also a mild univariate correlation between ESS score and a second daytime function measure; the psychomotor vigilance task.</p><p><strong>Conclusions: </strong>Objective measures of OSA pathology including hypoxia and sleep fragmentation were not associated with memory however ESS score, a subjective measure of daytime sleepiness, was associated with poorer memory task performance. This highlights the importance of considering subjective perceptions of sleep quality and daytime function in cognitive health outcomes of patients with OSA, particularly in older adults where they may integrate the myriad comorbidities that contribute to memory deficits in this group.</p><p><strong>Clinical trial registration: </strong>Registry: ClinicalTrials.gov; Identifier: NCT05094271; Title: Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?; URL: https://clinicaltrials.gov/study/NCT05094271.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between sleep and circadian-sleep phase angles based on dim light melatonin onset predicted from light and activity data.","authors":"Daniel J Reis, Joanna B Huang, Nazanin H Bahraini","doi":"10.5664/jcsm.11650","DOIUrl":"https://doi.org/10.5664/jcsm.11650","url":null,"abstract":"<p><strong>Study objectives: </strong>The objective of this study was to evaluate the relationships between various sleep outcomes and circadian-sleep phase angles based on dim light melatonin onset predicted only from light and activity data.</p><p><strong>Methods: </strong>Actigraphy and sleep questionnaire data were obtained from two independent datasets using the National Sleep Research Resource: the Multi-Ethnic Study of Atherosclerosis Sleep and the Hispanic Community Health Study/Study of Latinos Sueño visit. Predicted dim light melatonin onset (pDLMO) was calculated using the extended Kronauer limit-cycle model. Separate phase angles were calculated as the length of time between pDLMO and sleep timing (sleep onset, sleep midpoint, and sleep offset). Relationships between each phase angle and the following sleep outcomes were assessed separately across datasets: total sleep time, total wake time in bed, sleep maintenance efficiency, subjective sleep quality, and composite sleep health.</p><p><strong>Results: </strong>Total sleep time and composite sleep health were associated with all three pDLMO-based phase angles (<i>p</i> < .001 for all). Phase angles for sleep onset and sleep offset were also associated with total wake time in bed (<i>p</i> < .001 for both). Each relationship was characterized by a clear peak associated with a specific phase angle. No relationships were identified between phase angles and sleep maintenance efficiency or subjective sleep quality.</p><p><strong>Conclusions: </strong>These findings suggest that pDLMO-based phase angles, which can be easily measured in naturalistic settings, can help identify circadian-sleep misalignment in clinical practice. Expanded use of pDLMO may therefore help guide personalized sleep and chronobiological interventions.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A familial case of congenital central hypoventilation syndrome due to a combination of PARM and novel NPARM.","authors":"Kanako Omata, Takahiro Shindo, Mika Nagao, Yoshiyuki Namai","doi":"10.5664/jcsm.11702","DOIUrl":"https://doi.org/10.5664/jcsm.11702","url":null,"abstract":"<p><p>Congenital central hypoventilation syndrome (CCHS) is a rare disorder characterized by alveolar hypoventilation and autonomic dysregulation caused by mutations in the paired-like homeobox 2b (<i>PHOX2B</i>) gene. Among these mutations, the co-occurrence of two <i>PHOX2B</i> mutations is very rare. Herein, we report a case involving three individuals from a two-generation family, each carrying a heterozygous <i>PHOX2B</i> 20/25 polyalanine repeat mutation (PARM) and a novel non-polyalanine repeat mutation (NPARM), c.531C>G, on the same allele with variable phenotypes. Although many patients with 20/25 PARM are reported to exhibit normal psychomotor development, one individual presented with a significantly more severe psychomotor developmental delay. Determining whether the neurodevelopmental deficits in patients with CCHS stem from the underlying disease or hypoxic encephalopathy due to insufficient respiratory management is challenging. To understand the potential impact of the novel NPARM on phenotype, further research is necessary.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanded benefits of cognitive behavioral therapy for insomnia in people with COMISA.","authors":"Alexander Sweetman","doi":"10.5664/jcsm.11680","DOIUrl":"https://doi.org/10.5664/jcsm.11680","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of cannabinoid therapy in treatment-refractory isolated REM sleep behavior disorder: a case report.","authors":"Sahej Samra, Hrayr Attarian, Roneil Malkani","doi":"10.5664/jcsm.11704","DOIUrl":"https://doi.org/10.5664/jcsm.11704","url":null,"abstract":"<p><p>Current treatments for rapid eye movement (REM) sleep behavior disorder (RBD) are not always effective and can lead to dose-limited adverse events, and new treatments are needed for this condition. We present a case of a patient with treatment-refractory isolated RBD who had a dramatic and sustained improvement in dream enactment behaviors using oral tinctures containing cannabidiol and tetrahydrocannabinol without adverse events over 5 years of follow-up.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep and arousal in adults who recall chronic childhood trauma.","authors":"Albe Sin-Ying Ng, Wai Sze Chan","doi":"10.5664/jcsm.11684","DOIUrl":"https://doi.org/10.5664/jcsm.11684","url":null,"abstract":"<p><p>Subjective sleep disturbance is commonly reported by childhood trauma survivors. However, evidence for objective sleep disturbance and its association with arousal is limited, especially in individuals without post-traumatic stress disorder (PTSD). This study investigated subjective and objective measures of sleep and arousal in 50 adults who recalled having chronic childhood trauma and were free of PTSD and 50 age-and-gender-matched controls. We found that individuals who recalled childhood trauma had poorer subjective sleep quality and longer diary-assessed sleep onset latency and wakefulness after sleep onset (WASO) than controls, even after controlling for psychological distress. Differences in objective sleep parameters measured by polysomnography were not found. The childhood trauma group also had higher pre-sleep arousal and lower high-frequency heart rate variability (HF-HRV) at rest and under distress. HF-HRV under distress was found to be correlated with most subjective sleep parameters and objective WASO. Findings highlighted the need to investigate the potential role of dysregulation in parasympathetic activity in subjective sleep disturbance in adults recalling chronic childhood trauma.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}