Journal of Infection最新文献

{"title":"Malaysia outbreak survivors retain detectable Nipah antibodies and memory B cells after 25 years","authors":"Hui Ming Ong ,&nbsp;Puteri Ainaa S. Ibrahim ,&nbsp;Chee Ning Chong ,&nbsp;Chong Tin Tan ,&nbsp;Jie Ping Schee ,&nbsp;Michael Selorm Avumegah ,&nbsp;Raúl Gómez Román ,&nbsp;Neil George Cherian ,&nbsp;Won Fen Wong ,&nbsp;Li-Yen Chang","doi":"10.1016/j.jinf.2024.106398","DOIUrl":"10.1016/j.jinf.2024.106398","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the long-term humoral immune response to Nipah virus (NiV) in a cohort of 25 survivors after 25 years of post-infection.</div></div><div><h3>Methods</h3><div>A total of 25 survivors of NiV infection from the 1998 outbreak were recruited for sample collection. The serum IgG antibody response to NiV antigens, specifically nucleocapsid (N), fusion glycoprotein (F) and attachment glycoprotein (G) was evaluated using ELISA. Additionally, the samples were tested for neutralizing antibodies and memory B cell responses.</div></div><div><h3>Results</h3><div>Detection rates of anti-NiV-F and anti-NiV-G were 56% and 60%, respectively, among the survivors at a 1:100 dilution, whereas only 20% were specifically reactive to rNiV-N. Notably, all samples that tested positive for NiV-F and NiV-G at this dilution also exhibited neutralizing antibodies, highlighting the specificity of these assays. Live virus neutralization assay showed that 72% of survivors had detectable neutralizing antibodies, with varying titers, indicating long-lasting immune memory. Furthermore, memory B cell responses specific to NiV-F and NiV-G were observed in six randomly selected survivors, suggesting the presence of enduring immunological memory.</div></div><div><h3>Conclusions</h3><div>These findings highlight the potential of NiV-F and NiV-G as reliable markers for NiV exposure and underscore the need for continuous surveillance and research. Such efforts are crucial for advancing vaccine development and improving preparedness for future NiV outbreaks.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 2","pages":"Article 106398"},"PeriodicalIF":14.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccination against measles-mumps-rubella and rates of non-targeted infectious disease hospitalisations: Nationwide register-based cohort studies in Denmark, Finland, Norway, and Sweden","authors":"Lise Gehrt ,&nbsp;Sören Möller ,&nbsp;Hélène Englund ,&nbsp;Ida Laake ,&nbsp;Heta Nieminen ,&nbsp;Berit Feiring ,&nbsp;Mika Lahdenkari ,&nbsp;Arto A. Palmu ,&nbsp;Lill Trogstad ,&nbsp;Christine Stabell Benn ,&nbsp;Signe Sørup","doi":"10.1016/j.jinf.2024.106365","DOIUrl":"10.1016/j.jinf.2024.106365","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate if receipt of measles-mumps-rubella (MMR) vaccine following the third dose of diphtheria-tetanus-acellular pertussis (DTaP3) is associated with reduced rates of non-targeted infectious disease hospitalisations.</div></div><div><h3>Methods</h3><div>Register based cohort study following 1,397,027 children born in Denmark, Finland, Norway, and Sweden until 2 years of age. Rates of infectious disease hospitalisations with minimum one overnight stay according to time-varying vaccination status were compared using Cox proportional hazards regression analysis with age as the underlying timescale and including multiple covariates. Summary estimates were calculated using random-effects meta-analysis.</div></div><div><h3>Results</h3><div>Compared with DTaP3 and no MMR vaccine, MMR after DTaP3 was associated with reduced rates of infectious disease hospitalisations: aHR was 0.86 (0.83–0.89) in Denmark, 0.70 (0.64–0.75) in Finland, 0.71 (0.68–0.74) in Norway, and 0.71 (0.65–0.77) in Sweden: summary estimate was 0.75 (0.65 to 0.84). A beneficial association was also seen in a negative control exposure analysis (3 vs. 2 DTaP doses): summary estimate aHR was 0.81 (0.75–0.87).</div></div><div><h3>Conclusions</h3><div>Having MMR as the most recent vaccine was consistently associated with reduced rates of infectious disease hospitalisation. However, bias may account for at least some of the observed association. Randomised controlled trials are warranted to inform the optimal timing of MMR for both its specific and potential non-specific effects.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 2","pages":"Article 106365"},"PeriodicalIF":14.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning and clinician predictions of antibiotic resistance in Enterobacterales bloodstream infections","authors":"Kevin Yuan ,&nbsp;Augustine Luk ,&nbsp;Jia Wei ,&nbsp;A. Sarah Walker ,&nbsp;Tingting Zhu ,&nbsp;David W. Eyre","doi":"10.1016/j.jinf.2024.106388","DOIUrl":"10.1016/j.jinf.2024.106388","url":null,"abstract":"<div><h3>Background</h3><div>Patients with Gram-negative bloodstream infections are at risk of serious adverse outcomes without active treatment, but identifying who has antimicrobial resistance (AMR) to target empirical treatment is challenging.</div></div><div><h3>Methods</h3><div>We used XGBoost machine learning models to predict antimicrobial resistance to seven antibiotics in patients with Enterobacterales bloodstream infection. Models were trained using hospital and community data from Oxfordshire, UK, for patients with positive blood cultures between 01-January-2017 and 31-December-2021. Model performance was evaluated by comparing predictions to final microbiology results in test datasets from 01-January-2022 to 31-December-2023 and to clinicians’ prescribing.</div></div><div><h3>Findings</h3><div>4709 infection episodes were used for model training and evaluation; antibiotic resistance rates ranged from 7–67%. In held-out test data, resistance prediction performance was similar for the seven antibiotics (AUCs 0.680 [95%CI 0.641–0.720] to 0.737 [0.674–0.797]). Performance improved for most antibiotics when species identifications (available ∼24 h later) were included as model inputs (AUCs 0.723 [0.652–0.791] to 0.827 [0.797–0.857]). In patients treated with a beta-lactam, clinician prescribing led to 70% receiving an active beta-lactam: 44% were over-treated (broader spectrum treatment than needed), 26% optimally-treated (narrowest spectrum active agent), and 30% under-treated (inactive beta-lactam). Model predictions without species data could have led to 79% of patients receiving an active beta-lactam: 45% over-treated, 34% optimally-treated, and 21% under-treated.</div></div><div><h3>Conclusions</h3><div>Predicting AMR in bloodstream infections is challenging for both clinicians and models. Despite modest performance, machine learning models could still increase the proportion of patients receiving active empirical treatment by up to 9% over current clinical practice in an environment prioritising antimicrobial stewardship.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 2","pages":"Article 106388"},"PeriodicalIF":14.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA biomarkers and host response pathways in severe pulmonary hemorrhagic syndrome due to leptospirosis: A multi-omics study","authors":"Phu Nguyen Trong Tran ,&nbsp;Umaporn Limothai ,&nbsp;Janejira Dinhuzen ,&nbsp;Sasipha Tachaboon ,&nbsp;Theerapon Sukmark ,&nbsp;Chayomon Dokpong ,&nbsp;Sittiruk Roytrakul ,&nbsp;David A. Haake ,&nbsp;Nattachai Srisawat","doi":"10.1016/j.jinf.2024.106400","DOIUrl":"10.1016/j.jinf.2024.106400","url":null,"abstract":"<div><h3>Background</h3><div>Severe pulmonary hemorrhagic syndrome (SPHS) remains a fatal complication of leptospirosis with poorly understood mechanisms and an urgent need for effective biomarkers.</div></div><div><h3>Methods</h3><div>A nested case-control analysis was conducted using blood specimens from two previous Thai leptospirosis cohorts. Candidate microRNAs were initially discovered through a global profiling of 798 serum microRNAs in five SPHS and seven non-SPHS patients, and then validated using real-time polymerase chain reactions in 168 patients. Pathways enriched from microRNA targets were compared to those from an integrated transcriptomic-proteomic analysis. Proteins pertaining to the key resulting pathway were measured to validate significance and reveal correlation with microRNA biomarkers.</div></div><div><h3>Results</h3><div>Serum microRNA profiling revealed a total of 81 significantly expressed microRNAs, of which seven were selected for further validation in the whole cohort of 168 leptospirosis patients, including 28 in SPHS and 140 nonSPHS groups. Among the selected microRNAs, miR-5010–3p and miR-147b-3p had significantly higher expression in SPHS group compared to nonSPHS group, with consistently higher expression after adjusting for age, sex, days of illness, comorbidity, smoking status or recruitment site. The two had area under the curve (AUC) values of 0.76 (95% CI: 0.67–0.85) and 0.70 (95% CI: 0.56–0.81) for discriminating SPHS, respectively. These microRNAs also exhibited consistent AUC values in patients tested before chest radiograph shadows manifested. Combination of miR-5010–3p with miR-548ai and miR-224–5p, as selected by Bayesian Model Averaging algorithm, substantially boosts the AUC value to 0.86 (95% CI: 0.77−0.94). The miRNA biomarkers also enhanced the predictive values of a previously validated clinical model, increasing AUC value from 0.87 to 0.92 with a significant reclassification net index. Multi-omics pathway analysis incorporating microRNA targets and transcriptomic-proteomic data suggested TNF signaling as among the key pathways. In validation, seven out of ten pathway proteins were significantly different between groups, with principal components correlated with severity and miR-5010–3p.</div></div><div><h3>Conclusions</h3><div>MiR-5010-3p and miR-147b-3p are novel biomarkers with good predictability and potential relevance with TNF signaling pathway, an important host response mechanism in leptospirosis SPHS.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 2","pages":"Article 106400"},"PeriodicalIF":14.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual patient and donor seroprofiles in convalescent plasma treatment of COVID-19 in REMAP-CAP clinical trial","authors":"Visa Nurmi ,&nbsp;Richard Mayne ,&nbsp;Chanice Knight ,&nbsp;Hannia L. Almonacid-Mendoza ,&nbsp;Shannah Secret ,&nbsp;Lise Estcourt ,&nbsp;Jussi Hepojoki ,&nbsp;Tonći Šuštić ,&nbsp;Abigail A. Lamikanra ,&nbsp;Hoi Pat Tsang ,&nbsp;David K. Menon ,&nbsp;Manu Shankar-Hari ,&nbsp;C. Ellen van der Schoot ,&nbsp;Gestur Vidarsson ,&nbsp;David J. Roberts ,&nbsp;Peter Simmonds ,&nbsp;Klaus Hedman ,&nbsp;Heli Harvala","doi":"10.1016/j.jinf.2025.106412","DOIUrl":"10.1016/j.jinf.2025.106412","url":null,"abstract":"<div><h3>Objectives</h3><div>Convalescent plasma (CP) treatment of COVID-19 has shown significant therapeutic effect only when administered early. We investigated the importance of patient and CP seroprofiles on treatment outcome in REMAP-CAP CP trial.</div></div><div><h3>Methods</h3><div>We evaluated neutralising antibodies (nAb), anti-spike (S) IgM, IgG, IgG avidity, IgG fucosylation and respiratory viral loads in a sub-set of patients (n=80) and controls (n=51) before and after transfusion, comparing them to those in the CP units (n=157) they received.</div></div><div><h3>Results</h3><div>Most patients were SARS-CoV-2 seropositive pre-transfusion (72% nAb; 89% S-IgG seropositivity). The majority (80%) had higher pre-transfusion S-IgG levels (median 1.7×10⁶ arbitrary units (AU); 56%) or S-IgG production rates (median 1.1×10⁶ AU/day; 64%) than they received from CP (median 2.2×10⁵ AU). Only 22% of the patients demonstrated significant (median 24-fold) increase in their S-IgG levels acquired from transfusion. Better outcomes, measured by organ support-free days, were associated with increase in S-IgM levels (p=0.007), decreased S-IgG fucosylation (p&lt;0.001), lower patient age (p&lt;0.001) but not with receiving CP (p=0.337).</div></div><div><h3>Conclusions</h3><div>Based on our data, increased S-antibody levels linked to transfused CP were only observed in pre-seroconversion or immunodeficient patients lacking their own SARS-CoV-2 antibodies, representing the groups where CP treatment has previously shown most benefit.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 2","pages":"Article 106412"},"PeriodicalIF":14.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of metagenomic next-generation sequencing among hematological malignancy patients with bloodstream infections after antimicrobial therapy","authors":"Yueyi Xu ,&nbsp;Miaoxin Peng ,&nbsp;Tong Zhou ,&nbsp;Yonggong Yang ,&nbsp;Peipei Xu ,&nbsp;Ting Xie ,&nbsp;Xuefang Cao ,&nbsp;Bing Chen ,&nbsp;Jian Ouyang","doi":"10.1016/j.jinf.2024.106395","DOIUrl":"10.1016/j.jinf.2024.106395","url":null,"abstract":"<div><h3>Background</h3><div>Metagenomic next-generation sequencing (mNGS) is an effective method for detecting pathogenic pathogens of bloodstream infection (BSI). However, there is no consensus on whether the use of antibiotics affects the diagnostic performance of mNGS. We conducted a prospective clinical study aiming to evaluate the effect of antimicrobial treatment on mNGS.</div></div><div><h3>Methods</h3><div>Blood samples were collected for mNGS testing within 24 h of culture-confirmed with BSI, with re-examination conducted every 2–3 days.</div></div><div><h3>Results</h3><div>A total of 38 patients with BSI were enrolled. The mNGS positive (mNGS-pos) rate declined sharply after the use of antibiotics, with only 17 (44.78%) patients remaining mNGS-pos while the rest were mNGS negative (mNGS-neg). The median duration of pathogen identification was significantly longer for mNGS compared to blood culture (BC) (4 days vs 1 days; P &lt; 0.0001). A positivity duration of ≥ 3 days was an independent risk factor of septic shock (OR, 20.671; 95% CI, 1.958–218.190; P = 0.012). Patients with mNGS-pos and mNGS-neg differed by the median duration of fever (6 days vs 3 days; P = 0.038), rates of drug resistance (35.3% vs 4.8%; P = 0.017), rates of septic shock (47.1% vs 14.3%; P = 0.029), and 28-day mortality (29.4% vs 4.8%; P = 0.041).</div></div><div><h3>Conclusions</h3><div>The antimicrobial treatment will greatly reduce the positive rate of mNGS. The duration of mNGS is significantly longer than that of BC. The prolonged duration of mNGS suggests an increased risk of septic shock and could be identified as a high-risk factor of adverse infection outcome, requiring more aggressive anti-infective treatment measures.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 2","pages":"Article 106395"},"PeriodicalIF":14.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of interethnic lipidomic variation in falciparum malaria","authors":"Wael Abdrabou ,&nbsp;Saruul Zorigt ,&nbsp;Issiaka Soulama ,&nbsp;Dariga Bolatbay ,&nbsp;Mame Massar Dieng ,&nbsp;Jakub Jurkovic ,&nbsp;Samuel Sindié Sermé ,&nbsp;Salif Sombié ,&nbsp;Noëlie Béré Henry ,&nbsp;Désiré Kargougou ,&nbsp;Sam Aboubacar Coulibaly ,&nbsp;Aïssatou Diawara ,&nbsp;Youssef Idaghdour","doi":"10.1016/j.jinf.2024.106396","DOIUrl":"10.1016/j.jinf.2024.106396","url":null,"abstract":"<div><h3>Background</h3><div>Shifts in dietary patterns during lifestyle transitions are integral components of the dynamic interactions between humans and their environments. Investigating the link between dietary diversity, the composition of the human lipidome and infection is key to understanding the interplay between diet and susceptibility to pathogens.</div></div><div><h3>Methods</h3><div>Here we address this question by performing a comparative study of two ethnic groups with divergent dietary patterns: Fulani, who are nomad pastoralists with a dairy-centric diet, and Mossi, who are farmers with a plant-based diet. We generate 196 paired global lipidomes (927 lipid molecules) from both groups before and during natural <em>Plasmodium falciparum</em> infection.</div></div><div><h3>Results</h3><div>Our analysis revealed 211 significantly differentially abundant lipid molecules between the two ethnic groups in both infection states. We show that ethnicity has a greater impact on the lipidome of these children than do <em>P. falciparum</em> infection and report inter-ethnic differences that impact pathogenesis. We highlight elevated levels of pentadecanoic acid (C15:0)-containing phospholipids in Fulani and experimentally demonstrate the suppressive effects of lysophosphatidylcholine LysoPC (15:0) on <em>P. falciparum</em> gametocyte production.</div></div><div><h3>Conclusion</h3><div>These findings link the Fulani’s dairy-centric diet and lower <em>P. falciparum</em> gametocyte densities reported in this group and underscore the intricate links between dietary lipids and the host response to infection.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 2","pages":"Article 106396"},"PeriodicalIF":14.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial antigen encounter determines robust T-cell immunity against SARS-CoV-2 BA.2.86 variant three years later","authors":"Rocío Rubio ,&nbsp;Alexei Yavlinsky ,&nbsp;Marina Escalera Zamudio ,&nbsp;Luis M. Molinos-Albert ,&nbsp;Carla Martín Pérez ,&nbsp;Edwards Pradenas ,&nbsp;Mar Canyelles ,&nbsp;Cèlia Torres ,&nbsp;Cedric Tan ,&nbsp;Leo Swadling ,&nbsp;Anna Ramírez-Morros ,&nbsp;Benjamin Trinité ,&nbsp;Josep Vidal-Alaball ,&nbsp;Ruth Aguilar ,&nbsp;Anna Ruiz-Comellas ,&nbsp;Julià Blanco ,&nbsp;Lucy van Dorp ,&nbsp;François Balloux ,&nbsp;Carlota Dobaño ,&nbsp;Gemma Moncunill","doi":"10.1016/j.jinf.2024.106402","DOIUrl":"10.1016/j.jinf.2024.106402","url":null,"abstract":"<div><h3>Objectives</h3><div>We aimed to evaluate the adaptive immune responses cross-recognition of the hypermutated SARS-CoV-2 BA.2.86 variant and identify the determinants influencing this recognition.</div></div><div><h3>Methods</h3><div>We measured BA.2.86 neutralizing antibodies and T-cell responses cross-reactivity in previously exposed participants. We investigated clinical-demographic factors and used a novel in silico analysis to assess viral genetic determinants affecting T-cell responses.</div></div><div><h3>Results</h3><div>Despite notable escape from neutralizing antibodies, T-cell responses remained generally preserved, albeit with a significant but small loss in T-cell cross-recognition (7.5%, 14.2%, and 10.8% average loss for IFN-γ, IL-2, and IFN-γ + IL-2, respectively, p&lt;0.05). This is consistent with the prediction of 6 out of 10 immunodominant T-cell epitopes (TCEs) altered by BA.2.86 mutations to have reduced peptide presentation. This effect is expected to be mitigated by total TCEs across the genome. Remarkably, T-cell responses and cross-recognition were 3.5 (IFN-γ), 2 (IL-2) and 2.4 (IFN-γ + IL-2) times higher when first induced by infection rather than by vaccination three years earlier, by increasing number of infections, and by ancestral/Delta than Omicron infections.</div></div><div><h3>Conclusions</h3><div>Our findings underscore the critical role and factors influencing T-cell immunity against evolving SARS-CoV-2 variants, such as first antigen encounter (vaccination or infection), as it is essential for developing effective control strategies.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 2","pages":"Article 106402"},"PeriodicalIF":14.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Declining COVID-19 vaccination coverage in Brazil: A global health warning","authors":"Milena Silva Souza,&nbsp;Jéssica Pires Farias,&nbsp;Luís Carlos de Souza Ferreira,&nbsp;Jaime Henrique Amorim","doi":"10.1016/j.jinf.2025.106418","DOIUrl":"10.1016/j.jinf.2025.106418","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 2","pages":"Article 106418"},"PeriodicalIF":14.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-copy IncP-2 megaplasmid carrying blaAFM in clinical difficult-to-treat resistance Pseudomonas aeruginosa: Associated with high-level cefiderocol resistance","authors":"Wenhao Wu ,&nbsp;Meijun Song ,&nbsp;Xi Li,&nbsp;Piaopiao Zhang,&nbsp;Yue Li,&nbsp;Heng Cai,&nbsp;Yan Jiang,&nbsp;Yunsong Yu,&nbsp;Tingting Qu","doi":"10.1016/j.jinf.2025.106422","DOIUrl":"10.1016/j.jinf.2025.106422","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 2","pages":"Article 106422"},"PeriodicalIF":14.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}