Journal of Infection最新文献

{"title":"Is it time to retire the term ‘bloodstream infection’? (Submitted as Letter to the Editor)","authors":"Daniel M. Musher , Francisco X. Elisarraras","doi":"10.1016/j.jinf.2024.106184","DOIUrl":"10.1016/j.jinf.2024.106184","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S016344532400118X/pdfft?md5=e6f424bfd014e76f79ad39880612501c&pid=1-s2.0-S016344532400118X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutralization activity of HCWs’ sera after Omicron XBB.1.5-adapted monovalent COVID-19 mRNA vaccination","authors":"Masayuki Amano , Yasuko Ichikawa , Shota Matsumoto , Nobuyo Higashi-Kuwata , Yuki Takamatsu , Shuzo Matsushita , Shinya Shimada , Hiroaki Mitsuya","doi":"10.1016/j.jinf.2024.106179","DOIUrl":"10.1016/j.jinf.2024.106179","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163445324001130/pdfft?md5=402d2c39dd309572d6ee61e07c90cc64&pid=1-s2.0-S0163445324001130-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140917213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased incidence of invasive pneumococcal disease in Hong Kong in 2023","authors":"Chrissy W.K. Pang , Richard Vale , Kim Shijian Lao , Aaron T.K. Khan , Joseph T. Wu , Kathy Leung","doi":"10.1016/j.jinf.2024.106178","DOIUrl":"10.1016/j.jinf.2024.106178","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163445324001129/pdfft?md5=249477e8f9eddbe6d89b65788d06d58b&pid=1-s2.0-S0163445324001129-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140917200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The modern face of esophageal candidiasis in an oncology center: Correlating clinical manifestations, endoscopic grade, and pathological data in 323 contemporary cancer patients","authors":"Takahiro Matsuo ,&nbsp;Ben S. Singh ,&nbsp;Sebastian Wurster ,&nbsp;Ying Jiang ,&nbsp;Manoop S. Bhutani ,&nbsp;Deyali Chatterjee ,&nbsp;Dimitrios P. Kontoyiannis","doi":"10.1016/j.jinf.2024.106172","DOIUrl":"10.1016/j.jinf.2024.106172","url":null,"abstract":"<div><h3>Objectives</h3><p>Clinical presentation and outcomes of esophageal candidiasis (EC) in cancer patients are scarcely studied in the azole era, as is the correlation between clinical, endoscopic, and histopathological EC manifestations.</p></div><div><h3>Methods</h3><p>We retrospectively reviewed the risk factors, clinical features, and outcomes of pathology-documented EC cases at MD Anderson Cancer Center. We further assessed associations between presence of symptoms, standardized 4-stage endoscopic grade (Kodsi classification), histopathological data, and fluconazole treatment failure.</p></div><div><h3>Results</h3><p>Among 323 cancer patients with EC, 89% had solid tumors, most commonly esophageal cancer (29%). Thirty-three percent of EC patients were asymptomatic. The proportion of symptomatic EC patients significantly increased with endoscopic grade (<em>P</em> = 0.005). Among 202 patients receiving oral fluconazole, 27 (13%) had treatment failure. Underlying esophageal disease was the only independent predictor of fluconazole treatment failure (odds ratio: 3.88, <em>P</em> = 0.005). Endoscopic grade correlated significantly with <em>Candida</em> organism burden (Correlation coefficient [ρ] = 0.21, <em>P</em> &lt; 0.01) and neutrophilic inflammation (ρ = 0.18, <em>P</em> &lt; 0.01). <em>Candida</em> invasion of the squamous mucosal layer was associated with treatment failure (<em>P</em> = 0.049).</p></div><div><h3>Conclusions</h3><p>EC was predominantly encountered in patients with solid tumors. One-third of EC patients were asymptomatic, challenging traditional symptom-based diagnosis. The development of integrated clinicopathological scoring systems could further guide the therapeutic management of cancer patients with EC.</p></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163445324001063/pdfft?md5=291e81a7f49dfae8f9974107dcbb860c&pid=1-s2.0-S0163445324001063-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline and end-of-treatment host serum biomarkers predict relapse in adults with pulmonary tuberculosis","authors":"Hygon Mutavhatsindi ,&nbsp;Charles M. Manyelo ,&nbsp;Candice I. Snyders ,&nbsp;Ilana Van Rensburg ,&nbsp;Martin Kidd ,&nbsp;Kim Stanley ,&nbsp;Gerard Tromp ,&nbsp;Reynaldo Dietze ,&nbsp;Bonnie Thiel ,&nbsp;Paul D. van Helden ,&nbsp;John T. Belisle ,&nbsp;John L. Johnson ,&nbsp;W. Henry Boom ,&nbsp;Gerhard Walzl ,&nbsp;Novel N. Chegou","doi":"10.1016/j.jinf.2024.106173","DOIUrl":"10.1016/j.jinf.2024.106173","url":null,"abstract":"<div><h3>Background</h3><p>There is a need for new tools for monitoring of the response to TB treatment. Such tools may allow for tailored treatment regimens, and stratify patients initiating TB treatment into different risk groups. We evaluated combinations between previously published host biomarkers and new candidates, as tools for monitoring TB treatment response, and prediction of relapse.</p></div><div><h3>Methods</h3><p>Serum samples were collected at multiple time points, from patients initiating TB treatment at research sites situated in South Africa (<em>ActionTB study),</em> Brazil and Uganda (<em>TBRU study</em>). Using a multiplex immunoassay platform, we evaluated the concentrations of selected host inflammatory biomarkers in sera obtained from clinically cured patients with and without subsequent relapse within 2 years of TB treatment completion.</p></div><div><h3>Results</h3><p>A total of 130 TB patients, 30 (23%) of whom had confirmed relapse were included in the study. The median time to relapse was 9.7 months in the <em>ActionTB</em> study (n = 12 patients who relapsed), and 5 months (n = 18 patients who relapsed) in the <em>TBRU</em> study. Serum concentrations of several host biomarkers changed during TB treatment with IL-6, IP-10, IL-22 and complement C3 showing potential individually, in predicting relapse. A six-marker signature comprising of TTP, BMI, sICAM-1, IL-22, IL-1β and complement C3, predicted relapse, prior to the onset of TB treatment with 89% sensitivity and 94% specificity. Furthermore, a 3-marker signature (Apo-CIII, IP-10 and sIL-6R) predicted relapse in samples collected at the end of TB treatment with sensitivity of 71% and specificity of 74%. A previously identified baseline relapse prediction signature (TTP, BMI, TNF-β, sIL-6R, IL-12p40 and IP-10) also showed potential in the current study.</p></div><div><h3>Conclusion</h3><p>Serum host inflammatory biomarkers may be useful in predicting relapse in TB patients prior to the initiation of treatment. Our findings have implications for tailored patient management and require prospective evaluation in larger studies.</p></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163445324001075/pdfft?md5=2619ef61aba316eda0218ae1a16a13e3&pid=1-s2.0-S0163445324001075-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140909437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Undernutrition increases the risk of unsuccessful treatment outcomes of patients with tuberculosis in Ethiopia: A multicenter retrospective cohort study","authors":"Fasil Wagnew ,&nbsp;Kefyalew Addis Alene ,&nbsp;Matthew Kelly ,&nbsp;Darren Gray","doi":"10.1016/j.jinf.2024.106175","DOIUrl":"10.1016/j.jinf.2024.106175","url":null,"abstract":"<div><h3>Background</h3><p>While undernutrition has been identified as a common risk factor for tuberculosis (TB), its impact on treatment outcomes has yet to be investigated in high TB burden and low-income countries such as Ethiopia. Therefore, this study aimed to investigate the effect of undernutrition on treatment outcomes among patients with TB in northwest Ethiopia.</p></div><div><h3>Methods</h3><p>A retrospective cohort study was conducted using data from different hospitals in northwest Ethiopia, for the period from July 2017 to August 2023. A Cox proportional hazard model was performed to determine the effect of undernutrition on TB treatment outcomes, which were defined as a composite of death, treatment failure, or loss to follow-up.</p></div><div><h3>Results</h3><p>A total of 602 patients with TB were included in the analysis. Of these, 367 (60.9%) were male, and 344 (57.1%) were undernourished. Upon completion of the follow-up period, 65 (10.8%) adults with TB had unsuccessful treatment outcomes. After adjusting for potential confounders, patients with undernutrition had a two times higher risk of experiencing unsuccessful treatment outcomes compared to well-nourished patients (AHR: 2.0, 95% CI: 1.2, 3.6). In addition, patients residing in rural areas (AHR: 3.1, 95% CI: 1.7, 5.4), having a history of prior TB treatment (AHR: 2.2, 95%CI: 1.1, 4.1), and the presence of diabetes comorbidity (AHR: 2.4, 95% CI: 1.1, 5.2) were at higher risk of unsuccessful treatment outcomes.</p></div><div><h3>Conclusions</h3><p>Undernutrition increases the risk of unsuccessful treatment outcomes in Ethiopia. This finding suggests that nutritional support during TB treatment can improve successful treatment outcomes in high TB burden and low-income countries such as Ethiopia.</p></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163445324001099/pdfft?md5=32522e2d0069db5fef2803ba1d40634f&pid=1-s2.0-S0163445324001099-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140903863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of autumn 2023 COVID-19 vaccination and residual protection of prior doses against hospitalisation in England, estimated using a test-negative case-control study","authors":"Freja C.M. Kirsebom ,&nbsp;Julia Stowe ,&nbsp;Jamie Lopez Bernal ,&nbsp;Alex Allen ,&nbsp;Nick Andrews","doi":"10.1016/j.jinf.2024.106177","DOIUrl":"10.1016/j.jinf.2024.106177","url":null,"abstract":"<div><h3>Introduction</h3><p>The last COVID-19 vaccine offered to all adults in England became available from November 2021. The most recent booster programme commenced in September 2023. Bivalent BA.4–5 or monovalent XBB.1.5 boosters were given. During the study period, the JN.1 variant became dominant in England.</p></div><div><h3>Methods</h3><p>Vaccine effectiveness against hospitalisation was estimated throughout using the test-negative case-control study design where positive PCR tests from hospitalised individuals are cases and comparable negative PCR tests are controls. Multivariable logistic regression was used to assess vaccine effectiveness against hospitalisation with the test result as the outcome, vaccination status as the primary exposure variable of interest and confounder adjustment.</p></div><div><h3>Results</h3><p>There was no evidence of residual protection for boosters given as part of previous campaigns. There were 28,916 eligible tests included to estimate the effectiveness of the autumn 2023 boosters in those aged 65 years and older. VE peaked at 50.6% (95% CI: 44.2–56.3%) after 2–4 weeks, followed by waning to 13.6% (95% CI: −11.7 to 33.2%). Estimates were generally higher for the XBB.1.5 booster than the BA.4–5 booster, but this difference was not statistically significant. Point estimates were highest against XBB sub-lineages. Effectiveness was lower against both JN.1 and EG.5.1 variants with confidence intervals non-overlapping with the effectiveness of the XBB sub-lineages at 2–4 weeks for EG.5.1 where VE was 44.5% (95% CI: 20.2–61.4%) and at 5–9 weeks for JN.1 where VE was 26.4% (95%CI: −3.4 to 47.6%).</p></div><div><h3>Conclusions</h3><p>The recent monovalent XBB.1.5 and bivalent BA.4–5 boosters provided comparable and good protection against hospitalisation, however there was evidence of lower VE against hospitalisation of these boosters against JN.1.</p></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163445324001117/pdfft?md5=5ce185f0f6cdff92a0109e627ec1ac63&pid=1-s2.0-S0163445324001117-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modifying antibiotic treatment strategies in the face of pertussis surge associated to erythromycin resistance in China","authors":"Wei Shi,&nbsp;Qinghong Meng,&nbsp;Yahong Hu,&nbsp;Kaihu Yao","doi":"10.1016/j.jinf.2024.106174","DOIUrl":"10.1016/j.jinf.2024.106174","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163445324001087/pdfft?md5=678900bd10564c952d61e005cb33baa5&pid=1-s2.0-S0163445324001087-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-22 is increased in hospitalized patients with COVID-19 and associates with cardiac involvement","authors":"Bente Halvorsen ,&nbsp;Hans-Kittil Viermyr ,&nbsp;Thor Ueland ,&nbsp;Ellen L. Sagen ,&nbsp;Annika E. Michelsen ,&nbsp;Vigdis Bjerkeli ,&nbsp;The Nor-Solidarity Study Group,&nbsp;Anders A. Tveita ,&nbsp;Katerina N. Henriksen ,&nbsp;Trine Kåsine ,&nbsp;Anne Ma Dyrhol-Riise ,&nbsp;Marius Trøseid ,&nbsp;Tuva B. Dahl ,&nbsp;Pål Aukrust ,&nbsp;Ida Gregersen","doi":"10.1016/j.jinf.2024.106176","DOIUrl":"10.1016/j.jinf.2024.106176","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163445324001105/pdfft?md5=f5323da16526c45f7cc7a04dac282c07&pid=1-s2.0-S0163445324001105-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: “People living with HIV who have poor immune status are a key population for SARS-CoV-2 prevention” Journal of Infection, Volume 88, Issue 3, March 2024, 106122","authors":"Jie Zhou ,&nbsp;Liuyan Lan ,&nbsp;Sufang Ai ,&nbsp;Jianyan Lin ,&nbsp;Ningmei Liu ,&nbsp;Yulan Xie ,&nbsp;Ping Cui ,&nbsp;Hao Liang ,&nbsp;Li Ye ,&nbsp;Jiegang Huang ,&nbsp;Zhiman Xie","doi":"10.1016/j.jinf.2024.106157","DOIUrl":"https://doi.org/10.1016/j.jinf.2024.106157","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163445324000914/pdfft?md5=7e4630fcc0aeec8231a472513c758ce8&pid=1-s2.0-S0163445324000914-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140816372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}