Journal of Infection最新文献

{"title":"VIDISCA-NGS in cerebrospinal fluid of adults with a suspected viral meningoencephalitis","authors":"Steven L. Staal, Sabine E. Olie, Martin Deijs, Arthur W.D. Edridge, Lia van der Hoek, Diederik van de Beek, I-PACE Study Group , Matthijs C. Brouwer","doi":"10.1016/j.jinf.2025.106534","DOIUrl":"10.1016/j.jinf.2025.106534","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106534"},"PeriodicalIF":14.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infants of hepatitis B surface antigen-positive women of Black ethnicity in the UK may be at risk of acquiring human T-cell lymphotropic virus type 1","authors":"Daniel Bradshaw ,&nbsp;Panida Silalang ,&nbsp;Nick Andrews ,&nbsp;John Poh ,&nbsp;Arham Khawar ,&nbsp;Gary Murphy ,&nbsp;Ruth Simmons ,&nbsp;Monica Desai ,&nbsp;Sema Mandal ,&nbsp;Samreen Ijaz","doi":"10.1016/j.jinf.2025.106533","DOIUrl":"10.1016/j.jinf.2025.106533","url":null,"abstract":"<div><h3>Objectives</h3><div>The UK’s antenatal screening and neonatal immunisation programme prevents vertical HBV transmissions. However, it is unknown whether HTLV-1 transmissions are occurring. We determined HTLV seroprevalence among hepatitis B surface antigen-positive individuals identified through antenatal enhanced surveillance between 27/03/2021 to 30/03/2023.</div></div><div><h3>Results</h3><div>For 3583 individuals, eight were HTLV-1 positive (2.2 per 1000, 95% CI 1.0 per 1000 to 4.4 per 1000) and none were HTLV-2 positive (95% CI 0.0 to 1.0 per 1000). HTLV-1 seroprevalence in women of Black ethnicity was 5.3 per 1000 (95%CI 2.1 per 1000 to 10.8 per 1000). Assuming 20% vertical transmission rates, over five years of the surveillance, it is likely that four (95% CI 1.0 – 10.0) infants avoidably acquired HTLV-1. As transmission can be prevented through education of HTLV-1 positive individuals to avoid breastfeeding, this represents a missed opportunity for averting neonatal infection.</div></div><div><h3>Conclusions</h3><div>Avoidable HTLV-1 vertical transmissions are likely occurring in this population, calling for strengthened public health interventions.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106533"},"PeriodicalIF":14.3,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The waning of maternal measles antibodies: A multi-country maternal-infant seroprevalence study","authors":"Karen S. Tiley ,&nbsp;Hinke ten Hulscher-van Overbeek ,&nbsp;Sudha Basnet ,&nbsp;Rob van Binnendijk ,&nbsp;Ed Clarke ,&nbsp;Stephen Cose ,&nbsp;Duc Anh Dang ,&nbsp;Ha Thi Thu Hoang ,&nbsp;Beth Holder ,&nbsp;Olubukola T. Idoko ,&nbsp;Beate Kampmann ,&nbsp;Freddie Kibengo ,&nbsp;Fiona van der Klis ,&nbsp;Abdul Momin Kazi ,&nbsp;Elke Leuridan ,&nbsp;Kirsten Maertens ,&nbsp;Herberth Maldonado ,&nbsp;Mary Nyantaro ,&nbsp;Saad Omer ,&nbsp;Marcela F. Pasetti ,&nbsp;Merryn Voysey","doi":"10.1016/j.jinf.2025.106531","DOIUrl":"10.1016/j.jinf.2025.106531","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess geographical variation in maternal measles antibody levels from birth to nine months of age, to inform recommendations for the timing of the first measles vaccine dose.</div></div><div><h3>Methods</h3><div>Stored infant serum samples from 11 countries taken at delivery and/or follow-up time points prior to measles vaccination (N=2845) were tested for measles plaque reduction neutralisation (PRNT) and measles, mumps, and rubella immunoglobulin G at a central laboratory.</div><div>Antibody decay in infants was modelled using linear mixed effects models with participant-level random intercepts and random slopes. Proportions of infants with antibody concentrations above the clinical protection threshold (0.12 IU/mL) were estimated at each age.</div></div><div><h3>Results</h3><div>At birth, most (94%, 519/552) infants had PRNT ≥0.12 IU/mL, but geometric mean concentrations ranged from 0.32 IU/mL (Guatemala) to 1.60 IU/mL (Pakistan).</div><div>There was no geographical variation in the decay rate of PRNT nor immunoglobulin G.</div><div>Geometric mean PRNT fell below 0.12 IU/mL between ages 2.5 months (Guatemala) and 6.2 months (Pakistan).</div><div>At age 6 months, &lt;50% of infants had PRNT ≥0.12 IU/mL in all countries except Pakistan.</div></div><div><h3>Conclusions</h3><div>Reliance on maternal antibodies for protection until age 9 months or later leaves most infants with insufficient direct protection against measles infection between ages 6–9 months.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106531"},"PeriodicalIF":14.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gram-negative intratumoral bacteria mediate lymph node metastasis through LPS-TLR4/MAPK signaling pathway in cervical cancer","authors":"Yaqin Liu ,&nbsp;Peng Ma ,&nbsp;Dongdong Liu ,&nbsp;Yongzhu Liu ,&nbsp;Ziwei Ran ,&nbsp;Lunhao Yang ,&nbsp;Lingqing Xu ,&nbsp;Weiguo Yin ,&nbsp;Fu Chen ,&nbsp;Linhai Li ,&nbsp;Yang Lu","doi":"10.1016/j.jinf.2025.106532","DOIUrl":"10.1016/j.jinf.2025.106532","url":null,"abstract":"<div><h3>Background</h3><div>Intratumoral bacteria have been identified as prevalent in various solid tumors, playing a significant role in tumor progression. Lymph node metastasis is a major clinical feature and the primary cause of mortality in cervical cancer (CC). However, the effect of intratumoral bacteria on lymphatic node metastasis in CC remains unclear.</div></div><div><h3>Method</h3><div>This study employed 16S rDNA sequencing and targeted bacterial culture to investigate the distribution of intratumoral bacteria in human CC tissues. The identified Gram-negative bacteria, including <em>Escherichia coli</em> (<em>E. coli</em>), <em>Prevotella bivia</em> (<em>P. bivia</em>), and <em>Fusobacterium nucleatum</em> (<em>F. nucleatum</em>), were isolated, and their roles in metastasis were examined using <em>in vitro</em> transwell and capillary tube formation assays on human lymphatic endothelial cells (HLEC). The signaling pathways involved in metastasis were assessed by examining TLR4/MAPK activation and the expression of prometastatic factors EFNA1 and EDN2. <em>In vivo</em> studies using a mouse footpad tumorigenesis model were also conducted to observe the effect of LPS, which was extracted from these three gram-negative intratumoral bacteria and <em>E. coli</em> on lymph node metastasis.</div></div><div><h3>Result</h3><div>A higher abundance of Gram-negative bacteria, especially in metastatic CC tissues, was observed. <em>E. coli</em>, <em>P. bivia</em>, and <em>F. nucleatum</em> enhanced capillary tube formation in lymphatic endothelial cells and facilitated metastasis of uninfected tumor cells through paracrine signaling. These bacteria activated the TLR4/MAPK signaling pathway <em>via</em> lipopolysaccharide (LPS), leading to the upregulation of prometastatic factors EFNA1 and EDN2. Knockdown of EFNA1 and EDN2 attenuated the bacteria-induced metastasis, whereas overexpression of these factors mimicked the effects of bacterial infection. <em>In vivo</em>, LPS, which was extracted from <em>E. coli</em>, <em>P. bivia</em>, and <em>F. nucleatum</em> and live <em>E. coli</em> promoted lymph node metastasis, with elevated LPS levels and MAPK-EFNA1/EDN2 expression observed in infected mice compared to controls.</div></div><div><h3>Conclusion</h3><div>The study suggests that Gram-negative bacteria, particularly <em>E. coli</em>, <em>P. bivia</em>, and <em>F. nucleatum</em>, play a causal role in exacerbating lymph node metastasis in CC. These findings highlight the potential of targeting these bacteria and their associated signaling pathways as therapeutic strategies to improve clinical outcomes in CC patients.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106532"},"PeriodicalIF":14.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A benchmarking study of thirty-day mortality following Staphylococcus aureus or Escherichia coli bacteremia","authors":"Elizabeth Temkin ,&nbsp;Liat Wulffhart ,&nbsp;Timothy M. Pollington ,&nbsp;Dimple Chudasama ,&nbsp;Vered Schechner ,&nbsp;Amir Nutman ,&nbsp;Mitchell J. Schwaber ,&nbsp;Yehuda Carmeli ,&nbsp;Bacteremia Working Group","doi":"10.1016/j.jinf.2025.106529","DOIUrl":"10.1016/j.jinf.2025.106529","url":null,"abstract":"<div><h3>Objectives</h3><div>To compare the case-fatality rate (CFR) following bacteremia caused by <em>Staphylococcus aureus</em> or <em>Escherichia coli</em> between acute care hospitals in Israel, Israel and estimates from published meta-analyses, and Israel and England.</div></div><div><h3>Methods</h3><div>This epidemiologic assessment used nationwide data from Israel and England and meta-analyses. We included all patients with <em>S. aureus</em> or <em>E. coli</em> bacteremia in 2018–2019. The outcome was the case-fatality rate, defined as 30-day all-cause mortality.</div></div><div><h3>Results</h3><div>Crude CFR varied widely between Israeli hospitals, ranging from 20.0% to 45.0% for methicillin-susceptible <em>S. aureus</em> (MSSA), 22.9–66.7% for methicillin-resistant <em>S. aureus</em> (MRSA), 0.0–21.8% for third-generation cephalosporin-susceptible (3GC-S) <em>E. coli</em>, and 17.5–36.6% for third-generation cephalosporin-resistant (3GC-R) <em>E. coli</em>. Age-adjusted CFRs in Israel were significantly higher than in England: risk differences were 6.4% (95% CI: 5.2–7.6%) for MSSA, 13.0% (95% CI: 7.5%–18.5%) for MRSA, 1.4% (95% CI: 0.7–2.0%) for 3GC-S <em>E. coli</em>, and 8.8% (95% CI: 6.9–10.8%) for 3GC-R <em>E. coli</em>. CFRs in Israel were higher than in meta-analyses, although confidence intervals overlapped for <em>E. coli</em>.</div></div><div><h3>Conclusions</h3><div>Three determinants could explain elevated CFR following bacteremia: host factors, bacterial factors, and timeliness and appropriateness of treatment. The latter are modifiable. Benchmarking could direct improvement efforts that save lives.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106529"},"PeriodicalIF":14.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ivermectin and COVID-19","authors":"Christopher C Butler,&nbsp;F D Richard Hobbs,&nbsp;Paul Little,&nbsp;Duncan Richards,&nbsp;Benjamin R Saville,&nbsp;Ly-Mee Yu,&nbsp;For the PRINCIPLE Trial Collaborative Group","doi":"10.1016/j.jinf.2025.106530","DOIUrl":"10.1016/j.jinf.2025.106530","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106530"},"PeriodicalIF":14.3,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Attractive Targeted Sugar Baits, a new outdoor vector control strategy against malaria: Results from a cluster randomised open-label parallel arm controlled trial in Southwestern Mali","authors":"Sophie Sarrassat ,&nbsp;Mahamoudou Toure ,&nbsp;Ayouba Diarra ,&nbsp;Makan Keita ,&nbsp;Hamady Coulibaly ,&nbsp;Abdoul Zamilou Arou ,&nbsp;Mohamed Traore ,&nbsp;Cheick Oumar Tangara ,&nbsp;John Bradley ,&nbsp;Gunter Muller ,&nbsp;Silas Majambere ,&nbsp;John C. Beier ,&nbsp;John Vontas ,&nbsp;Sekou F. Traore ,&nbsp;Samba Diop ,&nbsp;Immo Kleinschmidt ,&nbsp;Seydou Doumbia","doi":"10.1016/j.jinf.2025.106524","DOIUrl":"10.1016/j.jinf.2025.106524","url":null,"abstract":"<div><h3>Background</h3><div>The Attractive Targeted Sugar Bait (ATSB) is a new malaria outdoor vector control tool targeting sugar-feeding behaviours of vector mosquitoes. In Mali, a two-year open-label two-arm cluster randomised controlled trial compared the efficacy and safety of ATSB plus insecticide treated mosquito nets (ITN) versus ITN alone on malaria burden.</div></div><div><h3>Methods</h3><div>76 clusters were formed, of which 38 were randomly allocated to the intervention. Cohort studies and household surveys were performed to assess clinical malaria incidence (primary outcome) in children aged 5 to 14 years and malaria infection prevalence in individuals aged 6 months or older, respectively. Primary analyses were performed on an intention-to-treat basis. The trial was designed to detect a minimum 30% reduction in the two outcomes over a two-year period with a power of at least 80%. The trial is registered at ClinicalTrial.gov (NCT04149119).</div></div><div><h3>Findings</h3><div>The proportion of sleeping buildings with at least 2 ATSB ranged between 70% and 80%. Coverage of ATSB in good condition was lower (50% or less). Over the two-year trial period, the clinical malaria incidence rate in the control and intervention arm was 0.726 and 0.660 cases per person-year, respectively, with no statistical evidence for an intervention effect (Incidence Rate Ratio (IRR) = 0.90; 95%CI 0.77, 1.05; p = 0.188). Malaria infection prevalence was approximately 37% in both arms (Odds Ratio (OR) = 0.96; 95%CI 0.76, 1.21; p = 0.729). In clusters with coverage of stations in good condition above 80%, there was evidence for a 26% reduction in malaria incidence compared to control clusters after controlling for confounders (adjusted IRR = 0.74; 95%CI 0.61, 0.90; p = 0.002).</div></div><div><h3>Interpretation</h3><div>Overall, the trial did not demonstrate evidence of additional protection against malaria of ATSB compared to using ITN alone. Suboptimal coverage and maintenance of ATSB in good condition in the field may explain the lack of an intervention effect.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 1","pages":"Article 106524"},"PeriodicalIF":14.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Less haste, more speed: Does delayed blood culture transport time lead to adverse incubation times or yield?","authors":"Gavin Deas ,&nbsp;Fergus Hamilton ,&nbsp;Philip Williams","doi":"10.1016/j.jinf.2025.106520","DOIUrl":"10.1016/j.jinf.2025.106520","url":null,"abstract":"<div><h3>Background</h3><div>Blood culture remains a vital diagnostic tool in the acutely unwell patient. The UK Standards for Microbiology Investigations (SMI) stipulate pre-analytical requirements that are aimed at increasing yield and reducing turnaround time. The requirement to load blood cultures on machines within 4 h has been shown to reduce turnaround time but limited evidence exists as to whether it improves yield.</div></div><div><h3>Methods</h3><div>We extracted blood culture results, including organism growth, time to detection, location and time of sample collection from 4 hospitals in Southwest England. We then used mixed effects, Bayesian linear and logistic regression models to examine the effect of predictor variables like time to laboratory (TTL) and sent time on the response variable of growth or time to detection. We fitted generalised additive models to explore non-linearity.</div></div><div><h3>Results</h3><div>449,191 culture sets were analysed, 398,077 of which had enough data to include in the final analysis. 37,255 sets flagged positive (9.36%) of which 21,330 were considered pathogens. Our primary analysis identified a small decrease in yield with each hours delay in loading (0.997 (95%CrI 0.994–1.001)). This effect was largest in <em>Streptococcus pneumoniae, agalactiae</em> and <em>pyogenes</em>. In our analysis on time on the machine, culture sets spend 10.03 (95%CrI 12.66–7.31) minutes less on incubators for each hour delay. Neither anaerobes nor yeasts showed any loss of recovery from increasing TTL. There was no convincing non-linearity in either of these effects.</div></div><div><h3>Conclusion</h3><div>There is a marginal loss of growth for every hour a blood culture is left unincubated, with the loss of recovery of <em>Streptococcus pyogenes</em> and other streptococci being most common. There was no evidence of a reduction in Gram-negatives, anaerobes, or yeasts. There was a small decrease in time to detection for delayed sets. This analysis suggests there may be marginal benefit in reducing time to load.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 1","pages":"Article 106520"},"PeriodicalIF":14.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clonorchiasis in China: Geospatial modeling of the population infected and at risk, based on national surveillance","authors":"Men-Bao Qian ,&nbsp;Ji-Lei Huang ,&nbsp;Li Wang ,&nbsp;Chang-Hai Zhou ,&nbsp;Ting-Jun Zhu ,&nbsp;Hui-Hui Zhu ,&nbsp;Yun-Ting He ,&nbsp;Xiao-Nong Zhou ,&nbsp;Ying-Si Lai ,&nbsp;Shi-Zhu Li","doi":"10.1016/j.jinf.2025.106528","DOIUrl":"10.1016/j.jinf.2025.106528","url":null,"abstract":"<div><h3>Objectives</h3><div>Clonorchiasis is highly endemic in China. The unavailability of fine-scale distribution of population with infection and at risk hinders the control.</div></div><div><h3>Methods</h3><div>This study established Bayesian geostatistical models to estimate age- and gender-specific prevalence of <em>Clonorchis sinensis</em> infection at high spatial resolution (5 × 5 km²), based on the surveillance data in China between 2016 and 2021, together with socioeconomic, environmental and behavioral determinants. The population at risk and under infection, as well as chemotherapy need were then estimated.</div></div><div><h3>Results</h3><div>In 2020, population-weighted prevalence of 0.67% (95% Bayesian credible interval (BCI): 0.58%−0.77%) was estimated for <em>C. sinensis</em> infection in China, corresponding to 9.46 million (95% BCI: 8.22 million-10.88 million) persons under infection. High prevalence was demonstrated in southern areas, including Guangxi (8.92%, 95% BCI: 7.10%−10.81%) and Guangdong (2.99%, 95% BCI: 2.43%−3.74%). A conservative estimation of 99.13 million (95% BCI: 88.61 million-114.40 million) people were at risk of infection, of which 51.69 million (95% BCI: 45.48 million-57.84 million) need chemotherapy.</div></div><div><h3>Conclusions</h3><div>Clonorchiasis is an important public health problem in China, especially in southern areas, due to the huge population at risk and large number of people under infection. Implementation of chemotherapy is urged to control the morbidity.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 1","pages":"Article 106528"},"PeriodicalIF":14.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large language models (LLMs) in tuberculosis patients' health consultation and patient education: A comprehensive performance analysis study","authors":"Chun-Yan Zhao ,&nbsp;Chang Song ,&nbsp;Chang-Yue Jiang ,&nbsp;Ren-Hao Liu,&nbsp;Liu-Ying Wei,&nbsp;Chun-Mei Zeng,&nbsp;Hang-Biao Qiang,&nbsp;Zhou-Hua Xie,&nbsp;Qing-Dong Zhu","doi":"10.1016/j.jinf.2025.106527","DOIUrl":"10.1016/j.jinf.2025.106527","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 1","pages":"Article 106527"},"PeriodicalIF":14.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}