Journal of Infection最新文献

Clinical Profile of Herpes Zoster-related Hospitalizations and Complications: A French Population-Based Database Study. 带状疱疹相关住院和并发症的临床概况：法国人口数据库研究

IF 14.3 1区医学

Journal of Infection Pub Date : 2024-11-04 DOI: 10.1016/j.jinf.2024.106330

Paul Loubet, Laetitia Roustand, Aurélie Schmidt, Pandora Jacquemet, Benoît de Wazières, Clémentine Vabre, Marie Nishimwe, Emmanuel Faure

{"title":"Clinical Profile of Herpes Zoster-related Hospitalizations and Complications: A French Population-Based Database Study.","authors":"Paul Loubet, Laetitia Roustand, Aurélie Schmidt, Pandora Jacquemet, Benoît de Wazières, Clémentine Vabre, Marie Nishimwe, Emmanuel Faure","doi":"10.1016/j.jinf.2024.106330","DOIUrl":"https://doi.org/10.1016/j.jinf.2024.106330","url":null,"abstract":"<p><strong>Objective: </strong>To estimate the incidence of hospitalization with a diagnosis of herpes zoster (HZ) and post-herpetic neuralgia (PHN) in France between 2013 and 2020, overall and stratified by age-group and immune status.</p><p><strong>Methods: </strong>Retrospective observational, database study, using the French hospital discharge database, which includes private and public data for all day-care and inpatient stays. Adults aged ≥18 years, hospitalized between January 1, 2013, and December 31, 2020, with a diagnosis of HZ or PHN were included.</p><p><strong>Results: </strong>Overall, 62 077 adults had a first hospitalization with a diagnosis of HZ or PHN during the observation period. HZ and/or PHN incidence ranged between 14.6 and 16.3 hospitalizations/100 000 persons and was highest in people aged ≥80 years (97.6 hospitalizations/100 000 persons). The immunocompromised (IC) population accounted for 22% of the overall study population. IC patients had longer lengths of stay for HZ per episode compared with non-IC patients (15.5 ± 19.4 days vs 12.2 ± 13.5 days) and higher in-patient mortality (8% vs 4%). Average annual hospitalization costs per patient were higher in the IC vs non-IC population (€8018 vs €5603).</p><p><strong>Conclusions: </strong>Older age increases hospitalization rates up to 6-fold and IC status increases in-patient mortality up to two-fold.</p>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic analysis confirmed the importation of first mPox Clade Ib case in Kerala, India from Dubai, UAE. 基因组分析证实，印度喀拉拉邦的首例 Ib 型 mPox 病例是从阿联酋迪拜传入的。

IF 14.3 1区医学

Journal of Infection Pub Date : 2024-11-04 DOI: 10.1016/j.jinf.2024.106342

Anita M Shete, Shubin Chenayil, Rima R Sahay, C B Sindhu, Savita Yadav, Pranita Gawande, Deepak Y Patil, Abhinendra Kumar, Sreelekshmy Mohandas, Pragya D Yadav

引用次数: 0

Characterization of a novel HIV-1 second-generation circulating recombinant form (CRF172_0755) among men who have sex with men in China. 中国男男性行为者中新型 HIV-1 第二代循环重组形式（CRF172_0755）的特征。

IF 14.3 1区医学

Journal of Infection Pub Date : 2024-11-01 DOI: 10.1016/j.jinf.2024.106345

Huan Li, Yi Feng, Yang Xu, Tang Li, Qi Li, Wei Lin, Wanqi Ni, Jianwei Yang, Wansi Mao, Zheng Wang, Hui Xing

引用次数: 0

Near real-time severe acute respiratory illness surveillance characterising influenza and COVID-19 epidemiology in hospitalised adults, 2021-22 近实时严重急性呼吸道疾病监测，描述 2021-22 年住院成人流感和 COVID-19 流行病学特征。

IF 14.3 1区医学

Journal of Infection Pub Date : 2024-11-01 DOI: 10.1016/j.jinf.2024.106338

{"title":"Near real-time severe acute respiratory illness surveillance characterising influenza and COVID-19 epidemiology in hospitalised adults, 2021-22","authors":"","doi":"10.1016/j.jinf.2024.106338","DOIUrl":"10.1016/j.jinf.2024.106338","url":null,"abstract":"<div><h3>Objectives</h3><div>We report the findings of a novel enhanced syndromic surveillance that characterised influenza- and SARS-CoV-2-associated severe acute respiratory illness (SARI) in the 2021/2022 winter season.</div></div><div><h3>Methods</h3><div>Prospective cohort study of adults admitted to the Queen Elizabeth University Hospital, Glasgow, with a severe acute respiratory illness. Patient demographics, clinical history, admission details, and outcomes were recorded. Data were available to Public Health Scotland (PHS) and clinicians weekly.</div></div><div><h3>Results</h3><div>Between November 2021 and May 2022, 1063 hospitalised SARI episodes in 1037 adult patients were identified. Median age was 72.0 years, and 44.5% were male. Most (82.6%) SARI cases had ≥1 co-morbidity; chronic lung disease (50.0%) and malignancy (22.5%) were the most frequently reported.</div><div>Overall, 229 (22%) and 33 (3%) SARI episodes were SARS-CoV-2 and influenza A PCR positive, respectively. 74.7%, 6.5% and 43.0% SARI episodes received antibiotics, antivirals, and steroids, respectively (54.5%, 11.0% and 51.3% among COVID-19 patients). 1.1% required mechanical ventilation and 7.8% died. Male sex, multimorbidity, frailty, respiratory rate >30, low GCS and chest X-ray consolidation were predictive of in-hospital mortality.</div></div><div><h3>Conclusion</h3><div>Near real-time hospitalised SARI syndromic surveillance characterised the evolving clinical epidemiology of SARS-CoV-2 and influenza, high antimicrobial use, and predictors of inpatient mortality among hospitalised SARI patients.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global Meningococcal Initiative: Insights on antibiotic resistance, control strategies and advocacy efforts in Western Europe. 全球脑膜炎球菌倡议：对西欧抗生素耐药性、控制策略和宣传工作的见解。

IF 14.3 1区医学

Journal of Infection Pub Date : 2024-11-01 DOI: 10.1016/j.jinf.2024.106335

Ray Borrow, Helen Campbell, Dominique A Caugant, Abdessalam Cherkaoui, Heike Claus, Ala-Eddine Deghmane, Ener Cagri Dinleyici, Lee H Harrison, William P Hausdorff, Paula Bajanca-Lavado, Corinne Levy, Wesley Mattheus, Claudia Mikula-Pratschke, Paula Mölling, Marco Ap Sáfadi, Vinny Smith, Nina M van Sorge, Paola Stefanelli, Muhamed-Kheir Taha, Maija Toropainen, Georgina Tzanakaki, Julio Vázquez

{"title":"Global Meningococcal Initiative: Insights on antibiotic resistance, control strategies and advocacy efforts in Western Europe.","authors":"Ray Borrow, Helen Campbell, Dominique A Caugant, Abdessalam Cherkaoui, Heike Claus, Ala-Eddine Deghmane, Ener Cagri Dinleyici, Lee H Harrison, William P Hausdorff, Paula Bajanca-Lavado, Corinne Levy, Wesley Mattheus, Claudia Mikula-Pratschke, Paula Mölling, Marco Ap Sáfadi, Vinny Smith, Nina M van Sorge, Paola Stefanelli, Muhamed-Kheir Taha, Maija Toropainen, Georgina Tzanakaki, Julio Vázquez","doi":"10.1016/j.jinf.2024.106335","DOIUrl":"https://doi.org/10.1016/j.jinf.2024.106335","url":null,"abstract":"<p><p>In Western Europe, many countries have robust and well-established surveillance systems and case reporting mechanisms. IMD incidence across Western Europe is low with a predominance of meningococcal serogroup B (MenB). Case confirmation and antimicrobial susceptibility testing is often standardised in this region, with many countries also having robust vaccination programmes in place. Both MenB and MenACWY vaccines form part of National Immunisation Programmes (NIPs) in most European countries, with Sweden only offering vaccination in special circumstances. Despite these established programmes, there remains a critical need for advocacy efforts in affecting change in diagnosis, testing, and treatment. Recent campaigns, such as the World Meningitis Day digital toolkit, have helped raise awareness and draw attention to meningococcal disease. Awareness around antibiotic resistance has also led to the identification of antibiotic-resistant meningococcal strains, with an increase, albeit small, in these strains noted across the region. Countries such as Spain, Portugal, Germany, Switzerland, and France have either reported strains resistant to penicillin, ciprofloxacin and/or isolates with a reduced susceptibility to third-generation cephalosporins.</p>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High rates of Dientamoeba fragilis and Blastocystis species in children's stool but minor clinical significance. 儿童粪便中的脆弱片阿米巴和布拉氏囊虫比率很高，但临床意义不大。

IF 14.3 1区医学

Journal of Infection Pub Date : 2024-10-29 DOI: 10.1016/j.jinf.2024.106340

David Shasha, Orit Treygerman, Etti Levy Dahari, Efraim Bilavsky, Dror Hacham, Daniel Grupel, Yael Paran, George Prajgrod, Galia Zacay

{"title":"High rates of Dientamoeba fragilis and Blastocystis species in children's stool but minor clinical significance.","authors":"David Shasha, Orit Treygerman, Etti Levy Dahari, Efraim Bilavsky, Dror Hacham, Daniel Grupel, Yael Paran, George Prajgrod, Galia Zacay","doi":"10.1016/j.jinf.2024.106340","DOIUrl":"10.1016/j.jinf.2024.106340","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to describe the epidemiology and the clinical significance of Dientamoeba fragilis (DF) and Blastocystis (Bs) in pediatric stool samples.</p><p><strong>Methods: </strong>A historical cohort study of children under 18 years of age who underwent stool multiplex PCR for bacteria and parasites. DF and Bs results were not routinely reported. We assessed the frequency of various stool microorganisms and analyzed a composite of symptoms occurring within 14 days before testing and four post-test composite outcomes (symptoms, further medical evaluation, prescriptions of symptomatic treatment or antibiotics). Comparisons were made between children mono-infected with DF or Bs, those with negative PCR results, and those positive for microorganisms with established pathogenicity.</p><p><strong>Results: </strong>Of 36,008 eligible children, 32.5% were positive for DF and 7.9% for Bs. Children positive for DF or Bs did not exhibit higher odds for pre- or post-test composite outcomes compared to those with all-negative PCR results, except for increased rates of abdominal pain and referrals for anti-TTG testing among DF-positive children. Antibiotic prescription was significantly more common among those positive for microorganisms of known pathogenicity.</p><p><strong>Conclusions: </strong>While DF and Bs are frequently detected in pediatric stool samples, their clinical significance appears to be limited.</p>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global antimicrobial resistance threats: Insights from the resurgence of whooping cough 全球抗菌药耐药性威胁：百日咳复发的启示》。

IF 14.3 1区医学

Journal of Infection Pub Date : 2024-10-29 DOI: 10.1016/j.jinf.2024.106337

引用次数: 0

Guardian-driven influenza vaccination intentions for children post-COVID-19 in the 2024-2025 season: The positive spillover effects 2024-2025 年接种 COVID-19 后监护人驱动的儿童流感疫苗接种意愿：积极的溢出效应。

IF 14.3 1区医学

Journal of Infection Pub Date : 2024-10-28 DOI: 10.1016/j.jinf.2024.106333

引用次数: 0

Global population structure and genomic insights into Chromobacterium violaceum of human invasive lethal infection and non-human origins 全球种群结构和基因组学对人类入侵性致命感染和非人类起源的暴力铬杆菌的深入了解。

IF 14.3 1区医学

Journal of Infection Pub Date : 2024-10-28 DOI: 10.1016/j.jinf.2024.106332