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Spatial-temporal dynamics and virus interference of respiratory viruses: Insights from multi-pathogen surveillance in China 呼吸道病毒的时空动态和病毒干扰:来自中国多病原体监测的见解。
IF 11.9 1区 医学
Journal of Infection Pub Date : 2025-08-01 DOI: 10.1016/j.jinf.2025.106556
Suyi Zhang , Hongbiao Liang , Jiahao Xu , Bingzhi Chen , Xiang Zheng , Haijiang Lin , Weibing Wang , Ye Yao
{"title":"Spatial-temporal dynamics and virus interference of respiratory viruses: Insights from multi-pathogen surveillance in China","authors":"Suyi Zhang ,&nbsp;Hongbiao Liang ,&nbsp;Jiahao Xu ,&nbsp;Bingzhi Chen ,&nbsp;Xiang Zheng ,&nbsp;Haijiang Lin ,&nbsp;Weibing Wang ,&nbsp;Ye Yao","doi":"10.1016/j.jinf.2025.106556","DOIUrl":"10.1016/j.jinf.2025.106556","url":null,"abstract":"<div><h3>Background</h3><div>It is evident that respiratory viruses exhibit a discernible spatial and temporal transmission pattern, and severe acute respiratory syndrome (SARS-CoV-2) has profoundly altered the dynamics of these pathogens. The viral interference has led to greater complexity in the surveillance. This study aims to examine the spatiotemporal transmission patterns of respiratory viruses in the post-pandemic era and assess the impact of virus interactions on virus outbreaks.</div></div><div><h3>Methods</h3><div>A multi-pathogen surveillance program was conducted in Taizhou, Zhejiang Province, commencing in 2021. The study utilized spatial-temporal modeling to analyze four respiratory viruses, namely SARS-CoV-2, influenza, human rhinovirus (HRV) and respiratory syncytial virus (RSV), with the objective of identifying interaction patterns and their lagged effects.</div></div><div><h3>Results</h3><div>Each virus is influenced to varying degrees by economic and traffic-related factors. Even after adjusting for spatiotemporal variables and baseline factors, significant interactions were observed between different viruses. These interactions were not always bidirectional and demonstrated specific patterns and lag times. RSV outbreaks are influenced by HRV, but the converse is not true. The effect of SARS-CoV-2 on influenza manifested 12 weeks later, whereas influenza affected SARS-CoV-2 with only 1-week lag. Potential competitive relationships between viruses were also evident in their spatial distribution, such as the nearly opposite high- and low-prevalence areas of influenza and HRV. Furthermore, the coexistence of multiple pathogens resulted in substantial alterations to virus diffusion patterns and epidemic duration.</div></div><div><h3>Conclusions</h3><div>This study integrates multi-pathogen surveillance with spatiotemporal modeling, confirming that the viral interference relationships derived from population-level incidence data are consistent with experimental findings, thereby revealing potential interactions between SARS-CoV-2 and other viruses. Our findings confirm that SARS-CoV-2 has altered transmission patterns of respiratory viruses and highlight the critical role of viral interactions in shaping epidemic dynamics.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106556"},"PeriodicalIF":11.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emergence of transferable aztreonam-avibactam resistance in the high-risk ST44 subclade of carbapenemase-producing Providencia hangzhouensis, 2012–2023 2012-2023年产碳青霉烯酶的杭州普罗维登菌ST44亚支中出现可转移性氨曲南-阿维巴坦耐药
IF 11.9 1区 医学
Journal of Infection Pub Date : 2025-08-01 DOI: 10.1016/j.jinf.2025.106562
Min Xu , Yiqi Fu , Yuchao Zhang, Haishen Kong, Wenxin Zhao, Haiyan Zeng
{"title":"Emergence of transferable aztreonam-avibactam resistance in the high-risk ST44 subclade of carbapenemase-producing Providencia hangzhouensis, 2012–2023","authors":"Min Xu ,&nbsp;Yiqi Fu ,&nbsp;Yuchao Zhang,&nbsp;Haishen Kong,&nbsp;Wenxin Zhao,&nbsp;Haiyan Zeng","doi":"10.1016/j.jinf.2025.106562","DOIUrl":"10.1016/j.jinf.2025.106562","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106562"},"PeriodicalIF":11.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surveillance of invasive beta-haemolytic streptococci in Denmark, 2012 to 2023: A nationwide study 2012 - 2023年丹麦侵袭性溶血链球菌监测:一项全国性研究
IF 11.9 1区 医学
Journal of Infection Pub Date : 2025-08-01 DOI: 10.1016/j.jinf.2025.106559
Cecilie Hviid Christiansen , Kirstine Kobberøe Søgaard , Gertrud Dam-Dalgeir , Ram B. Dessau , Esad Dzajic , Christian Salgård Jensen , Lisbeth Lützen , Michael Pedersen , Sissel Skovgaard , Thomas Vognbjerg Sydenham , Steen Hoffmann , Hans Linde Nielsen
{"title":"Surveillance of invasive beta-haemolytic streptococci in Denmark, 2012 to 2023: A nationwide study","authors":"Cecilie Hviid Christiansen ,&nbsp;Kirstine Kobberøe Søgaard ,&nbsp;Gertrud Dam-Dalgeir ,&nbsp;Ram B. Dessau ,&nbsp;Esad Dzajic ,&nbsp;Christian Salgård Jensen ,&nbsp;Lisbeth Lützen ,&nbsp;Michael Pedersen ,&nbsp;Sissel Skovgaard ,&nbsp;Thomas Vognbjerg Sydenham ,&nbsp;Steen Hoffmann ,&nbsp;Hans Linde Nielsen","doi":"10.1016/j.jinf.2025.106559","DOIUrl":"10.1016/j.jinf.2025.106559","url":null,"abstract":"<div><h3>Objectives</h3><div>To analyse trends in incidence, seasonality, and antimicrobial resistance of invasive beta-haemolytic streptococci (iBHS) in Denmark from 2012 to 2023.</div></div><div><h3>Methods</h3><div>Nationwide laboratory surveillance included submission of invasive isolates of Lancefield group A, B, C, and G streptococci from blood, cerebrospinal fluid, and other sterile sites to the National Reference Laboratory. Incidence rates (IRs) per 100,000 were calculated. Seasonality was analysed using Poisson regression, and antimicrobial susceptibility was determined by EUCAST disc diffusion.</div></div><div><h3>Results</h3><div>In total, 9470 iBHS cases were identified. Annual IRs increased from 2.6 to 9.4 for iGAS, 2.5 to 4.9 for iGBS, 1.4 to 4.8 for iGCS, and 3.1 to 8.5 for iGGS. iGAS exhibited marked seasonality, peaking in February and troughing in September (peak-to-trough ratio 3.2). Incidence declined during the COVID-19 pandemic but rebounded in 2023. No seasonality was observed for iGBS, iGCS, or iGGS. Incidences were highest in males and older adults, except iGBS, which showed a bimodal distribution. Recurrent infections occurred in 5.4% of cases, predominantly with iGGS and iGCS. All isolates were penicillin susceptible, but erythromycin and clindamycin resistance increased in iGBS and iGGS.</div></div><div><h3>Conclusions</h3><div>The rising incidence of iBHS, particularly iGAS resurgence and increasing resistance, highlights the need for continued surveillance.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106559"},"PeriodicalIF":11.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of distribution of facemasks on community incidence and outcomes of COVID-19: A cluster randomised trial in India 口罩分布对COVID-19社区发病率和结局的影响:印度的一项聚类随机试验
IF 11.9 1区 医学
Journal of Infection Pub Date : 2025-08-01 DOI: 10.1016/j.jinf.2025.106557
Poppy A.C. Mallinson , Teena Dasi , Santosh Kumar Banjara , Judith Lieber , Santhi Bhogadi , Srivalli Addanki , Prasad Undrajavarapu , Subhash Masapeta , Hemant Mahajan , Bharati Kulkarni , Sanjay Kinra
{"title":"Impact of distribution of facemasks on community incidence and outcomes of COVID-19: A cluster randomised trial in India","authors":"Poppy A.C. Mallinson ,&nbsp;Teena Dasi ,&nbsp;Santosh Kumar Banjara ,&nbsp;Judith Lieber ,&nbsp;Santhi Bhogadi ,&nbsp;Srivalli Addanki ,&nbsp;Prasad Undrajavarapu ,&nbsp;Subhash Masapeta ,&nbsp;Hemant Mahajan ,&nbsp;Bharati Kulkarni ,&nbsp;Sanjay Kinra","doi":"10.1016/j.jinf.2025.106557","DOIUrl":"10.1016/j.jinf.2025.106557","url":null,"abstract":"<div><h3>Background</h3><div>Randomised evidence on the effectiveness of delivering facemasks for reducing the health impact of COVID-19 remains limited.</div></div><div><h3>Methods</h3><div>We conducted a cluster randomised trial in Telangana, India, in August–November 2020 to investigate whether distribution and promotion of facemasks in villages reduces the incidence and adverse outcomes of COVID-19. We randomised 20 villages from the ongoing APCAPS surveillance study (1:1 ratio) to village-wide distribution of 3-layer cloth facemasks along with promotional messaging, or no intervention. Outcomes were incidence of notified COVID-19 (primary), hospitalised COVID-19 and all-cause mortality (secondary), collected through household surveillance by village health workers. Mask wearing was assessed through standardised observations in village centres. Data were analysed by multilevel Poisson regression.</div></div><div><h3>Findings</h3><div>Use of the study facemasks and any face coverings in public spaces was higher in intervention villages (19% and 59%, respectively) than control villages (0% and 38%). In the 10 intervention (N=16,741 adults) and 10 control villages (N=15,278 adults), respectively, the crude incidence per thousand person months (number of events) of notified COVID-19 was 2.15 (n=144) and 2.45 (n=150), of hospitalised COVID-19 was 0.07 (n=5) and 0.21 (n=13), and of all-cause mortality was 0.91 (n=61) and 1.10 (n=67). In models accounting for age, sex and pre-intervention COVID-19 rate, rate ratios in intervention versus control villages were 0.96 (95% confidence interval 0.57–1.63) for COVID-19 cases, 0.36 (0.12–1.05) for COVID-19 hospitalisations, and 0.84 (0.55–1.29) for all-cause mortality. No adverse effects were reported.</div></div><div><h3>Interpretation</h3><div>We are unable to draw firm conclusions about the effect of village-wide distribution and promotion of facemasks on COVID-19 incidence from these data due to a low number of events leading to imprecise effect estimates. Nonetheless, our findings are consistent with the modest protective effect on incident cases seen in previous randomised trials, extending these to adverse outcomes for the first time.</div></div><div><h3>Registration</h3><div>The trial was pre-registered on the Clinical Trials Registry of India on 25/07/2020 (CTRI/2020/07/026796).</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106557"},"PeriodicalIF":11.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long term evolution and functional impact of cerebral lesions detected by systematic brain magnetic resonance imaging in patients with infective endocarditis: the POST-IMAGE prospective cohort. 感染性心内膜炎患者系统脑磁共振成像检测脑病变的长期演变和功能影响:后成像前瞻性队列
IF 11.9 1区 医学
Journal of Infection Pub Date : 2025-07-25 DOI: 10.1016/j.jinf.2025.106560
Guillaume Creuzet, Monique Boukobza, Emila Ilic Habensus, Benoit Lalloue, Marie Préau, Toni Alfaiate, Nathan Peiffer-Smadja, Mikael Mazighi, Sarah Tubiana, Jean-Pierre Laissy, Bernard Iung, Xavier Duval, Romain Sonneville
{"title":"Long term evolution and functional impact of cerebral lesions detected by systematic brain magnetic resonance imaging in patients with infective endocarditis: the POST-IMAGE prospective cohort.","authors":"Guillaume Creuzet, Monique Boukobza, Emila Ilic Habensus, Benoit Lalloue, Marie Préau, Toni Alfaiate, Nathan Peiffer-Smadja, Mikael Mazighi, Sarah Tubiana, Jean-Pierre Laissy, Bernard Iung, Xavier Duval, Romain Sonneville","doi":"10.1016/j.jinf.2025.106560","DOIUrl":"https://doi.org/10.1016/j.jinf.2025.106560","url":null,"abstract":"<p><strong>Background and purpose: </strong>Systematic brain magnetic resonance imaging (MRI) reveals lesions in almost all patients with infective endocarditis (IE) but their long-term evolution and clinical impact have not been investigated. We aimed to describe the evolution of cerebral lesions detected by systematic MRI during acute IE and to assess their clinical consequences during follow-up.</p><p><strong>Methods: </strong>We conducted a single-center observational prospective study nested into the ECHO-IMAGE cohort, comparing systematic brain MRIs performed during a follow-up visit with those performed during the IE episode. We analyzed cerebral lesions evolution and their association with patients' functional disability, cognitive impairment, depression and quality of life.</p><p><strong>Results: </strong>Among the 100 included patients who underwent the follow-up visit after a median of 37 [21-74] months after the initial episode of IE, MRI neurological lesions were found in 80% of cases at follow-up, as compared to 84% during the IE episode. Most of these lesions were stable or decreased over time, except for the number of cerebral microbleeds, which increased significantly. At follow-up, functional disability, cognitive impairement, and depression were observed in 4%, 14%, and 59% of cases, respectively. Quality of life remained significantly altered in 3 dimensions, as compared to a control general French population. No association was found between the presence of cerebral lesions, the severity of IE episode and outcomes.</p><p><strong>Conclusion: </strong>Cerebral lesions on systematic MRI are frequent during IE and their evolution are stable over time, with the exception of cerebral microbleeds. We observed no association between cerebral lesions and long term clinical consequences of IE.</p>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":" ","pages":"106560"},"PeriodicalIF":11.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative infectivity, virulence and molecular epidemiology of MDR and XDR Acinetobacter baumannii isolates emerging from war-related injuries in Ukraine. 乌克兰战争相关损伤中出现的多耐药和广泛耐药鲍曼不动杆菌分离株的比较传染性、毒力和分子流行病学
IF 11.9 1区 医学
Journal of Infection Pub Date : 2025-07-25 DOI: 10.1016/j.jinf.2025.106561
Jale Boral, Chaitanya Tellapragada, Oskar Thofte, Valdemar Öhnström, Michal Magda, Erika Matuschek, Oleksandr Nazarchuk, Christian Giske, Anna M Blom, Kristian Riesbeck
{"title":"Comparative infectivity, virulence and molecular epidemiology of MDR and XDR Acinetobacter baumannii isolates emerging from war-related injuries in Ukraine.","authors":"Jale Boral, Chaitanya Tellapragada, Oskar Thofte, Valdemar Öhnström, Michal Magda, Erika Matuschek, Oleksandr Nazarchuk, Christian Giske, Anna M Blom, Kristian Riesbeck","doi":"10.1016/j.jinf.2025.106561","DOIUrl":"https://doi.org/10.1016/j.jinf.2025.106561","url":null,"abstract":"<p><strong>Background: </strong>Multidrug-resistant Acinetobacter baumannii remains a global concern with its ability to adhere, disperse and sustain in areas involving suboptimal infection control measures, particularly in war areas. In this study we aimed to evaluate the susceptibility profiles, molecular epidemiology and pathogenesis of A. baumannii isolates from conflict zones in Ukraine.</p><p><strong>Methods: </strong>A. baumannii wound isolates (n=46) were tested to comparatively assess antimicrobial resistance, molecular epidemiology, pathogenesis and infectivity. Briefly, antimicrobial susceptibility testing, whole genome sequencing, biofilm and capsule formation, as well as serum survival and bacterial viability in G. mellonella and a mouse infection model were performed.</p><p><strong>Results: </strong>Dominating sequence types were ST2, ST19, ST78 and ST400 while 65.21% of isolates were from international clones. All isolates were multidrug resistant (MDR), and 7 isolates were extensively drug resistant (XDR). ST19 isolates had higher encapsulation, lower serum survival and missing T6SS, omp33-36 and biofilm production associated genes. However, bacteria expressed higher virulence and lethality during early infection compared to later stages in vivo.</p><p><strong>Conclusion: </strong>We report the first results characterizing the pathogenesis and infectivity of the emerging A. baumannii ST19. High MDR and XDR rates alongside clonally related isolates are concerning and highlight the importance of infection prevention and control measures in conflict zones.</p>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":" ","pages":"106561"},"PeriodicalIF":11.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Umrah- and travel-associated meningococcal disease due to multiple serogroup W ST-11 sub-strains pre-Hajj 2024. 2024年朝觐前由多种血清组W ST-11亚菌株引起的朝觐和旅行相关脑膜炎球菌病
IF 14.3 1区 医学
Journal of Infection Pub Date : 2025-07-21 DOI: 10.1016/j.jinf.2025.106558
Jay Lucidarme, Ala-Eddine Deghmane, Shalabh Sharma, Courtney Meilleur, Lorraine Eriksson, Paula Mölling, Heike Claus, Nina M van Sorge, Célia Bettencourt, Paula Bajanca-Lavado, Raymond S W Tsang, Dominique A Caugant, Paola Stefanelli, Arianna Neri, Georgina Tzanakaki, Aiswarya Lekshmi, Helen Campbell, Stephen A Clark, Emma J Heymer, Sonia Ribeiro, Laura Willerton, Lloyd Walsh, Xilian Bai, Thiên-Trí Lâm, Basanta R Wagle, Vishakh Walia, Rebecca L Howie, John Neatherlin, Amy Rubis, Madhura Vachon, Lucy A McNamara, Shamez N Ladhani, Muhamed-Kheir Taha, Ray Borrow
{"title":"Umrah- and travel-associated meningococcal disease due to multiple serogroup W ST-11 sub-strains pre-Hajj 2024.","authors":"Jay Lucidarme, Ala-Eddine Deghmane, Shalabh Sharma, Courtney Meilleur, Lorraine Eriksson, Paula Mölling, Heike Claus, Nina M van Sorge, Célia Bettencourt, Paula Bajanca-Lavado, Raymond S W Tsang, Dominique A Caugant, Paola Stefanelli, Arianna Neri, Georgina Tzanakaki, Aiswarya Lekshmi, Helen Campbell, Stephen A Clark, Emma J Heymer, Sonia Ribeiro, Laura Willerton, Lloyd Walsh, Xilian Bai, Thiên-Trí Lâm, Basanta R Wagle, Vishakh Walia, Rebecca L Howie, John Neatherlin, Amy Rubis, Madhura Vachon, Lucy A McNamara, Shamez N Ladhani, Muhamed-Kheir Taha, Ray Borrow","doi":"10.1016/j.jinf.2025.106558","DOIUrl":"https://doi.org/10.1016/j.jinf.2025.106558","url":null,"abstract":"<p><strong>Objectives: </strong>Collectively, the Hajj and Umrah pilgrimages draw >30 million pilgrims to the Kingdom of Saudi Arabia (KSA) each year. Before Hajj 2024 (14 to 19 June), the meningococcal serogroup W ST-11 complex (W:cc11) Hajj-strain sublineage caused multiple international cases of invasive meningococcal disease (IMD) associated with travel to the Middle East and Asia. Here we identify the strains responsible.</p><p><strong>Methods: </strong>All Hajj strain sublineage genomes on PubMLST.org underwent core genome MLST comparisons (PubMLST.org).</p><p><strong>Results: </strong>Isolates from 30 cases, across seven countries, formed five phylogenetic clusters within two distinct strains. Travel histories included KSA, other Middle Eastern countries, India, Mauritius, via Turkey, and no known associated travel. The prevalent strain, representing four clusters, had no African, and limited Middle Eastern, representation. The geo-temporal distribution of available genomes suggested Eastern Europe as a possible source.</p><p><strong>Conclusions: </strong>The rapid expansion of Umrah/travel-related W:cc11 IMD cases in early 2024 was due to multiple strains/sublineages. Despite the involvement of non-KSA travel-destinations, the coincidence of cases with the busy month of Ramadan, and the abrupt cessation during Hajj (when vaccine compliance is maximal), suggest that Umrah was a key driver and highlight the need to reinforce mandatory vaccination whilst maintaining global vigilance.</p>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":" ","pages":"106558"},"PeriodicalIF":14.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of polymerase acidic subunit (PA) substitutions on fever and symptoms in pediatric influenza A patients treated with baloxavir: A pooled four-season analysis 聚合酶酸性亚基(PA)替代对Baloxavir治疗的儿童甲型流感患者发烧和症状的影响:一项汇总的四季分析
IF 14.3 1区 医学
Journal of Infection Pub Date : 2025-07-18 DOI: 10.1016/j.jinf.2025.106555
Reiko Saito , Irina Chon , Isamu Sato , Takashi Kawashima , Fujio Kakuya , Tadashi Saito , Michiyoshi Minato , Naoki Kodo , Eitaro Suzuki , Yasuhiko Ono , Hironori Masaki , Norichika Asou , Yoshiko Tsuchihashi , Yutaka Shirahige , Akito Kitano , Yasushi Shimada , Hirotsune Hamabata , Jiaming Li , Yuyang Sun , Nanjun Lee , Hisami Watanabe
{"title":"Impact of polymerase acidic subunit (PA) substitutions on fever and symptoms in pediatric influenza A patients treated with baloxavir: A pooled four-season analysis","authors":"Reiko Saito ,&nbsp;Irina Chon ,&nbsp;Isamu Sato ,&nbsp;Takashi Kawashima ,&nbsp;Fujio Kakuya ,&nbsp;Tadashi Saito ,&nbsp;Michiyoshi Minato ,&nbsp;Naoki Kodo ,&nbsp;Eitaro Suzuki ,&nbsp;Yasuhiko Ono ,&nbsp;Hironori Masaki ,&nbsp;Norichika Asou ,&nbsp;Yoshiko Tsuchihashi ,&nbsp;Yutaka Shirahige ,&nbsp;Akito Kitano ,&nbsp;Yasushi Shimada ,&nbsp;Hirotsune Hamabata ,&nbsp;Jiaming Li ,&nbsp;Yuyang Sun ,&nbsp;Nanjun Lee ,&nbsp;Hisami Watanabe","doi":"10.1016/j.jinf.2025.106555","DOIUrl":"10.1016/j.jinf.2025.106555","url":null,"abstract":"<div><h3>Background</h3><div>Baloxavir marboxil is used for influenza treatment in Japan. However, the clinical and virologic significance of baloxavir-associated PA variants in children remains unclear.</div></div><div><h3>Methods</h3><div>We conducted a four-season, multicenter study from 2018–2019 to 2023–2024 in pediatric patients under 19 years old with influenza A who were treated with baloxavir. Clinical data were collected at the first visit; diary cards were maintained for up to 8 days. Clinical specimens were collected twice, with a median interval of 4 days. PA substitutions were screened by real-time RT-PCR and confirmed by next-generation sequencing and Sanger methods.</div></div><div><h3>Results</h3><div>Among 247 patients, 24 (9.7%) harbored PA variants, one pre-treatment and 23 post-treatment. PA/I38T was the most common substitution. A(H3N2) patients had a higher frequency of PA variants than A(H1N1)pdm09 (13.8% vs. 5.1%). Although PA variants were associated with slower viral RNA decline, no significant differences were observed in fever duration (median 22.6 vs. 15.6 h) or symptom duration (median 105.0 vs. 113.3 h) compared to wild-type virus infections.</div></div><div><h3>Conclusion</h3><div>PA variants, especially PA/I38T, emerged more frequently in A(H3N2) infections but had minimal clinical impact. The rarity of pre-treatment variants supports limited community transmission. Continued surveillance is warranted, particularly in younger children.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106555"},"PeriodicalIF":14.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards real-time in vitro Enterobacteriaceae beta-lactamase quantification using iridium oxide-based biosensors 利用氧化铱为基础的生物传感器实现肠杆菌科β -内酰胺酶的实时体外定量。
IF 11.9 1区 医学
Journal of Infection Pub Date : 2025-07-18 DOI: 10.1016/j.jinf.2025.106554
Jennifer Lawrence , Danny O’Hare , Joseph van Batenburg-Sherwood , Stephanie d'Arc , Frances Davies , Lucy Bock , J. Mark Sutton , Alison Holmes , Timothy Miles Rawson
{"title":"Towards real-time in vitro Enterobacteriaceae beta-lactamase quantification using iridium oxide-based biosensors","authors":"Jennifer Lawrence ,&nbsp;Danny O’Hare ,&nbsp;Joseph van Batenburg-Sherwood ,&nbsp;Stephanie d'Arc ,&nbsp;Frances Davies ,&nbsp;Lucy Bock ,&nbsp;J. Mark Sutton ,&nbsp;Alison Holmes ,&nbsp;Timothy Miles Rawson","doi":"10.1016/j.jinf.2025.106554","DOIUrl":"10.1016/j.jinf.2025.106554","url":null,"abstract":"<div><div>The increasing prevalence of beta-lactamase-producing <em>Enterobacteriaceae</em> presents a critical challenge in clinical microbiology, complicating infection management due to resistance to most first- and second-line beta-lactam antibiotics. Current antimicrobial susceptibility testing (AST) approaches may not reliably detect and rapidly characterise beta-lactamase production, potentially leading to suboptimal treatment. In this study, we introduce a novel iridium oxide-based biosensor that detects in vitro beta-lactamase production in <em>Escherichia coli</em> (<em>E.coli</em>) type strains and genetically modified <em>E.coli</em> isolates within 10 min. The biosensor demonstrated high reproducibility (6.88% coefficient of variation). Clinical validation using 26 <em>E. coli</em> isolates from urinary tract infection patients showed a sensitivity of 100%, specificity of 57%, and accuracy of 88%. This biosensor-based method offers a rapid, reproducible, and cost-effective method for phenotypic detection of antimicrobial resistance, with the potential to significantly reduce diagnostic turnaround times and support individualised AST strategies.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106554"},"PeriodicalIF":11.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An 11-year multicentre clinical and genomic surveillance of listeriosis across Japan 日本李斯特菌病的10年多中心临床和基因组监测。
IF 14.3 1区 医学
Journal of Infection Pub Date : 2025-07-18 DOI: 10.1016/j.jinf.2025.106552
Koh Shinohara, Yusuke Tsuda, Yasuhiro Tsuchido, Masaki Yamamoto, Yasufumi Matsumura, Miki Nagao
{"title":"An 11-year multicentre clinical and genomic surveillance of listeriosis across Japan","authors":"Koh Shinohara,&nbsp;Yusuke Tsuda,&nbsp;Yasuhiro Tsuchido,&nbsp;Masaki Yamamoto,&nbsp;Yasufumi Matsumura,&nbsp;Miki Nagao","doi":"10.1016/j.jinf.2025.106552","DOIUrl":"10.1016/j.jinf.2025.106552","url":null,"abstract":"<div><h3>Objectives</h3><div>We conducted a multicenter retrospective study to characterize the clinical features of listeriosis and the genomic characteristics of causative <em>Listeria monocytogenes</em> isolates across Japan.</div></div><div><h3>Methods</h3><div>In this retrospective observational cohort study, we enrolled all microbiologically confirmed listeriosis cases between Jan 1, 2011, and Dec 31, 2021. We collected the causative isolates and performed whole genome sequencing. The isolates were compared using Multi-locus Sequence Typing (MLST), core-genome MLST, and single-nucleotide polymorphism (SNP)-based phylogeny.</div></div><div><h3>Results</h3><div>A total of 195 listeriosis cases from 22 hospitals were enrolled, including 134 cases of bacteremia, 43 cases of neurolisteriosis, 11 cases of perinatal infection, and 7 cases of other infections. Of the neurolisteriosis cases in patients aged one month to under 50 years, five out of six (83%) occurred in immunocompetent individuals. Nosocomial-onset cases accounted for 31 (17%) of the non-perinatal listeriosis cases, including four cases that presented with febrile neutropenia. Ninety-five <em>L. monocytogene</em>s isolates from 16 hospitals were collected, and cgMLST analysis revealed multiple previously unnoticed disease clusters. In MLST analysis, clonal complex (CC) 1 was the most predominant, followed by CC3, CC87, CC155, and CC2. International transmission events in the late 20th century contributed to the emergence of CC87 isolates in Eastern Asian countries.</div></div><div><h3>Conclusion</h3><div>This study highlighted concerns regarding neurolisteriosis occurring in immunocompetent children and young adults, as well as the significance of non-clustered nosocomial onset listeriosis. Genomic analysis using whole-genome sequencing revealed previously unnoticed disease clusters and the unique population structure of <em>L. monocytogenes</em> in Japan.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106552"},"PeriodicalIF":14.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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