{"title":"Corrigendum to “The IL-6 hypothesis in COVID-19: A phase 2, randomised, double-blind, placebo-controlled study to evaluate the efficacy and safety of free IL-6 sequestration by the monoclonal antibody sirukumab in severe and critical COVID-19” [J Infect 89 (2024) 106241]","authors":"Kap Sum Foong","doi":"10.1016/j.jinf.2024.106343","DOIUrl":"10.1016/j.jinf.2024.106343","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"89 6","pages":"Article 106343"},"PeriodicalIF":14.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of vaginal seeding on the gut microbiome of infants born via cesarean section: A systematic review.","authors":"Xiaochuan Wang, Hong Cui, Na Li, Borui Liu, Xiaoyan Zhang, Jing Yang, Ju-Sheng Zheng, Chong Qiao, Hui-Xin Liu, Jiajin Hu, Deliang Wen","doi":"10.1016/j.jinf.2024.106348","DOIUrl":"10.1016/j.jinf.2024.106348","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review summarizes eight studies involving 558 cesarean section (CS)-born infants (274 exposed to vaginal seeding (VS), 284 not exposed) and 261 infants born vaginally to investigate the effect of VS on gut microbiome colonization and development in CS-born infants.</p><p><strong>Methods: </strong>This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Relevant articles published before March 6, 2024, were identified through systematic searches of PubMed, Scopus, and Web of Science. We included experimental studies that investigated changes in the gut microbiota of CS-born infants following VS and reported changes in the gut microbiota. The relationship between VS and the gut microbiota composition of CS-born infants was assessed.</p><p><strong>Results: </strong>VS may selectively influence the abundance of bacterial genera from various phyla, such as an increased relative abundance of Bacteroides and Lactobacillus, in the gut microbiome of CS-seeded infants compared to CS-non-seeded infants. Conflicting results mainly concern microbial diversity.</p><p><strong>Conclusions: </strong>Current evidence indicates modest changes in the gut microbiome of CS-born infants following VS. However, further clinical studies are necessary to fully understand its impact on early-life health outcomes, particularly regarding potential microbiome alterations and associated health risks.</p>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":" ","pages":"106348"},"PeriodicalIF":14.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tiphaine Arlabosse, Alexandra Y Kreins, Philip Ancliff, Rossa Brugha, Iek Leng Cheng, Robert Chiesa, Bairavi Indrakumar, Winnie Ip, Amy I Jacobs, Giovanna Lucchini, Stephen D Marks, Elizabeth Rivers, Helen Spencer, Austen Worth, Seilesh Kadambari, Judith Breuer
{"title":"Combination therapy of favipiravir and nitazoxanide to treat respiratory viral infections in severe T-cell deficient children: A single centre experience.","authors":"Tiphaine Arlabosse, Alexandra Y Kreins, Philip Ancliff, Rossa Brugha, Iek Leng Cheng, Robert Chiesa, Bairavi Indrakumar, Winnie Ip, Amy I Jacobs, Giovanna Lucchini, Stephen D Marks, Elizabeth Rivers, Helen Spencer, Austen Worth, Seilesh Kadambari, Judith Breuer","doi":"10.1016/j.jinf.2024.106350","DOIUrl":"10.1016/j.jinf.2024.106350","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":" ","pages":"106350"},"PeriodicalIF":14.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alessandra Teixeira de Macedo, Daniel Wagner de Castro Lima Santos, Bram Spruijtenburg, Dayse Azevedo Coelho de Souza, Leila Ferreira Moreira Dos Santos Barbosa, Sirlei Garcia Marques, Julliana Ribeiro Alves Dos Santos, Eelco F J Meijer, Theun de Groot, Conceição de Maria Pedrozo E Silva de Azevedo, Jacques F Meis
{"title":"Clonal outbreak of Candida vulturna in a paediatric oncology ward in Maranhão, Brazil.","authors":"Alessandra Teixeira de Macedo, Daniel Wagner de Castro Lima Santos, Bram Spruijtenburg, Dayse Azevedo Coelho de Souza, Leila Ferreira Moreira Dos Santos Barbosa, Sirlei Garcia Marques, Julliana Ribeiro Alves Dos Santos, Eelco F J Meijer, Theun de Groot, Conceição de Maria Pedrozo E Silva de Azevedo, Jacques F Meis","doi":"10.1016/j.jinf.2024.106349","DOIUrl":"10.1016/j.jinf.2024.106349","url":null,"abstract":"<p><strong>Objective: </strong>To describe an outbreak due to Candida vulturna, a newly emerging Candida species belonging to the Candida haemulonii species complex in the Metschnikowiaceae family.</p><p><strong>Methods: </strong>In this retrospective cohort study we genotyped 14 C. vulturna bloodstream isolates, occurring in a 4-month-period in paediatric cancer patients in a Brazilian hospital. To prove an outbreak, ITS sequence analysis and whole genome sequencing (WGS) was done. Antifungal susceptibility was performed with the reference CLSI method and the commercial Sensititre YeastOne (SYO) YO10 plates. A control C. vulturna isolate from another region in Brazil was included in all analyses.</p><p><strong>Results: </strong>MALDI-TOF-MS identified isolates as C. pseudohaemulonii and C. duobushaemulonii albeit with low scores and therefore molecular methods were required for accurate identification. ITS sequence analyses clearly differentiated C. vulturna from other species in the C. haemulonii species complex. WGS proved the presence of a clonal outbreak with C. vulturna involving 14 paediatric patients. Antifungal susceptibility testing (AFST) with two methods showed the isolates had low MICs of commonly available antifungals.</p><p><strong>Conclusion: </strong>This study describes an outbreak due to the rare yeast C. vulturna, related to C. auris, during a four-month period in patients admitted to a paediatric oncology ward in a Brazilian hospital. In contrast to previous studies the yeast was susceptible to all antifungals and patient outcome was good.</p>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":" ","pages":"106349"},"PeriodicalIF":14.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clare Thakker, Clare Warrell, Jessica Barrett, Helen L Booth, Peter L Chiodini, Sylviane Defres, Jane Falconer, Nathan Jacobs, Jayne Jones, Jonathan Lambert, Clare Leong, Angela McBride, Elinor Moore, Tara Moshiri, Laura E Nabarro, Geraldine O'Hara, Neil Stone, Clare van Halsema, Anna M Checkley
{"title":"UK guidelines for the investigation and management of eosinophilia in returning travellers and migrants.","authors":"Clare Thakker, Clare Warrell, Jessica Barrett, Helen L Booth, Peter L Chiodini, Sylviane Defres, Jane Falconer, Nathan Jacobs, Jayne Jones, Jonathan Lambert, Clare Leong, Angela McBride, Elinor Moore, Tara Moshiri, Laura E Nabarro, Geraldine O'Hara, Neil Stone, Clare van Halsema, Anna M Checkley","doi":"10.1016/j.jinf.2024.106328","DOIUrl":"https://doi.org/10.1016/j.jinf.2024.106328","url":null,"abstract":"<p><p>Eosinophilia is a common finding in returning travellers, migrants and other travelling groups. In this setting it often indicates an underlying helminth infection. Infections associated with eosinophilia are frequently either asymptomatic or associated with non-specific symptoms but some can cause severe disease. Here the British Infection Association guidelines group has comprehensively reviewed and updated the UK recommendations for the investigation and management of eosinophilia in returning travellers, migrants and other relevant groups, first published in 2010.<sup>1</sup> Literature reviews have been undertaken to update the evidence on the prevalence and causes of eosinophilia in these groups and on the treatment of relevant pathogens and clinical conditions. Diagnostic tests available to UK-based clinicians are summarised. Changes made to the updated guidelines include in sections on the investigation and empirical treatment of asymptomatic eosinophilia and on the treatment of trichuriasis, lymphatic filariasis, onchocerciasis, hookworm, fascioliasis, taeniasis. Pathogens which are rarely encountered in UK practice have been removed from the guidelines and others added, including an expanded section on fungal infection. A section on off-license and rarely used drugs has been included.</p>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":" ","pages":"106328"},"PeriodicalIF":14.3,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sana Mahtab, Zachary J Madewell, Vicky Baillie, Ziyaad Dangor, Sanjay G Lala, Nega Assefa, Mulu Berihun, Lola Madrid, Lemma Demissie Regassa, J Anthony G Scott, Soter Ameh, Joseph S Bangura, Okokon Ita, Erick Kaluma, Ikechukwu Udo Ogbuanu, Brigitte Gaume, Karen L Kotloff, Samba O Sow, Milagritos D Tapia, Sara Ajanovic, Marcelino Garrine, Inacio Mandomando, Rosauro Varo, Elisio G Xerinda, Muntasir Alam, Shams El Arifeen, Emily S Gurley, Mohammad Zahid Hossain, Afruna Rahman, Victor Akelo, Kitiezo Aggrey Igunza, Clayton Onyango, Dickens Onyango, Jennifer R Verani, Portia Mutevedzi, Cynthia G Whitney, Dianna M Blau, Shabir A Madhi, Quique Bassat
{"title":"Etiologies and comorbidities of meningitis deaths in children under 5 years in high-mortality settings: Insights from the CHAMPS Network in the post-pneumococcal vaccine era.","authors":"Sana Mahtab, Zachary J Madewell, Vicky Baillie, Ziyaad Dangor, Sanjay G Lala, Nega Assefa, Mulu Berihun, Lola Madrid, Lemma Demissie Regassa, J Anthony G Scott, Soter Ameh, Joseph S Bangura, Okokon Ita, Erick Kaluma, Ikechukwu Udo Ogbuanu, Brigitte Gaume, Karen L Kotloff, Samba O Sow, Milagritos D Tapia, Sara Ajanovic, Marcelino Garrine, Inacio Mandomando, Rosauro Varo, Elisio G Xerinda, Muntasir Alam, Shams El Arifeen, Emily S Gurley, Mohammad Zahid Hossain, Afruna Rahman, Victor Akelo, Kitiezo Aggrey Igunza, Clayton Onyango, Dickens Onyango, Jennifer R Verani, Portia Mutevedzi, Cynthia G Whitney, Dianna M Blau, Shabir A Madhi, Quique Bassat","doi":"10.1016/j.jinf.2024.106341","DOIUrl":"10.1016/j.jinf.2024.106341","url":null,"abstract":"<p><strong>Background: </strong>The role of meningitis in causing deaths and in children under 5 is unclear, especially since widespread use of vaccines to prevent common causes of meningitis. Child Health and Mortality Prevention Surveillance (CHAMPS) uses post-mortem minimally invasive tissue sampling (MITS) and ante-mortem data to explore death causes. We aimed to assess meningitis's contribution to mortality and identify causative pathogens in children under 5 within CHAMPS Network sites.</p><p><strong>Method: </strong>In this observational study, we analyzed deaths in live-born children <5 years of age that occurred between December 16, 2016, and December 31, 2023, in CHAMPS catchments in six sub-Saharan African countries (Ethiopia, Kenya, Mali, Mozambique, Sierra Leone, South Africa) and Bangladesh. MITS was conducted within 24-72 h of death, including blood and cerebrospinal fluid (CSF) culture, multi-organism targeted nucleic acid amplification tests on blood, CSF and lung tissue, and histopathology of lung, liver and brain. Expert panels at each site reviewed data to attribute causes of death following ICD-10 standards.</p><p><strong>Result: </strong>Meningitis was in the causal pathway for 7.0% (270/3857) of deaths; in 4.8% (13/270) meningitis was considered the underlying condition. Neonates accounted for 65.9% (178/270) and infants or children 34.1% (92/270). Among neonatal meningitis deaths, 55.6% (99/178) occurred ≥72 h post-hospital admission; and common pathogens were Acinetobacter baumannii (49.5%, 49/99; mainly from South Africa) and Klebsiella pneumoniae (40.4%, 40/99). Forty-four percent (79/178) of neonatal meningitis deaths were community-associated, primarily due to K. pneumoniae (35.4%, 28/79) and Escherichia coli (13.9%, 11/79). Among infant and child meningitis deaths, 43.5% (40/92) occurred ≥72 h post-admission; and common pathogens were K. pneumoniae (42.5%,17/40) and A. baumannii (17.5%, 7/40). Among community-associated meningitis deaths in infants and children (56.5%, 52/92), Streptococcus pneumoniae (34.6%, 18/52) and K. pneumoniae (19.2%, 10/52) were common pathogens. Pathogen prevalence varied by region.</p><p><strong>Conclusion: </strong>Our study highlights meningitis as a significant contributor to under-5 mortality in low-middle-income countries. The prominent role of K. pneumoniae and A. baumannii, particularly in healthcare settings and specific regions, highlights the need for better infection control, targeted interventions, and more effective treatment strategies.</p>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":" ","pages":"106341"},"PeriodicalIF":14.3,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bing Han , Chunling Du , Min Deng , Renhong Tang , Jianping Dong , Xu Song , Yunfeng Qiao , Zheng Ni , WenJie Yang , Jiankun Yang , Tianxin Xiang , Yan Huang , Yu Zhong , Zhongfa Zhang , Lisheng Yang , Jikang Yang , Jinghua Wang , Lanbing Zheng , Libing Ma , Zhinan Shou , Rongmeng Jiang
{"title":"Real-world effectiveness and safety of simnotrelvir/ritonavir for COVID-19: A nationwide, multicenter, prospective, observational cohort study in China","authors":"Bing Han , Chunling Du , Min Deng , Renhong Tang , Jianping Dong , Xu Song , Yunfeng Qiao , Zheng Ni , WenJie Yang , Jiankun Yang , Tianxin Xiang , Yan Huang , Yu Zhong , Zhongfa Zhang , Lisheng Yang , Jikang Yang , Jinghua Wang , Lanbing Zheng , Libing Ma , Zhinan Shou , Rongmeng Jiang","doi":"10.1016/j.jinf.2024.106339","DOIUrl":"10.1016/j.jinf.2024.106339","url":null,"abstract":"<div><h3>Background</h3><div>Simnotrelvir has demonstrated potent anti-viral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In a Phase II/III study, Simnotrelvir plus ritonavir (S/R, co-packaged) shortened the time to the resolution of symptoms in adult COVID-19 patients. However, real-world data on effectiveness of simnotrelvir/ritonavir against SARS-CoV-2 during XBB variant surges are still limited.</div></div><div><h3>Study design and methods</h3><div>This was a nationwide, multicenter, prospective, observational real-world study at 42 sites in China. Adult patients with mild to moderate COVID-19 and at disease onset were eligible for participation. Patients were grouped in S/R group (treated with S/R) and control group (not receiving oral antivirals for COVID-19). The primary endpoint was the COVID-19-related hospitalization or all-cause mortality within 28 days. Secondary endpoints included the time from confirmed SARS-CoV-2 infection to negative conversion, and the time to resolution of COVID-19 symptoms. Besides, serious adverse events (SAE), adverse drug reactions (ADR) and combined medication were reported. Propensity Score-Matched (PSM) analysis (1:1) was performed for adjustment for baseline variables. Hazard ratios (HR) and adjusted risk ratios (aRR) were estimated using the Cox and Modified Poisson regression, respectively.</div></div><div><h3>Results</h3><div>Between June 6, 2023, and December 27, 2023, 3522 patients were enrolled. S/R was associated with a reduced incidence of COVID-19-related hospitalization (6/1896 [0.3%] vs. 43/1408 [3.1%]; HR: 0.110, 95% confidence interval [CI]: 0.043 to 0.283, p < 0.001 vs control), consistently with the results after PSM (4/1381 [0.3%] in S/R vs. 40/1381 patients [2.9%]; aRR: 0.12; 95% CI: 0.05, 0.29; <em>P</em> < 0.001). No deaths occurred in both S/R and control groups. Matched Patients over 65 and patients with risk factors who received S/R achieved significantly reduced risk of COVID-19-related hospitalization (aRR: 0.032; 95% CI: 0.004, 0.268; aRR: 0.034; 95% CI: 0.005, 0.252, respectively; all <em>P</em> < 0.001). Furthermore, S/R shortened the median time to viral clearance by 1 day (6.0 vs 7.0 days; 95% CI: −2.0 to −1.0; <em>P</em> < 0.001) and reduced the median time to symptom resolution by 2 days (8.0 days vs 10.0 days; 95% CI: −2.0 to −1.0; <em>P</em> < 0.001). Besides, the proportion of patients in the S/R group using combined medication was significantly lower than that in the control group (30.2% vs 49.4%). Subgroup analysis showed potential protective effect of S/R in the elderly and patients with more than 1 risk factor.</div></div><div><h3>Conclusion</h3><div>In real world, S/R significantly reduced the incidence of COVID-19-related hospitalization, demonstrated favorable safety profiles, and less use of combined medication.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"89 6","pages":"Article 106339"},"PeriodicalIF":14.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elisabeth A. Dulfer , Konstantin Föhse , Esther J.M. Taks , Simone J.C.F.M. Moorlag , Eva L. Koekenbier , Josephine S. van de Maat , Jaap ten Oever , Jacobien J. Hoogerwerf , Cornelis H. van Werkhoven , Marc J.M. Bonten , Astrid van Hylckama Vlieg , Frits R. Rosendaal , Mihai G. Netea
{"title":"The effect of BCG vaccination in the elderly on infectious and non-infectious immune-mediated diseases","authors":"Elisabeth A. Dulfer , Konstantin Föhse , Esther J.M. Taks , Simone J.C.F.M. Moorlag , Eva L. Koekenbier , Josephine S. van de Maat , Jaap ten Oever , Jacobien J. Hoogerwerf , Cornelis H. van Werkhoven , Marc J.M. Bonten , Astrid van Hylckama Vlieg , Frits R. Rosendaal , Mihai G. Netea","doi":"10.1016/j.jinf.2024.106344","DOIUrl":"10.1016/j.jinf.2024.106344","url":null,"abstract":"<div><h3>Objectives</h3><div>Previous research has suggested beneficial heterologous effects of the Bacillus Calmette-Guérin (BCG) vaccine on non-mycobacterial infections and other immune-mediated diseases. During the COVID-19 pandemic, randomized controlled trials BCG-PRIME (n = 5349) and BCG-CORONA-ELDERLY (n = 1907) investigated the impact of BCG on SARS-CoV-2 infections in older individuals. We extended the follow-up in these studies by one year (BCG-Long Term study), to assess the overall effects of BCG vaccination on infectious and immune-mediated diseases in individuals aged over 60.</div></div><div><h3>Methods</h3><div>Prior participants were invited to complete a one-year follow-up survey after their completion of the original trial. Data on vaccinations, hospital admissions, infectious episodes, and new medical diagnoses were collected and compared between BCG- and placebo-vaccinated participants. Variables of interest were combined with the previous trial databases and analyzed using relative risks (RR) and an adjusted Cox regression model accounting for participation probability.</div></div><div><h3>Results</h3><div>The response in the follow-up survey was 60%, including 4238 individuals in the final analysis (2317 had received BCG and 1921 placebo). Incidence and severity of infectious diseases and other diagnoses, including cardiovascular diseases and cancer, did not differ between the groups. The proportion of individuals hospitalized for cardiac arrhythmias after BCG was two-fold higher than reported after placebo (1.6% versus 0.8%, RR 2.0 (95% confidence interval 1.1–3.6)). Cardiac arrhythmia-related hospitalizations were primarily due to exacerbation of pre-existing arrhythmias.</div></div><div><h3>Conclusion</h3><div>The results of the present study confirm that BCG has no relevant effect on non-mycobacterial infectious diseases and other immune-mediated diseases in a population of generally mycobacteria-naïve older Dutch individuals in the two years following vaccination. However, our study suggests that BCG may aggravate pre-existing cardiac arrhythmia, which warrants further investigation.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"89 6","pages":"Article 106344"},"PeriodicalIF":14.3,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paul Loubet , Laetitia Roustand , Aurélie Schmidt , Pandora Jacquemet , Benoît de Wazières , Clémentine Vabre , Marie Nishimwe , Emmanuel Faure
{"title":"Clinical profile of herpes zoster-related hospitalizations and complications: A French population-based database study","authors":"Paul Loubet , Laetitia Roustand , Aurélie Schmidt , Pandora Jacquemet , Benoît de Wazières , Clémentine Vabre , Marie Nishimwe , Emmanuel Faure","doi":"10.1016/j.jinf.2024.106330","DOIUrl":"10.1016/j.jinf.2024.106330","url":null,"abstract":"<div><h3>Objective</h3><div>To estimate the incidence of hospitalization with a diagnosis of herpes zoster (HZ) and post-herpetic neuralgia (PHN) in France between 2013 and 2020, overall and stratified by age-group and immune status.</div></div><div><h3>Methods</h3><div>Retrospective observational, database study, using the French hospital discharge database, which includes private and public data for all day-care and inpatient stays. Adults aged ≥18 years, hospitalized between January 1, 2013, and December 31, 2020, with a diagnosis of HZ or PHN, were included.</div></div><div><h3>Results</h3><div>Overall, 62 077 adults had a first hospitalization with a diagnosis of HZ or PHN during the observation period. HZ and/or PHN incidence ranged between 14.6 and 16.3 hospitalizations/100 000 persons and was highest in people aged ≥80 years (97.6 hospitalizations/100 000 persons).</div><div>The immunocompromised (IC) population accounted for 22% of the overall study population. IC patients had longer lengths of stay for HZ per episode compared with non-IC patients (15.5 ± 19.4 days vs 12.2 ± 13.5 days) and higher in-patient mortality (8% vs 4%).</div><div>Average annual hospitalization costs per patient were higher in the IC vs non-IC population (€8018 vs €5603).</div></div><div><h3>Conclusions</h3><div>Older age increases hospitalization rates up to 6-fold and IC status increases in-patient mortality up to two-fold.</div></div><div><h3>Clinical Trial Registration</h3><div>The study was conducted by HEVA and data were provided by ATIH according to French regulatory and data protection procedures.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"89 6","pages":"Article 106330"},"PeriodicalIF":14.3,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anita M. Shete, Shubin Chenayil, Rima R. Sahay, CB Sindhu, Savita Yadav, Pranita Gawande, Deepak Y. Patil, Abhinendra Kumar, Sreelekshmy Mohandas, Pragya D. Yadav
{"title":"Genomic analysis confirmed the importation of first mPox Clade Ib case in Kerala, India from Dubai, UAE","authors":"Anita M. Shete, Shubin Chenayil, Rima R. Sahay, CB Sindhu, Savita Yadav, Pranita Gawande, Deepak Y. Patil, Abhinendra Kumar, Sreelekshmy Mohandas, Pragya D. Yadav","doi":"10.1016/j.jinf.2024.106342","DOIUrl":"10.1016/j.jinf.2024.106342","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"89 6","pages":"Article 106342"},"PeriodicalIF":14.3,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}