Journal of Infection最新文献

{"title":"Genomic analysis confirmed the importation of first mPox Clade Ib case in Kerala, India from Dubai, UAE","authors":"Anita M. Shete, Shubin Chenayil, Rima R. Sahay, CB Sindhu, Savita Yadav, Pranita Gawande, Deepak Y. Patil, Abhinendra Kumar, Sreelekshmy Mohandas, Pragya D. Yadav","doi":"10.1016/j.jinf.2024.106342","DOIUrl":"10.1016/j.jinf.2024.106342","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"89 6","pages":"Article 106342"},"PeriodicalIF":14.3,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of a novel HIV-1 second-generation circulating recombinant form (CRF172_0755) among men who have sex with men in China","authors":"Huan Li , Yi Feng , Yang Xu, , Tang Li , Qi Li, Wei Lin, Wanqi Ni, Jianwei Yang, Wansi Mao, Zheng Wang, Hui Xing","doi":"10.1016/j.jinf.2024.106345","DOIUrl":"10.1016/j.jinf.2024.106345","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"89 6","pages":"Article 106345"},"PeriodicalIF":14.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near real-time severe acute respiratory illness surveillance characterising influenza and COVID-19 epidemiology in hospitalised adults, 2021-22","authors":"Antonia Ho ,&nbsp;Neil McInnes ,&nbsp;Andrew Blunsum ,&nbsp;Joanna Quinn ,&nbsp;Daniel Lynagh ,&nbsp;Michael E. Murphy ,&nbsp;Rory Gunson ,&nbsp;Alisdair MacConnachie ,&nbsp;David J. Lowe","doi":"10.1016/j.jinf.2024.106338","DOIUrl":"10.1016/j.jinf.2024.106338","url":null,"abstract":"<div><h3>Objectives</h3><div>We report the findings of a novel enhanced syndromic surveillance that characterised influenza- and SARS-CoV-2-associated severe acute respiratory illness (SARI) in the 2021/2022 winter season.</div></div><div><h3>Methods</h3><div>Prospective cohort study of adults admitted to the Queen Elizabeth University Hospital, Glasgow, with a severe acute respiratory illness. Patient demographics, clinical history, admission details, and outcomes were recorded. Data were available to Public Health Scotland (PHS) and clinicians weekly.</div></div><div><h3>Results</h3><div>Between November 2021 and May 2022, 1063 hospitalised SARI episodes in 1037 adult patients were identified. Median age was 72.0 years, and 44.5% were male. Most (82.6%) SARI cases had ≥1 co-morbidity; chronic lung disease (50.0%) and malignancy (22.5%) were the most frequently reported.</div><div>Overall, 229 (22%) and 33 (3%) SARI episodes were SARS-CoV-2 and influenza A PCR positive, respectively. 74.7%, 6.5% and 43.0% SARI episodes received antibiotics, antivirals, and steroids, respectively (54.5%, 11.0% and 51.3% among COVID-19 patients). 1.1% required mechanical ventilation and 7.8% died. Male sex, multimorbidity, frailty, respiratory rate &gt;30, low GCS and chest X-ray consolidation were predictive of in-hospital mortality.</div></div><div><h3>Conclusion</h3><div>Near real-time hospitalised SARI syndromic surveillance characterised the evolving clinical epidemiology of SARS-CoV-2 and influenza, high antimicrobial use, and predictors of inpatient mortality among hospitalised SARI patients.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"89 6","pages":"Article 106338"},"PeriodicalIF":14.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Meningococcal Initiative: Insights on antibiotic resistance, control strategies and advocacy efforts in Western Europe","authors":"Ray Borrow ,&nbsp;Helen Campbell ,&nbsp;Dominique A. Caugant ,&nbsp;Abdessalam Cherkaoui ,&nbsp;Heike Claus ,&nbsp;Ala-Eddine Deghmane ,&nbsp;Ener Cagri Dinleyici ,&nbsp;Lee H. Harrison ,&nbsp;William P. Hausdorff ,&nbsp;Paula Bajanca-Lavado ,&nbsp;Corinne Levy ,&nbsp;Wesley Mattheus ,&nbsp;Claudia Mikula-Pratschke ,&nbsp;Paula Mölling ,&nbsp;Marco AP Sáfadi ,&nbsp;Vinny Smith ,&nbsp;Nina M. van Sorge ,&nbsp;Paola Stefanelli ,&nbsp;Muhamed-Kheir Taha ,&nbsp;Maija Toropainen ,&nbsp;Julio Vázquez","doi":"10.1016/j.jinf.2024.106335","DOIUrl":"10.1016/j.jinf.2024.106335","url":null,"abstract":"<div><div>In Western Europe, many countries have robust and well-established surveillance systems and case reporting mechanisms. IMD incidence across Western Europe is low with a predominance of meningococcal serogroup B (MenB). Case confirmation and antimicrobial susceptibility testing is often standardised in this region, with many countries also having robust vaccination programmes in place. Both MenB and MenACWY vaccines form part of National Immunisation Programmes (NIPs) in most European countries, with Sweden only offering vaccination in special circumstances. Despite these established programmes, there remains a critical need for advocacy efforts in affecting change in diagnosis, testing, and treatment. Recent campaigns, such as the World Meningitis Day digital toolkit, have helped raise awareness and draw attention to meningococcal disease. Awareness around antibiotic resistance has also led to the identification of antibiotic-resistant meningococcal strains, with an increase, albeit small, in these strains noted across the region. Countries such as Spain, Portugal, Germany, Switzerland, and France have either reported strains resistant to penicillin, ciprofloxacin and/or isolates with a reduced susceptibility to third-generation cephalosporins.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"89 6","pages":"Article 106335"},"PeriodicalIF":14.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High rates of Dientamoeba fragilis and Blastocystis species in children’s stool but minor clinical significance","authors":"David Shasha ,&nbsp;Orit Treygerman ,&nbsp;Etti Levy Dahari ,&nbsp;Efraim Bilavsky ,&nbsp;Dror Hacham ,&nbsp;Daniel Grupel ,&nbsp;Yael Paran ,&nbsp;George Prajgrod ,&nbsp;Galia Zacay","doi":"10.1016/j.jinf.2024.106340","DOIUrl":"10.1016/j.jinf.2024.106340","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to describe the epidemiology and the clinical significance of Dientamoeba fragilis (DF) and Blastocystis (Bs) in pediatric stool samples.</div></div><div><h3>Methods</h3><div>A historical cohort study of children under 18 years of age who underwent stool multiplex PCR for bacteria and parasites. DF and Bs results were not routinely reported. We assessed the frequency of various stool microorganisms and analyzed a composite of symptoms occurring within 14 days before testing and four post-test composite outcomes (symptoms, further medical evaluation, prescriptions of symptomatic treatment or antibiotics). Comparisons were made between children mono-infected with DF or Bs, those with negative PCR results, and those positive for microorganisms with established pathogenicity.</div></div><div><h3>Results</h3><div>Of 36,008 eligible children, 32.5% were positive for DF and 7.9% for Bs. Children positive for DF or Bs did not exhibit higher odds for pre- or post-test composite outcomes compared to those with all-negative PCR results, except for increased rates of abdominal pain and referrals for anti-TTG testing among DF-positive children. Antibiotic prescription was significantly more common among those positive for microorganisms of known pathogenicity.</div></div><div><h3>Conclusions</h3><div>While DF and Bs are frequently detected in pediatric stool samples, their clinical significance appears to be limited.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"89 6","pages":"Article 106340"},"PeriodicalIF":14.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global antimicrobial resistance threats: Insights from the resurgence of whooping cough","authors":"Biao Tang ,&nbsp;Xiaohe Hu ,&nbsp;Beibei Wu,&nbsp;Guoping Zhao,&nbsp;Min Yue","doi":"10.1016/j.jinf.2024.106337","DOIUrl":"10.1016/j.jinf.2024.106337","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"89 6","pages":"Article 106337"},"PeriodicalIF":14.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global population structure and genomic insights into Chromobacterium violaceum of human invasive lethal infection and non-human origins","authors":"Yuhang Pei ,&nbsp;Bei Wei ,&nbsp;Huarong Huang ,&nbsp;Yanan Wang,&nbsp;Xuebin Xu","doi":"10.1016/j.jinf.2024.106332","DOIUrl":"10.1016/j.jinf.2024.106332","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"89 6","pages":"Article 106332"},"PeriodicalIF":14.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guardian-driven influenza vaccination intentions for children post-COVID-19 in the 2024-2025 season: The positive spillover effects","authors":"Hongni Wang,&nbsp;Yi Zhou,&nbsp;Linchen Chu,&nbsp;Kan Chen,&nbsp;Chuanxi Fu","doi":"10.1016/j.jinf.2024.106333","DOIUrl":"10.1016/j.jinf.2024.106333","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"89 6","pages":"Article 106333"},"PeriodicalIF":14.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of pertussis among pediatric inpatients in mainland China","authors":"Wei Shi,&nbsp;Qinghong Meng,&nbsp;Yahong Hu,&nbsp;Guoshuang Feng,&nbsp;Xinyu Wang,&nbsp;Kaihu Yao","doi":"10.1016/j.jinf.2024.106327","DOIUrl":"10.1016/j.jinf.2024.106327","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"89 6","pages":"Article 106327"},"PeriodicalIF":14.3,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and prognosis of bloodstream infections with carbapenem-resistant Gram-negative organisms in patients with hematological malignancies: A multicenter case-control study in China","authors":"Junxin Zhou ,&nbsp;Jian Sun ,&nbsp;Shanshan Lu ,&nbsp;Xinhong Han ,&nbsp;Jintao He ,&nbsp;Ping Zhang ,&nbsp;Huangdu Hu ,&nbsp;Yuke Zhang ,&nbsp;Yanfei Wang ,&nbsp;Qin Yang ,&nbsp;Shujuan Ji ,&nbsp;Zhihui Zhou ,&nbsp;Xiaoting Hua ,&nbsp;Xueqing Wu ,&nbsp;Yan Jiang ,&nbsp;Xiaoxing Du ,&nbsp;Yunsong Yu","doi":"10.1016/j.jinf.2024.106331","DOIUrl":"10.1016/j.jinf.2024.106331","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate clinical characteristics of hematological malignancy (HM) patients with carbapenem-resistant gram-negative organism (CRO) bloodstream infections (BSI) in China, and to elucidate the prognostic risk factors of CRO BSI.</div></div><div><h3>Methods</h3><div>We conducted a multicenter case-control study of 201 HM patients with CRO BSI between 2018–2020. Antimicrobial susceptibility testing and whole genome sequencing were performed for CRO isolates. Independent risk factors for 28-day crude mortality were analyzed using Cox proportional hazards regression models. The subgroups of major species were also evaluated.</div></div><div><h3>Results</h3><div>The pathogens responsible for CRO BSI in HM patients dominated by ST11 CRKP, ST167 CREC and ST463 CRPA. Most isolates produced carbapenemases with KPC and NDM being the main. CRO isolates had resistance rates to conventional antimicrobials ranging from 55%−100% and poor susceptibility to novel antimicrobials related to carbapenemases and species. The 28-day crude mortality was 24.2%. Non-Hodgkin lymphoma, heart disease, <em>bla</em>_KPC-2 positive, empirical antibiotic therapy with linezolid, Pitt bacteremia score &gt;3.5 were risk factors for 28-day mortality and appropriate definitive antibiotic therapy, tigecycline-containing therapy and aminoglycoside-containing therapy were protective factors. <em>bla</em>_KPC-2 positive in CRKP and ST463 in CRPA were associated with Pitt bacteremia score &gt;3.5. Solid tumor and other site infections before BSI were risk factors for ST463 CRPA BSI and pulmonary infection before BSI was risk factor for KPC-KP BSI.</div></div><div><h3>Conclusions</h3><div>The antimicrobial resistance of CRO isolates for BSI in HM patients is critical. HM patients with CRO BSI should be treated with appropriate definitive antibiotic therapy based on early clarification of pathology and their antimicrobial susceptibility.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"89 6","pages":"Article 106331"},"PeriodicalIF":14.3,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}