{"title":"A cybernetic framework for synthetic biological intelligence in the era of neural tissue engineering.","authors":"Étienne P Sellar, Nicolas Rouleau","doi":"10.1038/s44335-026-00077-1","DOIUrl":"10.1038/s44335-026-00077-1","url":null,"abstract":"<p><p>Advances in synthetic biology and tissue engineering have enabled the design and assembly of neural constructs from first principles, renewing interest in cybernetics for understanding control, adaptation, and intelligence. To address shortcomings of artificial intelligence, researchers increasingly draw on the learning, robustness, and energy efficiency of living cognitive systems. Synthetic biological intelligences (SBIs) are beginning to leverage embodied biological computation, while cybernetics provides substrate-agnostic principles to guide minimal cognition research.</p>","PeriodicalId":501715,"journal":{"name":"npj Unconventional Computing","volume":"3 1","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13327941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148393301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vector symbolic algebras for the Abstraction and Reasoning Corpus.","authors":"Isaac Joffe, Chris Eliasmith","doi":"10.1038/s44335-026-00100-5","DOIUrl":"https://doi.org/10.1038/s44335-026-00100-5","url":null,"abstract":"<p><p>The Abstraction and Reasoning Corpus for Artificial General Intelligence (ARC-AGI) is a generative, few-shot fluid intelligence benchmark. Although humans effortlessly solve ARC-AGI, it remains extremely difficult for even the most advanced artificial intelligence systems. Inspired by methods for modelling human intelligence spanning neuroscience to psychology, we propose a cognitively inspired ARC-AGI solver. Our solver integrates System 1 intuitions with System 2 reasoning in an efficient and interpretable process using neurosymbolic methods based on Vector Symbolic Algebras (VSAs). Our solver works by object-centric program synthesis, leveraging VSAs to represent abstract objects, guide solution search, and enable sample-efficient neural learning. Preliminary results indicate success, with our solver scoring 10.8% on ARC-AGI-1-Train and 3.0% on ARC-AGI-1-Eval. Additionally, our solver performs well on simpler benchmarks, scoring 94.5% on Sort-of-ARC and 83.1% on 1D-ARC-the latter outperforming GPT-4 at a tiny fraction of the computational cost. Importantly, our approach is unique; we believe we are the first to apply VSAs to ARC-AGI and have developed one of the most cognitively plausible ARC-AGI solvers yet. Our code is available at: https://github.com/ijoffe/ARC-VSA-2025.</p>","PeriodicalId":501715,"journal":{"name":"npj Unconventional Computing","volume":"3 1","pages":"54"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Piergiulio Mannocci, Giacomo Larelli, Marco Bonomi, Daniele Ielmini
{"title":"Achieving high precision in analog in-memory computing systems.","authors":"Piergiulio Mannocci, Giacomo Larelli, Marco Bonomi, Daniele Ielmini","doi":"10.1038/s44335-025-00044-2","DOIUrl":"10.1038/s44335-025-00044-2","url":null,"abstract":"<p><p>Modern workloads challenge von Neumann architectures due to memory-processor data transfer. In-memory computing (IMC) enables in situ processing, with analog IMC (AIMC) based on resistive memories offering high-throughput and energy-efficient multiply-accumulate operations. Precision is limited by noise, device/circuit variations, and non-idealities. This work reviews error sources in AIMC and surveys mitigation strategies: bit slicing, residue number system, error correction codes, and mixed-precision iterative refinement, analyzing hardware implementations, overheads, and tradeoffs.</p>","PeriodicalId":501715,"journal":{"name":"npj Unconventional Computing","volume":"3 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145954912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shimeng Wu, Andrew Walter, Andy M Tyrrell, Martin A Trefzer
{"title":"Sliding-window training on readout layer enhances liquid state machines for temporal prediction.","authors":"Shimeng Wu, Andrew Walter, Andy M Tyrrell, Martin A Trefzer","doi":"10.1038/s44335-026-00093-1","DOIUrl":"10.1038/s44335-026-00093-1","url":null,"abstract":"<p><p>Temporal prediction is essential in scientific and engineering problems, particularly for low-power online inference. Reservoir computing is attractive because a fixed recurrent system maps inputs into a high-dimensional state decoded by a simple readout. Liquid state machines instantiate this idea with recurrent spiking neurons, yielding sparse event-driven states suited to neuromorphic and digital hardware. However, the stepwise protocol trains the readout from an instantaneous state, which can be information-limited when evidence is distributed across time. We improve temporal prediction by providing the readout with a finite temporal context. We concatenate a sliding window of recent reservoir spike states and train on either ridge regression or a transformer readout. On the Nonlinear AutoRegressive Moving Average (NARMA5) benchmark, increasing context length improves both readouts. Median test NRMSE for ridge regression decreases from 2.106 under stepwise decoding to 0.317, an 85% reduction. The transformer readout shows the same trend, decreasing from 0.807 to 0.179, a 78% reduction. The same qualitative trend is further observed on NARMA10 and Mackey Glass prediction tasks. These results demonstrate that exposing recent reservoir evolution at the decoder can substantially reduce the limitations of stepwise decoding while retaining the standard reservoir computing protocol.</p>","PeriodicalId":501715,"journal":{"name":"npj Unconventional Computing","volume":"3 1","pages":"52"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13581606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tristan Austin, Simon Bilodeau, Andrew Hayman, Nir Rotenberg, Bhavin J Shastri
{"title":"Hybrid quantum-classical photonic neural networks.","authors":"Tristan Austin, Simon Bilodeau, Andrew Hayman, Nir Rotenberg, Bhavin J Shastri","doi":"10.1038/s44335-025-00045-1","DOIUrl":"10.1038/s44335-025-00045-1","url":null,"abstract":"<p><p>Neuromorphic (brain-inspired) photonics accelerates AI<sup>1</sup> with high-speed, energy-efficient solutions for RF communication<sup>2</sup>, image processing<sup>3,4</sup>, and fast matrix multiplication<sup>5,6</sup>. However, integrated neuromorphic photonic hardware faces size constraints that limit network complexity. Recent advances in photonic quantum hardware<sup>7</sup> and performant trainable quantum circuits<sup>8</sup> offer a path to more scalable photonic neural networks. Here, we show that a combination of classical network layers with trainable continuous variable quantum circuits yields hybrid networks with improved trainability and accuracy. On a classification task, these hybrid networks match the performance of classical networks nearly twice their size. These performance benefits remain even when evaluated at state-of-the-art bit precisions for classical and quantum hardware. Finally, we outline available hardware and a roadmap to hybrid architectures. These hybrid quantum-classical networks demonstrate a unique route to enhance the computational capacity of integrated photonic neural networks without increasing the network size.</p>","PeriodicalId":501715,"journal":{"name":"npj Unconventional Computing","volume":"2 1","pages":"29"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12669026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145672906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M L Schneider, E M Jué, M R Pufall, K Segall, C W Anderson
{"title":"A self-training spiking superconducting neuromorphic architecture.","authors":"M L Schneider, E M Jué, M R Pufall, K Segall, C W Anderson","doi":"10.1038/s44335-025-00021-9","DOIUrl":"10.1038/s44335-025-00021-9","url":null,"abstract":"<p><p>Neuromorphic computing takes biological inspiration to the device level aiming to improve computational efficiency and capabilities. One of the major issues that arises is the training of neuromorphic hardware systems. Typically training algorithms require global information and are thus inefficient to implement directly in hardware. In this paper we describe a set of reinforcement learning based, local weight update rules and their implementation in superconducting hardware. Using SPICE circuit simulations, we implement a small-scale neural network with a learning time of order one nanosecond per update. This network can be trained to learn new functions simply by changing the target output for a given set of inputs, without the need for any external adjustments to the network. Further, this architecture does not require programing explicit weight values in the network, alleviating a critical challenge with analog hardware implementations of neural networks.</p>","PeriodicalId":501715,"journal":{"name":"npj Unconventional Computing","volume":"2 1","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chiara De Luca, Mirco Tincani, Giacomo Indiveri, Elisa Donati
{"title":"A neuromorphic multi-scale approach for real-time heart rate and state detection.","authors":"Chiara De Luca, Mirco Tincani, Giacomo Indiveri, Elisa Donati","doi":"10.1038/s44335-025-00024-6","DOIUrl":"10.1038/s44335-025-00024-6","url":null,"abstract":"<p><p>With the advent of novel sensor and machine learning technologies, it is becoming possible to develop wearable systems that perform continuous recording and processing of biosignals for health or body state assessment. For example, modern smartwatches can already track physiological functions, including heart rate and its anomalies, with high precision. However, stringent constraints on size and energy consumption pose significant challenges for always-on operation to detect trends across multiple time scales for extended periods of time. To address these challenges, we propose an alternative solution that exploits the ultra-low power consumption features of mixed-signal neuromorphic technologies. We present a biosignal processing architecture that integrates multimodal sensory inputs and processes them using the principles of neural computation to reliably detect trends in heart rate and physiological states. We validate this architecture on a mixed-signal neuromorphic processor and demonstrate its robust operation despite the inherent variability of the analog circuits present in the system. In addition, we demonstrate how the system can process multi scale signals, namely instantaneous heart rate and its long-term states discretized into distinct zones, effectively detecting monotonic changes over extended periods that indicate pathological conditions such as agitation. This approach paves the way for a new generation of energy-efficient stand-alone wearable devices that are particularly suited for scenarios that require continuous health monitoring with minimal device maintenance.</p>","PeriodicalId":501715,"journal":{"name":"npj Unconventional Computing","volume":"2 1","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aida Todri-Sanial, Corentin Delacour, Madeleine Abernot, Filip Sabo
{"title":"Computing with oscillators from theoretical underpinnings to applications and demonstrators","authors":"Aida Todri-Sanial, Corentin Delacour, Madeleine Abernot, Filip Sabo","doi":"10.1038/s44335-024-00015-z","DOIUrl":"10.1038/s44335-024-00015-z","url":null,"abstract":"Networks of coupled oscillators have far-reaching implications across various fields, providing insights into a plethora of dynamics. This review offers an in-depth overview of computing with oscillators covering computational capability, synchronization occurrence and mathematical formalism. We discuss numerous circuit design implementations, technology choices and applications from pattern retrieval, combinatorial optimization problems to machine learning algorithms. We also outline perspectives to broaden the applications and mathematical understanding of coupled oscillator dynamics.","PeriodicalId":501715,"journal":{"name":"npj Unconventional Computing","volume":" ","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44335-024-00015-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marco Massarotto, Stefano Saggini, Mirko Loghi, David Esseni
{"title":"Adiabatic leaky integrate and fire neurons with refractory period for ultra low energy neuromorphic computing","authors":"Marco Massarotto, Stefano Saggini, Mirko Loghi, David Esseni","doi":"10.1038/s44335-024-00013-1","DOIUrl":"10.1038/s44335-024-00013-1","url":null,"abstract":"In recent years, the in-memory-computing in charge domain has gained significant interest as a promising solution to further enhance the energy efficiency of neuromorphic hardware. In this work, we explore the synergy between the brain-inspired computation and the adiabatic paradigm by presenting an adiabatic Leaky Integrate-and-Fire neuron in 180 nm CMOS technology, that is able to emulate the most important primitives for a valuable neuromorphic computation, such as the accumulation of the incoming input spikes, an exponential leakage of the membrane potential and a tunable refractory period. Differently from previous contributions in the literature, our design can exploit both the charging and recovery phases of the adiabatic operation to ensure a seamless and continuous computation, all the while exchanging energy with the power supply with an efficiency higher than 90% over a wide range of resonance frequencies, and even surpassing 99% for the lowest frequencies. Our simulations unveil a minimum energy per synaptic operation of 470 fJ at a 500 kHz resonance frequency, which yields a 9x energy saving with respect to a non-adiabatic operation.","PeriodicalId":501715,"journal":{"name":"npj Unconventional Computing","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44335-024-00013-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maxwell Aifer, Kaelan Donatella, Max Hunter Gordon, Samuel Duffield, Thomas Ahle, Daniel Simpson, Gavin Crooks, Patrick J. Coles
{"title":"Thermodynamic linear algebra","authors":"Maxwell Aifer, Kaelan Donatella, Max Hunter Gordon, Samuel Duffield, Thomas Ahle, Daniel Simpson, Gavin Crooks, Patrick J. Coles","doi":"10.1038/s44335-024-00014-0","DOIUrl":"10.1038/s44335-024-00014-0","url":null,"abstract":"Linear algebra is central to many algorithms in engineering, science, and machine learning; hence, accelerating it would have tremendous economic impact. Quantum computing has been proposed for this purpose, although the resource requirements are far beyond current technological capabilities. We consider an alternative physics-based computing paradigm based on classical thermodynamics, to provide a near-term approach to accelerating linear algebra. At first sight, thermodynamics and linear algebra seem to be unrelated fields. Here, we connect solving linear algebra problems to sampling from the thermodynamic equilibrium distribution of a system of coupled harmonic oscillators. We present simple thermodynamic algorithms for solving linear systems of equations, computing matrix inverses, and computing matrix determinants. Under reasonable assumptions, we rigorously establish asymptotic speedups for our algorithms, relative to digital methods, that scale linearly in matrix dimension. Our algorithms exploit thermodynamic principles like ergodicity, entropy, and equilibration, highlighting the deep connection between these two seemingly distinct fields, and opening up algebraic applications for thermodynamic computers.","PeriodicalId":501715,"journal":{"name":"npj Unconventional Computing","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44335-024-00014-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}