Stephen P. Lee, Alexander J. Aranyosi, Roozbeh Ghaffari
{"title":"Wearable electrochemical biosensors for remote hydration and health management","authors":"Stephen P. Lee, Alexander J. Aranyosi, Roozbeh Ghaffari","doi":"10.1038/s44287-025-00184-4","DOIUrl":"10.1038/s44287-025-00184-4","url":null,"abstract":"Wearable sweat-sensing systems offer non-invasive routes for continuous monitoring and screening of metabolic, stress, environmental toxin, and hydration biomarkers in tandem with contextual physiological markers. Although progress has been rapid, translating nascent sweat-sensing technologies from laboratory to commercial adoption requires clinical validation, manufacturing scale up, and support from early customers.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"2 6","pages":"371-372"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recreating human ability with wearable robotics technology","authors":"Kyeongsu Shi, Kyoungchul Kong","doi":"10.1038/s44287-025-00182-6","DOIUrl":"10.1038/s44287-025-00182-6","url":null,"abstract":"Wearable robots are rapidly being adopted in the medical and healthcare sectors, outpacing other robotics technologies in commercialization. However, early products often fell short in delivering the desired therapeutic outcome. Through its experience, Angel Robotics has identified how to translate from research into successful commercial applications.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"2 6","pages":"369-370"},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The future of wearable bioelectronics in healthcare","authors":"Annalisa Bonfiglio","doi":"10.1038/s44287-025-00175-5","DOIUrl":"10.1038/s44287-025-00175-5","url":null,"abstract":"Wearable bioelectronics are reshaping patient care through seamless, personalized monitoring. As technology is gradually becoming smoothly integrated into our daily life, its success will depend not only on innovation, but also on our ability to ensure responsible integration — balancing performance, usability and equitable access.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"2 6","pages":"367-368"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexis Pengfei Zhao, Shuangqi Li, Da Xie, Yanjia Wang, Zhengmao Li, Paul Jen-Hwa Hu, Qianzhi Zhang
{"title":"Hydrogen as the nexus of future sustainable transport and energy systems","authors":"Alexis Pengfei Zhao, Shuangqi Li, Da Xie, Yanjia Wang, Zhengmao Li, Paul Jen-Hwa Hu, Qianzhi Zhang","doi":"10.1038/s44287-025-00178-2","DOIUrl":"10.1038/s44287-025-00178-2","url":null,"abstract":"Serving as a clean energy carrier, green hydrogen — hydrogen produced by the electrolysis of water — enables low-carbon transportation and facilitates the large-scale integration of intermittent renewable energy sources into the power grid, thereby enhancing system flexibility and decarbonization. Hydrogen fuel cell vehicles (HFCVs) are key to the integration of green hydrogen into the energy and transport systems. The adoption of HFCVs is being supported by advances in hydrogen production and fuel cell technologies, coupled with the development of hydrogen refuelling infrastructure. However, technological, economic and regulatory barriers to the growth of the hydrogen economy remain. This Review examines the progress and challenges in the integration of HFCVs into the energy and transport systems. We also consider challenges in scaling green hydrogen production using renewable energy and highlight the role of HFCVs in facilitating the integration of green hydrogen and renewable energy into the energy and transport systems. Finally, we provide a roadmap that outlines directions for research, policy and investment to overcome the obstacles to growing the hydrogen economy and harnessing hydrogen as a cornerstone of sustainable energy and transport systems. Hydrogen fuel cell vehicles (HFCVs) facilitate the integration of green hydrogen and intermittent renewable energy into the energy and transport systems. This Review examines progress and challenges in increasing HFCV adoption and realizing sustainable energy and transport systems based on green hydrogen.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"2 7","pages":"447-466"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intrinsic interdisciplinary nature of mediated social touch research","authors":"Giulia Barbareschi, Sakura Yamamura","doi":"10.1038/s44287-025-00185-3","DOIUrl":"10.1038/s44287-025-00185-3","url":null,"abstract":"As digitalization permeates societal interactions to connect people over physical distances, mediated social touch (haptics in human-to-human interaction) remains overlooked despite its high potential in times of social divides and mobility. Disciplinary silos must be broken, and an intercultural approach is needed to integrate touch into digital global societies.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"2 8","pages":"517-518"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2D bismuth oxyselenide semiconductor for future electronics","authors":"Congwei Tan, Junchuan Tang, Xin Gao, Chengyuan Xue, Hailin Peng","doi":"10.1038/s44287-025-00179-1","DOIUrl":"10.1038/s44287-025-00179-1","url":null,"abstract":"The continuous downscaling of silicon transistors has driven exponential improvements in computing performance and energy efficiency, but sub-10 nm channel lengths pose fundamental challenges in speed and power consumption. Emerging materials and architectures offer promising pathways for further miniaturization. Bismuth oxyselenide (Bi2O2Se), an air-stable 2D semiconductor, exhibits high mobility, a suitable bandgap and a native high-κ oxide (Bi2SeO5), resembling silicon and its SiO2 counterpart. These properties suggest compatibility with industrial processes, positioning Bi2O2Se for next-generation high-performance computing. This Review summarizes recent advances in material synthesis, wafer-scale integration and device architectures, highlighting key challenges in the lab-to-fab transition. Finally, a roadmap is proposed to guide future innovations in ultra-scaled, energy-efficient electronics. This Review explores Bi2O2Se as a promising 2D semiconductor for next-generation computing, highlighting its high mobility, suitable bandgap and native high-κ oxide, which enables wafer-scale integration and compatibility with industrial processes, while addressing key challenges in the lab-to-fab transition and proposing a roadmap for ultra-scaled, energy-efficient electronics.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"2 7","pages":"494-513"},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"LiDAR and cameras in autonomous driving","authors":"Javier Ibanez-Guzman, You Li","doi":"10.1038/s44287-025-00176-4","DOIUrl":"10.1038/s44287-025-00176-4","url":null,"abstract":"Autonomous vehicles rely on both LiDAR and cameras for perception, with each technology offering unique advantages — cameras provide rich contextual information, whereas LiDAR delivers precise depth data. Understanding their trade-offs is crucial for creating reliable and efficient autonomous vehicles.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"2 8","pages":"515-516"},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew T. Flavin, Jose A. Foppiani, Marek A. Paul, Angelica H. Alvarez, Lacey Foster, Dominika Gavlasova, Haobo Ma, John A. Rogers, Samuel J. Lin
{"title":"Bioelectronics for targeted pain management","authors":"Matthew T. Flavin, Jose A. Foppiani, Marek A. Paul, Angelica H. Alvarez, Lacey Foster, Dominika Gavlasova, Haobo Ma, John A. Rogers, Samuel J. Lin","doi":"10.1038/s44287-025-00177-3","DOIUrl":"10.1038/s44287-025-00177-3","url":null,"abstract":"Pain management in humans is an unresolved problem with substantial medical, societal and economic implications. Traditional strategies such as opioid-based medications are highly effective but pose many long-term risks, including addiction and overdose. In this Review, we discuss these persistent challenges in medical care along with advances in bioelectronics that enable safer and more effective alternative treatments. Emerging approaches leverage wireless embedded networks and machine learning to accurately detect and quantify the symptoms of pain, establishing a foundation for targeted, on-demand treatment. These platforms offer a powerful complement to wearable and implantable neural interfaces that can control these symptoms with unprecedented spatiotemporal and functional selectivity. Now, emotional and cognitive aspects of pain can be addressed through immersive multisensory engagement with systems for augmented and virtual reality. Trends in diagnostic and interventional technologies show how their integration is well suited to addressing some of the most intractable problems in pain management. Pain is a profound and unresolved health challenge, and current interventions are not sufficient for safe and effective pain management. Bioelectronics presents solutions for monitoring the symptoms of pain and treating these symptoms in a targeted manner.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"2 6","pages":"407-424"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Three-dimensional micro- and nanomanufacturing techniques for high-fidelity wearable bioelectronics","authors":"Peidi Fan, Ying Liu, Yuxiang Pan, Yibin Ying, Jianfeng Ping","doi":"10.1038/s44287-025-00174-6","DOIUrl":"10.1038/s44287-025-00174-6","url":null,"abstract":"High-fidelity wearable bioelectronics aims to establish seamless integration between electronic devices and biological systems to enable real-time health monitoring, disease diagnosis, and multimodal interaction. Central to this integration are the bio–electronic interfaces, which require conformal alignment and optimized electrical and mechanical properties to ensure stable and accurate signal acquisition. Traditional bioelectronic devices frequently fail to achieve good conformity at the microscale and nanoscale, lacking fabrication processes feasible for customized three-dimensional (3D) microstructures and nanostructures. In this Review, we discuss advances in 3D manufacturing technologies, focusing on those techniques that, enabling the fabrication of cross-scale, multimaterial structures, address key challenges in spatial complexity and mechanical mismatch at the bio–electronic interface. These innovations promote both long-term wearability and high-fidelity signal integrity. Interdisciplinary collaboration — particularly the integration of artificial intelligence — is essential for driving successful transformation in the field. Delivering cost-effective and scalable solutions for the fabrication of high-fidelity bioelectronic devices is crucial to realize their transformative potential in healthcare, human–machine interaction, and personalized medicine. Wearable bioelectronics integrates functional electronic devices with biological systems to enable real-time health monitoring and disease diagnosis. This Review explores advancements in three-dimensional manufacturing technologies for high-fidelity biosensors, addressing challenges related to fabrication, signal integrity, and long-term wearability.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"2 6","pages":"390-406"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenhao Xue (, ), Yi Ren (, ), Yi Tang (, ), Ziqi Gong (, ), Tianfang Zhang (, ), Zuobing Chen (, ), Xiaonan Dong (, ), Xuezhi Ma (, ), Ziyu Wang (, ), Heng Xu (, ), Jiaqing Zhao (, ), Yuan Ma (, )
{"title":"Interactive wearable digital devices for blind and partially sighted people","authors":"Wenhao Xue \u0000 (, ), Yi Ren \u0000 (, ), Yi Tang \u0000 (, ), Ziqi Gong \u0000 (, ), Tianfang Zhang \u0000 (, ), Zuobing Chen \u0000 (, ), Xiaonan Dong \u0000 (, ), Xuezhi Ma \u0000 (, ), Ziyu Wang \u0000 (, ), Heng Xu \u0000 (, ), Jiaqing Zhao \u0000 (, ), Yuan Ma \u0000 (, )","doi":"10.1038/s44287-025-00170-w","DOIUrl":"10.1038/s44287-025-00170-w","url":null,"abstract":"Digital information has permeated all aspects of life, and diverse forms of information exert a profound influence on social interactions and cognitive perceptions. In contrast to the flourishing of digital interaction devices for sighted users, the needs of blind and partially sighted users for digital interaction devices have not been adequately addressed. Current assistive devices often cause frustration in blind and partially sighted users owing to the limited efficiency and reliability of information delivery and the high cognitive load associated with their use. The expected rise in the prevalence of blindness and visual impairment due to global population ageing drives an urgent need for assistive devices that can deliver information effectively and non-visually, and thereby overcome the challenges faced by this community. This Perspective presents three potential directions in assistive device design: multisensory learning and integration; gestural interaction control; and the synchronization of tactile feedback with large-scale visual language models. Future trends in assistive devices for use by blind and partially sighted people are also explored, focusing on metrics for text delivery efficiency and the enhancement of image content delivery. Such devices promise to greatly enrich the lives of blind and partially sighted individuals in the digital age. Blind and partially sighted individuals face considerable challenges when interacting with digital information. This Perspective highlights important bottlenecks in information accessibility, design considerations for future wearable assistive devices and the outlook for improved access to and delivery of information in text and images.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"2 6","pages":"425-439"},"PeriodicalIF":0.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}