Charles Guan, Lydia J. Lin, Sunho Lee, Whitney S. Griggs
{"title":"Scaling ultrasonic brain computer interfaces beyond the lab","authors":"Charles Guan, Lydia J. Lin, Sunho Lee, Whitney S. Griggs","doi":"10.1038/s44287-026-00312-8","DOIUrl":"10.1038/s44287-026-00312-8","url":null,"abstract":"Functional ultrasound imaging (fUSI) offers a non-invasive, high-resolution path to brain–computer interfacing (BCI) but moving from laboratory prototypes to clinical use demands solutions to technical, clinical and scalability challenges. This Comment examines those challenges and outlines directions for bringing fUSI-BCIs out of the lab.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"3 8","pages":"467-468"},"PeriodicalIF":34.8,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148704536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Managing electrostatic hazards at the source","authors":"Zi Ye \u0000 (, ), Songkai Liu \u0000 (, ), Zhinan Zhang \u0000 (, )","doi":"10.1038/s44287-026-00316-4","DOIUrl":"10.1038/s44287-026-00316-4","url":null,"abstract":"Static electricity damages microchips the instant two surfaces touch and separate, long before conventional grounding can drain it away. Worse, the ‘dissipative’ materials meant to prevent this can deposit even more charge. In this Comment, we argue that the fix is to stop the charge at its source, not clear it up afterwards.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"3 9","pages":"544-545"},"PeriodicalIF":34.8,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhengyi Yang, Congying Chu, Weiyang Shi, Na Luo, Tianzi Jiang
{"title":"Digital twin brains must close the loop to prescribe, not just predict","authors":"Zhengyi Yang, Congying Chu, Weiyang Shi, Na Luo, Tianzi Jiang","doi":"10.1038/s44287-026-00313-7","DOIUrl":"10.1038/s44287-026-00313-7","url":null,"abstract":"A digital twin of a patient’s brain can forecast how that brain will respond to a treatment before it is ever tried. But forecasting is only the start. The real prize is a twin that tracks the living brain and adjusts therapy moment by moment, choosing the best option for each person.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"3 9","pages":"541-543"},"PeriodicalIF":34.8,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Engineering topolectrical circuits","authors":"Yuxin Jiang, Wenhao Li, Weixuan Zhang, Ce Shang, Yihao Yang, Xiangdong Zhang, Ching Hua Lee, Ronny Thomale","doi":"10.1038/s44287-026-00308-4","DOIUrl":"10.1038/s44287-026-00308-4","url":null,"abstract":"Topolectrical circuits are electrical networks that encode topological band theory. Their physical behaviour is set by how the components are wired together, not by where they are placed. This wiring-centred design delivers defect tolerance, directional signal flow without bulky magnetic parts, and amplified response at boundaries. Conventional electronics obtain these only by adding isolators, feedback or calibration after the circuit is laid out. In this Review, we identify which capabilities are engineering-ready and which remain confined to the laboratory. We cover the underlying physics, the resulting sensors and engineering applications, and cross-disciplinary uses in quantum simulation, artificial intelligence-assisted design and curved-space geometries. We then examine how co-integration with memristive devices makes the platform adaptive and history-dependent. We close with the hardware routes towards deployable electronics, from monolithic chips to flexible substrates and body-worn systems. Topolectrical circuits route signals one way without magnets and keep working when components fail. These capabilities come from how the components are wired together, not from added parts. This Review covers their physics, applications across sensing, wireless power and communications, and the path towards integrated, flexible and adaptive electronics.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"3 8","pages":"493-509"},"PeriodicalIF":34.8,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148704546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cheng Feng, Jianhua Pei, Zhijin Qin, Kaibin Huang, Dusit Niyato, Geoffrey Ye Li, Yi Wang, Ping Wang, Chongqing Kang
{"title":"Goal-oriented communications for future cyber–physical systems","authors":"Cheng Feng, Jianhua Pei, Zhijin Qin, Kaibin Huang, Dusit Niyato, Geoffrey Ye Li, Yi Wang, Ping Wang, Chongqing Kang","doi":"10.1038/s44287-026-00303-9","DOIUrl":"10.1038/s44287-026-00303-9","url":null,"abstract":"Future cyber–physical systems face a gap between surging data traffic and finite resources under stringent latency and reliability demands. Throughput-driven and latency-driven communication systems assign the same scheduling priority to all packets regardless of their relevance to the downstream task, which can undermine decision quality. Conversely, goal-oriented communications transmit only goal-relevant information, protecting control systems from destabilization due to indiscriminate data flooding. In this Review, we analyse how goal-oriented communications reshape cyber–physical system design across four tiers: networked sensing and control, decision-making, distributed intelligence and multimodal intelligence. The analysis reveals that task-level metrics, such as control error, inference accuracy and decision utility, rather than bit-level communication metrics, are key to ensuring reliable sensing, control and decision-making. We reframe cyber–physical communication from bit-level optimization toward task-oriented design, where communication decisions are driven by downstream task requirements. Finally, we posit a framework that will enable engineers and researchers to build intelligent cyber–physical systems. This framework will power smarter grids, safer autonomous vehicles and more adaptive industrial automation. This Review shows that transmitting targeted, goal-oriented bits rather than more data reshapes communication–performance trade-offs across four tiers of cyber-physical complexity, from control stability to multimodal intelligence.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"3 8","pages":"475-492"},"PeriodicalIF":34.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148704548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Making the impossible possible","authors":"Zhen Xu, Rachel Won","doi":"10.1038/s44287-026-00309-3","DOIUrl":"10.1038/s44287-026-00309-3","url":null,"abstract":"Zhen Xu, Li Ka Shing Endowed Professor of Biomedical Engineering and professor of Radiology and Neurosurgery at the University of Michigan, speaks to Nature Reviews Electrical Engineering about the journey that led to her success in inventing and advancing histotripsy to help patients, and shares her vision as the mid-career winner of the 2026 Sony Women in Technology Award with Nature. Zhen Xu reflects on the journey that led to her success in inventing and advancing histotripsy to help patients, and shares her vision as the mid-career winner of the 2026 Sony Women in Technology Award with Nature.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"3 8","pages":"471-472"},"PeriodicalIF":34.8,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148704547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Harnessing the Stark effect for advanced circuit design with black phosphorus","authors":"Miranda L. Vinay","doi":"10.1038/s44287-026-00310-w","DOIUrl":"10.1038/s44287-026-00310-w","url":null,"abstract":"Stark effect-induced bandgap tuning in black phosphorus (BP) provides precise control over carrier density and switching behaviour, enabling adjustable amplifier gain and bandwidth, facilitating compact binary and ternary logic implementations, and advancing BP transistor arrays for next-generation circuit applications.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"3 7","pages":"405-405"},"PeriodicalIF":34.8,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christopher Pantayatiwong Liu, Maria Pagliaro, Anastasiia Semenova, Grace Lindquist, Alessandro Lavacchi, Plamen Atanassov, Ilia Valov
{"title":"Rethinking alkaline water electrolysis under industrial conditions","authors":"Christopher Pantayatiwong Liu, Maria Pagliaro, Anastasiia Semenova, Grace Lindquist, Alessandro Lavacchi, Plamen Atanassov, Ilia Valov","doi":"10.1038/s44287-026-00302-w","DOIUrl":"10.1038/s44287-026-00302-w","url":null,"abstract":"Alkaline water electrolysis supplies most installed water-electrolyser capacity, yet the technology and its perceived limits have not fundamentally changed in a century. Rather than inherent chemistry, we argue that these limits are the consequence of traditional operating conditions at near-atmospheric pressure, low current density, and steady state. The performance gap with proton exchange membrane systems persists across a coupled hierarchy of losses: kinetic and ohmic losses at the electrodes and separator in concentrated KOH; shunt and reverse currents along the manifolds of bipolar stacks; and power-conversion, compression and thermal-management losses at the plant level. In this Review, we outline how closing this gap calls for coordinated advances in electrode and separator materials, stack architecture, power electronics and plant-level integration, evaluated under realistic industrial conditions of concentrated alkali, elevated temperature and pressure, and dynamic loads. By pursuing these advances, we can rebuild alkaline electrolysis from first principles into a flexible workhorse for low-carbon hydrogen production. Alkaline water electrolysis dominates global water-electrolyser capacity, but its architecture has remained largely unchanged for a century. This Review examines how losses at the cell, stack and system levels conventionally limit efficiency, and highlights how rethinking these constraints can unlock substantial gains for industrial hydrogen production.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"3 8","pages":"510-522"},"PeriodicalIF":34.8,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148704543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Weitong Pan (, ), Jianjun Yang (, ), Yunlong Zhao (, ), Zhigang Gao (, ), Haitao Liu (, ), Daqing Ma (, )
{"title":"Dynamic biophysical coupling in bioelectronic interfaces for peripheral nerve modulation","authors":"Weitong Pan \u0000 (, ), Jianjun Yang \u0000 (, ), Yunlong Zhao \u0000 (, ), Zhigang Gao \u0000 (, ), Haitao Liu \u0000 (, ), Daqing Ma \u0000 (, )","doi":"10.1038/s44287-026-00301-x","DOIUrl":"10.1038/s44287-026-00301-x","url":null,"abstract":"Peripheral nerve interfaces provide a bidirectional electrical link between implanted electronics and the peripheral nervous system, supporting therapies for sensory restoration, motor control and chronic disease management. Their long-term performance depends less on how well signals are transmitted at implantation and more on how the electrode–tissue relationship changes, as impedance, threshold, signal fidelity and selectivity drift over months to years. This Review describes these changes through dynamic biophysical coupling, in which mechanical, geometric, electrochemical, biochemical and biological variables co-evolve at the electrode–tissue interface and together determine how the device functions. In this view, keeping coupling within a useful operating window is not a one-time goal set at implantation but a state that must be maintained through coordinated design across materials, device structures, anatomy-specific implantation and system design. We then consider how coupling is measured, modelled and evaluated over the long term, and identify the shared metrics that would make next-generation peripheral nerve interfaces predictable and clinically scalable. Peripheral nerve interfaces typically fail not from acute signal loss but from slow drift in the electrode–tissue relationship. This Review reframes that drift through dynamic biophysical coupling, a unifying view of how materials, structures, anatomy and feedback control together keep interfaces stable, selective and predictable across years of implantation.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"3 7","pages":"450-464"},"PeriodicalIF":34.8,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Smartphones passively monitor heart health","authors":"Jiahao Liu","doi":"10.1038/s44287-026-00307-5","DOIUrl":"10.1038/s44287-026-00307-5","url":null,"abstract":"A study in Nature uses deep learning to passively monitor resting heart rates via front-facing smartphone cameras, yielding highly accurate cardiovascular tracking across all skin tones without the need for wearables.","PeriodicalId":501701,"journal":{"name":"Nature Reviews Electrical Engineering","volume":"3 7","pages":"404-404"},"PeriodicalIF":34.8,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}