Nature Chemical Engineering最新文献_第4页

IF 29.7

Nature Chemical Engineering Pub Date : 2026-08-12 DOI: 10.1038/s44286-026-00427-7

Ruirui Gu, Da-Hui Qu

引用次数: 0

Tunable polymers for polymer–lipid hybrid nanoparticles facilitate controlled organ-selective RNA delivery 可调聚合物的聚合物-脂质杂化纳米颗粒促进控制器官选择性RNA递送

IF 29.7

Nature Chemical Engineering Pub Date : 2026-08-12 DOI: 10.1038/s44286-026-00425-9

Xu Wang, Zeru Tian, Alexis Pacheco Benitez, Xiaoyan Bian, Amogh Vaidya, Erick Guerrero, Yehui Sun, Chuhan Zhang, Yaou Duan, Jingwen Wei, Yujin Kim, Yufen Xiao, Priyanka Patel, Daniel J. Siegwart

{"title":"Tunable polymers for polymer–lipid hybrid nanoparticles facilitate controlled organ-selective RNA delivery","authors":"Xu Wang, Zeru Tian, Alexis Pacheco Benitez, Xiaoyan Bian, Amogh Vaidya, Erick Guerrero, Yehui Sun, Chuhan Zhang, Yaou Duan, Jingwen Wei, Yujin Kim, Yufen Xiao, Priyanka Patel, Daniel J. Siegwart","doi":"10.1038/s44286-026-00425-9","DOIUrl":"10.1038/s44286-026-00425-9","url":null,"abstract":"RNA therapeutics hold immense promise to treat a wide range of diseases, yet their diverse physical properties create substantial delivery challenges. Current lipid nanoparticles, limited by the chemical constraints of small molecules, lack the versatility and adaptability required for efficient encapsulation of small to large payloads. Here we engineer a polymer–lipid hybrid nanoparticle platform that combines rational polymer design with lipid components to enable programmable RNA encapsulation and controlled organ-specific delivery. By systemically tuning polymer side chain functionalities, hydrophobic chain substitution and nanoparticle compositions, the optimized polymer–lipid hybrid nanoparticles achieve modulated RNA–nanoparticle interactions, enhancing the delivery precision and efficiency of diverse RNA cargoes including mRNA, siRNA, circRNA, gene editors and vaccines to the lungs, liver and spleen. This work advances chemical engineering strategies for RNA delivery by integrating materials design, molecular transport optimization and scalable nanoparticle synthesis, contributing to the broader development of biomolecular and polymer engineering solutions for therapeutic production and application. A polymer–lipid hybrid nanoparticle platform enables programmable encapsulation and controlled organ-specific delivery of diverse RNA payloads. Through rational polymer synthesis and formulation design, this platform improves the specific delivery of mRNA, siRNA, circRNA and genome editors to the lungs, liver and spleen.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"3 8","pages":"443-459"},"PeriodicalIF":29.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upcycling nanoscale fragments in industrial waste liquids for aqueous battery electrolytes 升级回收工业废液中的纳米级碎片用于水性电池电解质

IF 29.7

Nature Chemical Engineering Pub Date : 2026-08-12 DOI: 10.1038/s44286-026-00424-w

Xiwen Chi, Yuqi Li, Qi Zheng, Pu Zhang, Haiyan Mao, Junyan Li, Ge Zhang, Jing Wang, Zhouyi Chen, Hance Su, Ajay Ravi, Angela Cai, Zaichun Liu, Yuxuan Chen, Guangxia Feng, Yecun Wu, Jinlei Li, Xun Guan, Xueli Zheng, Qiusu Miao, Chenwei Liu, Yi Cui

{"title":"Upcycling nanoscale fragments in industrial waste liquids for aqueous battery electrolytes","authors":"Xiwen Chi, Yuqi Li, Qi Zheng, Pu Zhang, Haiyan Mao, Junyan Li, Ge Zhang, Jing Wang, Zhouyi Chen, Hance Su, Ajay Ravi, Angela Cai, Zaichun Liu, Yuxuan Chen, Guangxia Feng, Yecun Wu, Jinlei Li, Xun Guan, Xueli Zheng, Qiusu Miao, Chenwei Liu, Yi Cui","doi":"10.1038/s44286-026-00424-w","DOIUrl":"10.1038/s44286-026-00424-w","url":null,"abstract":"Industrial synthesis generates large amounts of waste liquid containing unreacted precursors and nanoscale fragments, posing environmental disposal challenges. However, research on the direct reutilization of raw industrial waste liquids remains limited. Here we develop a direct recycling strategy in which the waste liquid from zeolite synthesis is employed as the solvent for aqueous zinc (Zn)-ion battery electrolytes. During Zn deposition, the negatively charged zeolite fragments in the waste liquid can form a nanoscale interfacial layer. These zeolite fragments exhibit a charge gradient, generating a local electric field that facilitates the migration of Zn ions and enables uniform Zn metal deposition. The waste-derived electrolyte endows batteries with highly enhanced cycling stability, lower voltage polarization and improved Coulombic efficiency compared with those using conventional electrolytes prepared with deionized water. Importantly, this strategy offers a potential route to reduce deionized water use and alleviate waste-treatment demands while improving battery performance. This study upcycles industrial zeolite-washing supernatants as aqueous Zn-battery electrolyte solvents, leveraging charge-heterogeneous zeolite fragments that self-assemble on the Zn surface to form a gradient interphase with a local electric field that guides Zn2+ flux, stabilizes Zn deposition and couples waste valorization with improved energy-storage performance.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"3 8","pages":"460-469"},"PeriodicalIF":29.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tunable polymers expand selective organ targeting (SORT) for RNA delivery 可调聚合物扩展RNA递送的选择性器官靶向（SORT）

IF 29.7

Nature Chemical Engineering Pub Date : 2026-08-12 DOI: 10.1038/s44286-026-00428-6

引用次数: 0

Teaching ratios before Reynolds 雷诺兹之前的教学比率

IF 29.7

Nature Chemical Engineering Pub Date : 2026-07-21 DOI: 10.1038/s44286-026-00412-0

Kurt D. Ristroph

引用次数: 0

Assessing the industrial impact of an alternative lactide production method for polylactic acid manufacturing 评估一种用于聚乳酸制造的替代丙交酯生产方法的工业影响

IF 29.7

Nature Chemical Engineering Pub Date : 2026-07-21 DOI: 10.1038/s44286-026-00420-0

G. Pomalaza, M. V. Hickson, W. Arts, A. S. Narmon, M. G. Rigamonti, B. Lagrain, E. V. Makshina, M. Dusselier, B. F. Sels

{"title":"Assessing the industrial impact of an alternative lactide production method for polylactic acid manufacturing","authors":"G. Pomalaza, M. V. Hickson, W. Arts, A. S. Narmon, M. G. Rigamonti, B. Lagrain, E. V. Makshina, M. Dusselier, B. F. Sels","doi":"10.1038/s44286-026-00420-0","DOIUrl":"10.1038/s44286-026-00420-0","url":null,"abstract":"ʟ-Lactide, the key precursor for polylactic acid (PLA) production, is industrially produced through a complex oligomerization–depolymerization sequence. Here we present a process combining lactic acid esterification with subsequent cyclic dimerization in a fixed-bed reactor using a silica-supported titania catalyst to convert gaseous lactate esters into ʟ-lactide, an approach that yields fewer chiral impurities. Using industrial-scale simulations supported by a detailed kinetic model of the dimerization reaction, we performed techno-economic and lifecycle analyses. The results demonstrate that the esterification–dimerization route increases ʟ-lactide productivity by 16%, reduces production costs by at least 10% (with a mean of 19% across multiple scenarios) and lowers CO2e emissions by 15% compared with conventional methods. When integrated into the full production chain, this process decreases PLA minimum selling prices by 18%. Total emissions are further reduced using PLA waste-derived esters, positioning this approach as a promising route for a circular PLA economy. This study proposes an alternative industrial, gas-phase process for producing ʟ-lactide, a key intermediate in polylactic acid. Compared with conventional technology, this process has the potential to reduce production costs and environmental impacts while increasing productivity. When integrated into the polylactic acid production chain, these benefits are preserved, leading to lower minimum selling prices.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"3 7","pages":"414-427"},"PeriodicalIF":29.7,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disentangling thermosets from crosslinks 从交联中分离热固性物

IF 29.7

Nature Chemical Engineering Pub Date : 2026-07-21 DOI: 10.1038/s44286-026-00423-x

Thomas Dursch

引用次数: 0

Pinning ångström-size solid ionic channels for rare-earth element separation 钉住ångström-size固体离子通道分离稀土元素

IF 29.7

Nature Chemical Engineering Pub Date : 2026-07-21 DOI: 10.1038/s44286-026-00418-8

Siqi Zou, Jiadong Liu, Woo Cheol Jeon, Maoyu Wang, Ronghui Wu, Yu Han, Gangbin Yan, Grant T. Hill, Xiaolin Yue, Hua Zhou, George C. Schatz, Chong Liu

{"title":"Pinning ångström-size solid ionic channels for rare-earth element separation","authors":"Siqi Zou, Jiadong Liu, Woo Cheol Jeon, Maoyu Wang, Ronghui Wu, Yu Han, Gangbin Yan, Grant T. Hill, Xiaolin Yue, Hua Zhou, George C. Schatz, Chong Liu","doi":"10.1038/s44286-026-00418-8","DOIUrl":"10.1038/s44286-026-00418-8","url":null,"abstract":"High-purity rare-earth elements are essential for modern technologies, yet current solvent extraction processes are energy-intensive and environmentally harmful because of inadequate selectivity and ligand toxicity. Although combining size exclusion and binding affinity can improve lanthanide separation, the role of long-range confinement remains underexplored. Here we report lanthanide separation in aqueous systems using extremely confined manganese oxide solid ionic channels with optimized layer spacing. Different lanthanides induce distinct solid-state phase transformations in manganese oxide, creating a strong driving force for separation. Two lanthanide groups, differing by ~1.4 Å in spacing, were identified and confirmed to be stable by density functional theory. The narrower confinement of heavier Group II lanthanides improves cross-group separation by increasing the dehydration barrier for lighter Group I lanthanides without inducing strong binding. We further developed a strategy to pin the confinement dimensions and enhance same-group separation, increasing enrichment factors for La–Nd and La–Pr pairs from 1.6 ± 0.1 and 1.5 ± 0.1 to 5.4 ± 0.1 and 4.2 ± 0.1, respectively. This study develops ångström-scale hydrated manganese oxide ionic channels to separate lanthanides by coupling confinement-controlled dehydration and coordination. Group-dependent phase responses enable cross-group selectivity, whereas Mg2+ pinning fixes a narrow channel to enhance same-group separation, increasing La–Nd and La–Pr enrichment factors compared with ion exchange without pinning.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"3 7","pages":"402-413"},"PeriodicalIF":29.7,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing interfacial instabilities 利用界面不稳定性

IF 29.7

Nature Chemical Engineering Pub Date : 2026-07-21 DOI: 10.1038/s44286-026-00426-8

引用次数: 0

Beyond noble metals 贵金属之外

IF 29.7

Nature Chemical Engineering Pub Date : 2026-07-20 DOI: 10.1038/s44286-026-00421-z

Yanfei Zhu

引用次数: 0