{"title":"响应葡萄糖摄取速率的生物传感器可以动态调节代谢通量","authors":"","doi":"10.1038/s44286-025-00174-1","DOIUrl":null,"url":null,"abstract":"When glucose is used as the main carbon source in microbial cultures, its uptake rate directly influences the overall metabolic flux. This study presents genetic circuits that can detect the glucose uptake rate and dynamically regulate the associated metabolic fluxes and the synthesis of desired products.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 1","pages":"34-35"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Biosensors responsive to glucose uptake rates can dynamically regulate metabolic flux\",\"authors\":\"\",\"doi\":\"10.1038/s44286-025-00174-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"When glucose is used as the main carbon source in microbial cultures, its uptake rate directly influences the overall metabolic flux. This study presents genetic circuits that can detect the glucose uptake rate and dynamically regulate the associated metabolic fluxes and the synthesis of desired products.\",\"PeriodicalId\":501699,\"journal\":{\"name\":\"Nature Chemical Engineering\",\"volume\":\"2 1\",\"pages\":\"34-35\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Chemical Engineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44286-025-00174-1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Chemical Engineering","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44286-025-00174-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Biosensors responsive to glucose uptake rates can dynamically regulate metabolic flux
When glucose is used as the main carbon source in microbial cultures, its uptake rate directly influences the overall metabolic flux. This study presents genetic circuits that can detect the glucose uptake rate and dynamically regulate the associated metabolic fluxes and the synthesis of desired products.
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