Nature Chemical Engineering最新文献

Timescale analysis in cell factory design

Nature Chemical Engineering Pub Date : 2025-03-24 DOI: 10.1038/s44286-025-00192-z

Peng Xu

引用次数: 0

Connecting scales in reaction engineering

Nature Chemical Engineering Pub Date : 2025-03-24 DOI: 10.1038/s44286-025-00197-8

Jeremy Luterbacher, Bert Weckhuysen, Sophia Haussener, Beatriz Roldan Cuenya, Daniel E. Resasco, Carlos G. Morales-Guio, Feng Jiao, Nanfeng Zheng, Kazunari Domen, Patricia Concepción, Louise Olsson, Curtis Berlinguette, Hongliang Xin

引用次数: 0

Too much salt?

Nature Chemical Engineering Pub Date : 2025-03-24 DOI: 10.1038/s44286-025-00201-1

Yanfei Zhu

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Self-aggregating long-acting injectable microcrystals

Nature Chemical Engineering Pub Date : 2025-03-24 DOI: 10.1038/s44286-025-00194-x

Vivian R. Feig, Sanghyun Park, Pier Giuseppe Rivano, Jinhee Kim, Benjamin Muller, Ashka Patel, Caroline Dial, Sofia Gonzalez, Hannah Carlisle, Flavia Codreanu, Aaron Lopes, Ayten E. Erdogan, Niora Fabian, Ashley Guevara, Andrew Pettinari, Jason Li, Jia Liang, Gary W. Liu, Mark W. Tibbitt, Giovanni Traverso

{"title":"Self-aggregating long-acting injectable microcrystals","authors":"Vivian R. Feig, Sanghyun Park, Pier Giuseppe Rivano, Jinhee Kim, Benjamin Muller, Ashka Patel, Caroline Dial, Sofia Gonzalez, Hannah Carlisle, Flavia Codreanu, Aaron Lopes, Ayten E. Erdogan, Niora Fabian, Ashley Guevara, Andrew Pettinari, Jason Li, Jia Liang, Gary W. Liu, Mark W. Tibbitt, Giovanni Traverso","doi":"10.1038/s44286-025-00194-x","DOIUrl":"10.1038/s44286-025-00194-x","url":null,"abstract":"Injectable drug depots have transformed our capacity to enhance medication adherence through dose simplification. Central to patient adoption of injectables is the acceptability of needle injections, with needle gauge as a key factor informing patient discomfort. Maximizing drug loading in injectables supports longer drug release while reducing injection volume and discomfort. Here, to address these requirements, we developed self-aggregating long-acting injectable microcrystals (SLIM), an injectable formulation containing drug microcrystals that self-aggregate in the subcutaneous space to form a monolithic implant with a low ratio of polymer excipient to drug (0.0625:1 w/w). By minimizing polymer content, SLIM supports injection through low-profile needles (<25 G) with high drug loading (293 mg ml−1). We demonstrate in vitro and in vivo that self-aggregation is driven by solvent exchange at the injection site and that slower-exchanging solvents result in increased microcrystal compaction and reduced implant porosity. We further show that self-aggregation enhances long-term drug release in rodents. We anticipate that SLIM could enable low-cost interventions for contraceptives. This study reports on self-aggregating injectable microcrystals for administering long-acting drug implants via low-profile needles, a key factor in patient adoption. Microcrystal self-aggregation is engineered through a solvent exchange process to form depots with minimal polymer excipient, demonstrating enhanced long-term release of a model contraceptive drug in rodents.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 3","pages":"209-219"},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44286-025-00194-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programming fluid flow with biological active matter

Nature Chemical Engineering Pub Date : 2025-03-24 DOI: 10.1038/s44286-025-00200-2

Alessio Lavino

引用次数: 0

Reaction engineering in focus

Nature Chemical Engineering Pub Date : 2025-03-24 DOI: 10.1038/s44286-025-00206-w

引用次数: 0

Solar-powered flow reactor

Nature Chemical Engineering Pub Date : 2025-03-24 DOI: 10.1038/s44286-025-00202-0

Mo Qiao

引用次数: 0

Managing dynamic catalyst changes to upgrade reactors and reaction processes

Nature Chemical Engineering Pub Date : 2025-03-14 DOI: 10.1038/s44286-025-00199-6

Hai Wang, Yuexin Wu, Qingsong Luo, Huixin Wu, Feng-Shou Xiao, Liang Wang

{"title":"Managing dynamic catalyst changes to upgrade reactors and reaction processes","authors":"Hai Wang, Yuexin Wu, Qingsong Luo, Huixin Wu, Feng-Shou Xiao, Liang Wang","doi":"10.1038/s44286-025-00199-6","DOIUrl":"10.1038/s44286-025-00199-6","url":null,"abstract":"Metal nanoparticle catalysts can undergo dynamic structural changes within chemical environments. Reaction processes and reactors are often designed to accommodate or exploit these changes to achieve desired performance targets. Consequently, controlling dynamic structural changes can lead to upgrading of reactors and reaction processes. This Perspective summarizes the characteristic dynamic behaviors of supported metal catalysts and their corresponding reactors in current industrial processes. We explore recent advancements in the programmable changes of metal catalysts by controlling reaction environments and metal–support interactions. These techniques offer avenues for upgrading reactors and reaction routes, aiming to improve efficiency and simplify production processes. The need to upgrade existing reactors also raises demands for managing catalyst dynamic structural changes. This Perspective emphasizes the importance of connecting atomic-scale changes in catalyst structure with industrial-scale reactions and reactors, which will advance research in catalysis and reaction engineering. This Perspective discusses the dynamic structural changes of metal nanoparticle catalysts under working conditions and several industrial processes designed to accommodate such changes. The authors highlight the potential for reactor and process upgrades through managing these dynamic catalyst changes.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 3","pages":"169-180"},"PeriodicalIF":0.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Principles of metabolic pathway control by biomolecular condensates in cells

Nature Chemical Engineering Pub Date : 2025-03-12 DOI: 10.1038/s44286-025-00193-y

Dongheon Lee, Mackenzie T. Walls, Ka-Hei Siu, Yifan Dai, Ke Xu, Clifford P. Brangwynne, Ashutosh Chilkoti, José L. Avalos, Lingchong You

{"title":"Principles of metabolic pathway control by biomolecular condensates in cells","authors":"Dongheon Lee, Mackenzie T. Walls, Ka-Hei Siu, Yifan Dai, Ke Xu, Clifford P. Brangwynne, Ashutosh Chilkoti, José L. Avalos, Lingchong You","doi":"10.1038/s44286-025-00193-y","DOIUrl":"10.1038/s44286-025-00193-y","url":null,"abstract":"Phase separation of biomolecules regulates a wide variety of intracellular functions. This process generates membraneless compartments called biomolecular condensates, which can enrich or exclude macromolecules. This property has been exploited to control metabolic pathways by selectively sequestering enzymes within condensates. Here we analyze the conditions under which biomolecular condensates can amplify the yield or selectivity of diverse metabolic pathways. For all these pathways, we show that the efficacy of phase separation can be approximately predicted by a single metric comprising two coarse-grained parameters: the fraction of the enzyme partitioning into the condensates and the change in the enzyme activity inside compared with outside the condensates. We validated the metric using genetically encoded engineered—synthetic—condensates in yeast to regulate acetoin biosynthesis. This metric can guide future experimental efforts in quantifying the relevant parameters to optimize metabolic flux in engineered condensates. Biomolecular condensates have emerged as a promising strategy to control metabolic reactions in living cells. Here the authors use mathematical modeling to uncover the key physical parameters that govern the outcomes of metabolic reactions modulated by condensates. These governing principles are then demonstrated experimentally by modulating the biosynthesis of metabolites in Saccharomyces cerevisiae.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 3","pages":"198-208"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44286-025-00193-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrolyzer engineering through in situ catalyst regeneration

Nature Chemical Engineering Pub Date : 2025-03-12 DOI: 10.1038/s44286-025-00198-7

Yan Jiao, Yao Zheng

引用次数: 0