{"title":"Beyond the fourth paradigm of modeling in chemical engineering","authors":"John R. Kitchin, Victor Alves, Carl D. Laird","doi":"10.1038/s44286-024-00170-x","DOIUrl":"10.1038/s44286-024-00170-x","url":null,"abstract":"Differentiable programming underpins the foundations of machine learning, and enables new approaches to solving chemical engineering problems. This Comment discusses the opportunities and challenges in education and preparing the workforce to leverage these tools. Integration of these skills with domain knowledge can have a substantial impact on the future of chemical engineering.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 1","pages":"11-13"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44286-024-00170-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond molecular transformations in electrochemical porous solid electrolyte reactors","authors":"Ahmad Elgazzar, Haotian Wang","doi":"10.1038/s44286-024-00160-z","DOIUrl":"10.1038/s44286-024-00160-z","url":null,"abstract":"Electrolyzers have been refined to reach a minimized gap between the electrodes, exemplified by the ''zero gap'' membrane electrode assembly in water electrolyzers. This Comment discusses the porous solid electrolyte reactor, where this gap is re-opened to fully leverage ionic transport for broader applications beyond molecular transformations in electrolysis.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 1","pages":"3-7"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44286-024-00160-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yizhen Chen, Jiankang Zhao, Xiao Zhao, Di Wu, Nan Zhang, Junjie Du, Jie Zeng, Xu Li, Miquel Salmeron, Jingyue Liu, Bruce C. Gates
{"title":"Stabilizing supported atom-precise low-nuclearity platinum cluster catalysts by nanoscale confinement","authors":"Yizhen Chen, Jiankang Zhao, Xiao Zhao, Di Wu, Nan Zhang, Junjie Du, Jie Zeng, Xu Li, Miquel Salmeron, Jingyue Liu, Bruce C. Gates","doi":"10.1038/s44286-024-00162-x","DOIUrl":"10.1038/s44286-024-00162-x","url":null,"abstract":"Supported noble metal cluster catalysts provide the advantages of high atom efficiency and size-dependent properties, but their stabilization remains a major challenge for industrial applications. Now we report an approach for the stabilization of nuclearity-controlled platinum nanoclusters with a typical diameter of ~0.7 nm (Pt7−14) confined on CeOx nanoislands on a porous silica support. The clusters were synthesized by the reduction of platinum single atoms on the islands in H2 at 400 °C. Redox cycles led to cluster formation and breakup at hundreds of degrees Celsius, with platinum remaining confined to the respective islands. The clusters maintained their nuclearity and were resistant to sintering in H2 at temperatures of ≤600 °C and atmospheric pressure. Experimental catalyst performance data bolstered by computational results demonstrate that these platinum clusters are more active than mononuclear platinum, also exhibiting higher steady-state activity than larger and smaller platinum clusters for ethylene hydrogenation. Platinum nanoclusters comprising about ten atoms each made by reducing isolated platinum cations in CeOx nests isolated on high-area silica are demonstrated. Two forms of platinum were reversibly interconverted by oxidation/reduction, remaining stably confined to the nests even under severe conditions, in H2 at 600 °C and under atmospheric pressure.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 1","pages":"38-49"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44286-024-00162-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Monitoring and dynamically controlling glucose uptake rate and central metabolism","authors":"Dongqin Ding, Yaru Zhu, Danyang Bai, Tongxin Wan, Sang Yup Lee, Dawei Zhang","doi":"10.1038/s44286-024-00163-w","DOIUrl":"10.1038/s44286-024-00163-w","url":null,"abstract":"The rate of glucose import directly affects the maximum possible flux of central carbon metabolism. However, few tools can directly monitor the cellular glucose uptake rate. Here we report the development of a set of programmable bifunctional glucose uptake rate biosensors (GURBs) for real-time monitoring of glucose uptake rate, which enable the dynamic activation and inhibition of glucose uptake and central metabolism in Escherichia coli. These genetic circuits are used to monitor the glucose uptake rates of strains under different culture conditions. Also, feedback-loop control systems are designed to make cells rely on the glucose uptake rate to tune the target metabolic modules, resulting in a substantial increase of the titers of l-tryptophan, riboflavin and d-lactic acid. The glucose-uptake-rate-responsive genetic circuits developed in this study will serve as an effective tool for the dynamic control of glucose uptake and central metabolism. Glucose uptake is the initial step in cellular metabolism, and its uptake rate directly determines the overall metabolic flow. Here the authors develop a set of programmable bifunctional biosensors for real-time monitoring of glucose uptake rates and dynamic dual control of glucose uptake and central metabolism.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 1","pages":"50-62"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44286-024-00163-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modeling insights to navigate limitations in bipolar membranes","authors":"David Kitto, Jovan Kamcev","doi":"10.1038/s44286-024-00161-y","DOIUrl":"10.1038/s44286-024-00161-y","url":null,"abstract":"Fundamental transport modeling of bipolar membranes has identified sources of inefficiencies in power-generating applications. These insights can guide the development of improved membranes, ultimately aiding in energy recovery across various electrochemical technologies.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 1","pages":"30-31"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A framework for direct CO2 capture from air","authors":"Mo Qiao","doi":"10.1038/s44286-024-00166-7","DOIUrl":"10.1038/s44286-024-00166-7","url":null,"abstract":"","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 1","pages":"27-27"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The human element of process design","authors":"","doi":"10.1038/s44286-024-00165-8","DOIUrl":"10.1038/s44286-024-00165-8","url":null,"abstract":"Considering consumer behavioral norms is important to sustainable design. This Editorial discusses the need to incorporate behavioral patterns into product design and the role that the chemical engineering community can play in fostering a more informed understanding of sustainability among consumers.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"1 12","pages":"788-789"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44286-024-00165-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sustainable alternatives to microplastics from degradable polymer microparticles","authors":"","doi":"10.1038/s44286-024-00156-9","DOIUrl":"10.1038/s44286-024-00156-9","url":null,"abstract":"Degradable poly(β-amino ester) (PAE) polymers can be used as a scalable alternative to microplastics in personal care products and nutrient delivery. This study demonstrates the effectiveness of PAE microparticles in skin exfoliation and nutrient protection, providing a potential eco-friendly solution to reduce microplastic pollution and its associated environmental and health impacts.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 1","pages":"36-37"},"PeriodicalIF":0.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Life at low Reynolds number isn’t such a drag","authors":"Sujit S. Datta","doi":"10.1038/s44286-024-00147-w","DOIUrl":"10.1038/s44286-024-00147-w","url":null,"abstract":"Sujit Datta discusses how scaling arguments, dimensional analysis and chemical engineering fundamentals can be used to describe microbial swimming.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"1 12","pages":"787-787"},"PeriodicalIF":0.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Extracting lithium from salt-lake brine","authors":"Yanfei Zhu","doi":"10.1038/s44286-024-00158-7","DOIUrl":"10.1038/s44286-024-00158-7","url":null,"abstract":"","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"1 12","pages":"725-725"},"PeriodicalIF":0.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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