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System-level design of lipid nanoparticles for targeted RNA delivery 用于靶向RNA递送的脂质纳米颗粒的系统级设计
IF 29.7
Nature Chemical Engineering Pub Date : 2026-09-01 DOI: 10.1038/s44286-026-00431-x
Emily L. Han, Michael J. Mitchell
{"title":"System-level design of lipid nanoparticles for targeted RNA delivery","authors":"Emily L. Han, Michael J. Mitchell","doi":"10.1038/s44286-026-00431-x","DOIUrl":"10.1038/s44286-026-00431-x","url":null,"abstract":"Nucleic acid and gene therapies stand to revolutionize the treatment of cancers, genetic diseases, neurological disorders, and more. This Comment discusses critical biological phenomena across scales that should be considered when designing lipid nanoparticles for targeted delivery of nucleic acids, as well as computational and high-throughput technologies for studying these phenomena.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"3 9","pages":"483-487"},"PeriodicalIF":29.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149014810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting drug delivery technologies 靶向给药技术
IF 29.7
Nature Chemical Engineering Pub Date : 2026-08-24 DOI: 10.1038/s44286-026-00434-8
{"title":"Targeting drug delivery technologies","authors":"","doi":"10.1038/s44286-026-00434-8","DOIUrl":"10.1038/s44286-026-00434-8","url":null,"abstract":"In one of our earliest Editorials, we touched on the emergence of biomolecular engineering as a prominent subfield within chemical engineering. Here, we dive a level deeper to focus on drug delivery and its connections to core chemical engineering principles.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"3 8","pages":"431-431"},"PeriodicalIF":29.7,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44286-026-00434-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pinned solid-state MnO2 channels enhance lanthanide separation 固定的固态MnO2通道增强了镧系元素的分离
IF 29.7
Nature Chemical Engineering Pub Date : 2026-08-20 DOI: 10.1038/s44286-026-00436-6
{"title":"Pinned solid-state MnO2 channels enhance lanthanide separation","authors":"","doi":"10.1038/s44286-026-00436-6","DOIUrl":"10.1038/s44286-026-00436-6","url":null,"abstract":"Lanthanides can be challenging to efficiently separate with high selectivity. Now, ionic channels in layered manganese oxide are shown to facilitate the aqueous separation of lanthanides through differences in confinement-induced phase changes and ion dehydration and coordination. Pinning the channel spacing with Mg2+ ions increases selectivity between pairs of light lanthanides.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"3 9","pages":"494-495"},"PeriodicalIF":29.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149014755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydrogen on the move 氢在移动
IF 29.7
Nature Chemical Engineering Pub Date : 2026-08-20 DOI: 10.1038/s44286-026-00440-w
Yanfei Zhu
{"title":"Hydrogen on the move","authors":"Yanfei Zhu","doi":"10.1038/s44286-026-00440-w","DOIUrl":"10.1038/s44286-026-00440-w","url":null,"abstract":"","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"3 8","pages":"435-435"},"PeriodicalIF":29.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Merging performance with manufacturability 将性能与可制造性相结合
IF 29.7
Nature Chemical Engineering Pub Date : 2026-08-19 DOI: 10.1038/s44286-026-00439-3
Mo Qiao
{"title":"Merging performance with manufacturability","authors":"Mo Qiao","doi":"10.1038/s44286-026-00439-3","DOIUrl":"10.1038/s44286-026-00439-3","url":null,"abstract":"","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"3 8","pages":"434-434"},"PeriodicalIF":29.7,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shifting gears from scalability to efficiency in bioplastics manufacturing 生物塑料制造从可扩展性转向效率
IF 29.7
Nature Chemical Engineering Pub Date : 2026-08-19 DOI: 10.1038/s44286-026-00429-5
Marie J. Jones, Jeremy S. Luterbacher
{"title":"Shifting gears from scalability to efficiency in bioplastics manufacturing","authors":"Marie J. Jones, Jeremy S. Luterbacher","doi":"10.1038/s44286-026-00429-5","DOIUrl":"10.1038/s44286-026-00429-5","url":null,"abstract":"With polylactic acid being produced at an industrial scale, the next challenge is to improve efficiency and integrate recycled feedstocks. Now, an intensified esterification–dimerization route for producing l-lactide, identified through a combination of experiments, kinetic modeling and industrial-scale process simulations, offers the potential for higher yields, lower costs, reduced emissions and improved circularity.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"3 8","pages":"436-438"},"PeriodicalIF":29.7,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoclusters in waste-derived electrolyte build electric fields at battery interfaces 废电解液中的纳米团簇在电池界面处形成电场
IF 29.7
Nature Chemical Engineering Pub Date : 2026-08-19 DOI: 10.1038/s44286-026-00432-w
{"title":"Nanoclusters in waste-derived electrolyte build electric fields at battery interfaces","authors":"","doi":"10.1038/s44286-026-00432-w","DOIUrl":"10.1038/s44286-026-00432-w","url":null,"abstract":"Industrial waste liquids are often purified before reuse or discarded. Now, zeolite washing supernatants are shown to contain charge-heterogeneous nanofragments that can be used in aqueous Zn battery electrolytes. During Zn plating, these fragments self-assemble into a gradient interphase with a built-in electric field, guiding Zn ion transport and stabilizing Zn deposition.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"3 9","pages":"496-497"},"PeriodicalIF":29.7,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149014812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renewable energy that weathers the storm 可再生能源可以抵御风暴
IF 29.7
Nature Chemical Engineering Pub Date : 2026-08-18 DOI: 10.1038/s44286-026-00435-7
Thomas Dursch
{"title":"Renewable energy that weathers the storm","authors":"Thomas Dursch","doi":"10.1038/s44286-026-00435-7","DOIUrl":"10.1038/s44286-026-00435-7","url":null,"abstract":"","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"3 8","pages":"432-432"},"PeriodicalIF":29.7,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How the cell nucleus gets in shape 细胞核是如何形成的
IF 29.7
Nature Chemical Engineering Pub Date : 2026-08-18 DOI: 10.1038/s44286-026-00430-y
Richard B. Dickinson, Tanmay P. Lele
{"title":"How the cell nucleus gets in shape","authors":"Richard B. Dickinson, Tanmay P. Lele","doi":"10.1038/s44286-026-00430-y","DOIUrl":"10.1038/s44286-026-00430-y","url":null,"abstract":"Richard Dickinson and Tanmay Lele explain that the mammalian cell nucleus deforms with fixed surface area and volume and that limiting nuclear shapes in cells are governed by interfacial tension.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"3 8","pages":"481-481"},"PeriodicalIF":29.7,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transforming waste at droplet interfaces 在液滴界面处转化废物
IF 29.7
Nature Chemical Engineering Pub Date : 2026-08-18 DOI: 10.1038/s44286-026-00437-5
Alessio Lavino
{"title":"Transforming waste at droplet interfaces","authors":"Alessio Lavino","doi":"10.1038/s44286-026-00437-5","DOIUrl":"10.1038/s44286-026-00437-5","url":null,"abstract":"","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"3 8","pages":"433-433"},"PeriodicalIF":29.7,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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