Head & Neck最新文献_第6页

Significant association of SRC protein expression with the progression, recurrence, and prognosis of oral squamous cell carcinoma in Taiwan. SRC蛋白表达与台湾口腔鳞状细胞癌的进展、复发及预后有显著关联。

IF 2.9

Head & Neck Pub Date : 2012-09-01 Epub Date: 2011-11-02 DOI: 10.1002/hed.21923

Shih-Jung Cheng, Sang-Heng Kok, Jang-Jaer Lee, Mark Yen-Ping Kuo, Shih-Lung Cheng, Ying-Luo Huang, Hsin-Ming Chen, Hao-Hueng Chang, Chun-Pin Chiang

{"title":"Significant association of SRC protein expression with the progression, recurrence, and prognosis of oral squamous cell carcinoma in Taiwan.","authors":"Shih-Jung Cheng, Sang-Heng Kok, Jang-Jaer Lee, Mark Yen-Ping Kuo, Shih-Lung Cheng, Ying-Luo Huang, Hsin-Ming Chen, Hao-Hueng Chang, Chun-Pin Chiang","doi":"10.1002/hed.21923","DOIUrl":"https://doi.org/10.1002/hed.21923","url":null,"abstract":"Background: Src protein overexpression correlates with progression and prognosis of a variety of human cancers.Methods: This study used immunohistochemistry to examine the expression of Src protein in 93 specimens of oral squamous cell carcinoma (OSCC).Results: We found a significant association of high expression of Src protein (labeling indices >50%) with larger tumor size (p = .017), positive lymph node metastasis (p = .030), more advanced clinical stages (p = .007), and recurrence (p < .001) of OSCC. High expression of Src protein was identified as an independent unfavorable prognosis factor by multivariate Cox regression analysis. The Kaplan-Meier curve showed that patients with OSCC with high expression of Src protein had a significantly poorer cumulative survival than those with low expression of Src protein (log-rank test, p = .00267).Conclusion: The expression of Src protein is significantly associated with the progression, recurrence, and prognosis of OSCCs in Taiwan.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1340-5"},"PeriodicalIF":2.9,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.21923","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40128490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Highly selective A(1) -adenosine-agonist (2-chloro-N6-cyclopentyladenosine) and reduction of flap necrosis in adipocutaneous flaps in rats. 高选择性A(1) -腺苷激动剂(2-氯- n6 -环戊基腺苷)和减少大鼠脂肪皮肤皮瓣坏死。

IF 2.9

Head & Neck Pub Date : 2012-08-01 Epub Date: 2011-10-29 DOI: 10.1002/hed.21869

Andreas K Dacho, Stefan Lyutenski, Gabriela Aust, Andreas Dietz

{"title":"Highly selective A(1) -adenosine-agonist (2-chloro-N6-cyclopentyladenosine) and reduction of flap necrosis in adipocutaneous flaps in rats.","authors":"Andreas K Dacho, Stefan Lyutenski, Gabriela Aust, Andreas Dietz","doi":"10.1002/hed.21869","DOIUrl":"https://doi.org/10.1002/hed.21869","url":null,"abstract":"Background: The 2-chloro-N6-cyclopentyladenosine (CCPA) was proven to be a protective factor in ischemic reperfusion injury in myocardium and to reduce the infarct size in the heart. The purpose of this study was to determine whether flap necrosis could be reduced by intravenous administration of CCPA.Methods: Fifty-six male Wistar rats were divided into 4 experimental groups. An epigastric adipocutaneous flap was raised, and the area of flap necrosis was assessed for all groups on the fifth postoperative day with planimetry software.Results: The control group had a significantly lower rate of flap necrosis than the ischemic control group (p < .05). The nonischemic CCPA group had a significantly lower rate of flap necrosis than the nonischemic control group (p < .05). The ischemic CCPA group had a highly significant (p < .0001) rate of lower flap necrosis than the ischemic control group.Conclusion: Our data show that reduction of flap necrosis can be achieved both with and without ischemic periods by intravenous administration of CCPA.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1100-5"},"PeriodicalIF":2.9,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.21869","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40116052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Treatment of breast adenocarcinoma metastasis to the neck: dedifferentiation of the tumor as suggested by hormone markers. 乳腺腺癌颈部转移的治疗:激素标志物提示肿瘤去分化。

IF 2.9

Head & Neck Pub Date : 2012-08-01 Epub Date: 2011-10-29 DOI: 10.1002/hed.21852

Eleanor L Sproson, M Kerry Herd, Anne V Spedding, Peter A Brennan, Roberto Puxeddu

{"title":"Treatment of breast adenocarcinoma metastasis to the neck: dedifferentiation of the tumor as suggested by hormone markers.","authors":"Eleanor L Sproson, M Kerry Herd, Anne V Spedding, Peter A Brennan, Roberto Puxeddu","doi":"10.1002/hed.21852","DOIUrl":"https://doi.org/10.1002/hed.21852","url":null,"abstract":"Background: Breast carcinoma rarely metastasizes to the neck, and its management in this area is controversial. There is little published data about whether hormone receptor status changes between primary breast tumors and neck metastasis and whether this influences management.Methods: We evaluated the demographics and treatment of 13 patients presenting with neck metastasis. We used immunochemistry to assess estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 in the primary and metastatic neck nodes.Results: Hormone receptor status changed in some patients (23% for estrogen receptor, and 31% for progesterone receptor). Three patients had complete excision of their neck disease and subsequent good local control. None of our patients survived despite treatment.Conclusion: The change in hormone status could suggest tumor dedifferentiation. Surgical resection, where possible, achieves good local control for these patients, but, because survival is poor, it is only recommended when it results in little significant morbidity.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1095-9"},"PeriodicalIF":2.9,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.21852","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40115303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Gene-environment interactions of novel variants associated with head and neck cancer. 与头颈癌相关的新变异的基因-环境相互作用。

IF 2.9

Head & Neck Pub Date : 2012-08-01 Epub Date: 2011-11-02 DOI: 10.1002/hed.21867

Caihua Liang, Carmen J Marsit, E Andres Houseman, Rondi Butler, Heather H Nelson, Michael D McClean, Karl T Kelsey

{"title":"Gene-environment interactions of novel variants associated with head and neck cancer.","authors":"Caihua Liang, Carmen J Marsit, E Andres Houseman, Rondi Butler, Heather H Nelson, Michael D McClean, Karl T Kelsey","doi":"10.1002/hed.21867","DOIUrl":"https://doi.org/10.1002/hed.21867","url":null,"abstract":"Background: A genome-wide association study for upper aerodigestive tract cancers identified 19 candidate single-nucleotide polymorphisms (SNPs). We used these SNPs to investigate the potential gene-gene and gene-environment interactions in head and neck squamous cell carcinoma (HNSCC) risk.Methods: The 19 variants were genotyped using Taqman assays among 575 cases and 676 controls in our population-based case-control study.Results: A restricted cubic spline model suggested both ADH1B and HEL308 modified the association between smoking pack-years and HNSCC. Classification and regression tree analysis demonstrated a higher-order interaction between smoking status, ADH1B, FLJ13089, and FLJ35784 in HNSCC risk. Compared with ever smokers carrying ADH1B T/C+T/T genotypes, smokers carrying ADH1B C/C genotype and FLJ13089 A/G+A/A genotypes had the highest risk of HNSCC (odds ratio = 1.84).Conclusions: Our results suggest that the risk associated with these variants may be specifically important among specific exposure groups.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1111-8"},"PeriodicalIF":2.9,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.21867","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40128212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Feasibility of reirradiation of recurrent sinonasal carcinoma in the periorbital region using hypofractionated image-guided intensity-modulated radiation therapy. 低分割图像引导调强放射治疗眶周复发鼻窦癌再照射的可行性。

IF 2.9

Head & Neck Pub Date : 2011-09-01 Epub Date: 2010-05-19 DOI: 10.1002/hed.21385

Anuradha Thiagarajan, James Mechalakos, Nancy Lee

{"title":"Feasibility of reirradiation of recurrent sinonasal carcinoma in the periorbital region using hypofractionated image-guided intensity-modulated radiation therapy.","authors":"Anuradha Thiagarajan, James Mechalakos, Nancy Lee","doi":"10.1002/hed.21385","DOIUrl":"https://doi.org/10.1002/hed.21385","url":null,"abstract":"Background: Recurrent periorbital tumors pose management challenges because they are often unresectable and chemorefractory. Proximity to critical structures renders reirradiation difficult. With image-guided intensity-modulated radiation therapy (IG-IMRT), real-time corrections to patient setup are possible, enabling significant shrinkage of planning target volume margins and safe dose escalation with hypofractionation. Here, we present our experience with hypofractionated IG-IMRT in a patient with multiply recurrent sinonasal carcinomas in the periorbital region.Methods: The patient is a 67-year-old woman with sinonasal carcinoma, treated with surgery and 2 prior courses of high-dose radiotherapy. She developed a second tumor recurrence in the right lateral orbit, which was reirradiated using hypofractionated IG-IMRT (24 Gy in 3 fractions).Results: Near-complete resolution of her ocular symptoms was observed at 4 months. Progress scans demonstrated a decrease in size of the orbital lesion.Conclusion: Preliminary results of reirradiation using hypofractionated IG-IMRT suggest that it is safe and effective.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1372-8"},"PeriodicalIF":2.9,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.21385","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40076390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Necrotizing fasciitis of the head and neck. 头颈部坏死性筋膜炎。

IF 2.9

Head & Neck Pub Date : 2010-12-01 DOI: 10.1002/hed.21367

Henning Wolf, Maria Rusan, Karin Lambertsen, Therese Ovesen

{"title":"Necrotizing fasciitis of the head and neck.","authors":"Henning Wolf, Maria Rusan, Karin Lambertsen, Therese Ovesen","doi":"10.1002/hed.21367","DOIUrl":"https://doi.org/10.1002/hed.21367","url":null,"abstract":"Background: Necrotizing fasciitis of the head and neck is a rapidly progressing and life-threatening condition. The purpose of this study was to describe the patients with a focus on clinical presentation, microbiology, treatment, and prognosis.Patients and results: Seventeen patients (10 men; median age, 54 years) were included. Nine patients underwent minor head and neck surgery immediately prior to necrotizing fasciitis. The typical course was a quickly spreading erythema, pronounced tenderness, and severe pain. Imaging demonstrated diffuse swelling of the soft tissue, poorly differentiated dilated fat layers, and subcutaneous gas. All patients underwent surgical debridement within 2 days, and received broad-spectrum antibiotics and hemodynamic support, hyperbaric oxygen, and immunoglobulin. All patients survived, although 12 of 17 suffered sequelae.Conclusions: Early diagnosis is of utmost importance. Quickly spreading erythema and extreme pain in the affected area serve as red flags. With the current intensive multimodality regimen, the mortality was zero, although 70% suffered sequelae.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1592-6"},"PeriodicalIF":2.9,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.21367","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40075335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 63

Temoporfin-mediated photodynamic therapy in patients with advanced, incurable head and neck cancer: A multicenter study. 临时oporfin介导的光动力治疗晚期无法治愈的头颈癌患者:一项多中心研究

IF 2.9

Head & Neck Pub Date : 2010-12-01 DOI: 10.1002/hed.21368

Ing Bing Tan, Gilles Dolivet, Philippe Ceruse, Vincent Vander Poorten, Gerda Roest, Winrich Rauschning

{"title":"Temoporfin-mediated photodynamic therapy in patients with advanced, incurable head and neck cancer: A multicenter study.","authors":"Ing Bing Tan, Gilles Dolivet, Philippe Ceruse, Vincent Vander Poorten, Gerda Roest, Winrich Rauschning","doi":"10.1002/hed.21368","DOIUrl":"https://doi.org/10.1002/hed.21368","url":null,"abstract":"Background: The aim of this study was to confirm the efficacy of temoporfin (Foscan)-mediated photodynamic therapy (PDT) in patients with end-stage head and neck squamous cell carcinoma (HNSCC).Methods: Thirty-nine patients with recurring HNSCC lesions ≤10 mm in depth were injected with temoporfin, followed by illumination of the tumor surface.Results: Of 39 treated patients, 19 achieved complete response, 2 partial response, 5 stable disease, 5 had progressive disease, and 8 patients were nonevaluable. Thus, in the per-protocol analysis, the response rate was 68%. Of the treated patients 54% had a response. Median survival was significantly longer for responders (37 months) than for nonresponders (7.4 months). Nine patients were alive at 3.7 to 6.5 years (median, 4.8 years) post-treatment, 7 free of disease. No major toxicities were observed.Conclusions: Patients with advanced HNSCC with lesions ≤10 mm in depth, who have exhausted other treatment options, can achieve significant local control and survival benefit from temoporfin-mediated PDT.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1597-604"},"PeriodicalIF":2.9,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.21368","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40075336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 87

Squamous cell carcinoma of base of tongue in a patient with Fanconi's anemia treated with radiation therapy: case report and review of literature. 放射治疗范可尼贫血患者舌底鳞状细胞癌1例报告及文献复习。

IF 2.9

Head & Neck Pub Date : 2010-10-01 DOI: 10.1002/hed.21211

Ashwini Budrukkar, Tanweer Shahid, Vedang Murthy, Tabish Hussain, Rita Mulherkar, Babu Rao Vundinti, Mandar Deshpande, Manju Sengar, Sarbani Ghosh Laskar, Jai Prakash Agarwal

{"title":"Squamous cell carcinoma of base of tongue in a patient with Fanconi's anemia treated with radiation therapy: case report and review of literature.","authors":"Ashwini Budrukkar, Tanweer Shahid, Vedang Murthy, Tabish Hussain, Rita Mulherkar, Babu Rao Vundinti, Mandar Deshpande, Manju Sengar, Sarbani Ghosh Laskar, Jai Prakash Agarwal","doi":"10.1002/hed.21211","DOIUrl":"https://doi.org/10.1002/hed.21211","url":null,"abstract":"Background: Fanconi's anemia (FA) is a rare autosomal recessive genetic disorder characterized by congenital anomalies, progressive aplastic anemia, and a predisposition for malignancies. Solid tumors in the head and neck region, especially in the tongue, are rarely observed. Management of these patients is a challenge because of hematological complications and increased toxicities.Methods: We report a case of Fanconi's anemia in a 27-year-old man with carcinoma of the base of tongue (T2N0M0) who was treated with radical radiation therapy to a dose of 70 Gy/35 fractions/51 days. We have also done in vitro radiosensitivity tests.Results: The patient tolerated the radiation treatment well and completed it without any interruptions. In vitro studies did not show any increased radiosensitivity in this patient.Conclusion: Head and neck cancer in a patient with FA requires individualized treatment. The decision about opting for different modalities should be based on a balanced approach with respect to locoregional control and toxicities of the treatment.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1422-7"},"PeriodicalIF":2.9,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.21211","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40028081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Epidermal growth factor receptor targeted therapy of squamous cell carcinoma of the head and neck. 表皮生长因子受体靶向治疗头颈部鳞状细胞癌。

IF 2.9

Head & Neck Pub Date : 2010-10-01 DOI: 10.1002/hed.21365

Mark E Sharafinski, Robert L Ferris, Soldano Ferrone, Jennifer R Grandis

{"title":"Epidermal growth factor receptor targeted therapy of squamous cell carcinoma of the head and neck.","authors":"Mark E Sharafinski, Robert L Ferris, Soldano Ferrone, Jennifer R Grandis","doi":"10.1002/hed.21365","DOIUrl":"https://doi.org/10.1002/hed.21365","url":null,"abstract":"Background: Cumulative evidence implicates the epidermal growth factor receptor (EGFR) as an important therapeutic target in head and neck squamous cell carcinoma (HNSCC). The basis for the lack of correlation between EGFR expression in the HNSCC tumor and clinical responses to EGFR inhibitors is incompletely understood. Although a variety of mechanisms likely contribute to the effectiveness of EGFR blockade, this review focuses on the biologic implications of known EGFR variations and the role of the immune system in mediating clinical responses to EGFR inhibitors.Methods: A Medline review of articles published in the last 10 years (1999-present) on EGFR in HNSCC was performed in combination with preliminary data from our laboratories.Results: Studies published to date suggest no association between the expression of EGFR on HNSCC tumors and clinical responses to EGFR inhibitors. Several mechanisms have been proposed to mediate clinical response to EGFR inhibitors in HNSCC. Cumulative results from our laboratories support the role of several mechanisms, including cellular immune activation and mutated EGFR variants, in contributing to the discrepancy between level of EGFR expression and clinical response to EGFR inhibitors.Conclusion: The efficacy of EGFR targeted therapies may be mediated, at least in part, by the immune system and the presence of the truncated EGFR variant, EGFRvIII, among other factors. Criteria to identify the subset of patients likely to be responsive to EGFR targeted therapies are needed.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1412-21"},"PeriodicalIF":2.9,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.21365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40075334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 124

Giant funicular intrapharyngeal schwannoma. 巨大索状咽内神经鞘瘤。

IF 2.9

Head & Neck Pub Date : 2008-08-01 DOI: 10.1002/hed.20754

Milan B Jovanovic, Zoran S Milutinovic, Mile S Strbac, Jelena V Perovic, Sanja A Milenkovic

引用次数: 4