Squamous cell carcinoma of base of tongue in a patient with Fanconi's anemia treated with radiation therapy: case report and review of literature.

Head & Neck Pub Date : 2010-10-01 DOI:10.1002/hed.21211

Ashwini Budrukkar, Tanweer Shahid, Vedang Murthy, Tabish Hussain, Rita Mulherkar, Babu Rao Vundinti, Mandar Deshpande, Manju Sengar, Sarbani Ghosh Laskar, Jai Prakash Agarwal

{"title":"Squamous cell carcinoma of base of tongue in a patient with Fanconi's anemia treated with radiation therapy: case report and review of literature.","authors":"Ashwini Budrukkar, Tanweer Shahid, Vedang Murthy, Tabish Hussain, Rita Mulherkar, Babu Rao Vundinti, Mandar Deshpande, Manju Sengar, Sarbani Ghosh Laskar, Jai Prakash Agarwal","doi":"10.1002/hed.21211","DOIUrl":null,"url":null,"abstract":"Background: Fanconi's anemia (FA) is a rare autosomal recessive genetic disorder characterized by congenital anomalies, progressive aplastic anemia, and a predisposition for malignancies. Solid tumors in the head and neck region, especially in the tongue, are rarely observed. Management of these patients is a challenge because of hematological complications and increased toxicities.Methods: We report a case of Fanconi's anemia in a 27-year-old man with carcinoma of the base of tongue (T2N0M0) who was treated with radical radiation therapy to a dose of 70 Gy/35 fractions/51 days. We have also done in vitro radiosensitivity tests.Results: The patient tolerated the radiation treatment well and completed it without any interruptions. In vitro studies did not show any increased radiosensitivity in this patient.Conclusion: Head and neck cancer in a patient with FA requires individualized treatment. The decision about opting for different modalities should be based on a balanced approach with respect to locoregional control and toxicities of the treatment.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1422-7"},"PeriodicalIF":0.0000,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.21211","citationCount":"18","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Head & Neck","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/hed.21211","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 18

Abstract

Background: Fanconi's anemia (FA) is a rare autosomal recessive genetic disorder characterized by congenital anomalies, progressive aplastic anemia, and a predisposition for malignancies. Solid tumors in the head and neck region, especially in the tongue, are rarely observed. Management of these patients is a challenge because of hematological complications and increased toxicities.

Methods: We report a case of Fanconi's anemia in a 27-year-old man with carcinoma of the base of tongue (T2N0M0) who was treated with radical radiation therapy to a dose of 70 Gy/35 fractions/51 days. We have also done in vitro radiosensitivity tests.

Results: The patient tolerated the radiation treatment well and completed it without any interruptions. In vitro studies did not show any increased radiosensitivity in this patient.

Conclusion: Head and neck cancer in a patient with FA requires individualized treatment. The decision about opting for different modalities should be based on a balanced approach with respect to locoregional control and toxicities of the treatment.

查看原文本刊更多论文

放射治疗范可尼贫血患者舌底鳞状细胞癌1例报告及文献复习。

背景:范可尼贫血(FA)是一种罕见的常染色体隐性遗传疾病，以先天性异常、进行性再生障碍性贫血和恶性肿瘤易感性为特征。在头颈部的实体瘤，特别是在舌头，是很少观察到的。由于血液学并发症和毒性增加，这些患者的管理是一项挑战。方法:我们报告一例27岁男性舌底癌(T2N0M0)的范可尼贫血，他接受了70 Gy/35次/51天的放射治疗。我们还进行了体外放射敏感性试验。结果:患者对放疗耐受良好，无间断完成放疗。体外研究未显示该患者放射敏感性增加。结论:FA患者的头颈癌需要个体化治疗。选择不同方式的决定应基于局部区域控制和治疗毒性的平衡方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Head & Neck

自引率

0.00%

发文量