Gene-environment interactions of novel variants associated with head and neck cancer.

Head & Neck Pub Date : 2012-08-01 Epub Date: 2011-11-02 DOI:10.1002/hed.21867

Caihua Liang, Carmen J Marsit, E Andres Houseman, Rondi Butler, Heather H Nelson, Michael D McClean, Karl T Kelsey

{"title":"Gene-environment interactions of novel variants associated with head and neck cancer.","authors":"Caihua Liang, Carmen J Marsit, E Andres Houseman, Rondi Butler, Heather H Nelson, Michael D McClean, Karl T Kelsey","doi":"10.1002/hed.21867","DOIUrl":null,"url":null,"abstract":"Background: A genome-wide association study for upper aerodigestive tract cancers identified 19 candidate single-nucleotide polymorphisms (SNPs). We used these SNPs to investigate the potential gene-gene and gene-environment interactions in head and neck squamous cell carcinoma (HNSCC) risk.Methods: The 19 variants were genotyped using Taqman assays among 575 cases and 676 controls in our population-based case-control study.Results: A restricted cubic spline model suggested both ADH1B and HEL308 modified the association between smoking pack-years and HNSCC. Classification and regression tree analysis demonstrated a higher-order interaction between smoking status, ADH1B, FLJ13089, and FLJ35784 in HNSCC risk. Compared with ever smokers carrying ADH1B T/C+T/T genotypes, smokers carrying ADH1B C/C genotype and FLJ13089 A/G+A/A genotypes had the highest risk of HNSCC (odds ratio = 1.84).Conclusions: Our results suggest that the risk associated with these variants may be specifically important among specific exposure groups.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1111-8"},"PeriodicalIF":0.0000,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.21867","citationCount":"24","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Head & Neck","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/hed.21867","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2011/11/2 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 24

Abstract

Background: A genome-wide association study for upper aerodigestive tract cancers identified 19 candidate single-nucleotide polymorphisms (SNPs). We used these SNPs to investigate the potential gene-gene and gene-environment interactions in head and neck squamous cell carcinoma (HNSCC) risk.

Methods: The 19 variants were genotyped using Taqman assays among 575 cases and 676 controls in our population-based case-control study.

Results: A restricted cubic spline model suggested both ADH1B and HEL308 modified the association between smoking pack-years and HNSCC. Classification and regression tree analysis demonstrated a higher-order interaction between smoking status, ADH1B, FLJ13089, and FLJ35784 in HNSCC risk. Compared with ever smokers carrying ADH1B T/C+T/T genotypes, smokers carrying ADH1B C/C genotype and FLJ13089 A/G+A/A genotypes had the highest risk of HNSCC (odds ratio = 1.84).

Conclusions: Our results suggest that the risk associated with these variants may be specifically important among specific exposure groups.

Abstract Image

查看原文本刊更多论文

与头颈癌相关的新变异的基因-环境相互作用。

背景:一项上消化道癌症的全基因组关联研究发现了19个候选单核苷酸多态性(snp)。我们使用这些snp来研究头颈部鳞状细胞癌(HNSCC)风险中潜在的基因-基因和基因-环境相互作用。方法:在我们基于人群的病例对照研究中，采用Taqman法对575例患者和676例对照组的19种变异进行基因分型。结果:限制三次样条模型表明，ADH1B和HEL308都改变了吸烟包年与HNSCC之间的关系。分类和回归树分析表明，吸烟状况、ADH1B、FLJ13089和FLJ35784在HNSCC风险中存在高阶相互作用。与携带ADH1B T/C+T/T基因型的吸烟者相比，携带ADH1B C/C基因型和FLJ13089 A/G+A/A基因型的吸烟者发生HNSCC的风险最高(优势比= 1.84)。结论:我们的研究结果表明，与这些变异相关的风险可能在特定暴露组中特别重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Head & Neck

自引率

0.00%

发文量