{"title":"SRC蛋白表达与台湾口腔鳞状细胞癌的进展、复发及预后有显著关联。","authors":"Shih-Jung Cheng, Sang-Heng Kok, Jang-Jaer Lee, Mark Yen-Ping Kuo, Shih-Lung Cheng, Ying-Luo Huang, Hsin-Ming Chen, Hao-Hueng Chang, Chun-Pin Chiang","doi":"10.1002/hed.21923","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Src protein overexpression correlates with progression and prognosis of a variety of human cancers.</p><p><strong>Methods: </strong>This study used immunohistochemistry to examine the expression of Src protein in 93 specimens of oral squamous cell carcinoma (OSCC).</p><p><strong>Results: </strong>We found a significant association of high expression of Src protein (labeling indices >50%) with larger tumor size (p = .017), positive lymph node metastasis (p = .030), more advanced clinical stages (p = .007), and recurrence (p < .001) of OSCC. High expression of Src protein was identified as an independent unfavorable prognosis factor by multivariate Cox regression analysis. The Kaplan-Meier curve showed that patients with OSCC with high expression of Src protein had a significantly poorer cumulative survival than those with low expression of Src protein (log-rank test, p = .00267).</p><p><strong>Conclusion: </strong>The expression of Src protein is significantly associated with the progression, recurrence, and prognosis of OSCCs in Taiwan.</p>","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1340-5"},"PeriodicalIF":0.0000,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.21923","citationCount":"18","resultStr":"{\"title\":\"Significant association of SRC protein expression with the progression, recurrence, and prognosis of oral squamous cell carcinoma in Taiwan.\",\"authors\":\"Shih-Jung Cheng, Sang-Heng Kok, Jang-Jaer Lee, Mark Yen-Ping Kuo, Shih-Lung Cheng, Ying-Luo Huang, Hsin-Ming Chen, Hao-Hueng Chang, Chun-Pin Chiang\",\"doi\":\"10.1002/hed.21923\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Src protein overexpression correlates with progression and prognosis of a variety of human cancers.</p><p><strong>Methods: </strong>This study used immunohistochemistry to examine the expression of Src protein in 93 specimens of oral squamous cell carcinoma (OSCC).</p><p><strong>Results: </strong>We found a significant association of high expression of Src protein (labeling indices >50%) with larger tumor size (p = .017), positive lymph node metastasis (p = .030), more advanced clinical stages (p = .007), and recurrence (p < .001) of OSCC. High expression of Src protein was identified as an independent unfavorable prognosis factor by multivariate Cox regression analysis. The Kaplan-Meier curve showed that patients with OSCC with high expression of Src protein had a significantly poorer cumulative survival than those with low expression of Src protein (log-rank test, p = .00267).</p><p><strong>Conclusion: </strong>The expression of Src protein is significantly associated with the progression, recurrence, and prognosis of OSCCs in Taiwan.</p>\",\"PeriodicalId\":501638,\"journal\":{\"name\":\"Head & Neck\",\"volume\":\" \",\"pages\":\"1340-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/hed.21923\",\"citationCount\":\"18\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Head & Neck\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/hed.21923\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2011/11/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Head & Neck","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/hed.21923","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2011/11/2 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Significant association of SRC protein expression with the progression, recurrence, and prognosis of oral squamous cell carcinoma in Taiwan.
Background: Src protein overexpression correlates with progression and prognosis of a variety of human cancers.
Methods: This study used immunohistochemistry to examine the expression of Src protein in 93 specimens of oral squamous cell carcinoma (OSCC).
Results: We found a significant association of high expression of Src protein (labeling indices >50%) with larger tumor size (p = .017), positive lymph node metastasis (p = .030), more advanced clinical stages (p = .007), and recurrence (p < .001) of OSCC. High expression of Src protein was identified as an independent unfavorable prognosis factor by multivariate Cox regression analysis. The Kaplan-Meier curve showed that patients with OSCC with high expression of Src protein had a significantly poorer cumulative survival than those with low expression of Src protein (log-rank test, p = .00267).
Conclusion: The expression of Src protein is significantly associated with the progression, recurrence, and prognosis of OSCCs in Taiwan.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
