Significant association of SRC protein expression with the progression, recurrence, and prognosis of oral squamous cell carcinoma in Taiwan.

Head & Neck Pub Date : 2012-09-01 Epub Date: 2011-11-02 DOI:10.1002/hed.21923

Shih-Jung Cheng, Sang-Heng Kok, Jang-Jaer Lee, Mark Yen-Ping Kuo, Shih-Lung Cheng, Ying-Luo Huang, Hsin-Ming Chen, Hao-Hueng Chang, Chun-Pin Chiang

{"title":"Significant association of SRC protein expression with the progression, recurrence, and prognosis of oral squamous cell carcinoma in Taiwan.","authors":"Shih-Jung Cheng, Sang-Heng Kok, Jang-Jaer Lee, Mark Yen-Ping Kuo, Shih-Lung Cheng, Ying-Luo Huang, Hsin-Ming Chen, Hao-Hueng Chang, Chun-Pin Chiang","doi":"10.1002/hed.21923","DOIUrl":null,"url":null,"abstract":"Background: Src protein overexpression correlates with progression and prognosis of a variety of human cancers.Methods: This study used immunohistochemistry to examine the expression of Src protein in 93 specimens of oral squamous cell carcinoma (OSCC).Results: We found a significant association of high expression of Src protein (labeling indices >50%) with larger tumor size (p = .017), positive lymph node metastasis (p = .030), more advanced clinical stages (p = .007), and recurrence (p < .001) of OSCC. High expression of Src protein was identified as an independent unfavorable prognosis factor by multivariate Cox regression analysis. The Kaplan-Meier curve showed that patients with OSCC with high expression of Src protein had a significantly poorer cumulative survival than those with low expression of Src protein (log-rank test, p = .00267).Conclusion: The expression of Src protein is significantly associated with the progression, recurrence, and prognosis of OSCCs in Taiwan.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1340-5"},"PeriodicalIF":0.0000,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.21923","citationCount":"18","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Head & Neck","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/hed.21923","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2011/11/2 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 18

Abstract

Background: Src protein overexpression correlates with progression and prognosis of a variety of human cancers.

Methods: This study used immunohistochemistry to examine the expression of Src protein in 93 specimens of oral squamous cell carcinoma (OSCC).

Results: We found a significant association of high expression of Src protein (labeling indices >50%) with larger tumor size (p = .017), positive lymph node metastasis (p = .030), more advanced clinical stages (p = .007), and recurrence (p < .001) of OSCC. High expression of Src protein was identified as an independent unfavorable prognosis factor by multivariate Cox regression analysis. The Kaplan-Meier curve showed that patients with OSCC with high expression of Src protein had a significantly poorer cumulative survival than those with low expression of Src protein (log-rank test, p = .00267).

Conclusion: The expression of Src protein is significantly associated with the progression, recurrence, and prognosis of OSCCs in Taiwan.

查看原文本刊更多论文

SRC蛋白表达与台湾口腔鳞状细胞癌的进展、复发及预后有显著关联。

背景:Src蛋白过表达与多种人类癌症的进展和预后相关。方法:应用免疫组织化学方法检测93例口腔鳞癌(OSCC)标本中Src蛋白的表达。结果:Src蛋白高表达(标记指数>50%)与肿瘤较大(p = 0.017)、淋巴结转移阳性(p = 0.030)、临床分期较晚期(p = 0.007)、复发(p < 0.001)有显著相关性。多因素Cox回归分析发现Src蛋白高表达为独立的不良预后因素。Kaplan-Meier曲线显示，Src蛋白高表达的OSCC患者的累积生存期明显低于Src蛋白低表达的OSCC患者(log-rank检验，p = 0.00267)。结论:Src蛋白的表达与台湾地区OSCCs的进展、复发及预后有显著关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Head & Neck

自引率

0.00%

发文量