Head & Neck最新文献

{"title":"Surgical innovation, industry partnership, and the enemy within.","authors":"Walter T Lee, Daniel Rocke, F Christopher Holsinger","doi":"10.1002/hed.23476","DOIUrl":"https://doi.org/10.1002/hed.23476","url":null,"abstract":"Innovation is an integral part of the practice of surgery. Itis a concept that many surgeons are familiar with, butmany do not fully appreciate the issues surrounding surgi-cal innovation and partnership with industry. Herein, wereview key issues and concepts of surgical innovation,industry partnership, and the potential pitfalls that arepresent. We conclude with principles that every surgeonshould maintain when pursuing surgical innovation.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"461-5"},"PeriodicalIF":2.9,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.23476","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31700722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoimmune thyroiditis in benign and malignant thyroid nodules: 16-year results.","authors":"Irene Giagourta,&nbsp;Catherine Evangelopoulou,&nbsp;Garyfallia Papaioannou,&nbsp;Georgia Kassi,&nbsp;Evangelia Zapanti,&nbsp;Maria Prokopiou,&nbsp;Konstantinos Papapostolou,&nbsp;Helen Karga","doi":"10.1002/hed.23331","DOIUrl":"https://doi.org/10.1002/hed.23331","url":null,"abstract":"<p><strong>Background: </strong>It is controversial whether autoimmune thyroiditis is associated with higher frequency of papillary thyroid carcinoma (PTC).</p><p><strong>Methods: </strong>This was a cross-sectional, retrospective study. PTCs were compared to benign nodules regarding the prevalence of autoimmune thyroiditis over 16 years.</p><p><strong>Results: </strong>A similar proportion of autoimmune thyroiditis was observed in both benign and/or malignant nodules. Mean nodule size in cases with autoimmune thyroiditis was smaller than those without autoimmune thyroiditis. Multivariate analysis showed a negative association between the coexistence of autoimmune thyroiditis and lymph node and/or distant metastases. Lymph nodes involvement and distant metastases were lower in the PTC with autoimmune thyroiditis compared to those without autoimmune thyroiditis. Capsular invasion was a strong predictor for distant metastases attenuated by the presence of autoimmune thyroiditis.</p><p><strong>Conclusion: </strong>Thyroid nodules with autoimmune thyroiditis are not more likely to be malignant than those without autoimmune thyroiditis. The coexistent autoimmune thyroiditis may be beneficial as a decreased incidence of lymph nodes involvement and distant metastasis was seen in those patients.</p>","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"531-5"},"PeriodicalIF":2.9,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.23331","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31476428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor volume reduction rate measured during adaptive definitive radiation therapy as a potential prognosticator of locoregional control in patients with oropharyngeal cancer.","authors":"Hyebin Lee,&nbsp;Yong Chan Ahn,&nbsp;Dongryul Oh,&nbsp;Heerim Nam,&nbsp;Young Il Kim,&nbsp;Su Yeon Park","doi":"10.1002/hed.23328","DOIUrl":"https://doi.org/10.1002/hed.23328","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study was to evaluate the prognostic significance of the tumor volume reduction rate (TVRR) measured during adaptive definitive radiation therapy (RT) in patients with oropharyngeal cancer.</p><p><strong>Methods: </strong>We reviewed the RT records of 59 patients with oropharyngeal cancer who were treated with definitive RT with or without concurrent chemotherapy between January 2006 and October 2010. Adaptive replanning was performed in all patients during RT. The pre-RT and mid-RT gross tumor volumes (GTVs) of the primary and the metastatic lymph nodes were measured and analyzed for their possible impacts on locoregional control.</p><p><strong>Results: </strong>After the median follow-up period of 41.3 months (range, 9.3-73.5 months) for survivors, there were 10 treatment failures (8 locoregional recurrences and 2 distant metastases). The locoregional control rate at 3 years in all the patients was 84.1%. The mean pre-RT and mid-RT total GTVs were 27.5 cm(3) (±17.9 cm(3) ) and 16.9 cm(3) (±12.1 cm(3) ), and the mean GTV reduction rate was 37.9% (±22.6%), respectively. The patients who achieved locoregional control had a higher TVRR than those with locoregional failure (p = .010), and those with the TVRR >35% achieved significantly higher locoregional control at 3 years (94.4% vs 72.4%; p = .018). On multivariate analysis when adjusted with other clinical prognostic factors, the TVRR was found to be a significant factor affecting the locoregional control (hazard ratio = 0.136; 95% confidence interval = 0.022-0.852; p = .033).</p><p><strong>Conclusion: </strong>The TVRR measured during adaptive RT proved a significant prognosticator on locoregional disease control in patients with oropharyngeal cancer, based on which a few therapeutic modifications may be considered.</p>","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"499-504"},"PeriodicalIF":2.9,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.23328","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31518024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of super-selective neck dissection for indeterminate lateral neck nodes in papillary thyroid carcinoma.","authors":"Heejin Kim,&nbsp;Young Ju Jin,&nbsp;Wonjae Cha,&nbsp;Woo-Jin Jeong,&nbsp;Soon-Hyun Ahn","doi":"10.1002/hed.23320","DOIUrl":"https://doi.org/10.1002/hed.23320","url":null,"abstract":"<p><strong>Background: </strong>Therapeutic lateral compartment neck dissection is recommended for cases of papillary thyroid carcinoma with biopsy-proven lymph node metastasis. The purpose of this study was to evaluate the efficacy and safety of super-selective neck dissection for patients with clinically suspicious lymph node metastasis not confirmed by biopsy.</p><p><strong>Methods: </strong>Among 620 patients treated for papillary thyroid carcinoma between 2008 and 2010, 34 had suspicious lymph node enlargement in the lateral neck and underwent total thyroidectomy with super-selective neck dissection.</p><p><strong>Results: </strong>Metastatic disease was confirmed in 38.2% patients (13 of 34) with indeterminate lymph nodes identified by preoperative CT and/or ultrasonography who underwent super-selective neck dissection. Most harvested lymph nodes were located at level IV. There was no recurrence during a mean follow-up period of 31.6 months.</p><p><strong>Conclusion: </strong>Patients with clinically suspicious lateral neck nodes that are not confirmed by biopsy may be good candidates for super-selective neck dissection, which had minimal morbidity and did not compromise oncologic outcomes.</p>","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"487-91"},"PeriodicalIF":2.9,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.23320","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31475159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-EGFR-targeting agents in recurrent or metastatic head and neck carcinoma: a meta-analysis.","authors":"Fausto Petrelli,&nbsp;Sandro Barni","doi":"10.1002/hed.21858","DOIUrl":"https://doi.org/10.1002/hed.21858","url":null,"abstract":"<p><strong>Background: </strong>Anti-epidermal growth factor receptor (EGFR) therapies are effective in head and neck carcinoma. A meta-analysis was performed to assess their efficacy and safety in advanced head and neck carcinoma.</p><p><strong>Methods: </strong>Six trials randomizing 2257 patients with recurrent/metastatic head and neck carcinoma for chemotherapy or best supportive care with or without anti-EGFR therapies were identified. The efficacy data included progression-free survival (PFS), overall survival (OS), response rate, and toxicity.</p><p><strong>Results: </strong>The response rate was higher in the experimental arm (p < .0001; relative risk = 1.62). A significant PFS benefit (p < .0001; hazard ratio [HR] = 0.70) favored the anti-EGFR treatment. Survival was significantly increased if trials of monoclonal antibodies were included (p = .004; HR = 0.83). A higher incidence of diarrhea, skin rash, anorexia, and hypomagnesemia was observed.</p><p><strong>Conclusions: </strong>This meta-analysis suggests that in recurrent/metastatic head and neck cancer the addition of anti-EGFR monoclonal antibodies to standard therapy confers a statistically significant improvement in OS, PFS, and overall response rate.</p>","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1657-64"},"PeriodicalIF":2.9,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.21858","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30027825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of routine ultrasound-guided fine-needle aspiration cytology to assess the neck in patients with head and neck squamous cell carcinoma.","authors":"Jr-Hung Chen,&nbsp;Chen-Chi Wang","doi":"10.1002/hed.23133","DOIUrl":"https://doi.org/10.1002/hed.23133","url":null,"abstract":"To the Editor: As faithful readers of Head & Neck, we read with great interest the article entitled \"Initial staging of the neck in head and neck squamous cell carcinoma: a comparison of CT, PET/CT, and ultrasound-guided fine-needle aspiration cytology'' by Stoeckli et al. We would like to compliment the authors on their large-scale prospective analysis of different imaging modalities for staging neck metastasis in patients with head and neck squamous cell carcinoma (HNSCC). This is a very important issue, and different results and conclusions exist in the literature. In their study, Stoeckli et al concluded that ultrasound-guided fineneedle aspiration cytology (ultrasound-guided FNAC) seems to correlate best with the exact histologic staging and they will always complement CT with ultrasoundguided FNAC to assess patients with HNSCC. However, some details of their use of ultrasound-guided FNAC were not described in the article, and according to their result, the value of routine ultrasound-guided FNAC needs further discussion. In general, pretreatment imaging for HNSCC has 2 purposes. The first purpose is to document the extent of primary tumor and possible neck metastasis. The second purpose is to detect occult neck metastasis and guide further neck management. As mentioned by Stoeckli et al and Grandi et al, the status of the regional lymphatic involvement is considered the strongest prognosticator for HNSCC. Therefore, a sensitive method for detecting occult neck metastasis would be very helpful in determining treatment intensity and posttreatment follow-up. In regard to the documentation issue, it is clear that the extent of the primary lesion usually cannot be well documented by ultrasound images. That should be the reason why Stoeckli et al still routinely use CT or MRI for patients before treatment. According to a meta-analysis conducted by de Bondt et al, CT and MRI have several advantages, including lower interobserver variation, relatively standardized techniques that can be performed at most institutions, ease of interpretation by general radiologists, and less time consumption compared with ultrasound scans and ultrasound-guided FNAC. Therefore, CT and MRI are more commonly used for HNSCC. Under such circumstances, ultrasound-guided FNAC should provide much higher accuracy to stage the neck or much higher sensitivity to detect occult metastasis to justify its routine use. However, the rate of correct staging of the pathologic result of the neck for ultrasound-guided FNAC (69%) was only slightly better than that for CT (62%). Furthermore, the sensitivities of CT and ultrasound-guided FNAC in differentiating N0 from Nþ neck were almost equal (86.9% vs 86.4%). The relative positive predictive value (PPV) of ultrasound-guided FNAC PPV versus the CT PPV was 1.08 (95% confidence interval, 1.00 to approximately 1.17) indicated that these 2 techniques have almost equal PPV. Therefore, we could not find any strong evidence to encourage routine","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1678-9; author reply 179"},"PeriodicalIF":2.9,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.23133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30912656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative imaging and surgical margins in maxillectomy patients.","authors":"Anne Marijn Kreeft,&nbsp;Ludwig E Smeele,&nbsp;Coen R N Rasch,&nbsp;Michael Hauptmann,&nbsp;Derk H F Rietveld,&nbsp;C René Leemans,&nbsp;Alfons J M Balm","doi":"10.1002/hed.21987","DOIUrl":"https://doi.org/10.1002/hed.21987","url":null,"abstract":"<p><strong>Background: </strong>High rates of positive surgical margins are reported after a maxillectomy. A large part of tumors that are preoperatively considered \"operable\" can thus not be resected with tumor-free margins.</p><p><strong>Methods: </strong>This was a retrospective study on medical files of 69 patients that underwent maxillectomy as primary treatment for a squamous cell carcinoma.</p><p><strong>Results: </strong>More than one third (39%) of all resections performed is incomplete, with dorsal or dorsocranial-positive surgical margins in two thirds. Correlation of tumor extension on preoperative imaging to surgical margins status revealed that dorsal and cranial tumor extension were significant prognostic factors for tumor positive surgical margins (p = .006 and p = .031, respectively). Positive margins were associated with a 2-fold increased risk of death (hazard ratio, 2.4; 95% confidence interval, 1.2-4.9).</p><p><strong>Conclusion: </strong>Cranial or dorsal tumor extension on preoperative imaging was a significant risk factor for positive surgical margins after maxillectomy with significant negative influence on overall survival.</p>","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1652-6"},"PeriodicalIF":2.9,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.21987","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30392738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular biology of adenoid cystic carcinoma.","authors":"Jia Liu, Chunbo Shao, Marietta L Tan, David Mu, Robert L Ferris, Patrick K Ha","doi":"10.1002/hed.21849","DOIUrl":"10.1002/hed.21849","url":null,"abstract":"<p><strong>Background: </strong>Adenoid cystic carcinoma (ACC) is an unusual salivary gland malignancy that remains poorly understood. Standard treatment, including surgery with postoperative radiation therapy, has attained reasonable local control rates, but the propensity for distant metastases has limited any improvement in survival over time. Our understanding of the molecular mechanisms driving ACC is quite rudimentary, due to the infrequent nature of its occurrence.</p><p><strong>Methods: </strong>An extensive literature review was performed on salivary gland ACCs and basic science research findings.</p><p><strong>Results: </strong>This review highlights many findings that are emerging about the carcinogenesis of ACC including cytogenetics, tumor suppressor genes, oncogenes, epigenetic alterations, mitochondrial alterations, and biomarker studies.</p><p><strong>Conclusion: </strong>Although there have been many discoveries, much still remains unknown about this rare malignancy. © 2011 Wiley Periodicals, Inc. Head Neck, 2011.</p>","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1665-77"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262103/pdf/nihms299817.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30213827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved treatment outcomes with (18) F-FDG PET/CT for patients with advanced head and neck squamous cell carcinoma.","authors":"Stephan K Haerle,&nbsp;M B Soyka,&nbsp;D T Schmid,&nbsp;N Ahmad,&nbsp;G F Huber,&nbsp;D W Crook,&nbsp;T F Hany","doi":"10.1002/hed.21887","DOIUrl":"https://doi.org/10.1002/hed.21887","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to assess the impact of (18) F-fluoro-2-deoxy-D-glucose ((18) F-FDG) PET/CT on survival for patients with head and neck squamous cell carcinoma correlated with a matched patient cohort.</p><p><strong>Methods: </strong>In all, disease in 58 patients was initially staged using (18) F-FDG PET/CT. A case-control analysis was done with 63 patients who disease was staged without (18) F-FDG-PET/CT.</p><p><strong>Results: </strong>Disease-specific survival (DSS) and overall survival (OS) did not show significant differences between both groups. Statistical analysis revealed no difference in DSS and OS between the 2 groups for patients treated by radiochemotherapy (p = .975 and p = .671). In the analysis of survival in patients treated by a combined approach (surgery + radiochemotherapy), a significant difference in favor of patients evaluated by (18) F-FDG PET/CT was found (p = .05 and p = .027).</p><p><strong>Conclusions: </strong>Addition of (18) F-FDG PET/CT in patients treated by surgery and conformal radiochemotherapy improves outcome. This may be due to the more comprehensive topographic orientation of the primary tumor for the surgeon.</p>","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1205-11"},"PeriodicalIF":2.9,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.21887","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40116500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of insulin-like growth factor-II mRNA-binding protein-3 in invadopodia formation and the growth of oral squamous cell carcinoma in athymic nude mice.","authors":"Young Sun Hwang,&nbsp;Kwang-Kyun Park,&nbsp;In Ho Cha,&nbsp;Jin Kim,&nbsp;Won-Yoon Chung","doi":"10.1002/hed.21929","DOIUrl":"https://doi.org/10.1002/hed.21929","url":null,"abstract":"<p><strong>Background: </strong>The invadopodia are specialized structures that degrade the extracellular matrix (ECM) and promote cell invasion and metastasis. Understanding the forms and functions of invadopodia should facilitate the proper identification of novel targets for antiinvasive therapy.</p><p><strong>Methods: </strong>To understand the role of insulin-like growth factor-II mRNA-binding protein-3 (IMP-3) in invadopodia formation and cancer invasion, we performed IMP-3 gene silencing, invadopodia formation, ECM degradation assay, zymography, western blot, and mouse xenograft.</p><p><strong>Results: </strong>We demonstrate that invadopodia evidenced ECM degradation activity in oral squamous cell carcinoma (OSCC). Downregulation of IMP-3 inhibited invadopodia formation, ECM degradation, and tumor growth and invasiveness. Epidermal growth factor receptor (EGFR) signaling may perform a critical function in invadopodia formation, ECM degradation, IMP-3, and cortactin expression.</p><p><strong>Conclusion: </strong>IMP-3 may be intimately correlated with cancer invasion through invadopodia in oral cancer. The overexpression of IMP-3 in oral cancer was predictive of a high correlation with cancer growth and invasion.</p>","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"1329-39"},"PeriodicalIF":2.9,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.21929","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40127858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}