Head & Neck最新文献_第4页

Management of orocutaneous fistulas using a vacuum-assisted closure system. 使用真空辅助闭合系统处理口皮瘘。

IF 2.9

Head & Neck Pub Date : 2014-06-01 Epub Date: 2013-09-11 DOI: 10.1002/hed.23393

Brian Tian, Deborah Khoo, Ai Choo Tay, Khee-Chee Soo, Ngian Chye Tan, Hiang Khoon Tan, N Gopalakrishna Iyer

{"title":"Management of orocutaneous fistulas using a vacuum-assisted closure system.","authors":"Brian Tian, Deborah Khoo, Ai Choo Tay, Khee-Chee Soo, Ngian Chye Tan, Hiang Khoon Tan, N Gopalakrishna Iyer","doi":"10.1002/hed.23393","DOIUrl":"https://doi.org/10.1002/hed.23393","url":null,"abstract":"Background: The vacuum-assisted closure (VAC) system has been used to manage complicated wounds. The purpose of this study was to describe a novel technique in using the VAC system for orocutaneous fistulas.Methods: A retrospective study was performed on 10 patients treated at the National Cancer Centre, Singapore, who developed postoperative orocutaneous fistulas. Hydrogum dental paste was used as a sealant together with the VAC system to close the fistulas. We used either the RENASYS or VAC ATS system with 50 mm Hg to 125 mm Hg continuous suction.Results: The 10 patients developed 11 fistulas. The median age of this cohort was 67 years (range, 33-80 years). Nine patients had successful closure of their fistulas with VAC therapy whereas 1 patient had unsuccessful VAC therapy and required flap reconstruction. The median time to fistula closure was 19 days (range, 6-36 days). The median time to radiotherapy after surgery was 46 days (range, 26-62 days).Conclusion: VAC therapy is an effective treatment option for orocutaneous fistulas.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"873-81"},"PeriodicalIF":2.9,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.23393","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31571827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Value of preoperative mandibular plating in reconstruction of the mandible. 术前下颌钢板在下颌骨重建中的应用价值。

IF 2.9

Head & Neck Pub Date : 2014-06-01 Epub Date: 2013-09-02 DOI: 10.1002/hed.23382

Eitan Prisman, Stephan K Haerle, Jonathan C Irish, Michael Daly, Brett Miles, Harley Chan

{"title":"Value of preoperative mandibular plating in reconstruction of the mandible.","authors":"Eitan Prisman, Stephan K Haerle, Jonathan C Irish, Michael Daly, Brett Miles, Harley Chan","doi":"10.1002/hed.23382","DOIUrl":"https://doi.org/10.1002/hed.23382","url":null,"abstract":"Background: The purpose of this study was to evaluate the efficacy of preoperative versus intraoperative mandibular contouring using rapid prototyping technology.Methods: Ten patients requiring mandibular reconstruction had a preoperative mandibular plate contoured to a fabricated 3D mandibular model based on preoperative imaging. A traditional intraoperative plate was also contoured. Two surgeons blinded to the study compared the plates with respect to conformance, surface-area contact, and best overall match. A cost-benefit analysis was then performed.Results: The average time to contour was 867 ± 243 seconds and 833 ± 289 seconds for the preoperative and intraoperative plates, respectively (p = .83). Interobserver analysis revealed no statistically significant differences in conformance (p = .38) or surface area contact (p = .14). In 7 of 9 cases, the preoperative plate was selected for the final reconstruction. In 1 case, an intraoperative plate was not contoured because of the lateral extent of the tumor.Conclusion: In cases of mandibular distortion secondary to disease, pathologic fracture or defects involving multiple mandibular subsites this method is particularly advantageous.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"828-33"},"PeriodicalIF":2.9,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.23382","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31466655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

New device for single-stage in-office secondary tracheoesophageal puncture: animal studies. 用于单阶段室内气管食管二次穿刺的新装置:动物实验。

IF 2.9

Head & Neck Pub Date : 2014-06-01 Epub Date: 2014-01-29 DOI: 10.1002/hed.23392

David P Lau, Chin Boon Chng, Chee Kong Chui

引用次数: 13

Human papillomavirus and Epstein-Barr virus in nasopharyngeal carcinoma in a low-incidence population. 人乳头瘤病毒和eb病毒在鼻咽癌低发病率人群中的作用。

IF 2.9

Head & Neck Pub Date : 2014-04-01 Epub Date: 2013-06-18 DOI: 10.1002/hed.23318

Snjezana Dogan, Matthew L Hedberg, Robert L Ferris, Tanya J Rath, Adel M Assaad, Simion I Chiosea

{"title":"Human papillomavirus and Epstein-Barr virus in nasopharyngeal carcinoma in a low-incidence population.","authors":"Snjezana Dogan, Matthew L Hedberg, Robert L Ferris, Tanya J Rath, Adel M Assaad, Simion I Chiosea","doi":"10.1002/hed.23318","DOIUrl":"https://doi.org/10.1002/hed.23318","url":null,"abstract":"Background: The significance of human papillomavirus (HPV) in nasopharyngeal carcinomas (NPCs) in a low-incidence population remains unknown.Methods: Samples from 90 patients with NPC (years, 1957-2012) were analyzed for Epstein-Barr virus (EBV). Clinical data, EBV, HPV, and p16 status were correlated with overall survival (OS; 63 cases; years, 1981-2012).Results: Of 9 HPV-positive cases, 3 extended from extra-nasopharyngeal sites. Nasopharyngeal origin was confirmed in 6 cases. HPV-positive NPC had OS similar to EBV-positive NPC (85 vs 141 months; p > .05). The OS of patients with EBV/HPV-negative NPC was worse (34 months; p = .004). Nonkeratinizing histology was associated with better outcome than keratinizing (115 vs 25 months; p = .001). Over the last several decades, the proportion of keratinizing NPC decreased from 34.5% to 14.3% (p = .026).Conclusion: The etiologic role of HPV in NPC is confirmed. The favorable prognostic significance of HPV positivity is similar to that of EBV positivity.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"511-6"},"PeriodicalIF":2.9,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.23318","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31517866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 75

Regeneration of facial nerve defects with xenogeneic acellular nerve grafts in a rat model. 异种脱细胞神经移植再生面神经缺损大鼠模型。

IF 2.9

Head & Neck Pub Date : 2014-04-01 Epub Date: 2013-06-01 DOI: 10.1002/hed.23321

Guochen Zhu, Weihua Lou

引用次数: 11

Predictors of cervical lymph node metastasis in salivary gland cancer. 涎腺癌颈部淋巴结转移的预测因素。

IF 2.9

Head & Neck Pub Date : 2014-04-01 Epub Date: 2013-06-18 DOI: 10.1002/hed.23332

Tobias Ettl, Martin Gosau, Gero Brockhoff, Stephan Schwarz-Furlan, Abbas Agaimy, Torsten E Reichert, Christian Rohrmeier, Johannes Zenk, Heinrich Iro

{"title":"Predictors of cervical lymph node metastasis in salivary gland cancer.","authors":"Tobias Ettl, Martin Gosau, Gero Brockhoff, Stephan Schwarz-Furlan, Abbas Agaimy, Torsten E Reichert, Christian Rohrmeier, Johannes Zenk, Heinrich Iro","doi":"10.1002/hed.23332","DOIUrl":"https://doi.org/10.1002/hed.23332","url":null,"abstract":"Background: This study compares clinicopathological parameters with novel molecular markers for predicting cervical lymph node metastasis in salivary gland cancer.Methods: Three hundred sixteen salivary gland carcinomas were included in this study. Genomic epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), phosphatase and tensin homolog (PTEN), and hepatocyte growth factor receptor (MET) was determined by fluorescence in situ hybridization (FISH). Chi-square tests, multivariate regression, and Kaplan-Meier survival analysis were used for statistics.Results: Nodal staging determines long-term survival. Clinicopathological parameters associated with positive neck nodes are advanced age (p = .006), T3/T4 classification, histological high-grade malignancy, and diagnosis of salivary duct carcinoma (p < .001 each). Neck node metastases also correlate with copy number gain of EGFR (p = .004) and HER2, aberration of MET, and deletion of PTEN (p < .001 each). Multivariate analysis showed SDC (p = .002) to be the strongest predictor of lymph node metastasis, followed by MET aberration (p = .009), T3/T4 classification (p = .017), PTEN deletion (p = .042), and adenocarcinoma not otherwise specified (NOS; p = .047).Conclusion: The histological subtype is crucial for decisions regarding neck dissection. New molecular parameters may also indicate elective treatment of the neck.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"517-23"},"PeriodicalIF":2.9,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.23332","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31517111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47

Long-term functional and survival outcomes after induction chemotherapy and risk-based definitive therapy for locally advanced squamous cell carcinoma of the head and neck. 头颈部局部晚期鳞状细胞癌诱导化疗和基于风险的最终治疗后的长期功能和生存结果

IF 2.9

Head & Neck Pub Date : 2014-04-01 Epub Date: 2013-06-18 DOI: 10.1002/hed.23330

Katherine A Hutcheson, Jan S Lewin, F Christopher Holsinger, Ganene Steinhaus, Asher Lisec, Denise A Barringer, Heather Y Lin, Sandra Villalobos, Adam S Garden, Vali Papadimitrakopoulou, Merrill S Kies

{"title":"Long-term functional and survival outcomes after induction chemotherapy and risk-based definitive therapy for locally advanced squamous cell carcinoma of the head and neck.","authors":"Katherine A Hutcheson, Jan S Lewin, F Christopher Holsinger, Ganene Steinhaus, Asher Lisec, Denise A Barringer, Heather Y Lin, Sandra Villalobos, Adam S Garden, Vali Papadimitrakopoulou, Merrill S Kies","doi":"10.1002/hed.23330","DOIUrl":"https://doi.org/10.1002/hed.23330","url":null,"abstract":"Background: The purpose of this study was to evaluate long-term outcomes after induction chemotherapy followed by \"risk-based\" local therapy for locally-advanced squamous cell carcinoma of the head and neck (SCCHN).Methods: Forty-seven patients (stage IV; ≥N2b) were enrolled in a phase II trial. Baseline and 24-month functional measures included modified barium swallow (MBS) studies, oropharyngeal swallow efficiency (OPSE), and the MD Anderson Dysphagia Inventory (MDADI). Functional status was assessed at 5 years.Results: Five-year overall survival (OS) was 89% (95% confidence interval [CI], 81% to 99%). A nonsignificant 13% average reduction in swallowing efficiency (OPSE) was observed at 24 months relative to baseline (p = .191). MDADI scores approximated baseline at 24 months. Among 42 long-term survivors (median, 5.9 years), 3 patients (7.1%) had chronic dysphagia. The rate of final gastrostomy dependence was 4.8% (2 of 42).Conclusion: Sequential chemoradiotherapy achieved favorable outcomes among patients with locally advanced SCCHN, mainly of oropharyngeal origin. MBS and MDADI scores found modest swallowing deterioration at 2 years, and chronic aspiration was uncommon in long-term survivors.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"474-80"},"PeriodicalIF":2.9,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.23330","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31516851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 48

Treatment outcomes and feasibility of partial neck irradiation for patients with nasopharyngeal carcinoma with only retropharyngeal lymph node metastasis after intensity-modulated radiotherapy. 调强放疗后鼻咽癌仅咽后淋巴结转移患者部分颈部照射的治疗效果及可行性

IF 2.9

Head & Neck Pub Date : 2014-04-01 Epub Date: 2013-06-18 DOI: 10.1002/hed.23314

Mo Chen, Ling-Long Tang, Ying Sun, Yan-Ping Mao, Wen-Fei Li, Rui Guo, Li-Zhi Liu, Li Li, Ai-Hua Lin, Jun Ma

{"title":"Treatment outcomes and feasibility of partial neck irradiation for patients with nasopharyngeal carcinoma with only retropharyngeal lymph node metastasis after intensity-modulated radiotherapy.","authors":"Mo Chen, Ling-Long Tang, Ying Sun, Yan-Ping Mao, Wen-Fei Li, Rui Guo, Li-Zhi Liu, Li Li, Ai-Hua Lin, Jun Ma","doi":"10.1002/hed.23314","DOIUrl":"https://doi.org/10.1002/hed.23314","url":null,"abstract":"Background: The purpose of this study was to summarize the treatment outcomes and evaluate the feasibility of partial neck irradiation in patients with nasopharyngeal carcinoma (NPC) with only retropharyngeal lymph nodes (RLNs) metastasis.Methods: Between January 2003 and December 2007, 54 patients with NPC who received partial neck irradiation to levels II, III, and VA and 100 patients who received whole neck irradiation were reviewed.Results: The 5-year disease free survival (DFS), disease metastasis-free survival, (DMFS) local relapse-free survival (LRFS), and regional relapse-free survival (RRFS) rates were 81.8%, 87.7%, 94.8%, and 98.1%, respectively. The 5-year RRFS and DFS rates for the partial neck irradiation group and whole neck irradiation group were 98.1% versus 98.0% (p = .882), 87.0% vs 77.0% (p = .117), respectively. Partial neck irradiation was not considered a significant prognostic factor for any endpoint in univariate and multivariate analyses.Conclusion: Partial irradiation of neck levels II, III, and VA might be acceptable for patients with NPC with only RLN metastasis.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"468-73"},"PeriodicalIF":2.9,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.23314","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31517864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Intensity-modulated versus conventional radiation therapy for oropharyngeal carcinoma: long-term dysphagia and tumor control outcomes. 口咽癌的调强放疗与常规放疗:长期吞咽困难和肿瘤控制结果。

IF 2.9

Head & Neck Pub Date : 2014-04-01 Epub Date: 2013-06-01 DOI: 10.1002/hed.23319

Sean M McBride, Ron J Parambi, Joanne W Jang, Tessa Goldsmith, Paul M Busse, Annie W Chan

{"title":"Intensity-modulated versus conventional radiation therapy for oropharyngeal carcinoma: long-term dysphagia and tumor control outcomes.","authors":"Sean M McBride, Ron J Parambi, Joanne W Jang, Tessa Goldsmith, Paul M Busse, Annie W Chan","doi":"10.1002/hed.23319","DOIUrl":"https://doi.org/10.1002/hed.23319","url":null,"abstract":"Background: The purpose of this study was to determine the relative clinical benefits of intensity-modulated radiation therapy (IMRT) versus conventional radiotherapy (CRT) in the treatment of patients with oropharyngeal carcinoma.Methods: We compared tumor control and toxicity outcomes in 132 patients with stage III to IVA/B oropharyngeal carcinoma treated with definitive chemoradiation in the human papillomavirus (HPV) era.Results: Patients treated with IMRT had lower rates of xerostomia (p = .01) and shorter duration of gastrostomy-tube dependence (p < .0001), but increased risk of cervical esophageal stricture (p = .03). The overall rates of late dysphagia were not different between the 2 groups (p = .40). In multivariate analysis, IMRT was a significant predictor of decreased disease-specific mortality (hazard ratio [HR] = 0.24; p = .03) after adjustment for T-category and active smoking. After adjustment for T classification, IMRT use was associated with a trend toward a significant decrease in locoregional failure (HR = 0.17; p = .08).Conclusion: The incidence of late dysphagia is similar in IMRT and CRT, but the mechanism of dysphagia is different.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"492-8"},"PeriodicalIF":2.9,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.23319","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31475574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Prevalence and trends of human papillomavirus in oropharyngeal cancer in a predominantly north Indian population. 人乳头瘤病毒在印度北部主要人群口咽癌中的流行和趋势。

IF 2.9

Head & Neck Pub Date : 2014-04-01 Epub Date: 2013-06-01 DOI: 10.1002/hed.23317

Ankur Bahl, Pankaj Kumar, Lalit Dar, Bidhu K Mohanti, Atul Sharma, Alok Thakar, Venkat Karthikeyan, Kapil Sikka, Chiromamit Singh, Kamala Poo, Jaini Lodha

{"title":"Prevalence and trends of human papillomavirus in oropharyngeal cancer in a predominantly north Indian population.","authors":"Ankur Bahl, Pankaj Kumar, Lalit Dar, Bidhu K Mohanti, Atul Sharma, Alok Thakar, Venkat Karthikeyan, Kapil Sikka, Chiromamit Singh, Kamala Poo, Jaini Lodha","doi":"10.1002/hed.23317","DOIUrl":"https://doi.org/10.1002/hed.23317","url":null,"abstract":"Background: Human papillomavirus (HPV) prevalence in oropharyngeal squamous cell cancer (SCC) remains variable and studies have estimated that up to 60% may be positive.Methods: One hundred five treatment-naïve oropharyngeal SCC patients were included. HPV genotyping was done by consensus polymerase chain reaction (PCR) and reverse line-blot hybridization assay. HPV prevalence was co-related with sex, age, tobacco consumption, alcohol use, and high-risk sexual behavior.Results: HPV prevalence was 22.8%. No significant associations were seen between tobacco or alcohol consumption with HPV status. The mean number of lifetime sexual partners and indulgence in high-risk sexual behavior was significantly more in patients who are HPV positive. There were no significant associations between the 2 groups with respect to the stage of the tumor.Conclusion: Results of this study confirms that patients who are HPV positive are younger, and with high-risk sexual behavior. We did not find any impact of smoking and alcohol consumption on HPV status.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"505-10"},"PeriodicalIF":2.9,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.23317","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31567989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 60