Prevalence and trends of human papillomavirus in oropharyngeal cancer in a predominantly north Indian population.

Head & Neck Pub Date : 2014-04-01 Epub Date: 2013-06-01 DOI:10.1002/hed.23317

Ankur Bahl, Pankaj Kumar, Lalit Dar, Bidhu K Mohanti, Atul Sharma, Alok Thakar, Venkat Karthikeyan, Kapil Sikka, Chiromamit Singh, Kamala Poo, Jaini Lodha

{"title":"Prevalence and trends of human papillomavirus in oropharyngeal cancer in a predominantly north Indian population.","authors":"Ankur Bahl, Pankaj Kumar, Lalit Dar, Bidhu K Mohanti, Atul Sharma, Alok Thakar, Venkat Karthikeyan, Kapil Sikka, Chiromamit Singh, Kamala Poo, Jaini Lodha","doi":"10.1002/hed.23317","DOIUrl":null,"url":null,"abstract":"Background: Human papillomavirus (HPV) prevalence in oropharyngeal squamous cell cancer (SCC) remains variable and studies have estimated that up to 60% may be positive.Methods: One hundred five treatment-naïve oropharyngeal SCC patients were included. HPV genotyping was done by consensus polymerase chain reaction (PCR) and reverse line-blot hybridization assay. HPV prevalence was co-related with sex, age, tobacco consumption, alcohol use, and high-risk sexual behavior.Results: HPV prevalence was 22.8%. No significant associations were seen between tobacco or alcohol consumption with HPV status. The mean number of lifetime sexual partners and indulgence in high-risk sexual behavior was significantly more in patients who are HPV positive. There were no significant associations between the 2 groups with respect to the stage of the tumor.Conclusion: Results of this study confirms that patients who are HPV positive are younger, and with high-risk sexual behavior. We did not find any impact of smoking and alcohol consumption on HPV status.","PeriodicalId":501638,"journal":{"name":"Head & Neck","volume":" ","pages":"505-10"},"PeriodicalIF":0.0000,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hed.23317","citationCount":"60","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Head & Neck","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/hed.23317","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2013/6/1 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 60

Abstract

Background: Human papillomavirus (HPV) prevalence in oropharyngeal squamous cell cancer (SCC) remains variable and studies have estimated that up to 60% may be positive.

Methods: One hundred five treatment-naïve oropharyngeal SCC patients were included. HPV genotyping was done by consensus polymerase chain reaction (PCR) and reverse line-blot hybridization assay. HPV prevalence was co-related with sex, age, tobacco consumption, alcohol use, and high-risk sexual behavior.

Results: HPV prevalence was 22.8%. No significant associations were seen between tobacco or alcohol consumption with HPV status. The mean number of lifetime sexual partners and indulgence in high-risk sexual behavior was significantly more in patients who are HPV positive. There were no significant associations between the 2 groups with respect to the stage of the tumor.

Conclusion: Results of this study confirms that patients who are HPV positive are younger, and with high-risk sexual behavior. We did not find any impact of smoking and alcohol consumption on HPV status.

查看原文本刊更多论文

人乳头瘤病毒在印度北部主要人群口咽癌中的流行和趋势。

背景:人乳头瘤病毒(HPV)在口咽鳞状细胞癌(SCC)中的患病率仍然是可变的，研究估计高达60%可能是阳性的。方法:105例treatment-naïve口咽鳞状细胞癌患者。采用聚合酶链反应(PCR)和逆行杂交法进行HPV基因分型。HPV患病率与性别、年龄、吸烟、饮酒和高危性行为相关。结果:HPV患病率为22.8%。烟草或酒精消费与HPV状态之间没有明显的关联。HPV阳性患者终生性伴侣和高危性行为的平均数量明显增加。两组在肿瘤分期方面无显著相关性。结论:本研究结果证实HPV阳性患者年龄偏小，性行为高危。我们没有发现吸烟和饮酒对HPV状态有任何影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Head & Neck

自引率

0.00%

发文量