Journal of Neuroscience最新文献

{"title":"Theta Oscillons in Behaving Rats.","authors":"M S Zobaer, Nastaran Lotfi, Carli M Domenico, Clarissa Hoffman, Luca Perotti, Daoyun Ji, Yuri Dabaghian","doi":"10.1523/JNEUROSCI.0164-24.2025","DOIUrl":"10.1523/JNEUROSCI.0164-24.2025","url":null,"abstract":"<p><p>Recently discovered constituents of the brain waves-the <i>oscillons</i>-provide a high-resolution representation of the extracellular field dynamics. Here, we study the most robust, highest-amplitude oscillons recorded in actively behaving male rats, which underlie the traditional <i>θ</i>-waves. The resemblances between <i>θ</i>-oscillons and the conventional <i>θ</i>-waves are manifested primarily at the ballpark level-mean frequencies, mean amplitudes, and bandwidths. In addition, both hippocampal and cortical oscillons exhibit a number of intricate, behavior-attuned, transient properties that suggest a new vantage point for understanding the <i>θ</i>-rhythms' structure, origins and functions. In particular, we demonstrate that oscillons are frequency-modulated waves, with speed-controlled parameters, embedded into a weak noise background. We also use a basic model of neuronal synchronization to contextualize and to interpret the oscillons. The results suggest that the synchronicity levels in physiological networks are fairly low and are modulated by the animal's physiological state.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbitofrontal High-Gamma Reflects Spike-Dissociable Value and Decision Mechanisms.","authors":"Dixit Sharma, Shira M Lupkin, Vincent B McGinty","doi":"10.1523/JNEUROSCI.0789-24.2025","DOIUrl":"10.1523/JNEUROSCI.0789-24.2025","url":null,"abstract":"<p><p>The orbitofrontal cortex (OFC) plays a crucial role in value-based decisions. While much is known about how OFC neurons represent values, far less is known about information encoded in OFC local field potentials (LFPs). LFPs are important because they can reflect subthreshold activity not directly coupled to spiking and because they are potential targets for less invasive forms of brain-machine interface (BMI). We recorded neural activity in the OFC of male macaques performing a two-option value-based decision task. We compared the value- and decision-coding properties of high-gamma LFPs (HG, 50-150 Hz) to the coding properties of spiking multiunit activity (MUA) recorded concurrently on the same electrodes. HG and MUA both represented the values of decision targets, but HG signals had value-coding features that were distinct from concurrently measured MUA. On average HG amplitude increased monotonically with value, whereas in MUA the value encoding was net neutral on average. HG encoded a signal consistent with a comparison between target values, a signal which was negligible in MUA. In individual channels, HG could predict choice outcomes more accurately than MUA; however, when channels were combined in a population-based decoder, MUA was more accurate than HG. In summary, HG signals reveal value-coding features in OFC that could not be observed from spiking activity, including representation of value comparisons and more accurate behavioral predictions. These results have implications for the role of OFC in value-based decisions and suggest that high-frequency LFPs may be a viable-or even preferable-target for BMIs to assist cognitive function.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Similar Computational Hierarchies for Reading and Speech in the Occipital Cortex of Sighed and Blind: Converging Evidence from fMRI and Chronometric TMS.","authors":"Jacek Matuszewski, Łukasz Bola, Olivier Collignon, Artur Marchewka","doi":"10.1523/JNEUROSCI.1153-24.2024","DOIUrl":"10.1523/JNEUROSCI.1153-24.2024","url":null,"abstract":"<p><p>High-level perception results from interactions between hierarchical brain systems responsive to gradually increasing feature complexities. During reading, the initial evaluation of simple visual features in the early visual cortex (EVC) is followed by orthographic and lexical computations in the ventral occipitotemporal cortex (vOTC). While similar visual regions are engaged in tactile Braille reading in congenitally blind people, it is unclear whether the visual network maintains or reorganizes its hierarchy for reading in this population. Combining fMRI and chronometric transcranial magnetic stimulation (TMS), our study revealed a clear correspondence between sighted and blind individuals (both male and female) on how their occipital cortices functionally supports reading and speech processing. Using fMRI, we first observed that vOTC, but not EVC, showed an enhanced response to lexical vs nonlexical information in both groups and sensory modalities. Using TMS, we further found that, in both groups, the processing of written words and pseudowords was disrupted by the EVC stimulation at both early and late time windows. In contrast, the vOTC stimulation disrupted the processing of these written stimuli only when applied at late time windows, again in both groups. In the speech domain, we observed TMS effects only for meaningful words and only in the blind participants. Overall, our results suggest that, while the responses in the deprived visual areas might extend their functional response to other sensory modalities, the computational gradients between early and higher-order occipital regions are retained, at least for reading.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Role for {delta} Subunit-Containing GABAA Receptors on Parvalbumin-Positive Neurons in Maintaining Electrocortical Signatures of Sleep States","authors":"Peter M. Lambert, Sofia V. Salvatore, Xinguo Lu, Hong-Jin Shu, Ann Benz, Nicholas Rensing, Carla M. Yuede, Michael Wong, Charles F. Zorumski, Steven Mennerick","doi":"10.1523/jneurosci.0601-24.2025","DOIUrl":"https://doi.org/10.1523/jneurosci.0601-24.2025","url":null,"abstract":"<p>GABA<SUB>A</SUB> receptors containing subunits have been shown to mediate tonic/slow inhibition in the CNS. These receptors are typically found extrasynaptically and are activated by relatively low levels of ambient GABA in the extracellular space. In the mouse neocortex, subunits are expressed by some pyramidal cells as well as on parvalbumin-positive (PV+) interneurons. An important function of PV+ interneurons is the organization of coordinated network activity that can be measured by EEG. However, it remains unclear what role tonic/slow inhibitory control of PV+ neurons may play in shaping oscillatory activity. After validating expected functional loss of -associated current in cortex of PV cKO mice of both sexes, we performed EEG recordings to survey network activity across wake and sleep states. PV cKO mice showed altered spectral content of EEG during NREM and REM sleep that was a result of increased oscillatory activity in NREM and the emergence of transient high-amplitude bursts of theta-frequency activity during REM. Viral reintroduction of <I>Gabrd</I> to PV+ interneurons in PV cKO mice rescued REM EEG phenotypes, supporting an important role for subunit-mediated inhibition of PV+ interneurons for maintaining normal REM cortical oscillations.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"52 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LUZP1 Regulates Dendritic Spine Maturation and Synaptic Plasticity in the Hippocampal Dentate Gyrus of Mice.","authors":"Xiaojie Wang, Liang Wang, Qian Bu, Yuzhou Xiao, Yue Zhao, Linhong Jiang, Yanping Dai, Hongchun Li, Haxiaoyu Liu, Yaxing Chen, Angelo D Flores, Yinglan Zhao, Xiaobo Cen","doi":"10.1523/JNEUROSCI.1867-24.2025","DOIUrl":"10.1523/JNEUROSCI.1867-24.2025","url":null,"abstract":"<p><p>Leucine zipper protein 1 (LUZP1) functions in the maintenance and dynamics of the cytoskeleton by interacting with actin and microtubules. Deficiency or mutation of LUZP1 is associated with brain developmental disorders; however, its precise role in brain function remains unclear. We showed that LUZP1 localizes to actin and is highly expressed in CaMKIIα-expressing neurons within the mouse hippocampal dentate gyrus. Depletion of LUZP1 impedes dendritic spine maturation, which is characterized by excess immature filopodia and loss of mature mushroom spines both in vitro and in vivo. LUZP1 knockdown reduces spontaneous electrical activity and synaptic plasticity in hippocampal neurons. Conditional deletion of LUZP1 in CaMKIIα-expressing neurons causes impaired learning and memory behavior in mice of both sexes. Mechanistically, LUZP1 control dendritic maturation by directly interacting with filamin A and modulating the Rac1-PAK1 signaling pathway. These findings shed light on the role of LUZP1 in regulating synaptic plasticity and brain function.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequence diversity and encoded enzymatic differences of monocistronic L1 ORF2 mRNA variants in the aged normal and Alzheimer's disease brain.","authors":"Juliet Nicodemus,Christine S Liu,Linnea Ransom,Valerie Tan,William Romanow,Natalia Jimenez,Jerold Chun","doi":"10.1523/jneurosci.2298-24.2025","DOIUrl":"https://doi.org/10.1523/jneurosci.2298-24.2025","url":null,"abstract":"Reverse transcriptase (RT) activity in the human brain has been inferred through somatic retroinsertion/retrotransposition events, however actual endogenous enzymatic activities and sources remain unclear. L1 (LINE-1) retrotransposons bicistronically express ORF2, containing RT and endonuclease (EN) domains, and RNA binding protein ORF1, together enabling L1 retrotransposition and contributing to somatic genomic mosaicism (SGM). Here, we assessed endogenous RT activities and L1 mRNA diversity from cerebral cortical samples of 31 Alzheimer's disease (AD) and non-diseased (ND) brains (both sexes) using enzymatic functional assays, targeted PacBio HiFi long-read sequencing, and quantitative spatial transcriptomics. Expected bicistronic, full-length L1 transcripts were absent from most samples, constituting <0.01% of L1 sequences, of which >80% were non-coding. Monocistronic ORF1 and ORF2 transcripts were identified across all samples, consistent with quantitative spatial transcriptomics that identified discordant ORF2 and ORF1 expression in neurons. All brains had RT activity, with AD samples showing less activity, consistent with neuronal loss of terminal AD vs. aged ND donors. Brain RT activity was higher in grey matter and correlated with increased neuronal ORF2 expression, further supporting neuronal contributions. Remarkably, >550 protein-encoding, polyA+ ORF2 sequence variants were identified, over 2x more than identified in the human reference genome (hg38). Experimental overexpression of full-length and truncated ORF2 variants revealed ∼50-fold RT and ∼1.3-fold EN activity ranges, supporting endogenous functional capacity of monocistronic ORF2 variants in the human brain. The vast sequence diversity of monocistronic ORF2 mRNAs could underlie functional differences in RT-mediated somatic gene recombination/retroinsertion and resulting genomic mosaicism in the normal and diseased brain.Significance Statement Human brain reverse transcriptase activity has been inferred through the \"copy-and-paste life-cycle\" of L1, which can generate genomic mosaicism via self-retrotransposition via a full-length L1 mRNA. However, their presence in aged and Alzheimer's disease neurons remains unclear. We examined aged normal and Alzheimer's brains for reverse transcriptase activity in prefrontal and medial-temporal cortices and its relationship to L1 via enzymatic activity assays and targeted PacBio sequencing. Reverse transcriptase activity was pervasive, however full-length L1 was largely absent. Instead, hundreds of different, truncated, novel L1 mRNA variants were identified, and experimental sampling revealed diverse reverse transcriptase activities. These data implicate truncated L1 variants as a source of functionally diverse and novel reverse transcriptases in the normal and Alzheimer's disease brain.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"68 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optogenetic Mapping of Rhythmic Phase-Dependent Excitability in the Mouse Striatum","authors":"Manish Mohapatra, James Eric Carmichael, Kyle S. Smith, Matthijs A. A. van der Meer","doi":"10.1523/jneurosci.0218-24.2025","DOIUrl":"https://doi.org/10.1523/jneurosci.0218-24.2025","url":null,"abstract":"<p>The striatum is thought to switch flexibly between multiple converging inputs to support adaptive behavior. The \"communication through coherence\" (CTC) hypothesis is a potential mechanism to implement such a flexible switching. For CTC to work in the striatum, striatal excitability must show rhythmic fluctuations, such as those related to the phase of the striatal local field potential (LFP). To test this fundamental requirement, we delivered a constant input stimulus to ChR2-expressing striatal fast-spiking PV+ interneurons (FSIs) in head-fixed awake mice (PV-Cre:Ai-32, <I>n</I> = 18, 9 female) and determined whether the response to this stimulus varied with LFP phase. We found that approximately one-third (41.2%) of FSIs exhibited significant phase-dependent excitability in at least one LFP frequency band. Phase-dependent excitability was most prominent in the delta (2&ndash;5&nbsp;Hz) frequency band, both in terms of prevalence (23.5% of FSIs sampled) and magnitude (phase modulation strength: 22% of average response). The most excitable phase tended to align with endogenous phase-locking, again most clearly in the delta band. These results bolster the functional relevance of the striatal field potential and spike-field relationships and provide proof-of-principle support for the possibility of CTC in the striatum.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"116 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Inattentional Rhythm in Audition.","authors":"Troby Ka-Yan Lui, Eva Boglietti, Benedikt Zoefel","doi":"10.1523/JNEUROSCI.1544-24.2025","DOIUrl":"10.1523/JNEUROSCI.1544-24.2025","url":null,"abstract":"<p><p>The detection of temporally unpredictable visual targets depends on the preceding phase of alpha oscillations (∼7-12 Hz). In audition, however, such an effect seemed to be absent. Due to the transient nature of its input, the auditory system might be particularly vulnerable to information loss that occurs if relevant information coincides with the low-excitability phase of the oscillation. We therefore hypothesized that effects of oscillatory phase in audition will be restored if auditory events are made task irrelevant and information loss can be tolerated. To this end, we collected electroencephalography (EEG) data from 29 human participants (21F) while they detected pure tones at one sound frequency and ignored others. Confirming our hypothesis, we found that the neural response to task-irrelevant but not to task-relevant tones depends on the prestimulus phase of neural oscillations. Alpha oscillations modulated early stages of stimulus processing, whereas theta oscillations (∼3-7 Hz) affected later components, possibly related to distractor inhibition. We also found evidence that alpha oscillations alternate between sound frequencies during divided attention. Together, our results suggest that the efficacy of auditory oscillations depends on the context they operate in and demonstrate how they can be employed in a system that heavily relies on information unfolding over time.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"What\" and \"When\" Predictions Jointly Modulate Speech Processing","authors":"Ryszard Auksztulewicz, Ozan Bahattin Ödül, Saskia Helbling, Ana Böke, Drew Cappotto, Dan Luo, Jan Schnupp, Lucía Melloni","doi":"10.1523/jneurosci.1049-24.2025","DOIUrl":"https://doi.org/10.1523/jneurosci.1049-24.2025","url":null,"abstract":"<p>Adaptive behavior rests on predictions based on statistical regularities in the environment. Such regularities pertain to stimulus contents (\"what\") and timing (\"when\"), and both interactively modulate sensory processing. In speech streams, predictions can be formed at multiple hierarchical levels of contents (e.g., syllables vs words) and timing (faster vs slower time scales). Whether and how these hierarchies map onto each other remains unknown. Under one hypothesis, neural hierarchies may link \"what\" and \"when\" predictions within sensory processing areas: with lower versus higher cortical regions mediating interactions for smaller versus larger units (syllables vs words). Alternatively, interactions between \"what\" and \"when\" regularities might rest on a generic, sensory-independent mechanism. To address these questions, we manipulated \"what\" and \"when\" regularities at two levels&mdash;single syllables and disyllabic pseudowords&mdash;while recording neural activity using magnetoencephalography (MEG) in healthy volunteers (<I>N</I> = 22). We studied how neural responses to syllable and/or pseudoword deviants are modulated by \"when\" regularity. \"When\" regularity modulated \"what\" mismatch responses with hierarchical specificity, such that responses to deviant pseudowords (vs syllables) were amplified by temporal regularity at slower (vs faster) time scales. However, both these interactive effects were source-localized to the same regions, including frontal and parietal cortices. Effective connectivity analysis showed that the integration of \"what\" and \"when\" regularity selectively modulated connectivity within regions, consistent with gain effects. This suggests that the brain integrates \"what\" and \"when\" predictions that are congruent with respect to their hierarchical level, but this integration is mediated by a shared and distributed cortical network.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"58 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeated tDCS at Clinically Relevant Field Intensity Can Boost Concurrent Motor Learning in Rats","authors":"Forouzan Farahani, Mihály Vöröslakos, Andrew M. Birnbaum, Mohamad FallahRad, Preston T.J.A. Williams, John H. Martin, Lucas C. Parra","doi":"10.1523/jneurosci.1495-24.2025","DOIUrl":"https://doi.org/10.1523/jneurosci.1495-24.2025","url":null,"abstract":"<p>Clinical trials with transcranial direct current stimulation (tDCS) use weak electric fields that have yet to demonstrate measurable behavioral effects in animal models. We hypothesized that weak stimulation will produce sizable effects, provided it is applied concurrently with behavioral training and repeated over multiple sessions. We tested this in a rodent model of dexterous motor skill learning using a pellet-reaching task in <I>ad libitum</I> behaving rats. The task was automated to minimize experimenter bias. We measured field magnitudes intracranially to calibrate the stimulation current. Male rats were trained for 20&nbsp;min with concurrent epicranial tDCS over 10 daily sessions. We developed a new electrode montage that enabled stable stimulation over the 10 sessions with a field intensity of 2 V/m at the motor cortex. Behavior was recorded with high-speed video to quantify reaching dynamics. We also measured motor-evoked potentials (MEPs) bilaterally with epidural microstimulation. The number of successful reaches improved across days of training, and the rate of learning was higher in the anodal group as compared with sham-control animals (<I>F</I><SUB>(1)</SUB> = 7.12; <I>p</I> = 0.008; <I>N</I> = 24). MEPs were not systematically affected by tDCS. Post hoc analysis suggests that tDCS modulated motor learning only for right-pawed animals, improving success of reaching but limiting stereotypy in these animals. Repeated and concurrent anodal tDCS can boost motor skill learning at clinically relevant field intensities. In this animal model, the effect interacted with paw preference and was not associated with corticospinal excitability.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"29 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}