Journal of Neuroscience最新文献

{"title":"Large-Scale High-Resolution Probabilistic Maps of the Human Superior Longitudinal Fasciculus Subdivisions and their Cortical Terminations.","authors":"Matthew Amandola, Katherine Farber, Roma Kidambi, Hoi-Chung Leung","doi":"10.1523/JNEUROSCI.0821-24.2025","DOIUrl":"https://doi.org/10.1523/JNEUROSCI.0821-24.2025","url":null,"abstract":"<p><p>The superior longitudinal fasciculus (SLF) is the large white matter association tract connecting the prefrontal and posterior parietal cortices. Past studies in non-human primates have parcellated the SLF into three subdivisions and have outlined the specific cortico-cortical organization and terminations for each subdivision. However, it is difficult to characterize these structural connections in humans to the specificity of tract-tracing studies in animals. This has led to disagreement on how the SLF subdivisions are organized in the human brain, including if the dorsomedial SLF (SLF-I) is part of the cingulum subsystem. Here, we present a novel large-scale, probabilistic map of the SLF subdivisions, using high-resolution diffusion imaging data from the Human Connectome Project (HCP). We used image data from 302 adult males and 405 adult females to model the three SLF subdivisions in each hemisphere, and attempted to characterize the frontal and parietal termination points for each subdivision. SLF subdivisions were successfully modeled in each subject, showing the dorsomedial-to-ventrolateral organization similar to that in nonhuman primate histological studies. We also found minimal differences between SLF-I models with and without the cingulate gyrus excluded, suggesting that the SLF-I may be a separable tract from the cingulum. Lastly, the SLF subdivisions showed differentiable associations with major cognitive domains such as memory and executive functions. While histological confirmation is needed beyond tractography, these probabilistic masks offer a first step in guiding future exploration of frontoparietal organization by providing detailed characterization of the SLF subdivisions and their potential cortical terminations.<b>Significance statement</b> The prefrontal and posterior parietal areas are interconnected via the SLF, which has been characterized in great detail in monkeys. However, it is difficult to map the SLF organization in the human brain, and previous diffusion MRI findings have been inconsistent. Using diffusion MRI data from 707 individuals, our probabilistic tractography revealed dorsomedial-to-ventrolateral organization of the three SLF subdivisions and their cortical terminations. Our tractography also suggests limited shared volume between the SLF-I and the cingulum, a controversy in recent literature. The SLF subdivisions also differ in their cognitive associations. As a result, we created a large-scale, high-resolution probabilistic parcellation of the SLF, representing an advancement toward standardizing the mapping of human frontoparietal structural connections for clinical and scientific research.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing Human Disparity Tuning Properties Using Population Receptive Field Mapping.","authors":"Ivan Alvarez, Alessandro Mancari, I Betina Ip, Andrew J Parker, Holly Bridge","doi":"10.1523/JNEUROSCI.0795-24.2025","DOIUrl":"10.1523/JNEUROSCI.0795-24.2025","url":null,"abstract":"<p><p>Our visual percept of small differences in depth is largely informed by binocular stereopsis, the ability to decode depth from the horizontal offset between the retinal images in each eye. While multiple cortical areas are associated with stereoscopic processing, it is unclear how tuning to specific binocular disparities is organized across the human visual cortex. We used 3 T functional magnetic resonance imaging to generate population receptive fields (pRFs) in response to modulation of binocular disparity to characterize the neural tuning to disparity. We also used psychophysics to measure stereoacuity thresholds compared with backgrounds at different depths (pedestal disparity). Ten human participants (seven females) observed correlated or anticorrelated random-dot stereograms with disparity ranging from -0.3 to 0.3°, and responses were modeled as one-dimensional tuning curves along the depth dimension. First, we demonstrate that lateral and dorsal visual areas show the greatest proportion of vertices selective for binocular disparity. Second, with binocularly correlated stimuli, we show a polynomial relationship between preferred disparity and tuning curve width, with sharply tuned disparity responses at near-zero disparities, and broader disparity tuning profiles at near or far disparities. This relationship held across visual areas and was not present for anticorrelated stimuli. Finally, the individual thresholds for psychophysical stereoacuity at the three different pedestal disparities were broadly related to pRF tuning width in area V1, suggesting a possible limit for fine stereopsis at the earliest level of cortical processing. Together, these findings point to heterogeneity of disparity processing across human visual areas, comparable with nonhuman primates.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involvement of aSPOC in the Online Updating of Reach-to-Grasp to Mechanical Perturbations of Hand Transport.","authors":"Mariusz P Furmanek, Luis F Schettino, Mathew Yarossi, Madhur Mangalam, Kyle Lockwood, Sergei V Adamovich, Eugene Tunik","doi":"10.1523/JNEUROSCI.0173-24.2025","DOIUrl":"10.1523/JNEUROSCI.0173-24.2025","url":null,"abstract":"<p><p>Humans adjust their movement to changing environments effortlessly via multisensory integration of the effector's state, motor commands, and sensory feedback. It is postulated that frontoparietal (FP) networks are involved in the control of prehension, with dorsomedial (DM) and dorsolateral (DL) regions processing the reach and the grasp, respectively. This study tested (five female and five male participants) the differential involvement of FP nodes [ventral premotor cortex (PMv), dorsal premotor cortex (PMd), anterior intraparietal sulcus (aIPS), and anterior superior parieto-occipital cortex (aSPOC)] in online adjustments of reach-to-grasp coordination to mechanical perturbations (MP) that disrupted arm transport. We used event-related transcranial magnetic stimulation (TMS) to test whether the nodes of these pathways causally contribute to the processing of proprioceptive information when reaching for a virtual visual target at two different perturbation latencies. TMS over aSPOC selectively altered the correction magnitude of arm transport during late perturbations, demonstrating that aSPOC processes proprioceptive inputs related to mechanical perturbations in a movement phase-dependent manner.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping Eye, Arm, and Reward Information in Frontal Motor Cortices Using Electrocorticography in Nonhuman Primates.","authors":"Tomohiro Ouchi, Leo R Scholl, Pavithra Rajeswaran, Ryan A Canfield, Lydia I Smith, Amy L Orsborn","doi":"10.1523/JNEUROSCI.1536-24.2025","DOIUrl":"10.1523/JNEUROSCI.1536-24.2025","url":null,"abstract":"<p><p>Goal-directed reaches give rise to dynamic neural activity across the brain as we move our eyes and arms and process outcomes. High spatiotemporal resolution mapping of multiple cortical areas will improve our understanding of how these neural computations are spatially and temporally distributed across the brain. In this study, we used micro-electrocorticography (µECoG) recordings in two male monkeys performing visually guided reaches to map information related to eye movements, arm movements, and receiving rewards over primary motor cortex, premotor cortex, frontal eye field, and dorsolateral prefrontal cortex. Time-frequency and decoding analyses revealed that eye and arm movement information shifts across brain regions during a reach, likely reflecting shifts from planning to execution. Although eye and arm movement temporally overlapped, phase clustering analyses enabled us to resolve differences in eye and arm information across brain regions. This analysis revealed that eye and arm information spatially overlapped in motor cortex, which we further confirmed by demonstrating that arm movement decoding performance from motor cortex activity was impacted by task-irrelevant eye movements. Phase clustering analyses also identified reward-related activity in the prefrontal and premotor cortex. Our results demonstrate µECoG's strengths for functional mapping and provide further detail on the spatial distribution of eye, arm, and reward information processing distributed across frontal cortices during reaching. These insights advance our understanding of the overlapping neural computations underlying coordinated movements and reveal opportunities to leverage these signals to enhance future brain-computer interfaces.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of Pitch Perception in the Auditory Cortex.","authors":"Ellie Bean Abrams, Alec Marantz, Isaac Krementsov, Laura Gwilliams","doi":"10.1523/JNEUROSCI.1111-24.2025","DOIUrl":"10.1523/JNEUROSCI.1111-24.2025","url":null,"abstract":"<p><p>The ability to perceive pitch allows human listeners to experience music, recognize the identity and emotion conveyed by conversational partners, and make sense of their auditory environment. A pitch percept is formed by weighting different acoustic cues (e.g., signal fundamental frequency and interharmonic spacing) and contextual cues (expectation). How and when such cues are neurally encoded and integrated remains debated. In this study, 28 participants (16 female) listened to tone sequences with different acoustic cues (pure tones, complex missing fundamental tones, and tones with an ambiguous mixture), placed in predictable and less predictable sequences, while magnetoencephalography was recorded. Decoding analyses revealed that pitch was encoded in neural responses to all three tone types in the low-to-mid auditory cortex and sensorimotor cortex bilaterally, with right-hemisphere dominance. The pattern of activity generalized across cue types, offset in time: pitch was neurally encoded earlier for harmonic tones (∼85 ms) than pure tones (∼95 ms). For ambiguous tones, pitch emerged significantly earlier in predictable contexts than in unpredictable. The results suggest that a unified neural representation of pitch emerges by integrating independent pitch cues and that context alters the dynamics of pitch generation when acoustic cues are ambiguous.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering a Timescale Hierarchy by Studying the Brain in a Natural Context.","authors":"Uri Hasson","doi":"10.1523/JNEUROSCI.2368-24.2025","DOIUrl":"10.1523/JNEUROSCI.2368-24.2025","url":null,"abstract":"<p><p>As we train multiple generations of students to narrowly design clever, carefully controlled experiments in our confined lab spaces, we may fail to notice, as a field, that we have overlooked fundamental aspects of human cognition. This is a first-person account of how our research and understanding of the neural code were forever transformed when we decided to open the lab's door to the natural world. This journey started with the decision to shift from controlled stimuli to natural dynamic and \"messy\" stimuli. This transition enabled us to focus on how information is accumulated and processed over time. As a result, we have discovered a new topographic mapping of the hierarchy of cortical processing timescales. I will conclude with a general observation of the paradigm shift occurring in the field as it increasingly emphasizes the study of the neural processes that underlie human behavior in natural, everyday contexts. I am excited to share this journey with you.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"45 12","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient Upregulation of Procaspase-3 during Oligodendrocyte Fate Decisions.","authors":"Yasmine Kamen, Timothy W Chapman, Enrique T Piedra, Matthew E Ciolkowski, Robert A Hill","doi":"10.1523/JNEUROSCI.2066-24.2025","DOIUrl":"10.1523/JNEUROSCI.2066-24.2025","url":null,"abstract":"<p><p>Oligodendrocytes are generated throughout life and in neurodegenerative conditions from brain resident oligodendrocyte precursor cells (OPCs). The transition from OPC to oligodendrocyte involves a complex cascade of molecular and morphological states that position the cell to make a fate decision to integrate as a myelinating oligodendrocyte or die through apoptosis. Oligodendrocyte maturation impacts the cell death mechanisms that occur in degenerative conditions, but it is unclear if and how the cell death machinery changes as OPCs transition into oligodendrocytes. Here, we discovered that differentiating oligodendrocytes transiently upregulate the zymogen procaspase-3 in both female and male mice, equipping these cells to make a survival decision during differentiation. Pharmacological inhibition of caspase-3 decreases oligodendrocyte density, indicating that procaspase-3 upregulation is linked to successful oligodendrocyte generation. Moreover, using procaspase-3 as a marker, we show that oligodendrocyte differentiation continues in the aging cortex and white matter. Taken together, our data establish procaspase-3 as a differentiating oligodendrocyte marker and provide insight into the underlying mechanisms occurring during the decision to integrate or die.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurons of the Central Nucleus of the Amygdala That Express Angiotensin Type 2 Receptors Couple Lowered Blood Pressure with Anxiolysis in Male Mice.","authors":"Khalid Elsaafien, Matthew K Kirchner, Karen A Scott, Eliot A Spector, Francesca E Mowry, Colin Sumners, Javier E Stern, Annette D de Kloet, Eric G Krause","doi":"10.1523/JNEUROSCI.1482-24.2025","DOIUrl":"10.1523/JNEUROSCI.1482-24.2025","url":null,"abstract":"<p><p>Relief from psychological stress confers cardio-protection by altering brain activity and lowering blood pressure; however, the neuronal circuits orchestrating these effects are unknown. Here, we used male mice to discern neuronal circuits conferring stress relief and reduced blood pressure. We found that neurons residing in the central nucleus of the amygdala (CeA) expressing angiotensin type 2 receptors (AT₂R), deemed CeA^AT2R, innervate brain nuclei regulating stress responding. In vivo optogenetic excitation of CeA^AT2R lowered blood pressure, and this effect was abrogated by systemic hexamethonium or antagonism of GABA receptors within the CeA. Intriguingly, in vivo optogenetic excitation of CeA^AT2R was also potently anxiolytic. Delivery of an AT₂R agonist into the CeA recapitulated the hypotensive and anxiolytic effects, but ablating AT₂R(s) from the CeA was anxiogenic. The results suggest that the excitation of CeA^AT2R couples lowered blood pressure with anxiolysis. The implication is that therapeutics targeting CeA^AT2R may provide stress relief and protection against cardiovascular disease.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Representation of Stimulus Features during Stable Fixation and Active Vision.","authors":"Caoimhe Moran, Philippa A Johnson, Hinze Hogendoorn, Ayelet N Landau","doi":"10.1523/JNEUROSCI.1652-24.2024","DOIUrl":"10.1523/JNEUROSCI.1652-24.2024","url":null,"abstract":"<p><p>Predictive updating of an object's spatial coordinates from presaccade to postsaccade contributes to stable visual perception. Whether object features are predictively remapped remains contested. We set out to characterize the spatiotemporal dynamics of feature processing during stable fixation and active vision. To do so, we applied multivariate decoding methods to EEG data collected while human participants (male and female) viewed brief visual stimuli. Stimuli appeared at different locations across the visual field at either high or low spatial frequency (SF). During fixation, classifiers were trained to decode SF presented at one parafoveal location and cross-tested on SF from either the same, adjacent, or more peripheral locations. When training and testing on the same location, SF was classified shortly after stimulus onset (∼79 ms). Decoding of SF at locations farther from the trained location emerged later (∼144-295 ms), with decoding latency modulated by eccentricity. This analysis provides a detailed time course for the spread of feature information across the visual field. Next, we investigated how active vision impacts the emergence of SF information. In the presence of a saccade, the decoding time of peripheral SF at parafoveal locations was earlier, indicating predictive anticipation of SF due to the saccade. Crucially, however, this predictive effect was not limited to the specific remapped location. Rather, peripheral SF was correctly classified, at an accelerated time course, at all parafoveal positions. This indicates spatially coarse, predictive anticipation of stimulus features during active vision, likely enabling a smooth transition on saccade landing.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kv4.2 Regulates Basal Synaptic Strength by Inhibiting R-Type Calcium Channels in the Hippocampus.","authors":"Seung Yeon Lee, Jiwoo Shin, Min Jeong Kwon, Yujin Kim, Won-Kyung Ho, Suk-Ho Lee","doi":"10.1523/JNEUROSCI.0444-24.2025","DOIUrl":"10.1523/JNEUROSCI.0444-24.2025","url":null,"abstract":"<p><p>Kv4.2 subunits, which mediate transient A-type K⁺ current, are crucial in regulating neuronal excitability and synaptic responses within the hippocampus. While their contribution to activity-dependent regulation of synaptic response is well-established, the impact of Kv4.2 on basal synaptic strength remains elusive. To address this gap, we introduced a Kv4.2-specific antibody (anti-Kv4.2) into hippocampal neurons of mice of both sexes to selectively inhibit postsynaptic Kv4.2, enabling direct examination of its impact on excitatory postsynaptic potentials (EPSPs) and currents (EPSCs) during basal synaptic activity. Our results demonstrated that blocking Kv4.2 significantly enhanced the amplitude of EPSPs. This amplification was proportional to the increase in the amplitude of EPSCs, which, in turn, correlated with the expression level of Kv4.2 in the dendritic regions of the hippocampus. Furthermore, the anti-Kv4.2-induced increase in EPSC amplitude was associated with a decrease in the failure rate of EPSCs evoked by minimal stimulation, suggesting that blocking Kv4.2 facilitates the recruitment of AMPA receptors to both silent and functional synapses to enhance synaptic efficacy. The anti-Kv4.2-induced synaptic potentiation was effectively abolished by intracellular 10 mM BAPTA or by blocking R-type calcium channels (RTCCs) and downstream signaling molecules, including protein kinases A and C. Importantly, Kv4.2 inhibition did not occlude further synaptic potentiation induced by high-frequency stimulation, suggesting that anti-Kv4.2-induced synaptic strengthening involves unique mechanisms that are distinct from long-term potentiation pathways. Taken together, these findings underscore the essential role of Kv4.2 in the regulation of basal synaptic strength, which is mediated by the inhibition of RTCCs.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}