Journal of Neuroscience最新文献

{"title":"Muscle derived BMP4 regulates morphology and function of endplates on extrafusal and intrafusal muscle fibers in adult mice.","authors":"Julia M Harrison,Borbala Podor,Asal Yans,Victor F Rafuse","doi":"10.1523/jneurosci.0707-25.2025","DOIUrl":"https://doi.org/10.1523/jneurosci.0707-25.2025","url":null,"abstract":"Understanding factors contributing to neuromuscular junction (NMJ) stability post-development will shed light on how this stability is lost during aging and in neuromuscular diseases. Previous work in Drosophila suggests that morphogens within the bone morphogenetic protein (BMP) family are potential candidates because the BMP homolog, gbb, along with its receptor, wit, have key roles in NMJ structure, stability, and function. Whether BMPs have similar roles at vertebrate NMJs is currently unknown. To examine this question, we generated doxycycline-inducible, muscle specific BMP4 null mice, referred to here as HSACreBMP4fl/fl mice. Motor behavior tasks were examined pre- and post-induction while electrophysiological and morphological characteristics were examined 4 months later in mice of both sexes. Soleus muscles from HSACreBMP4fl/fl mice had significantly reduced contractile force compared to wild-type (WT) littermates. Cross-sectional areas of type I, but not type IIa, muscle fibers were reduced. NMJs were also larger in HSACreBMP4fl/fl muscles compared to controls due to a significant increase in acetylcholine receptor fragment number and distribution. HSACreBMP4fl/fl NMJs displayed reduced amplitude and frequency of miniature endplate potentials (mEPPs), evoked EPP amplitude, quantal content, and had increased failure rates when stimulating at high frequencies. Behaviorally, HSACreBMP4fl/fl mice performed increasingly worse over time on the rotarod after doxycycline administration compared to their WT littermates. Finally, muscle spindle structure and proprioceptive function were significantly compromised in HSACreBMP4fl/fl mice. These results indicate that muscle derived BMP4 regulates morphological and electrophysiological attributes of the NMJ in adult mice as well as the structure and function of muscle spindles.Significance statement Understanding the cellular mechanisms underlying neuromuscular junction (NMJ) stability is critically important in understanding why it is compromised during aging and in motoneuron diseases. Studies in Drosophila larvae have shown that gbb and wit, a ligand and receptor in the BMP signaling pathway, are critical for the stability and function of the NMJ. This paper uses a novel doxycycline-inducible, muscle-specific BMP4 knockdown approach to eliminate muscular BMP4 expression in adult mice. When BMP4 was excised in the adult, we found that muscle strength and neurotransmission were attenuated, endplates fragmented, and mice had locomotor deficits. Furthermore, muscle spindle innervation and proprioceptive function were impaired. Therefore, as in Drosophila larvae, BMP4 is required for normal function and morphology of adult vertebrate NMJs.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"125 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint population coding and temporal coherence link an attended talker's voice and location features in naturalistic multi-talker scenes.","authors":"Kiki van der Heijden, Prachi Patel, Stephan Bickel, Jose L Herrero, Ashesh D Mehta, Nima Mesgarani","doi":"10.1523/JNEUROSCI.0754-25.2025","DOIUrl":"https://doi.org/10.1523/JNEUROSCI.0754-25.2025","url":null,"abstract":"<p><p>Listeners effortlessly extract multidimensional auditory objects, such as a localized talker, from complex acoustic scenes. However, the neural mechanisms that enable simultaneous encoding and linking of distinct sound features-such as a talker's voice and location-are not fully understood. Using invasive intracranial recordings in seven neurosurgical patients (4 male, 3 female), we investigated how the human auditory cortex processes and integrates these features during naturalistic multi-talker scenes and how attentional mechanisms modulate such feature integration. We found that cortical sites exhibit a continuum of feature sensitivity, ranging from single-feature sensitive sites (responsive primarily to voice spectral features or to location features) to dual-feature sensitive sites (responsive to both features). At the population level, neural response patterns from both single- and dual-feature sensitive sites jointly encoded the attended talker's voice and location. Notably, single-feature sensitive sites encoded their primary feature with greater precision but also represented coarse information about the secondary feature. Sites selectively tracking a single, attended speech stream concurrently encoded both voice and location features, demonstrating a link between selective attention and feature integration. Additionally, attention selectively enhanced temporal coherence between voice- and location-sensitive sites, suggesting that temporal synchronization serves as a mechanism for linking these features. Our findings highlight two complementary neural mechanisms-joint population coding and temporal coherence-that enable the integration of voice and location features in the auditory cortex. These results provide new insights into the distributed, multidimensional nature of auditory object formation during active listening in complex environments.<b>Significance statement</b> In everyday life, listeners effortlessly extract individual sound sources from complex acoustic scenes which contain multiple sound sources. Yet, how the brain links the different features of a particular sound source to each other - such as a talker's voice characteristics and location - is poorly understood. Here, we show that two neural mechanisms contribute to encoding and integrating voice and location features in multi-talker sound scenes: (1) some neuronal sites are sensitive to both voice and location and their activity patterns encode these features jointly; (2) the responses of neuronal sites that process only one sound feature - that is, location or voice - align temporally to form a stream that is segregated from the other talker.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor control processes moderate visual working memory gating.","authors":"Şahcan Özdemir, Eren Günseli, Daniel Schneider","doi":"10.1523/JNEUROSCI.0673-25.2025","DOIUrl":"https://doi.org/10.1523/JNEUROSCI.0673-25.2025","url":null,"abstract":"<p><p>Gating processes that regulate sensory input into visual working memory (WM) and the execution of planned actions share neural mechanisms, suggesting a mutual interaction. In a preregistered study (OSF), we examined how this interaction may result in sensory interference during WM storage using a delayed-match-to-sample task. Participants (12 male, 20 female) memorized the color of a target stimulus for later report on a color wheel. The shape of the target indicated which hand they would adjust the color wheel with. During the retention interval, an interference task was presented, requiring a response with either the same or different hand as the main task. In half of the interference trials, the interfering task cue was also colored to introduce visual interference. EEG results showed early motor planning during sensory encoding, evidenced by mu/beta suppression contralateral to the responding hand. The interference task only impaired WM performance when it included an irrelevant color, indicating that the interference effect was primarily driven by the irrelevant sensory information. In addition, color reporting in the WM task was biased toward the irrelevant color. This was more pronounced when both tasks were performed with the same hand, suggesting a selective gating mechanism dependent on motor control processes. This effect was mitigated by a control mechanism, which was evident in frontal theta activity, where higher power predicted lower bias on the single-trial level. Our findings thus reveal that sensory WM updating can be induced by interfering motor actions, which can be compensated by a reactive control mechanism.<b>Significance statement</b> Working memory is increasingly recognized not just as a passive information storage but as an active mechanism that constructs prospective representations to guide future actions. We investigated how future-oriented plans regulate the entry of new information for maintenance. We found that when a stored memory is linked to a response, it becomes particularly vulnerable to interference from sensory input that demands the same response. We also identified neural signatures of this interaction where a control mechanism mitigates interference from irrelevant information. These findings provide key insights into the fundamental architecture of memory, demonstrating for the first time that prospective motor codes not only shape the use of stored information but also influence how new information is integrated into working memory.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered electrophysiology and transcriptome of GnRH neurons in middle-aged female mice.","authors":"Imre Farkas,Csaba Vastagh,Imre Kalló,Levente Kontra,Zsolt Liposits","doi":"10.1523/jneurosci.0410-25.2025","DOIUrl":"https://doi.org/10.1523/jneurosci.0410-25.2025","url":null,"abstract":"Aging affects the reproductive system, although its impact on GnRH neurons is mainly unexplored. Thus, we compared the transcriptome and electrophysiology of GnRH neurons obtained from female middle-aged (MA, 400-430 days) and young (Y, 70 days), diestrous mice, respectively. Transcriptomic analysis revealed reproductive senescence-related molecular changes in one-third of the MA mice. The upregulated genes (n=225) were linked to immune signalling, olfactory- and vomero-nasal receptors. The downregulated genes (n=233) were related to mRNA processing, G-protein-coupled receptors, oxidative phosphorylation, electron transport, and estrogen signalling. In addition, ion channel (Na, K, Ca), neurotransmitter (ACh, GABA, glutamate)- and various neuropeptide receptor-coding genes showed differential expression indicating functional alterations of the cells. Accordingly, whole-cell patch-clamp recordings revealed a two-fold increase in spontaneous firing frequency of MA GnRH neurons. Significant changes were also observed in characteristics of action potentials and afterhyperpolarization amplitudes. Conspicuously, miniature postsynaptic currents were absent in 72% of MA-GnRH neurons and pharmacological blockade of GABA-A and glutamate receptors didn't affect firing rate. However, administration of their ligands evoked inward currents and facilitated firing in both animal groups, although with a decreased efficacy in MA animals. MA-GnRH neurons sustained responsiveness to estradiol, G-protein inhibition and kisspeptin (KP) like those of young animals. While KP receptor antagonist, KP-234 diminished firing frequency of MA GnRH neurons, it had no effect on young GnRH cells. Collectively, these findings revealed that both the transcriptome and electrophysiological activity of GnRH neurons change at middle-age and the explored alterations are hallmarks of early phase of reproductive senescence.Significance statement Aging reduces gonadal hormone production, which is centrally regulated by GnRH neurons. Understanding how the early phase of reproductive senescence affects the GnRH system is crucial. Using middle-aged (MA) female mice, we demonstrate that GnRH neurons undergo transcriptomic changes indicating altered, house-keeping mechanisms and modification of cellular activity. Accordingly, MA-GnRH neurons showed increased firing activity despite the attenuated GABA and glutamate neurotransmission, and sustained estradiol responsiveness. G-protein-coupled receptor signalling remained functional, and kisspeptin (KP) further increased the firing frequency. Contrasting young GnRH neurons, the MA cells received a tonic KP modulation. These findings also highlight the heterogeneity of middle-aged mice population and provide molecular and functional markers of GnRH neurons characteristic for the early phase of reproductive senescence.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"4 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cofilin inhibition ameliorates PIEZO2 and AMPA dysfunction in a mouse model of Angelman syndrome.","authors":"Luis O Romero,Manisha Bade,Elisa Carrillo,Sonia Paz-López,Syed A M Hasan,William James Antonisamy,Vasanthi Jayaraman,Zahoor A Shah,Valeria Vásquez,Julio F Cordero-Morales","doi":"10.1523/jneurosci.0965-25.2025","DOIUrl":"https://doi.org/10.1523/jneurosci.0965-25.2025","url":null,"abstract":"Angelman syndrome (AS) is a neurogenetic disorder characterized by motor coordination and cognitive deficits. In AS, hippocampal neurons show reduced filamentous actin, a decrease we also reported in dorsal root ganglia (DRG) neurons, along with impaired mechanosensitive ion channel activity. Currently, there are no pharmacological targets to prevent the decrease of filamentous actin in AS. Here, we utilize a first-in-class selective cofilin inhibitor (SZ-3) to restore PIEZO2 function in DRG neurons and glutamate-evoked currents in hippocampal neurons from AS mice. Using atomic force microscopy, we demonstrate that inhibiting cofilin, an actin-severing protein, with SZ-3 increases cellular stiffness by stabilizing the actin cytoskeleton. Furthermore, systemic administration of SZ-3 in male and female AS mice enhances their performance in the rotarod and T-maze tests. These findings support that cytoskeletal dysregulation contributes to impaired ion channel function and behavioral deficits, and that actin-binding proteins could serve as a target for enhancing motor coordination and spatial learning in AS.Significance Statement Angelman syndrome (AS) is a severe neurogenetic disorder characterized by significant motor and cognitive impairments; however, effective treatments remain elusive. Recent evidence implicates deficits in the mechanosensitive PIEZO2 channel and AMPA receptor function, as well as cytoskeletal abnormalities in AS pathology. Our study identifies cofilin, an actin-binding protein, as a regulator of ion channel function. We demonstrate that pharmacological inhibition of cofilin restores PIEZO2 channel and AMPA receptor activities, enhances neuronal excitability, and improves motor coordination and learning in a mouse model of AS. These findings reveal a novel mechanism by which actin dynamics influence sensory and cognitive function.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"50 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maturation of Neuronal Activity in the Human Cortex Exhibits Robust Spatial Gradients across the Birth Transition.","authors":"Nathan J Stevenson, Kartik Iyer, Anton Tokariev, James A Roberts, Sampsa Vanhatalo","doi":"10.1523/JNEUROSCI.0610-25.2025","DOIUrl":"10.1523/JNEUROSCI.0610-25.2025","url":null,"abstract":"<p><p>Early structural and molecular development of the human cortex is extensively studied, but little is known about the development of neuronal activity across cortical regions. We used dense array electroencephalography recordings and a machine learning-based measure, functional brain age (FBA), to study spatiotemporally resolved maturation of cortical activity across the birth transition in human infants (male and female). We found clear spatial FBA gradients indicating more mature frontal cortical activity relative to other brain regions (geometric axis), as well as more mature activity in association cortices relative to sensory cortices (hierarchical axis). The frontal advance was explained by more mature bursting characteristics, a hallmark of early endogenous neuronal activity. The findings jointly support an advanced maturation of neuronal ensemble activity in cortical regions that are preparing to host synergistic, large-scale network interactions, a key global characteristic of mature brain function.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12509498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Development of Neural Inhibition across Species: Insights from the Hurst Exponent.","authors":"Monami Nishio, Monica E Ellwood-Lowe, Mackenzie Woodburn, Cassidy L McDermott, Anne T Park, Ursula A Tooley, Austin L Boroshok, Joanes Grandjean, Allyson P Mackey","doi":"10.1523/JNEUROSCI.0025-25.2025","DOIUrl":"10.1523/JNEUROSCI.0025-25.2025","url":null,"abstract":"<p><p>The maturation of inhibitory neurons is crucial for regulating plasticity in developing brains. Previous work has suggested that the Hurst exponent, the measure of autocorrelation in time series, reflects inhibition, but empirical data supporting this link are sparse. Here, we demonstrate significant spatial correlations between the Hurst exponent and ex vivo parvalbumin (PV) inhibitory mRNA expression in human children and adults, as well as between the Hurst exponent and PV-positive cell counts in mice, across both sexes. We further identified developmental plateaus in inhibition, as indicated by both PV inhibitory mRNA expression and the Hurst exponent, occurring prior to adolescence in humans and rats. In sum, this work suggests that the Hurst exponent can be used to study the development of inhibition in vivo and to understand inhibitory development across species.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12509484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholinergic Dynamics in the Septo-hippocampal System Provide Phasic Multiplexed Signals for Spatial Novelty and Correlate with Behavioral States.","authors":"Fatemeh Farokhi Moghadam, Blanca E Gutiérrez-Guzmán, Xihui Zheng, Mina Parsa, Lojy M Hozyen, Holger Dannenberg","doi":"10.1523/JNEUROSCI.0133-25.2025","DOIUrl":"10.1523/JNEUROSCI.0133-25.2025","url":null,"abstract":"<p><p>In the hippocampal formation, cholinergic modulation from the medial septum/diagonal band of Broca is known to correlate with the speed of an animal's movements at subsecond timescales and also supports spatial memory formation. Yet, the extent to which subsecond cholinergic dynamics, if at all, align with transient behavioral and cognitive states supporting the encoding of novel spatial information remains unknown. In this study, we used fiber photometry to record the temporal dynamics in the population activity of septo-hippocampal cholinergic neurons at subsecond resolution during a hippocampus-dependent object location memory task using ChAT-Cre mice of both sexes. Using a linear mixed-effects model, we quantified the extent to which cholinergic dynamics were explained by changes in movement speed; behavioral states such as locomotion, grooming, and rearing; and hippocampus-dependent cognitive states such as recognizing a novel location of a familiar object. The data show that cholinergic dynamics contain a multiplexed code of fast and slow signals (1) coding for the logarithm of movement speed at subsecond timescales, (2) providing a phasic spatial novelty signal during the brief periods of exploring a novel object location, and (3) coding for recency of environmental change at a seconds-long timescale. Furthermore, behavioral event-related phasic cholinergic activity demonstrates that fast cholinergic transients correlate with a switch in cognitive and behavioral states. These findings enhance understanding of the mechanisms by which cholinergic modulation contributes to the coding of movement speed and encoding of novel spatial information.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12509495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional connectivity is dominated by aperiodic, rather than oscillatory, coupling.","authors":"N Monchy, J Duprez, J-F Houvenaghel, A Legros, B Voytek, J Modolo","doi":"10.1523/JNEUROSCI.1041-25.2025","DOIUrl":"https://doi.org/10.1523/JNEUROSCI.1041-25.2025","url":null,"abstract":"<p><p>Functional connectivity (FC) has attracted significant interest in the identification of specific circuits underlying brain (dys-)function. Classical analyses to estimate FC (<i>i.e</i>, filtering electrophysiological signals in canonical frequency bands and using connectivity metrics) assume that these reflect oscillatory networks. However, this approach conflates non-oscillatory, aperiodic neural activity with oscillations; raising the possibility that these functional networks may reflect aperiodic rather than oscillatory activity. Here, we provide the first study quantifying, in two different human electroencephalography (EEG) databases (<i>n</i>=59, 30 females and 29 males; <i>n</i>=103, 62 females and 41 males), the contribution of aperiodic activity on reconstructed oscillatory functional networks in resting state. We also followed the same approach on cognitive task recordings (<i>n</i>=59, 30 females and 29 males) as a complementary analysis. We found that about 99% of delta, theta, and gamma functional networks, over 90% of beta functional networks and between 23 and 61% of alpha functional networks were actually driven by aperiodic activity. While there is no universal consensus on how to identify and quantify neural oscillations, our results demonstrate that oscillatory functional networks may be drastically sparser than commonly assumed. These findings suggest that most FC studies focusing on resting state data actually reflect aperiodic networks instead of oscillations-based networks. We highly recommend that oscillatory network analyses first check the presence of aperiodicity-unbiased neural oscillations before estimating their statistical coupling to strengthen the robustness, interpretability, and reproducibility of FC studies.<b>Significance statement</b> Assessing how brain regions communicate is critical for understanding behavior and cognition. In electroencephalography and magnetoencephalography, neural networks are commonly identified through functional connectivity estimated under the assumption that inter-regional coupling between brain regions reflects oscillatory networks. Our findings demonstrate that a substantial portion of presumed oscillatory networks are instead driven by aperiodic activity, thereby challenging a central methodological assumption in the field. By explicitly disentangling oscillatory and aperiodic components, this work calls for a reassessment of existing approaches, showing that oscillatory networks are far less widespread than commonly assumed, and provides a refined framework to improve the robustness and reproducibility of function connectivity research, with implications for both cognitive and clinical neuroscience.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic Repression of miR-216a-3p via H3K27me3 Drives STIM1-Mediated Neuronal Excitability in Neuropathic Pain.","authors":"Sapphire Newman-Fogel","doi":"10.1523/jneurosci.0378-25.2025","DOIUrl":"https://doi.org/10.1523/jneurosci.0378-25.2025","url":null,"abstract":"","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"55 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}