Journal of Neuroscience最新文献

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Shifting GnRH neuron ensembles underlie successive preovulatory luteinizing hormone surges. 排卵前黄体生成素连续激增的基础是不断变化的 GnRH 神经元组合。
IF 4.4 2区 医学
Journal of Neuroscience Pub Date : 2024-11-06 DOI: 10.1523/JNEUROSCI.1383-24.2024
Shel-Hwa Yeo, Su Young Han, Allan E Herbison
{"title":"Shifting GnRH neuron ensembles underlie successive preovulatory luteinizing hormone surges.","authors":"Shel-Hwa Yeo, Su Young Han, Allan E Herbison","doi":"10.1523/JNEUROSCI.1383-24.2024","DOIUrl":"https://doi.org/10.1523/JNEUROSCI.1383-24.2024","url":null,"abstract":"<p><p>The gonadotropin-releasing hormone (GnRH) neurons operate as a neuronal ensemble exhibiting coordinated activity once every reproductive cycle to generate the preovulatory GnRH surge. Using GCaMP fibre photometry at the GnRH neuron distal dendrons to measure the output of this widely scattered population in female mice, we find that the onset, amplitude, and profile of GnRH neuron surge activity exhibits substantial variability from cycle to cycle both between and within individual mice. This was also evident when measuring successive proestrous luteinizing hormone surges. Studies combining short (c-Fos and c-Jun) and long (genetic Robust Activity Marking) term indices of immediate early gene activation revealed that, while ∼50% of GnRH neurons were activated at the time of each surge, only half of these neurons had been active during the previous proestrous surge. These observations reveal marked inter- and intra-individual variability in the GnRH surge mechanism. Remarkably, different sub-populations of overlapping GnRH neurons are recruited to the ensemble each estrous cycle to generate the GnRH surge. While engendering variability in the surge mechanism itself, this likely provides substantial robustness to a key event underlying mammalian reproduction.<b>Significance Statement</b> The mid-cycle luteinizing hormone (LH) surge driven by the gonadotropin-releasing hormone (GnRH) neurons represents the key event triggering ovulation in all mammals. Using GCaMP fibre photometry and genetic activation markers, we unexpectedly find that different sub-populations of GnRH neurons are responsible for driving consecutive LH surges every 4-5 days in cycling female mice. This remarkable oscillatory pattern of network plasticity within the ensemble occurs under normal physiological conditions and likely contributes to the variable timing of the onset of LH surge both within and between individuals. The ability of individual GnRH neurons to take turns within the ensemble in driving the LH surge likely provides a robust fail-safe mechanism for ovulation and contributes to the robustness of mammalian fertility.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural Representations of Concreteness and Concrete Concepts Are Specific to the Individual. 具体性和具体概念的神经表征是个人特有的。
IF 4.4 2区 医学
Journal of Neuroscience Pub Date : 2024-11-06 DOI: 10.1523/JNEUROSCI.0288-24.2024
Thomas L Botch, Emily S Finn
{"title":"Neural Representations of Concreteness and Concrete Concepts Are Specific to the Individual.","authors":"Thomas L Botch, Emily S Finn","doi":"10.1523/JNEUROSCI.0288-24.2024","DOIUrl":"10.1523/JNEUROSCI.0288-24.2024","url":null,"abstract":"<p><p>Different people listening to the same story may converge upon a largely shared interpretation while still developing idiosyncratic experiences atop that shared foundation. What linguistic properties support this individualized experience of natural language? Here, we investigate how the \"concrete-abstract\" axis-the extent to which a word is grounded in sensory experience-relates to within- and across-subject variability in the neural representations of language. Leveraging a dataset of human participants of both sexes who each listened to four auditory stories while undergoing functional magnetic resonance imaging, we demonstrate that neural representations of \"concreteness\" are both reliable across stories and relatively unique to individuals, while neural representations of \"abstractness\" are variable both within individuals and across the population. Using natural language processing tools, we show that concrete words exhibit similar neural representations despite spanning larger distances within a high-dimensional semantic space, which potentially reflects an underlying representational signature of sensory experience-namely, imageability-shared by concrete words but absent from abstract words. Our findings situate the concrete-abstract axis as a core dimension that supports both shared and individualized representations of natural language.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Hippocampus Preorders Movements for Skilled Action Sequences. 海马体为熟练动作序列预设动作顺序
IF 4.4 2区 医学
Journal of Neuroscience Pub Date : 2024-11-06 DOI: 10.1523/JNEUROSCI.0832-24.2024
Rhys Yewbrey, Katja Kornysheva
{"title":"The Hippocampus Preorders Movements for Skilled Action Sequences.","authors":"Rhys Yewbrey, Katja Kornysheva","doi":"10.1523/JNEUROSCI.0832-24.2024","DOIUrl":"10.1523/JNEUROSCI.0832-24.2024","url":null,"abstract":"<p><p>Plasticity in the subcortical motor basal ganglia-thalamo-cerebellar network plays a key role in the acquisition and control of long-term memory for new procedural skills, from the formation of population trajectories controlling trained motor skills in the striatum to the adaptation of sensorimotor maps in the cerebellum. However, recent findings demonstrate the involvement of a wider cortical and subcortical brain network in the consolidation and control of well-trained actions, including a brain region traditionally associated with declarative memory-the hippocampus. Here, we probe which role these subcortical areas play in skilled motor sequence control, from sequence feature selection during planning to their integration during sequence execution. An fMRI dataset (<i>N</i> = 24; 14 females) collected after participants learnt to produce four finger press sequences entirely from memory with high movement and timing accuracy over several days was examined for both changes in BOLD activity and their informational content in subcortical regions of interest. Although there was a widespread activity increase in effector-related striatal, thalamic, and cerebellar regions, in particular during sequence execution, the associated activity did not contain information on the motor sequence identity. In contrast, hippocampal activity increased during planning and predicted the order of the upcoming sequence of movements. Our findings suggest that the hippocampus preorders movements for skilled action sequences, thus contributing to the higher-order control of skilled movements that require flexible retrieval. These findings challenge the traditional taxonomy of episodic and procedural memory and carry implications for the rehabilitation of individuals with neurodegenerative disorders.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatiotemporal Neural Network for Sublexical Information Processing: An Intracranial SEEG Study. 用于副词汇信息处理的时空神经网络:颅内 SEEG 研究。
IF 4.4 2区 医学
Journal of Neuroscience Pub Date : 2024-11-06 DOI: 10.1523/JNEUROSCI.0717-24.2024
Chunyu Zhao, Yi Liu, Jiahong Zeng, Xiangqi Luo, Weijin Sun, Guoming Luan, Yuxin Liu, Yumei Zhang, Gaofeng Shi, Yuguang Guan, Zaizhu Han
{"title":"Spatiotemporal Neural Network for Sublexical Information Processing: An Intracranial SEEG Study.","authors":"Chunyu Zhao, Yi Liu, Jiahong Zeng, Xiangqi Luo, Weijin Sun, Guoming Luan, Yuxin Liu, Yumei Zhang, Gaofeng Shi, Yuguang Guan, Zaizhu Han","doi":"10.1523/JNEUROSCI.0717-24.2024","DOIUrl":"10.1523/JNEUROSCI.0717-24.2024","url":null,"abstract":"<p><p>Words offer a unique opportunity to separate the processing mechanisms of object subcomponents from those of the whole object, because the phonological or semantic information provided by the word subcomponents (i.e., sublexical information) can conflict with that provided by the whole word (i.e., lexical information). Previous studies have revealed some of the specific brain regions and temporal information involved in sublexical information processing. However, a comprehensive spatiotemporal neural network for sublexical processing remains to be fully elucidated due to the low temporal or spatial resolutions of previous neuroimaging studies. In this study, we recorded stereoelectroencephalography signals with high spatial and temporal resolutions from a large sample of 39 epilepsy patients (both sexes) during a Chinese character oral reading task. We explored the activated brain regions and their connectivity related to three sublexical effects: phonological regularity (whether the whole character's pronunciation aligns with its phonetic radical), phonological consistency (whether characters with the same phonetic radical share the same pronunciation), and semantic transparency (whether the whole character's meaning aligns with its semantic radical). The results revealed that sublexical effects existed in the inferior frontal gyrus, precentral and postcentral gyri, temporal lobe, and middle occipital gyrus. Additionally, connectivity from the middle occipital gyrus to the postcentral gyrus and from postcentral gyrus to the fusiform gyrus was associated with the sublexical effects. These findings provide valuable insights into the spatiotemporal dynamics of sublexical processing and object recognition in the brain.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alpha Traveling Waves during Working Memory: Disentangling Bottom-up Gating and Top-down Gain Control. 工作记忆中的α游走波:区分自下而上的门控和自上而下的增益控制
IF 4.4 2区 医学
Journal of Neuroscience Pub Date : 2024-11-06 DOI: 10.1523/JNEUROSCI.0532-24.2024
Yifan Zeng, Paul Sauseng, Andrea Alamia
{"title":"Alpha Traveling Waves during Working Memory: Disentangling Bottom-up Gating and Top-down Gain Control.","authors":"Yifan Zeng, Paul Sauseng, Andrea Alamia","doi":"10.1523/JNEUROSCI.0532-24.2024","DOIUrl":"https://doi.org/10.1523/JNEUROSCI.0532-24.2024","url":null,"abstract":"<p><p>While previous works established the inhibitory role of alpha oscillations during working memory maintenance, it remains an open question whether such an inhibitory control is a top-down process. Here, we attempted to disentangle this issue by considering the spatio-temporal component of waves in the alpha band, i.e., alpha traveling waves. We reanalyzed two pre-existing and open-access EEG datasets (N = 180, 90 males, 80 females, 10 unknown) where participants performed lateralized, visual delayed match-to-sample working memory tasks. In the first dataset, the distractor load was manipulated (2, 4, or 6), whereas in the second dataset, the memory span varied between 1, 3, and 6 items. We focused on the propagation of alpha waves on the anterior-posterior axis during the retention period. Our results reveal an increase in alpha-band forward waves as the distractor load increased, but also an increase in forward waves and a decrease in backward waves as the memory set size increased. Our results also showed a lateralization effect: alpha forward waves exhibited a more pronounced increase in the hemisphere contralateral to the distractors, whereas the reduction in backward waves was stronger in the hemisphere contralateral to the targets. In short, the forward waves were regulated by distractors, whereas targets inversely modulated backward waves. Such a dissociation of goal-related and goal-irrelevant physiological signals suggests the co-existence of bottom-up and top-down inhibitory processes: alpha forward waves might convey a gating effect driven by distractor load, while backward waves may represent direct top-down gain control of downstream visual areas.<b>Significance Statement</b> When exploring the functional role of alpha band neural oscillations during working memory, mostly amplitude modulations have been considered so far, with relatively limited exploration of spatial-temporal dynamics of this rather global brain oscillatory signature. The present study seeks to address this gap by examining the directionality of alpha wave propagation during working memory retention. Our findings offer novel insights into the well-established inhibitory role of alpha waves, demonstrating that this function is manifested differently according to their propagation directions: forward waves seem to facilitate bottom-up gating, while backward waves might mediate top-down gain control.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persistent threat avoidance following negative reinforcement is not associated with elevated state anxiety. 负强化后的持续威胁回避与状态焦虑升高无关。
IF 4.4 2区 医学
Journal of Neuroscience Pub Date : 2024-11-06 DOI: 10.1523/JNEUROSCI.0815-24.2024
E A Crummy, B L Chamberlain, J P Gamboa, J L Pierson, S E Ahmari
{"title":"Persistent threat avoidance following negative reinforcement is not associated with elevated state anxiety.","authors":"E A Crummy, B L Chamberlain, J P Gamboa, J L Pierson, S E Ahmari","doi":"10.1523/JNEUROSCI.0815-24.2024","DOIUrl":"https://doi.org/10.1523/JNEUROSCI.0815-24.2024","url":null,"abstract":"<p><p>Obsessive-Compulsive Disorder (OCD) is a debilitating illness consisting of obsessions and compulsions. OCD severity and treatment response are correlated with avoidant behaviors thought be performed to alleviate obsession-related anxiety. However, little is known about either the role of avoidance in the development of OCD or the interplay between anxiety states and avoidance behaviors. We have developed an instrumental negative reinforcement (i.e. active avoidance) paradigm in which mice must lever-press to avoid upcoming foot shocks. We show that mice (both sexes) can learn this task with high acquisition rates (75%) and that this behavior is largely stable when introducing uncertainty and modifying task structure. Furthermore, mice continue to perform avoidance responses on trials where lever pressing is not reinforced and increase response rates as they are maintained on this paradigm. With this paradigm, we did not find a relationship between negative reinforcement history and anxiety-related behaviors in well-established anxiety assays. Finally, we performed exploratory analyses to identify candidate regions involved in well-trained negative reinforcement using expression of the immediate early gene c-Fos. We detected correlated c-Fos expression in 1) cortico-striatal regions which regulate active avoidance in other paradigms and 2) amygdala circuits known to regulate conditioned defensive behaviors.<b>Significance Statement</b> Studies in patients with OCD suggest that compulsions are performed to avoid perceived threats and modulate anxiety tied to obsessions and/or compulsions. The negative reinforcement of avoidance and alleviated anxiety could therefore be a key driver of compulsive behaviors. However, there are still outstanding questions concerning the relationship between these two behaviors and the neural circuits involved in mediating negative reinforcement. We have developed an operant negative reinforcement paradigm in mice with discrete avoid and escape behaviors that can be learned without prior reward training with high throughput (75% acquisition) with responding that persists during nonreinforced trials. However, no differences were observed between negative reinforcement vs. unshocked and inescapably shocked controls, suggesting that continued negative reinforcement did not impact anxiety.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The scope and limits of fine-grained image and category information in the ventral visual pathway. 腹侧视觉通路中细粒度图像和类别信息的范围和局限。
IF 4.4 2区 医学
Journal of Neuroscience Pub Date : 2024-11-06 DOI: 10.1523/JNEUROSCI.0936-24.2024
Markus W Badwal, Johanna Bergmann, Johannes Roth, Christian F Doeller, Martin N Hebart
{"title":"The scope and limits of fine-grained image and category information in the ventral visual pathway.","authors":"Markus W Badwal, Johanna Bergmann, Johannes Roth, Christian F Doeller, Martin N Hebart","doi":"10.1523/JNEUROSCI.0936-24.2024","DOIUrl":"https://doi.org/10.1523/JNEUROSCI.0936-24.2024","url":null,"abstract":"<p><p>Humans can easily abstract incoming visual information into discrete semantic categories. Previous research employing functional MRI (fMRI) in humans has identified cortical organizing principles that allow not only for coarse-scale distinctions such as animate versus inanimate objects but also more fine-grained distinctions at the level of individual objects. This suggests that fMRI carries rather fine-grained information about individual objects. However, most previous work investigating fine-grained category representations either additionally included coarse-scale category comparisons of objects, which confounds fine-grained and coarse-scale distinctions, or only used a single exemplar of each object, which confounds visual and semantic information. To address these challenges, here we used multisession human fMRI (female and male) paired with a broad yet homogenous stimulus class of 48 terrestrial mammals, with 2 exemplars per mammal. Multivariate decoding and representational similarity analysis (RSA) revealed high image-specific reliability in low- and high-level visual regions, indicating stable representational patterns at the image level. In contrast, analyses across exemplars of the same animal yielded only small effects in the lateral occipital complex (LOC), indicating rather subtle category effects in this region. Variance partitioning with a deep neural network and shape model showed that across exemplar effects in EVC were largely explained by low-level visual appearance, while representations in LOC appeared to also contain higher category-specific information. These results suggest that representations typically measured with fMRI are dominated by image-specific visual or coarse-grained category information but indicate that commonly employed fMRI protocols may reveal subtle yet reliable distinctions between individual objects.<b>Significance Statement</b> While it has been suggested that functional MRI (fMRI) responses in ventral visual cortex carry fine-grained information about individual objects, much previous research has confounded fine-grained with coarse-scale category information or only used individual visual exemplars, which potentially confounds semantic and visual object information. Here we address these challenges in a multisession fMRI study where participants viewed a highly homogenous stimulus set of 48 land mammals with 2 exemplars per animal. Our results reveal a strong dominance of image-specific effects and additionally indicate subtle yet reliable category-specific effects in lateral occipital complex, underscoring the capacity of commonly employed fMRI protocols to uncover fine-grained visual information.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective Vulnerability of GABAergic Inhibitory Interneurons to Bilirubin Neurotoxicity in the Neonatal Brain. 新生儿大脑中 GABA 能抑制性中间神经元对胆红素神经毒性的选择脆弱性
IF 4.4 2区 医学
Journal of Neuroscience Pub Date : 2024-11-06 DOI: 10.1523/JNEUROSCI.0442-24.2024
Li-Na Gong, Han-Wei Liu, Ke Lai, Zhen Zhang, Lin-Fei Mao, Zhen-Qi Liu, Ming-Xian Li, Xin-Lu Yin, Min Liang, Hai-Bo Shi, Lu-Yang Wang, Shan-Kai Yin
{"title":"Selective Vulnerability of GABAergic Inhibitory Interneurons to Bilirubin Neurotoxicity in the Neonatal Brain.","authors":"Li-Na Gong, Han-Wei Liu, Ke Lai, Zhen Zhang, Lin-Fei Mao, Zhen-Qi Liu, Ming-Xian Li, Xin-Lu Yin, Min Liang, Hai-Bo Shi, Lu-Yang Wang, Shan-Kai Yin","doi":"10.1523/JNEUROSCI.0442-24.2024","DOIUrl":"10.1523/JNEUROSCI.0442-24.2024","url":null,"abstract":"<p><p>Hyperbilirubinemia (HB) is a key risk factor for hearing loss in neonates, particularly premature infants. Here, we report that bilirubin (BIL)-dependent cell death in the auditory brainstem of neonatal mice of both sexes is significantly attenuated by ZD7288, a blocker for hyperpolarization-activated cyclic nucleotide-gated (HCN) channel-mediated current (<i>I</i> <sub>h</sub>), or by genetic deletion of HCN1. GABAergic inhibitory interneurons predominantly express HCN1, on which BIL selectively acts to increase their intrinsic excitability and mortality by enhancing HCN1 activity and Ca<sup>2+</sup>-dependent membrane targeting. Chronic BIL elevation in neonatal mice in vivo increases the fraction of spontaneously active interneurons and their firing frequency, <i>I</i> <sub>h</sub>, and death, compromising audition at the young adult stage in HCN1<sup>+/+</sup>, but not in HCN1<sup>-/-</sup> genotype. We conclude that HB preferentially targets HCN1 to injure inhibitory interneurons, fueling a feedforward loop in which lessening inhibition cascades hyperexcitability, Ca<sup>2+</sup> overload, neuronal death, and auditory impairments. These findings rationalize HCN1 as a potential target for managing HB encephalopathy.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread. 在种子型 Tauopathy 模型中靶向内源性 Tau 可抑制 Tau 的扩散。
IF 4.4 2区 医学
Journal of Neuroscience Pub Date : 2024-11-05 DOI: 10.1523/JNEUROSCI.0877-24.2024
Elliot Jang, Kevt'her Hoxha, Damian Mozier, Abigail Insana, Ethan Farber, Lakshmi Changolkar, Bin Zhang, Tak-Ian Chio, Alex Crowe, Richard Chen, Marc Mercken, Edward B Lee, Kelvin C Luk, Kurt R Brunden, Virginia M-Y Lee, Hong Xu
{"title":"Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread.","authors":"Elliot Jang, Kevt'her Hoxha, Damian Mozier, Abigail Insana, Ethan Farber, Lakshmi Changolkar, Bin Zhang, Tak-Ian Chio, Alex Crowe, Richard Chen, Marc Mercken, Edward B Lee, Kelvin C Luk, Kurt R Brunden, Virginia M-Y Lee, Hong Xu","doi":"10.1523/JNEUROSCI.0877-24.2024","DOIUrl":"https://doi.org/10.1523/JNEUROSCI.0877-24.2024","url":null,"abstract":"<p><p>The transmission of tau pathology has been proposed as one of the major mechanisms for the spatiotemporal spreading of tau pathology in neurodegenerative diseases. Over the last decade, studies have demonstrated that targeting total or pathological tau using tau antibodies can mitigate the development of tau pathology in tauopathy or Alzheimer's disease (AD) mouse models, and multiple tau immunotherapy agents have progressed to clinical trials. Tau antibodies are believed to inhibit the internalization of pathologic seeds and/or block seed elongation after seed internalization. To further address the mechanism of tau antibody inhibition of pathological spread, we conducted immunotherapy studies in mouse primary neurons and wild-type mice (females) seeded with AD patient-derived tau to induce the formation and spreading of tau pathology. Notably, we evaluated the effect of a mouse tau-specific antibody (mTau8) which does not interact with AD-tau seeds in these models. Our results show that mTau8 crosses the blood-brain barrier at levels similar to other antibodies and effectively decreases AD-tau-seeded tau pathology in vitro and in vivo. Importantly, our data suggest that mTau8 binds to endogenous intraneuronal mouse tau, thereby inhibiting the elongation of internalized tau seeds. These findings provide valuable insights into the possible mechanism underlying antibody-based therapies for treating tauopathies.<b>Significance Statement</b> The transmission of tau pathology plays key role in the pathoclinical progression of tauopathy. Studies have shown that tau antibody treatment can mitigate tau pathology in transgenic and spreading models of tauopathy. To explore the mechanisms involved in this procedure, we conducted immunotherapy studies on human tau seeds induced tau spreading models using a mouse tau-specific antibody (mTau8), which does not interact with human-tau seeds. Our findings in the study enhance our understanding of antibody-based therapies for tauopathies.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Input / Output Relationships for the Primary Hippocampal Circuit. 初级海马回路的输入/输出关系
IF 4.4 2区 医学
Journal of Neuroscience Pub Date : 2024-11-05 DOI: 10.1523/JNEUROSCI.0130-24.2024
B G Gunn, B S Pruess, C M Gall, G Lynch
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