Journal of Neuroscience最新文献

{"title":"Multimodal MEG and Microstructure-MRI Investigations of the Human Hippocampal Scene Network.","authors":"Marie-Lucie Read, Carl J Hodgetts, Andrew D Lawrence, C John Evans, Krish D Singh, Katja Umla-Runge, Kim S Graham","doi":"10.1523/JNEUROSCI.1700-24.2025","DOIUrl":"10.1523/JNEUROSCI.1700-24.2025","url":null,"abstract":"<p><p>Although several studies have demonstrated that perceptual discrimination of complex scenes relies on an extended hippocampal posteromedial system, we currently have limited insight into the specific functional and structural properties of this system in humans. Here, combining electrophysiological (magnetoencephalography) and advanced microstructural (multishell diffusion magnetic resonance imaging; quantitative magnetization transfer) imaging in healthy human adults (30 females/10 males), we show that both theta power modulation of the hippocampus and fiber restriction/hindrance (reflecting axon packing/myelination) of the fornix (a major input/output pathway of the hippocampus) were independently related to scene, but not face, perceptual discrimination accuracy. Conversely, microstructural features of the inferior longitudinal fasciculus (a long-range occipitoanterotemporal tract) correlated with face, but not scene, perceptual discrimination accuracy. Our results provide new mechanistic insight into the neurocognitive systems underpinning complex scene discrimination, providing novel support for the idea of multiple processing streams within the human medial temporal lobe.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single Neuron Contributions to the Auditory Brainstem EEG.","authors":"Paula T Kuokkanen, Ira Kraemer, Christine Köppl, Catherine E Carr, Richard Kempter","doi":"10.1523/JNEUROSCI.1139-24.2025","DOIUrl":"10.1523/JNEUROSCI.1139-24.2025","url":null,"abstract":"<p><p>The auditory brainstem response (ABR) is an acoustically evoked EEG potential that is an important diagnostic tool for hearing loss, especially in newborns. The ABR originates from the response sequence of auditory nerve and brainstem nuclei, and a click-evoked ABR typically shows three positive peaks (\"waves\") within the first six milliseconds. However, an assignment of the waves of the ABR to specific sources is difficult, and a quantification of contributions to the ABR waves is not available. Here, we exploit the large size and physical separation of the barn owl first-order cochlear nucleus magnocellularis (NM) to estimate single-cell contributions to the ABR. We simultaneously recorded NM neurons' spikes and the EEG in owls of both sexes, and found that [Formula: see text] spontaneous single-cell spikes are necessary to isolate a significant spike-triggered average (STA) response at the EEG electrode. An average single-neuron contribution to the ABR was predicted by convolving the STA with the cell's peri-stimulus time histogram. Amplitudes of predicted contributions of single NM cells typically reached 32.9 ± 1.1 nV (mean ± SE, range: 2.5-162.7 nV), or [Formula: see text] (median ± SE; range from 0.01% to 1%) of the ABR amplitude. The time of the predicted peak coincided best with the peak of the ABR wave II, independent of the click sound level. Our results suggest that individual neurons' contributions to an EEG can vary widely, and that wave II of the ABR is shaped by NM units.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Neural Development of Social Interaction Perception in the Superior Temporal Sulcus.","authors":"Waldir M Sampaio","doi":"10.1523/JNEUROSCI.0253-25.2025","DOIUrl":"https://doi.org/10.1523/JNEUROSCI.0253-25.2025","url":null,"abstract":"","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"45 22","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decomposing Cognitive Processes in the mPFC during Self-Thinking.","authors":"Marie Levorsen, Ryuta Aoki, Constantine Sedikides, Keise Izuma","doi":"10.1523/JNEUROSCI.2378-24.2025","DOIUrl":"10.1523/JNEUROSCI.2378-24.2025","url":null,"abstract":"<p><p>Past cognitive neuroscience research has demonstrated that thinking about both the self and other activates the medial prefrontal cortex (mPFC), a central hub of the default mode network. The mPFC is also implicated in other cognitive processes, such as introspection and autobiographical memory, rendering elusive its exact role during thinking about the self. Specifically, it is unclear whether the same cognitive process explains the common mPFC involvement or distinct processes are responsible for the mPFC activation overlap. In this preregistered functional magnetic resonance imaging study with 35 male and female human participants, we investigated whether and to what extent mPFC activation patterns during self-reference judgment could be explained by activation patterns during the tasks of other-reference judgment, introspection, and autobiographical memory. Multivoxel pattern analysis showed that only in the mPFC were neural responses both concurrently different and similar across tasks. Furthermore, multiple regression and variance partitioning analyses indicated that each task (i.e., other-reference, introspection, and memory) uniquely and jointly explained significant variances in mPFC activation during self-reference. These findings suggest that the self-reference task engages multiple cognitive processes shared with other tasks, with the mPFC serving as a crucial hub where essential information is integrated to support judgments based on internally constructed representations.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Beta and Gamma Activity Modulation during Unimanual and Bimanual Motor Learning.","authors":"Min Wu, Marleen J Schoenfeld, Carl Lindersson, Sven Braeutigam, Catharina Zich, Charlotte J Stagg","doi":"10.1523/JNEUROSCI.2187-24.2025","DOIUrl":"10.1523/JNEUROSCI.2187-24.2025","url":null,"abstract":"<p><p>Movement-related dynamics in the beta and gamma bands have been studied in relation to motor execution and learning during unimanual movements, but their roles in complex bimanual tasks remain largely unexplored. This study aimed to investigate how beta and gamma activity differs between unimanual and bimanual movements and how these neural signatures evolve during the learning process. Our motor task incorporated varying levels of bimanual interaction: unimanual, bimanual-equal, and bimanual-unequal. Magnetoencephalography data were recorded in healthy participants (<i>N</i> = 43, 27 females) during task performance, and beta and gamma activity was quantified. As expected, increasing task complexity from unimanual to bimanual-equal and then to bimanual-unequal movements resulted in slower and less accurate performance. Across all conditions, significant beta event-related desynchronization (ERD) and gamma event-related synchronization (ERS) were observed during movement, as well as beta ERS after movement. Bimanual movements exhibited greater beta ERD, beta ERS, and gamma ERS compared with unimanual movements. With practice, participants demonstrated faster and more accurate movements, accompanied by enhanced beta ERS responses. Furthermore, learning-related reductions in errors correlated with increases in beta ERS. These findings suggest the distinct behavioral and neural demands of unimanual versus bimanual movements and highlight the important role of beta activity in motor performance and learning.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct regulation of early trafficking of the NMDA receptors by the ligand-binding domains of the GluN1 and GluN2A subunits.","authors":"Jakub Netolicky, Petra Zahumenska, Anna Misiachna, Marharyta Kolcheva, Kristyna Rehakova, Katarina Hemelikova, Stepan Kortus, Emily Langore, Jovana Doderovic, Marek Ladislav, Michal Otyepka, Martin Srejber, Martin Horak","doi":"10.1523/JNEUROSCI.0226-24.2025","DOIUrl":"https://doi.org/10.1523/JNEUROSCI.0226-24.2025","url":null,"abstract":"<p><p>N-methyl-D-aspartate receptors (NMDARs) play a crucial role in excitatory neurotransmission, with numerous pathogenic variants identified in the GluN subunits, including their ligand-binding domains (LBDs). The prevailing hypothesis postulates that the endoplasmic reticulum (ER) quality control machinery verifies the agonist occupancy of NMDARs, but this was tested in a limited number of studies. Using microscopy and electrophysiology in the HEK293 cells, we found that surface expression of GluN1/GluN2A receptors containing a set of alanine substitutions within the LBDs correlated with the measured EC₅₀ values for glycine (GluN1 subunit mutations), while did not correlate with the measured EC₅₀ values for L-glutamate (GluN2A subunit mutations). The mutant cycle of GluN1-S688 residue, including the pathogenic GluN1-S688Y and GluN1-S688P variants, showed a correlation between relative surface expression of the GluN1/GluN2A receptors and the measured EC₅₀ values for glycine, as well as with the calculated ΔG_binding values for glycine obtained from molecular dynamics (MD) simulations. In contrast, the mutant cycle of GluN2A-S511 residue did not show any correlation between the relative surface expression of the GluN1/GluN2A receptors and the measured EC₅₀ values for L-glutamate or calculated ΔG_binding values for L-glutamate. Co-expression of both mutated GluN1 and GluN2A subunits led to additive or synergistic alterations in the surface number of GluN1/GluN2A receptors. The synchronized ER release by ARIAD technology confirmed the altered early trafficking of GluN1/GluN2A receptors containing the mutated LBDs. The microscopical analysis from embryonal rat hippocampal neurons (both sexes) corroborated our conclusions from the HEK293 cells.<b>Significant statement</b> We examined >80 mutant GluN1/GluN2 receptor combinations, including pathogenic and potentially pathogenic variants in the LBDs of GluN1 and GluN2A subunits. The combination of the experimentally measured (relative surface expression, EC₅₀ values) and calculated (ΔG_binding values, RMSD, and SASA) parameters revealed that the LBDs of the GluN1 and GluN2A subunits distinctly regulate the early trafficking of GluN1/GluN2A receptors. In addition, we validated a novel system of synchronized release of GluN1/GluN2A receptors from the ER. Our findings support the urgency of further detailed research on the regulation of early trafficking of NMDARs, as it may open the avenue to targeted intervention of central nervous system disorders associated with pathogenic variants in GluN subunits.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Pachitariu et al., \"Robustness of Spike Deconvolution for Neuronal Calcium Imaging\".","authors":"","doi":"10.1523/JNEUROSCI.0905-25.2025","DOIUrl":"https://doi.org/10.1523/JNEUROSCI.0905-25.2025","url":null,"abstract":"","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurophysiological evidence of sensory prediction errors driving speech sensorimotor adaptation.","authors":"Kwang S Kim, Leighton B Hinkley, Kurtis Brent, Jessica L Gaines, Alvincé L Pongos, Saloni Gupta, Corby L Dale, Srikantan S Nagarajan, John F Houde","doi":"10.1523/JNEUROSCI.2084-24.2025","DOIUrl":"https://doi.org/10.1523/JNEUROSCI.2084-24.2025","url":null,"abstract":"<p><p>The human sensorimotor system has a remarkable ability to learn movements from sensory experience. A prominent example is sensorimotor adaptation, learning that characterizes the sensorimotor system's response to persistent sensory errors by adjusting future movements to compensate for those errors. A component of sensorimotor adaptation is implicit (i.e., the learner is unaware of the learning) which has been suggested to result from sensory prediction errors-discrepancies between predicted sensory consequences of motor commands and actual sensory feedback. However, neurophysiological evidence that sensory prediction errors drive adaptation has never been directly demonstrated. Here, we examined prediction errors via magnetoencephalography imaging of the auditory cortex during sensorimotor adaptation of speech to altered auditory feedback, an entirely implicit adaptation task. Specifically, we measured how speaking-induced suppression (SIS)-a neural representation of auditory prediction errors-changed over the trials of the adaptation experiment. In both male and female speakers, reduction in SIS (reflecting larger prediction errors) during the early learning phase compared to the initial unaltered feedback phase positively correlated with behavioral adaptation extents, suggesting that larger prediction errors were associated with more learning. In contrast, such a reduction in SIS was not found in a control experiment in which participants heard unaltered feedback and thus did not adapt. In addition, in some participants who reached a plateau in the late learning phase, SIS increased, demonstrating that prediction errors were minimal when there was no further adaptation. Together, these findings provide the first direct neurophysiological evidence for the hypothesis that prediction errors drive sensorimotor adaptation.<b>Significance Statement</b> This work investigates mechanisms of sensorimotor adaptation, the phenomenon of motor learning due to exposure to altered sensory feedback. Models of motor control have hypothesized that sensorimotor adaptation is driven by sensory prediction errors - the discrepancy between predicted and actual sensory feedback. Here, we provide for the first time direct neurophysiological evidence that speech sensorimotor adaptation is indeed driven by sensory prediction errors using magnetoencephalography (MEG) imaging of auditory cortex during speaking.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Alavash and Obleser, \"Brain Network Interconnectivity Dynamics Explain Metacognitive Differences in Listening Behavior\".","authors":"","doi":"10.1523/jneurosci.0893-25.2025","DOIUrl":"https://doi.org/10.1523/jneurosci.0893-25.2025","url":null,"abstract":"","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"146 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amygdala regulates social motivation for selective vocal imitation in zebra finches.","authors":"Tomoko G Fujii,Masashi Tanaka","doi":"10.1523/jneurosci.2435-24.2025","DOIUrl":"https://doi.org/10.1523/jneurosci.2435-24.2025","url":null,"abstract":"Imitation plays a key role in the acquisition of speech and cultural behaviors. Studies suggest that social interaction facilitates imitative learning, indicating that neural circuits involved in social behaviors can also influence the process of imitation. Vocal imitation in juvenile songbirds serves as a valuable model to investigate this idea. Here, we explore the mechanisms of tutor-pupil social interaction and selective song learning in male zebra finches, with a particular focus on the amygdala, which can regulate social behaviors via its processing of values and emotions in mammals. When sequentially exposed to two tutors, normal pupils selectively learned song from the tutor who sang longer but less frequently. When hearing songs, pupils preferentially approached the selected tutor. Excitotoxic lesions of the amygdala increased pupils' social motivation toward tutors yet diminished their song-responsive approach, especially to the selected tutor. Whereas the pupils with amygdala lesions retained their ability to imitate song, the tutor selection became more unpredictable with diminished preference for a specific tutor. Neuronal tracing confirmed that the zebra finch amygdala is connected to the circuits involved in social functions but lacks direct connections to those critical for song control and learning. These results suggest that the amygdala regulates social motivation and tutor selection in juvenile zebra finches, highlighting its role in imitative learning.Significance Statement Social interaction plays a critical role in imitation, particularly in the acquisition of speech and cultural behaviors like dance and song. Although studies in rodents indicate the involvement of the amygdala in social behaviors and social learning, the mechanisms coordinating social behaviors and imitative learning remain poorly understood. Vocal imitation in juvenile songbirds is an ideal model to investigate such mechanisms. Here, we report that lesioning the amygdala in juvenile zebra finches increases overall social motivation but disrupts selective song learning and their preferential approach to the selected tutor. These findings provide new insights into the social function of the amygdala in imitation.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"33 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}