Journal of Neuroscience最新文献

VTA µ-Opioidergic Neurons Facilitate Low Sociability in Protracted Opioid Abstinence. 在阿片类药物长期戒断的情况下，VTAµ-肽能神经元有助于降低社交能力。

IF 4.4 2区医学

Journal of Neuroscience Pub Date : 2025-04-02 DOI: 10.1523/JNEUROSCI.1154-24.2025

Adrienne Y Jo, Yihan Xie, Lisa M Wooldridge, Sophie A Rogers, Blake A Kimmey, Amrith Rodrigues, Raquel Adaia Sandoval Ortega, Kate Townsend Creasy, Kevin T Beier, Julie A Blendy, Gregory Corder

{"title":"VTA µ-Opioidergic Neurons Facilitate Low Sociability in Protracted Opioid Abstinence.","authors":"Adrienne Y Jo, Yihan Xie, Lisa M Wooldridge, Sophie A Rogers, Blake A Kimmey, Amrith Rodrigues, Raquel Adaia Sandoval Ortega, Kate Townsend Creasy, Kevin T Beier, Julie A Blendy, Gregory Corder","doi":"10.1523/JNEUROSCI.1154-24.2025","DOIUrl":"10.1523/JNEUROSCI.1154-24.2025","url":null,"abstract":"Opioids initiate dynamic maladaptation in brain reward and affect circuits that occur throughout chronic exposure and withdrawal that persist beyond cessation. Protracted abstinence is characterized by negative affective behaviors such as heightened anxiety, irritability, dysphoria, and anhedonia, which pose a significant risk factor for relapse. While the ventral tegmental area (VTA) and μ-opioid receptors (MORs) are critical for opioid reinforcement, the specific contributions of VTAMOR neurons in mediating protracted abstinence-induced negative affect is not fully understood. In our study, we elucidate the role of VTAMOR neurons in mediating negative affect and altered brain-wide neuronal activities following forced opioid exposure and abstinence in male and female mice. Utilizing a chronic oral morphine administration model, we observe increased social deficit, anxiety-related, and despair-like behaviors during protracted forced abstinence. VTAMOR neurons show heightened neuronal FOS activation at the onset of withdrawal and connect to an array of brain regions that mediate reward and affective processes. Viral re-expression of MORs selectively within the VTA of MOR knock-out mice demonstrates that the disrupted social interaction observed during protracted abstinence is facilitated by this neural population, without affecting other protracted abstinence behaviors. Lastly, VTAMORs contribute to heightened neuronal FOS activation in the anterior cingulate cortex (ACC) in response to an acute morphine challenge, suggesting their unique role in modulating ACC-specific neuronal activity. These findings identify VTAMOR neurons as critical modulators of low sociability during protracted abstinence and highlight their potential as a mechanistic target to alleviate negative affective behaviors associated with opioid abstinence.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Microsaccades in the Primary Visual Cortex: Increased Synchronization in the Fovea during a Two-Phase Response Modulation.

IF 4.4 2区医学

Journal of Neuroscience Pub Date : 2025-04-02 DOI: 10.1523/JNEUROSCI.1547-24.2025

Yarden Nativ, Tomer Bouhnik, Hamutal Slovin

{"title":"The Effect of Microsaccades in the Primary Visual Cortex: Increased Synchronization in the Fovea during a Two-Phase Response Modulation.","authors":"Yarden Nativ, Tomer Bouhnik, Hamutal Slovin","doi":"10.1523/JNEUROSCI.1547-24.2025","DOIUrl":"10.1523/JNEUROSCI.1547-24.2025","url":null,"abstract":"Our eyes are never still. Even when we attempt to fixate, the visual gaze is never motionless, as we continuously perform miniature oculomotor movements termed as fixational eye movements. The fastest eye movements during the fixation epochs are termed microsaccades (MSs) that are leading to continual motion of the visual input, affecting mainly neurons in the fovea. Yet our vision appears to be stable. To explain this gap, previous studies suggested the existence of an extraretinal input (ERI) into the visual cortex that can account for the motion and produce visual stability. Here, we investigated the existence of an ERI to V1 fovea in macaque monkeys (male) while they performed spontaneous MSs, during fixation. We used voltage-sensitive dye imaging (VSDI) to measure and characterize at high spatiotemporal resolution the influence of MSs on neural population activity, in the foveal region of the primary visual cortex (V1). Microsaccades, performed over a blank screen, induced a two-phase response modulation: an early suppression followed by an enhancement. A correlation analysis revealed a widespread foveal increase in neural synchronization, peaking around ∼100 ms after MS onset. Next, we investigated the MS effects in the presence of a small visual stimulus and found that this modulation was different from the blank condition yet both modulations coexisted in the fovea. Finally, the VSD response to an external motion of the fixation point could not explain the MS modulation. These results support an ERI that may be involved in visual stabilization already at the level of V1.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Memory Boost for Recurring Emotional Events Is Driven by Initial Amygdala Response Promoting Stable Neocortical Patterns across Repetitions.

IF 4.4 2区医学

Journal of Neuroscience Pub Date : 2025-04-02 DOI: 10.1523/JNEUROSCI.2406-23.2025

Valentina Krenz, Arjen Alink, Benno Roozendaal, Tobias Sommer, Lars Schwabe

{"title":"Memory Boost for Recurring Emotional Events Is Driven by Initial Amygdala Response Promoting Stable Neocortical Patterns across Repetitions.","authors":"Valentina Krenz, Arjen Alink, Benno Roozendaal, Tobias Sommer, Lars Schwabe","doi":"10.1523/JNEUROSCI.2406-23.2025","DOIUrl":"10.1523/JNEUROSCI.2406-23.2025","url":null,"abstract":"Emotionally arousing events are typically vividly remembered, which is generally adaptive but may contribute to mental disorders such as post-traumatic stress disorder. Previous research on emotional memory focused primarily on events that were experienced only once, leaving the memory mechanisms underlying repeatedly encountered emotional events largely unexplored. Here, we aimed to elucidate the brain mechanisms associated with memory for recurring emotional events. Specifically, we sought to determine whether the memory enhancement for recurring emotional events is linked to more variable neural representations, as predicted by the encoding-variability hypothesis, or to more stable representations across repetitions, as suggested by a memory reinstatement account. To investigate this, we repeatedly presented healthy men and women with images of emotionally negative or neutral scenes during three consecutive runs in an MRI scanner. Subsequent free recall was, as expected, enhanced for emotional compared with neutral images. Neural data showed that this emotional enhancement of memory was linked to (1) activation of the amygdala and anterior hippocampus during the initial encounter of the emotional event and (2) increased neural pattern similarity in frontoparietal cortices across event repetitions. Most importantly, a multilevel-moderated mediation analysis revealed that the impact of neocortical pattern stability across repetitions on emotional memory enhancement was moderated by amygdala activity during the initial exposure to the emotional event. Together, our findings show that the amygdala response during the initial encounter of an emotional event boosts subsequent remembering through a more precise reinstatement of the event representation during subsequent encounters of the same event.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Distinct Down-to-Up Transition Assembly in the Retrosplenial Cortex during Slow-Wave Sleep.

IF 4.4 2区医学

Journal of Neuroscience Pub Date : 2025-04-02 DOI: 10.1523/JNEUROSCI.1484-24.2025

Ashley N Opalka, Kimberly J Dougherty, Dong V Wang

{"title":"A Distinct Down-to-Up Transition Assembly in the Retrosplenial Cortex during Slow-Wave Sleep.","authors":"Ashley N Opalka, Kimberly J Dougherty, Dong V Wang","doi":"10.1523/JNEUROSCI.1484-24.2025","DOIUrl":"10.1523/JNEUROSCI.1484-24.2025","url":null,"abstract":"Understanding the intricate mechanisms underlying slow-wave sleep (SWS) is crucial for deciphering the brain's role in memory consolidation and cognitive functions. It is well established that cortical delta oscillations (0.5-4 Hz) coordinate communications among cortical, hippocampal, and thalamic regions during SWS. These delta oscillations feature periods of Up and Down states, with the latter previously thought to represent complete cortical silence; however, new evidence suggests that Down states serve important functions for information exchange during memory consolidation. The retrosplenial cortex (RSC) is pivotal for memory consolidation due to its extensive connectivity with memory-associated regions, although it remains unclear how RSC neurons engage in delta-associated consolidation processes. Here, we employed multichannel in vivo electrophysiology to study RSC neuronal activity in ad libitum behaving male mice during natural SWS. We discovered a discrete assembly of putative excitatory RSC neurons (∼20%) that initiated firing at SWS Down states and reached maximal firing at the Down-to-Up transitions. Therefore, we termed these RSC neurons the Down-to-Up transition assembly (DUA) and the remaining RSC excitatory neurons as non-DUA. Compared with non-DUA, DUA neurons appear to exhibit higher firing rates and larger cell body size and lack monosynaptic connectivity with nearby RSC neurons. Furthermore, optogenetics combined with electrophysiology revealed differential innervation of RSC excitatory neurons by memory-associated inputs. Collectively, these findings provide insight into the distinct activity patterns of RSC neuronal subpopulations during sleep and their potential role in memory processes.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salience-Dependent Disruption of Sustained Auditory Attention Can Be Inferred from Evoked Pupil Responses and Neural Tracking of Task-Irrelevant Sounds.

IF 4.4 2区医学

Journal of Neuroscience Pub Date : 2025-04-02 DOI: 10.1523/JNEUROSCI.2066-23.2025

Lorenz Fiedler, Ingrid Johnsrude, Dorothea Wendt

{"title":"Salience-Dependent Disruption of Sustained Auditory Attention Can Be Inferred from Evoked Pupil Responses and Neural Tracking of Task-Irrelevant Sounds.","authors":"Lorenz Fiedler, Ingrid Johnsrude, Dorothea Wendt","doi":"10.1523/JNEUROSCI.2066-23.2025","DOIUrl":"10.1523/JNEUROSCI.2066-23.2025","url":null,"abstract":"Stimulus-driven attention allows us to react to relevant stimuli (and imminent danger!) outside our current focus of attention. But irrelevant stimuli can also disrupt attention, for example, during listening to speech. The degree to which sound captures attention is called salience, which can be estimated by existing, behaviorally validated, computational models (Huang and Elhilali, 2017). Here we examined whether neurophysiological responses to task-irrelevant sounds indicate the degree of distraction during a sustained-listening task and how much this depends on individual hearing thresholds. Forty-seven Danish-speaking adults (28/19 female/male; mean age, 60.1; SD, 15.9 years) with heterogenous hearing thresholds (PTA; mean, 25.5; SD, 18.0 db HL) listened to continuous speech while 1-s-long, task-irrelevant natural sounds (distractors) of varying computed salience were presented at unpredictable times and locations. Eye tracking and electroencephalography were used to estimate pupil response and neural tracking, respectively. The task-irrelevant sounds evoked a consistent pupil response (PR), distractor-tracking (DT), and a drop of target-tracking (ΔTT), and statistical modeling of these three measures within subjects showed that all three are enhanced for sounds with higher computed salience. Participants with larger PR showed a stronger drop in target tracking (ΔTT) and performed worse in target speech comprehension. We conclude that distraction can be inferred from neurophysiological responses to task-irrelevant stimuli. These results are a first step toward neurophysiological assessment of attention dynamics during continuous listening, with potential applications in hearing care diagnostics.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rab27b Promotes Lysosomal Function and Alpha-Synuclein Clearance in Neurons.

IF 4.4 2区医学

Journal of Neuroscience Pub Date : 2025-04-02 DOI: 10.1523/JNEUROSCI.1579-24.2025

Kasandra Scholz, Rudradip Pattanayak, Roschongporn Ekkatine, F Sanders Pair, Amber Nobles, William J Stone, Talene A Yacoubian

{"title":"Rab27b Promotes Lysosomal Function and Alpha-Synuclein Clearance in Neurons.","authors":"Kasandra Scholz, Rudradip Pattanayak, Roschongporn Ekkatine, F Sanders Pair, Amber Nobles, William J Stone, Talene A Yacoubian","doi":"10.1523/JNEUROSCI.1579-24.2025","DOIUrl":"10.1523/JNEUROSCI.1579-24.2025","url":null,"abstract":"Alpha-synuclein (αsyn) is the key pathogenic protein implicated in synucleinopathies including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In these diseases, αsyn is thought to spread between cells where it accumulates and induces pathology; however, mechanisms that drive its propagation or aggregation are poorly understood. We have previously reported that the small GTPase Rab27b is elevated in human PD and DLB and that it can mediate the autophagic clearance and toxicity of αsyn in a paracrine αsyn cell culture model. Here, we expanded our previous work and characterized the role of Rab27b in neuronal lysosomal processing and αsyn clearance. We found that Rab27b KD in this αsyn-inducible neuronal model resulted in lysosomal dysfunction and increased αsyn levels in lysosomes. Similar lysosomal proteolytic defects and enzymatic dysfunction were observed in both primary neuronal cultures and brain lysates from male and female Rab27b knock-out (KO) mice. αSyn aggregation was exacerbated in Rab27b KO neurons upon treatment with αsyn preformed fibrils. We found no changes in lysosomal counts or lysosomal pH in either model, but we did identify changes in acidic vesicle trafficking and in lysosomal enzyme maturation and localization, which may drive lysosomal dysfunction and promote αsyn aggregation. Rab27b OE enhanced lysosomal activity and reduced insoluble αsyn accumulation. Finally we found elevated Rab27b levels in human postmortem incidental Lewy body disease subjects relative to healthy controls. These data suggest the role of Rab27b in neuronal lysosomal activity and identify it as a potential therapeutic target in synucleinopathies.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Molecular Mechanism for the Late-Onset Alzheimer's Disease Risk Gene CD2AP.

IF 4.4 2区医学

Journal of Neuroscience Pub Date : 2025-04-02 DOI: 10.1523/JNEUROSCI.0046-25.2025

Elisabetta Battocchio

引用次数: 0

Increased Modulation of Low-Frequency Cardiac Rhythms on Resting-State Left Insula Alpha Oscillations in Major Depressive Disorder: Evidence from a Magnetoencephalography Study.

IF 4.4 2区医学

Journal of Neuroscience Pub Date : 2025-04-02 DOI: 10.1523/JNEUROSCI.1327-24.2025

Qian Liao, Zhongpeng Dai, Cong Pei, Han Zhang, Lingling Hua, Junling Sheng, Hongliang Zhou, Zhijian Yao, Qing Lu

{"title":"Increased Modulation of Low-Frequency Cardiac Rhythms on Resting-State Left Insula Alpha Oscillations in Major Depressive Disorder: Evidence from a Magnetoencephalography Study.","authors":"Qian Liao, Zhongpeng Dai, Cong Pei, Han Zhang, Lingling Hua, Junling Sheng, Hongliang Zhou, Zhijian Yao, Qing Lu","doi":"10.1523/JNEUROSCI.1327-24.2025","DOIUrl":"10.1523/JNEUROSCI.1327-24.2025","url":null,"abstract":"A growing body of evidence suggests that the link between the cardiac autonomic nervous system (ANS) and the central nervous system (CNS) is crucial to the onset and development of major depressive disorder (MDD), affecting perception, cognition, and emotional processing. The bottom-up heart-brain communication pathway plays a significant role in this process. Previous studies have shown that slow-frequency oscillations of peripheral signals (e.g., respiration, stomach) can influence faster neural activities in the CNS via phase-amplitude coupling (PAC). However, the understanding of heart-brain coupling remains limited. Additionally, while MDD patients exhibit altered brain activity patterns, little is known about how heart rate variability (HRV) affects brain oscillations. Therefore, we used PAC to investigate heart-brain coupling and its association with depression. We recorded MEG and ECG data from 55 MDD patients (35 females) and 52 healthy subjects (28 females) at rest and evaluated heart-brain PAC at a broadband level. The results showed that the low-frequency component of HRV (HRV-LF) significantly modulated MEG alpha power (10 Hz) in humans. Compared with the healthy group, the MDD group exhibited more extensive heart-brain coupling cortical networks, including the pars triangularis. LF-alpha coupling was observed in the bilateral insula in both groups. Notably, results revealed a significantly increased sympathetic-dominated HRV-LF modulation effect on left insula alpha oscillations, along with increased depressive severity. These findings suggest that MDD patients may attempt to regulate their internal state through enhanced heart-brain modulation, striving to restore normal physiological and psychological balance.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serotonergic Input into the Cerebellar Cortex Modulates Anxiety-Like Behavior.

IF 4.4 2区医学

Journal of Neuroscience Pub Date : 2025-04-02 DOI: 10.1523/JNEUROSCI.1825-24.2024

Pei Wern Chin, George J Augustine

{"title":"Serotonergic Input into the Cerebellar Cortex Modulates Anxiety-Like Behavior.","authors":"Pei Wern Chin, George J Augustine","doi":"10.1523/JNEUROSCI.1825-24.2024","DOIUrl":"10.1523/JNEUROSCI.1825-24.2024","url":null,"abstract":"Because of the important roles of both serotonin (5-HT) and the cerebellum in regulating anxiety, we asked whether 5-HT signaling within the cerebellum is involved in anxiety behavior. Physiological 5-HT levels were measured in vivo by expressing a fluorescent sensor for 5-HT in lobule VII of the cerebellum, while using fiber photometry to measure sensor fluorescence during anxiety behavior on the elevated zero maze. Serotonin increased in lobule VII when male mice were less anxious and decreased when mice were more anxious. To establish a causal role for this serotonergic input in anxiety behavior, we photostimulated or photoinhibited serotonergic terminals in lobule VII while mice were in an elevated zero maze. Photostimulating these terminals reduced anxiety behavior in mice, while photoinhibiting them enhanced anxiety behavior. Our findings add to evidence that cerebellar lobule VII is a topographical locus for anxiety behavior and establish that 5-HT input into this lobule is necessary and sufficient to bidirectionally influence anxiety behavior. These results represent progress toward understanding how the cerebellum regulates anxiety behavior and provide new evidence for a functional connection between the cerebellum and the serotonin system within the anxiety circuit.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple Distinct Timescales of Rapid Sensory Adaption in the Thalamocortical Circuit.

IF 4.4 2区医学

Journal of Neuroscience Pub Date : 2025-04-02 DOI: 10.1523/JNEUROSCI.1057-24.2025

Yi Juin Liew, Elaida D Dimwamwa, Nathaniel C Wright, Yong Zhang, Garrett B Stanley

{"title":"Multiple Distinct Timescales of Rapid Sensory Adaption in the Thalamocortical Circuit.","authors":"Yi Juin Liew, Elaida D Dimwamwa, Nathaniel C Wright, Yong Zhang, Garrett B Stanley","doi":"10.1523/JNEUROSCI.1057-24.2025","DOIUrl":"10.1523/JNEUROSCI.1057-24.2025","url":null,"abstract":"Numerous studies have shown that neuronal representations in sensory pathways are far from static but are instead strongly shaped by the complex properties of the sensory inputs they receive. Adaptation dynamically shapes the neural signaling that underlies our perception of the world yet remains poorly understood. We investigated rapid adaptation across timescales from hundreds of milliseconds to seconds through simultaneous multielectrode recordings from the ventro-posteromedial nucleus of the thalamus (VPm) and layer 4 of the primary somatosensory cortex (S1) in male and female anesthetized mice in response to controlled, persistent whisker stimulation. Observations in VPm and S1 reveal a degree of adaptation that progresses through the pathway. Under these experimental conditions, signatures of two distinct timescales of rapid adaptation in the firing rates of both thalamic and cortical neuronal populations were revealed, also reflected in the synchrony of the thalamic population and in the thalamocortical synaptic efficacy that was measured in putatively monosynaptically connected thalamocortical pairs. Controlled optogenetic activation of VPm further demonstrated that the longer timescale adaptation observed in S1 is likely inherited from slow decreases in thalamic firing rate and synchrony. Despite the degraded sensory responses, adaptation induced by the controlled repetitive stimulation presented here resulted in a shift in coding strategy that favors theoretical discrimination over detection across the observed timescales of adaptation. Overall, although multiple mechanisms contribute to rapid adaptation at distinct timescales, they support a unifying framework on the role of adaptation in sensory processing.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0