Phase consistency dynamics of memory encoding.

IF 4 2区 医学 Q1 NEUROSCIENCES
Ryan A Colyer, Michael J Kahana
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引用次数: 0

Abstract

Human and animal studies implicate theta and alpha oscillations in memory function. We tested whether theta, alpha, and beta phase consistency predicts memory encoding dynamics in neurosurgical patients performing delayed free recall tasks with either unrelated (N=188: 99 male, 89 female) or categorized words (N=157: 88 male, 69 female). We observed widespread post-stimulus phase consistency (3-21 Hz) and, crucially, identified distinct frequency-specific patterns predictive of successful encoding. Specifically, increased early-list item recall was significantly correlated across subjects with increased theta (3-7 Hz) phase consistency. Subsequent recall analyses, controlling for serial position, revealed distinct frequency signatures for successfully encoded items: theta (3-6 Hz) and alpha (9-14 Hz) for unrelated lists, and theta (3-6 Hz) and beta (14-19 Hz) for categorized lists. Regional analyses for unrelated lists highlighted the lateral temporal cortex for theta effects and the prefrontal cortex for both theta and alpha consistency. These findings provide novel evidence for the frequency-specific presence of increased phase consistency during episodic encoding, revealing its sensitivity to both item context and temporal position within a learning sequence.Significance statement Neural oscillations are implicated in memory encoding, but their precise roles are still being defined. Our study leverages large-scale intracranial EEG from participants undergoing word recall experiments, and introduces analytical innovations for robustly quantifying phase consistency with differing numbers of recalled versus forgotten items. This methodology reveals that phase consistency across different frequency bands (theta, alpha, beta) predicts memory formation. We demonstrate a role for theta consistency in encoding early list items and show that the brain recruits different oscillatory patterns (alpha or beta alongside theta) depending on item context (unrelated vs. categorized lists). These findings advance our understanding of the frequency-specific neural mechanisms supporting human episodic memory, revealing how the brain adapts its encoding strategies based on informational structure.

记忆编码的相位一致性动力学。
人类和动物的研究表明,θ和α振荡与记忆功能有关。我们测试了theta, alpha和beta相一致性是否预测神经外科患者在执行不相关(N=188: 99名男性,89名女性)或分类词(N=157: 88名男性,69名女性)延迟自由回忆任务时的记忆编码动态。我们观察到广泛的刺激后相位一致性(3-21 Hz),并且至关重要的是,确定了预测成功编码的不同频率特定模式。具体而言,增加的早期列表项目回忆在受试者之间与增加的θ (3-7 Hz)相位一致性显著相关。随后的召回分析,在控制序列位置的情况下,揭示了成功编码项目的不同频率特征:不相关列表的theta (3-6 Hz)和alpha (9-14 Hz),分类列表的theta (3-6 Hz)和beta (14-19 Hz)。对不相关列表的区域分析强调了颞外侧皮层对θ效应的影响,以及前额皮质对θ和α一致性的影响。这些发现为情景编码过程中增加的相位一致性的频率特异性存在提供了新的证据,揭示了其对学习序列中项目上下文和时间位置的敏感性。神经振荡与记忆编码有关,但其确切作用仍未明确。我们的研究利用了接受单词回忆实验的参与者的大规模颅内脑电图,并引入了分析创新,以强有力地量化不同数量的回忆和遗忘项目的相一致性。这种方法揭示了不同频带(theta, alpha, beta)的相位一致性可以预测记忆的形成。我们证明了theta一致性在编码早期列表项目中的作用,并表明大脑根据项目背景(无关列表与分类列表)招募不同的振荡模式(alpha或beta与theta一起)。这些发现促进了我们对支持人类情景记忆的频率特异性神经机制的理解,揭示了大脑如何根据信息结构调整其编码策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Neuroscience
Journal of Neuroscience 医学-神经科学
CiteScore
9.30
自引率
3.80%
发文量
1164
审稿时长
12 months
期刊介绍: JNeurosci (ISSN 0270-6474) is an official journal of the Society for Neuroscience. It is published weekly by the Society, fifty weeks a year, one volume a year. JNeurosci publishes papers on a broad range of topics of general interest to those working on the nervous system. Authors now have an Open Choice option for their published articles
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