Journal of Neuroscience最新文献

{"title":"Diverse Frontoparietal Connectivity Supports Semantic Prediction and Integration in Sentence Comprehension.","authors":"Yaji He, Ximing Shao, Chang Liu, Chen Fan, Elizabeth Jefferies, Meichao Zhang, Xiaoqing Li","doi":"10.1523/JNEUROSCI.1404-24.2024","DOIUrl":"10.1523/JNEUROSCI.1404-24.2024","url":null,"abstract":"<p><p>Predictive processing in the parietal, temporal, frontal, and sensory cortex allows us to anticipate future meanings to maximize the efficiency of language comprehension, with the temporoparietal junction (TPJ) and inferior frontal gyrus (IFG) thought to be situated toward the top of a predictive hierarchy. Although the regions underpinning this fundamental brain function are well-documented, it remains unclear how they interact to achieve efficient comprehension. To this end, we recorded functional magnetic resonance imaging (fMRI) in 22 participants (11 males) while they comprehended sentences presented part by part, in which we manipulated the constraint provided by sentential contexts on upcoming semantic information. Using this paradigm, we examined the connectivity patterns of bilateral TPJ and IFG during anticipatory phases (i.e., before the onset of targets) and integration phases (i.e., after the onset of targets). When upcoming semantic content was highly predictable in strong constraint contexts, both the left TPJ and bilateral IFG showed stronger visual coupling, while the right TPJ showed stronger connectivity with regions within control, default mode, and visual networks, including the IFG, parahippocampal gyrus, posterior cingulate, and fusiform gyrus. These connectivity patterns were weaker when predicted semantic content appeared, in line with predictive coding theory. Conversely, for less-predictable content, these connectivity patterns were stronger during the integration phase. Overall, these results suggest that both top-down semantic prediction and bottom-up integration during predictive processing are supported by flexible coupling of frontoparietal regions with control, memory, and sensory systems.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Communication Between Microglia and Nonparenchymal Immune Cells in the Anti-Aβ Antibody-Injected Cortex.","authors":"Kate E Foley, Erica M Weekman, Katelynn E Krick, Sherika N Johnson, Tiffany L Sudduth, Donna M Wilcock","doi":"10.1523/JNEUROSCI.1456-24.2024","DOIUrl":"10.1523/JNEUROSCI.1456-24.2024","url":null,"abstract":"<p><p>Anti-Aβ immunotherapy use to treat Alzheimer's disease is on the rise. While anti-Aβ antibodies provide hope in targeting Aβ plaques in the brain, there still remains a lack of understanding regarding the cellular responses to these antibodies in the brain. In this study, we sought to identify the acute effects of anti-Aβ antibodies on immune responses. To determine cellular changes due to anti-Aβ antibody exposure, we intracranially injected 14 mo APP male and female mice with anti-Aβ IgG1 (6E10) or control IgG1 into the cortex. After 24 h or 3 d, we harvested the cortex and performed a glial cell-enriched preparation for single-cell sequencing. Cell types, proportions, and cell-to-cell signaling were evaluated between the two injection conditions and two acute timepoints. We identified 23 unique cell clusters including microglia, astrocytes, endothelial cells, neurons, oligos/OPCs, immune cells, and unknown. The anti-Aβ antibody-injected cortices revealed more ligand-receptor (L-R) communications between cell types, as well as stronger communications at only 24 h. At 3 d, while there were more L-R communications for the anti-Aβ antibody condition, the strength of these connections was stronger in the control IgG condition. We also found evidence of an initial and strong communication emphasis in microglia-to-nonparenchymal immune cells at 24 h, specifically in the TGFβ signaling pathway. We identify several pathways that are specific to anti-Aβ antibody exposure at acute timepoints. These data lay the groundwork for understanding the brain's unique response to anti-Aβ antibodies.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of rat insular cortex to stimulus-guided action.","authors":"Yacine Tensaouti, Louis Morel, Shauna L Parkes","doi":"10.1523/JNEUROSCI.1923-24.2025","DOIUrl":"https://doi.org/10.1523/JNEUROSCI.1923-24.2025","url":null,"abstract":"<p><p>Anticipating rewards is fundamental for decision-making. Animals often use cues to assess reward availability and to make predictions about future outcomes. The gustatory region of the insular cortex (IC), the so-called gustatory cortex, has a well-established role in the representation of predictive cues, such that IC neurons encode both a general form of outcome expectation as well as anticipatory outcome-specific knowledge. Here, we used Pavlovian-instrumental transfer (PIT) in male rats to assess if the IC is also required for predictive cues to exert both a general and specific influence over instrumental actions. Chemogenetic inhibition of IC impaired the ability of a reward-predictive stimulus to energize instrumental responding for reward. This deficit in general transfer was evident whether the same or different outcomes were used in the Pavlovian and instrumental conditioning phases. We observed a similar deficit in specific PIT, such that rats with IC inhibition failed to use a reward-predictive stimulus to guide choice toward actions that deliver the same food reward. Finally, we show that rats with IC inhibition also fail to show outcome-selective reinstatement. Together, these data suggest a crucial role for IC in the representation of appetitive outcomes, and particularly in using this representation to guide instrumental action.<b>Significance statement</b> Animals frequently use cues to infer the availability of rewards and to make predictions about future outcomes. The influence of these predictive cues on behaviour can be studied using Pavlovian-instrumental transfer (PIT), in which Pavlovian outcome expectancies can energise (general PIT) or selectively guide (specific PIT) instrumental actions. In the current study, we show that chemogenetic inhibition of the gustatory region of insular cortex (IC) attenuates both general and specific transfer, as well as the selectivity of outcome-induced reinstatement. These results demonstrate a critical role for the IC in the representation of appetitive outcomes and significantly contribute to a broader understanding of the cortical bases of PIT.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing olfactory brain responses in young infants.","authors":"Laura K Shanahan, Leena B Mithal, Marci Messina, Emma Office, Lauren Wakschlag, Patrick Seed, Thorsten Kahnt","doi":"10.1523/JNEUROSCI.1780-24.2025","DOIUrl":"https://doi.org/10.1523/JNEUROSCI.1780-24.2025","url":null,"abstract":"<p><p>Odor perception plays a critical role in early human development, but the underlying neural mechanisms are not fully understood. To investigate these, we presented appetitive and aversive odors to infants of both sexes at one month of age while recording functional magnetic resonance imaging (fMRI) and nasal airflow data. Infants slept during odor presentation to allow MRI scanning. We found that odors evoke robust fMRI activity in bilateral olfactory cortex and thalamus, and that fMRI response magnitudes in olfactory cortex differ across odors. However, in contrast with prior work in adults, we did not find compelling evidence that odor stimuli evoke discriminable fMRI activity patterns in olfactory cortex or thalamus using two different multivariate pattern analysis techniques. Finally, the average inhale airflow rate was higher for appetitive odors than aversive odors, which tentatively suggests that infants could modulate their respiration to reflect odor valence. Overall, these results show strong neural responses to odors at this early developmental stage, and highlight nasal airflow as a behavioral metric for assessing odor preference in infants.<b>Significance statement</b> The sense of smell facilitates several adaptive behaviors in infants (e.g., feeding, soothing), but the brain areas supporting infant olfaction are understudied. Here, we delivered appetitive and aversive odors to sleeping infants during functional magnetic resonance imaging. We show that odors evoke activity in olfactory brain regions and thalamus already at one month of age, and activity levels vary across odors in some of these regions (e.g., piriform cortex, amygdala). However, we did not find strong evidence for pattern-based odor information in the same brain areas. Finally, preliminary nasal airflow findings suggest that infants inhale more vigorously in response to appetitive compared to aversive odors. Taken together, these findings advance our understanding of the neural mechanisms of infant olfaction.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involvement of aSPOC in the online updating of reach-to-grasp to mechanical perturbations of hand transport.","authors":"Mariusz P Furmanek, Luis F Schettino, Mathew Yarossi, Madhur Mangalam, Kyle Lockwood, Sergei V Adamovich, Eugene Tunik","doi":"10.1523/JNEUROSCI.0173-24.2025","DOIUrl":"https://doi.org/10.1523/JNEUROSCI.0173-24.2025","url":null,"abstract":"<p><p>Humans adjust their movement to changing environments effortlessly via multisensory integration of the effector's state, motor commands, and sensory feedback. It is postulated that frontoparietal (FP) networks are involved in the control of prehension, with dorsomedial (DM) and dorsolateral (DL) regions processing the reach and the grasp, respectively. This study tested (5F, 5M participants) the differential involvement of FP nodes (ventral premotor cortex - PMv, dorsal premotor cortex - PMd, anterior intraparietal sulcus - aIPS, and anterior superior parietal-occipital cortex - aSPOC) in online adjustments of reach-to-grasp coordination to mechanical perturbations that disrupted arm transport. We used event-related transcranial magnetic stimulation (TMS) to test whether the nodes of these pathways causally contribute to the processing of proprioceptive information when reaching for a virtual visual target at two different perturbation latencies. TMS over aSPOC selectively altered correction magnitude of arm transport during late perturbations, demonstrating that aSPOC processes proprioceptive inputs related to mechanical perturbations in a movement phase-dependent manner.<b>Significance Statement</b> Detailed knowledge regarding specific brain regions, the timing of their involvement, and roles in the online updating of sensory input during the control of the reach-to-grasp movement is critical for understanding the deficits resulting from various diseases, such as stroke, as well as for the development of effective intervention strategies. Our results provide evidence for the involvement of aSPOC in the modulation of the response to a mechanical perturbation of arm transport during the later stage of the movement, suggesting that this area participates in estimating the effector state based on proprioceptive input. Our results can provide key information for identifying brain targets of engagement in therapeutic applications of noninvasive brain stimulation to ameliorate motor deficits stemming from parietal damage.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain state-dependent neocortico-hippocampal network dynamics are modulated by postnatal stimuli.","authors":"Yoshiaki Shinohara, Shinnosuke Koketsu, Nobuhiko Ohno, Hajime Hirase, Takatoshi Ueki","doi":"10.1523/JNEUROSCI.0053-21.2025","DOIUrl":"https://doi.org/10.1523/JNEUROSCI.0053-21.2025","url":null,"abstract":"<p><p>Neurons in the cerebral cortex and hippocampus discharge synchronously in brain state-dependent manner to transfer information. Published studies have highlighted the temporal coordination of neuronal activities between the hippocampus and a neocortical area, however, how the spatial extent of neocortical activity relates to hippocampal activity remains partially unknown. We imaged mesoscopic neocortical activity while recording hippocampal local field potentials in anesthetized and unanesthetized GCaMP-expressing transgenic mice. We found that neocortical activity elevates around hippocampal sharp wave ripples (SWR). SWR-associated neocortical activities occurred predominantly in vision-related regions including visual, retrosplenial and frontal cortex. While pre-SWR neocortical activities were frequently observed in awake and natural sleeping states, post-SWR neocortical activity decreased significantly in the latter. Urethane anesthetized mice also exhibited SWR-correlated calcium elevation, but in longer time scale than observed in natural sleeping mice. During hippocampal theta oscillation states, phase-locked oscillations of calcium activity were observed throughout the entire neocortical areas. In addition, possible environmental effects on neocortico-hippocampal dynamics were assessed in this study by comparing mice reared in ISO (isolated condition) and ENR (enriched environment). In both SWR and theta oscillations, mice reared in ISO exhibited clearer brain state-dependent dynamics than those reared in ENR. Our data demonstrate that the neocortex and hippocampus exhibit heterogeneous activity patterns that characterize brain states, and postnatal experience plays a significant role in modulating these patterns.<b>Significant Statement</b> The hippocampus is a center for memory formation. However, the memory formed in the hippocampus is not stored forever, but gradually transferred into the cerebral cortex synchronized activities between the neocortex and hippocampus has been hypothesized (for hippocampus-independent memory see (Sutherland and Rudy, 1989)). However, spatio-temporal dynamics between hippocampus and whole neocortical areas remains partially unexplored. We measured cortical calcium activities with hippocampal electroencephalogram (EEG) simultaneously and found that the activities of widespread neocortical areas are temporally associated with hippocampal EEG. The neocortico-hippocampal dynamics is primarily regulated by animal awake/sleep state. Even if similar EEG patters were observed, temporal dynamics between the neocortex and hippocampus exhibit distinct patterns between awake and sleep period. In addition, animals' postnatal experience modulates the dynamics.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prioritizing working memory resources depends on prefrontal cortex.","authors":"Grace E Hallenbeck, Nathan Tardiff, Thomas C Sprague, Clayton E Curtis","doi":"10.1523/JNEUROSCI.1552-24.2025","DOIUrl":"10.1523/JNEUROSCI.1552-24.2025","url":null,"abstract":"<p><p>How the prefrontal cortex contributes to working memory remains controversial, as theories differ in their emphasis on its role in storing memories versus controlling their content. To adjudicate between these competing ideas, we tested how perturbations to the human (both sexes) lateral prefrontal cortex impact the storage and control aspects of working memory during a task that requires human subjects to allocate resources to memory items based on their behavioral priority. Our computational model made a strong prediction that disruption of this control process would counterintuitively improve memory for low-priority items. Remarkably, transcranial magnetic stimulation of retinotopically-defined superior precentral sulcus, but not intraparietal sulcus, unbalanced the prioritization of resources, improving memory for low-priority items as predicted by the model. Therefore, these results provide direct causal support for models in which the prefrontal cortex controls the allocation of resources that support working memory, rather than simply storing the features of memoranda.<b>Significance statement</b> Although higher-order cognition depends on working memory, the resources that support our memory are severely limited in capacity. To mitigate this limitation, we allocate memory resources according to the behavioral relevance of items. Nonetheless, the neural basis of these abilities remains unclear. Here, we tested the hypothesis that a region in lateral prefrontal cortex controls prioritization in working memory. Indeed, perturbing this region with transcranial magnetic stimulation disrupted the prioritization of working memory resources. Our results provide causal evidence for the hypothesis that prefrontal cortex primarily controls the allocation of memory resources, rather than storing the contents of working memory.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From circuits to lifespan: translating mouse and human timelines with neuroimaging based tractography.","authors":"Nicholas C Cottam, Kwadwo Ofori, Kevin T Stoll, Madison Bryant, Jessica R Rogge, Khan Hekmatyar, Jianli Sun, Christine J Charvet","doi":"10.1523/JNEUROSCI.1429-24.2025","DOIUrl":"10.1523/JNEUROSCI.1429-24.2025","url":null,"abstract":"<p><p>Animal models are commonly used to investigate developmental processes and disease risk, but humans and model systems (e.g., mice) differ substantially in the pace of development and aging. The timeline of human developmental circuits is well known, butit is unclear how such timelines compare to those in mice. We lack age alignments across the lifespan of mice and humans. Here, we build upon our Translating Time resource, which is a tool that equates corresponding ages during development. We collected 1,125 observations from age-related changes in body, bone, dental, and brain processes to equate corresponding ages across humans, mice, and rats to boost power for comparison across humans and mice. We acquired high-resolution diffusion MR scans of mouse brains (n=16) of either sex at sequential stages of postnatal development (postnatal day 3, 4, 12, 21, 60) to track brain circuit maturation (e.g., olfactory association, transcallosal pathways). We found heterogeneity in white matter pathway growth. Corpus callosum growth largely ceases days after birth while the olfactory association pathway grows through P60. We found that a P3-4 mouse equates to a human at roughly GW24, and a P60 mouse equates to a human in teenage years. Therefore, white matter pathway maturation is extended in mice as it is in humans, but there are species-specific adaptations. For example, olfactory-related wiring is protracted in mice, which is linked to their reliance on olfaction. Our findings underscore the importance of translational tools to map common and species-specific biological processes from model systems to humans.<b>Significance statement</b> Mice are essential models of human brain development, but we currently lack precise age alignments across their lifespan. Here, we equate corresponding ages across mice and humans. We utilize high-resolution diffusion mouse brain scans to track the growth of brain white matter pathways, and we use our cross-species age alignments to map the timeline of these growth patterns from mouse to humans. In mice, olfactory association pathway growth continues well into the equivalent of human teenage years. The protracted development of olfactory association pathways in mice aligns with their specialized sense of smell. The generation of translational tools bridges the gap between animal models and human biology while enhancing our understanding of developmental processes generating variation across species.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network mechanisms underlying the regional diversity of variance and time scales of the brain's spontaneous activity fluctuations.","authors":"Adrián Ponce-Alvarez","doi":"10.1523/JNEUROSCI.1699-24.2024","DOIUrl":"https://doi.org/10.1523/JNEUROSCI.1699-24.2024","url":null,"abstract":"<p><p>The brain's activity fluctuations have different temporal scales across the brain regions, with associative regions displaying slower timescales than sensory areas. This so-called hierarchy of timescales has been shown to correlate with both structural brain connectivity and intrinsic regional properties. Here, using publicly available human resting-state fMRI and dMRI data it was found that, while more structurally connected brain regions presented activity fluctuations with longer timescales, their activity fluctuations presented lower variance. The opposite relationships between the structural connectivity and the variance and temporal scales of resting-state fluctuations, respectively, were not trivially explained by simple network propagation principles. To understand these structure-function relationships, two commonly used whole-brain models were studied, namely the Hopf and Wilson-Cowan models. These models use the brain's connectome to coupled local nodes (representing brain regions) displaying noise-driven oscillations. The models show that the variance and temporal scales of activity fluctuations can oppositely relate to connectivity within specific model's parameter regions, even when all nodes have the same intrinsic dynamics -but also when intrinsic dynamics are constrained by the myelinization-related macroscopic gradient. These results show that, setting aside intrinsic regional differences, connectivity and network state are sufficient to explain the regional differences in fluctuations' scales. State-dependence supports the vision that structure-function relationships can serve as biomarkers of altered brain states. Finally, the results indicate that the hierarchies of timescales and variances reflect a balance between stability and responsivity, with greater and faster responsiveness at the network periphery, while the network core ensures overall system robustness.<b>Significance Statement</b> Brain regions exhibit activity fluctuations at different temporal scales, with associative areas displaying slower timescales than sensory areas. This hierarchical organization is shaped by both large-scale connectivity and local properties. The present study demonstrates that the variance of fluctuations is also hierarchically organized but, in contrast to timescales, it decreases as a function of structural connectivity. Whole-brain models show that the hierarchies of timescales and variances jointly emerge within specific parameter regions, indicating a state-dependence that could serve as a biomarker for brain states and disorders. Furthermore, these hierarchies link to the responsivity of different network parts, with greater and faster responsiveness at the network periphery and more stable dynamics at the core, achieving a balance between stability and responsiveness.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parietofrontal Networks Mediate Contextual Influences in the Appraisal of Pain and Disgust Facial Expressions.","authors":"Giada Dirupo, Vincent Di Paolo, Emilie Lettry, Kevin Schwab, Corrado Corradi-Dell'Acqua","doi":"10.1523/JNEUROSCI.2233-23.2024","DOIUrl":"10.1523/JNEUROSCI.2233-23.2024","url":null,"abstract":"<p><p>We appraise other people's emotions by combining multiple sources of information, including somatic facial/body reactions and the surrounding context. Wealthy literature revealed how people take into account contextual information in the interpretation of facial expressions, but the mechanisms mediating such influence still need to be duly investigated. Across two experiments, we mapped the neural representations of distinct (but comparably unpleasant) negative states, pain, and disgust, as conveyed by naturalistic facial expressions or contextual sentences. Negative expressions led to shared activity in the fusiform gyrus and superior temporal sulcus. Instead, pain contexts recruited the supramarginal, postcentral, and insular cortex, whereas disgust contexts triggered the temporoparietal cortex and hippocampus/amygdala. When pairing the two sources of information together, we found a higher likelihood of classifying an expression according to the sentence preceding it. Furthermore, networks specifically involved in processing contexts were re-enacted whenever a face followed said context. Finally, the perigenual medial prefrontal cortex (mPFC) showed increased activity for consistent (vs inconsistent) face-context pairings, suggesting that it integrates state-specific information from the two sources. Overall, our study reveals the heterogeneous nature of face-context information integration, which operates both according to a state-general and state-specific principle, with the latter mediated by the perigenual medial prefrontal cortex.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}