Distinct Cortical Populations Drive Multisensory Modulation of Segregated Auditory Sources.

IF 4 2区 医学 Q1 NEUROSCIENCES
Huaizhen Cai, Harry Shirley, Monty A Escabí, Yale E Cohen
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Abstract

Auditory perception can be modulated by other sensory stimuli. However, we do not fully understand the neural mechanisms that support multisensory behavior. Here, while male nonhuman primates detected a target vocalization that was embedded in a background chorus of vocalizations, we recorded spiking activity from the primary auditory cortex (A1). We found that a congruent video of a monkey eliciting the target vocalization improved the monkeys' behavior, relative to their performance when we only presented a static image of the monkey. As a proxy for the functional organization of A1, we compared the contribution of neurons with significant spectrotemporal response fields (STRFs) with those that had nonsignificant STRFs (nSTRFs). Because, on average, STRF and nSTRF neurons have different spike waveform shapes, firing rates, and neural-correlation structure, we hypothesized that they might belong to different neural populations. Consistent with this, we found that, although STRF neurons encode stimulus information through synchronized activity, task-related information in the primate A1 is encoded more as a structured dynamic process in the population of nSTRF neurons. Together, these findings suggest that modulatory multisensory behavior is supported by nSTRF neurons and identifies, for the first time, a functional differentiation between the role that STRF and nSTRF neurons contribute to behavior.

不同的皮质种群驱动分离的听觉来源的多感觉调节。
听觉可以被其他感官刺激调节。然而,我们并不完全了解支持多感觉行为的神经机制。在这里,当雄性非人类灵长类动物检测到嵌入在背景合唱中的目标发声时,我们记录了初级听觉皮层(A1)的尖峰活动。我们发现,相对于我们只呈现猴子的静态图像,一个连贯的猴子发出目标声音的视频改善了猴子的行为。作为A1功能组织的代表,我们比较了具有显著光谱响应场(strf)和不具有显著光谱响应场(nstrf)的神经元的贡献。因为,平均而言,STRF和nSTRF神经元具有不同的峰值波形形状、放电速率和神经相关结构,我们假设它们可能属于不同的神经种群。与此一致的是,我们发现,尽管STRF神经元通过同步活动编码刺激信息,但灵长类动物A1的任务相关信息在nSTRF神经元群体中更多地作为结构化的动态过程编码。总之,这些发现表明,调节性多感觉行为是由nSTRF神经元支持的,并首次确定了STRF和nSTRF神经元对行为的作用之间的功能差异。我们的研究结果表明,具有线性听觉反应场的神经元和不具有线性听觉反应场的神经元代表了灵长类动物初级听觉皮层(A1)中不同的神经元群体。这两个神经群对多感觉行为的贡献是不同的,这在A1群中表现为一个结构化的动态过程。更一般地说,这是第一个发现神经元对任何类型的行为有线性听觉反应场和没有线性听觉反应场的差异贡献的报告。
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来源期刊
Journal of Neuroscience
Journal of Neuroscience 医学-神经科学
CiteScore
9.30
自引率
3.80%
发文量
1164
审稿时长
12 months
期刊介绍: JNeurosci (ISSN 0270-6474) is an official journal of the Society for Neuroscience. It is published weekly by the Society, fifty weeks a year, one volume a year. JNeurosci publishes papers on a broad range of topics of general interest to those working on the nervous system. Authors now have an Open Choice option for their published articles
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