听觉、触觉和视觉的联合功能磁共振成像揭示了人类额叶皮层的感觉偏倚和超模态工作记忆区域。

IF 4 2区 医学 Q1 NEUROSCIENCES
Sean M Tobyne, James A Brissenden, Abigail L Noyce, David C Somers
{"title":"听觉、触觉和视觉的联合功能磁共振成像揭示了人类额叶皮层的感觉偏倚和超模态工作记忆区域。","authors":"Sean M Tobyne, James A Brissenden, Abigail L Noyce, David C Somers","doi":"10.1523/JNEUROSCI.0773-25.2025","DOIUrl":null,"url":null,"abstract":"<p><p>Selectivity for sensory modality characterizes distinct subregions of the human brain, well beyond the primary sensory cortices. We previously identified frontal and posterior cortical regions that are preferentially recruited for visual versus auditory attention and working memory (WM). Here, we extend our approach to include tactile cognition and to characterize cortical regions recruited by WM in each of three sensory modalities. The joint organization of visual-selective, auditory-selective, tactile-selective, and supramodal WM recruitment within individual subjects has not been fully investigated previously. Male and female human subjects participated in a blocked fMRI task requiring them to perform <i>N-</i>back WM judgments in auditory, visual, or tactile (haptic) modalities. We confirmed our prior reports of multiple visual-biased and auditory-biased frontal lobe regions. We also observed several bilateral tactile-selective regions abutting previously described visual- and auditory-selective regions, including the dorsal and ventral precentral sulcus, the postcentral sulcus, and the anterior intraparietal sulcus. Several cortical regions were recruited by WM in all three sensory modalities in individual subjects, including the precentral sulcus, inferior frontal sulcus, intraparietal sulcus, anterior insula, and presupplementary motor area. Supramodal regions exhibited substantial overlap with visual-biased regions in the frontal and parietal cortex and comparatively little overlap with tactile- or auditory-biased regions. Lastly, resting-state analyses revealed that auditory-, visual-, and tactile-selective WM regions segregate into modality-specific networks that span the frontal and posterior cortex. Together, these results shed light on the functional organization of sensory-selective and supramodal regions supporting higher-order cognition.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.0000,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444861/pdf/","citationCount":"0","resultStr":"{\"title\":\"Combined Auditory, Tactile, and Visual FMRI Reveals Sensory-Biased and Supramodal Working Memory Regions in the Human Frontal Cortex.\",\"authors\":\"Sean M Tobyne, James A Brissenden, Abigail L Noyce, David C Somers\",\"doi\":\"10.1523/JNEUROSCI.0773-25.2025\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Selectivity for sensory modality characterizes distinct subregions of the human brain, well beyond the primary sensory cortices. We previously identified frontal and posterior cortical regions that are preferentially recruited for visual versus auditory attention and working memory (WM). Here, we extend our approach to include tactile cognition and to characterize cortical regions recruited by WM in each of three sensory modalities. The joint organization of visual-selective, auditory-selective, tactile-selective, and supramodal WM recruitment within individual subjects has not been fully investigated previously. Male and female human subjects participated in a blocked fMRI task requiring them to perform <i>N-</i>back WM judgments in auditory, visual, or tactile (haptic) modalities. We confirmed our prior reports of multiple visual-biased and auditory-biased frontal lobe regions. We also observed several bilateral tactile-selective regions abutting previously described visual- and auditory-selective regions, including the dorsal and ventral precentral sulcus, the postcentral sulcus, and the anterior intraparietal sulcus. Several cortical regions were recruited by WM in all three sensory modalities in individual subjects, including the precentral sulcus, inferior frontal sulcus, intraparietal sulcus, anterior insula, and presupplementary motor area. Supramodal regions exhibited substantial overlap with visual-biased regions in the frontal and parietal cortex and comparatively little overlap with tactile- or auditory-biased regions. Lastly, resting-state analyses revealed that auditory-, visual-, and tactile-selective WM regions segregate into modality-specific networks that span the frontal and posterior cortex. Together, these results shed light on the functional organization of sensory-selective and supramodal regions supporting higher-order cognition.</p>\",\"PeriodicalId\":50114,\"journal\":{\"name\":\"Journal of Neuroscience\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-09-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444861/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1523/JNEUROSCI.0773-25.2025\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1523/JNEUROSCI.0773-25.2025","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

对感觉模式的选择性是人类大脑不同亚区域的特征,远远超出了初级感觉皮层。我们之前已经确定了前额和后皮层区域优先用于视觉和听觉注意和工作记忆(WM)。在这里,我们将我们的方法扩展到包括触觉认知,并表征WM在三种感觉模式中招募的皮层区域。在个体受试者中,视觉选择性、听觉选择性、触觉选择性和超模态WM招募的联合组织尚未得到充分的研究。男性和女性受试者参与了一项阻塞的fMRI任务,要求他们以听觉、视觉或触觉(触觉)的方式执行N-back WM判断。我们证实了我们先前的报告,即多个视觉和听觉偏倚的额叶区域。我们还观察到几个双侧触觉选择区域毗邻先前描述的视觉和听觉选择区域,包括中央前沟、中央后沟和顶骨前沟。在个体受试者的所有三种感觉模式中,WM招募了几个皮质区域,包括中央前沟、额下沟、顶内沟、前岛和前辅助运动区。在额叶和顶叶皮层中,模态上区与视觉偏倚区有大量重叠,而与触觉或听觉偏倚区重叠较少。最后,静息状态分析显示,听觉、视觉和触觉选择性WM区域分离成跨越额叶和后叶皮层的模式特异性网络。总之,这些结果揭示了支持高阶认知的感觉选择和超模态区域的功能组织。通过对三种不同感觉模态的被试fMRI分析,我们确定了人类额叶皮层中感觉偏倚和超模态工作记忆结构的精细结构。确定了16个双侧额叶区域:5个听觉偏倚,4个视觉偏倚,2个触觉偏倚和5个多需求/超模态区域。除了视觉偏倚区域与超模态区域部分重叠外,这些区域在很大程度上是不同的,这表明视觉和超模态工作记忆表征之间存在紧密联系。感觉偏置额叶区域与传统识别的后感觉皮质区域形成模式特异性网络。研究结果表明,感觉模式在额叶皮层的功能组织中起着普遍的作用,并提供了支持工作记忆的人类额叶区域的精细分割。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Combined Auditory, Tactile, and Visual FMRI Reveals Sensory-Biased and Supramodal Working Memory Regions in the Human Frontal Cortex.

Selectivity for sensory modality characterizes distinct subregions of the human brain, well beyond the primary sensory cortices. We previously identified frontal and posterior cortical regions that are preferentially recruited for visual versus auditory attention and working memory (WM). Here, we extend our approach to include tactile cognition and to characterize cortical regions recruited by WM in each of three sensory modalities. The joint organization of visual-selective, auditory-selective, tactile-selective, and supramodal WM recruitment within individual subjects has not been fully investigated previously. Male and female human subjects participated in a blocked fMRI task requiring them to perform N-back WM judgments in auditory, visual, or tactile (haptic) modalities. We confirmed our prior reports of multiple visual-biased and auditory-biased frontal lobe regions. We also observed several bilateral tactile-selective regions abutting previously described visual- and auditory-selective regions, including the dorsal and ventral precentral sulcus, the postcentral sulcus, and the anterior intraparietal sulcus. Several cortical regions were recruited by WM in all three sensory modalities in individual subjects, including the precentral sulcus, inferior frontal sulcus, intraparietal sulcus, anterior insula, and presupplementary motor area. Supramodal regions exhibited substantial overlap with visual-biased regions in the frontal and parietal cortex and comparatively little overlap with tactile- or auditory-biased regions. Lastly, resting-state analyses revealed that auditory-, visual-, and tactile-selective WM regions segregate into modality-specific networks that span the frontal and posterior cortex. Together, these results shed light on the functional organization of sensory-selective and supramodal regions supporting higher-order cognition.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Neuroscience
Journal of Neuroscience 医学-神经科学
CiteScore
9.30
自引率
3.80%
发文量
1164
审稿时长
12 months
期刊介绍: JNeurosci (ISSN 0270-6474) is an official journal of the Society for Neuroscience. It is published weekly by the Society, fifty weeks a year, one volume a year. JNeurosci publishes papers on a broad range of topics of general interest to those working on the nervous system. Authors now have an Open Choice option for their published articles
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信