Sean M Tobyne, James A Brissenden, Abigail L Noyce, David C Somers
{"title":"听觉、触觉和视觉的联合功能磁共振成像揭示了人类额叶皮层的感觉偏倚和超模态工作记忆区域。","authors":"Sean M Tobyne, James A Brissenden, Abigail L Noyce, David C Somers","doi":"10.1523/JNEUROSCI.0773-25.2025","DOIUrl":null,"url":null,"abstract":"<p><p>Selectivity for sensory modality characterizes distinct subregions of the human brain, well beyond the primary sensory cortices. We previously identified frontal and posterior cortical regions that are preferentially recruited for visual versus auditory attention and working memory (WM). Here, we extend our approach to include tactile cognition and to characterize cortical regions recruited by WM in each of three sensory modalities. The joint organization of visual-selective, auditory-selective, tactile-selective, and supramodal WM recruitment within individual subjects has not been fully investigated previously. Male and female human subjects participated in a blocked fMRI task requiring them to perform <i>N-</i>back WM judgments in auditory, visual, or tactile (haptic) modalities. We confirmed our prior reports of multiple visual-biased and auditory-biased frontal lobe regions. We also observed several bilateral tactile-selective regions abutting previously described visual- and auditory-selective regions, including the dorsal and ventral precentral sulcus, the postcentral sulcus, and the anterior intraparietal sulcus. Several cortical regions were recruited by WM in all three sensory modalities in individual subjects, including the precentral sulcus, inferior frontal sulcus, intraparietal sulcus, anterior insula, and presupplementary motor area. Supramodal regions exhibited substantial overlap with visual-biased regions in the frontal and parietal cortex and comparatively little overlap with tactile- or auditory-biased regions. Lastly, resting-state analyses revealed that auditory-, visual-, and tactile-selective WM regions segregate into modality-specific networks that span the frontal and posterior cortex. Together, these results shed light on the functional organization of sensory-selective and supramodal regions supporting higher-order cognition.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.0000,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444861/pdf/","citationCount":"0","resultStr":"{\"title\":\"Combined Auditory, Tactile, and Visual FMRI Reveals Sensory-Biased and Supramodal Working Memory Regions in the Human Frontal Cortex.\",\"authors\":\"Sean M Tobyne, James A Brissenden, Abigail L Noyce, David C Somers\",\"doi\":\"10.1523/JNEUROSCI.0773-25.2025\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Selectivity for sensory modality characterizes distinct subregions of the human brain, well beyond the primary sensory cortices. We previously identified frontal and posterior cortical regions that are preferentially recruited for visual versus auditory attention and working memory (WM). Here, we extend our approach to include tactile cognition and to characterize cortical regions recruited by WM in each of three sensory modalities. The joint organization of visual-selective, auditory-selective, tactile-selective, and supramodal WM recruitment within individual subjects has not been fully investigated previously. Male and female human subjects participated in a blocked fMRI task requiring them to perform <i>N-</i>back WM judgments in auditory, visual, or tactile (haptic) modalities. We confirmed our prior reports of multiple visual-biased and auditory-biased frontal lobe regions. We also observed several bilateral tactile-selective regions abutting previously described visual- and auditory-selective regions, including the dorsal and ventral precentral sulcus, the postcentral sulcus, and the anterior intraparietal sulcus. Several cortical regions were recruited by WM in all three sensory modalities in individual subjects, including the precentral sulcus, inferior frontal sulcus, intraparietal sulcus, anterior insula, and presupplementary motor area. Supramodal regions exhibited substantial overlap with visual-biased regions in the frontal and parietal cortex and comparatively little overlap with tactile- or auditory-biased regions. Lastly, resting-state analyses revealed that auditory-, visual-, and tactile-selective WM regions segregate into modality-specific networks that span the frontal and posterior cortex. Together, these results shed light on the functional organization of sensory-selective and supramodal regions supporting higher-order cognition.</p>\",\"PeriodicalId\":50114,\"journal\":{\"name\":\"Journal of Neuroscience\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-09-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444861/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1523/JNEUROSCI.0773-25.2025\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1523/JNEUROSCI.0773-25.2025","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Combined Auditory, Tactile, and Visual FMRI Reveals Sensory-Biased and Supramodal Working Memory Regions in the Human Frontal Cortex.
Selectivity for sensory modality characterizes distinct subregions of the human brain, well beyond the primary sensory cortices. We previously identified frontal and posterior cortical regions that are preferentially recruited for visual versus auditory attention and working memory (WM). Here, we extend our approach to include tactile cognition and to characterize cortical regions recruited by WM in each of three sensory modalities. The joint organization of visual-selective, auditory-selective, tactile-selective, and supramodal WM recruitment within individual subjects has not been fully investigated previously. Male and female human subjects participated in a blocked fMRI task requiring them to perform N-back WM judgments in auditory, visual, or tactile (haptic) modalities. We confirmed our prior reports of multiple visual-biased and auditory-biased frontal lobe regions. We also observed several bilateral tactile-selective regions abutting previously described visual- and auditory-selective regions, including the dorsal and ventral precentral sulcus, the postcentral sulcus, and the anterior intraparietal sulcus. Several cortical regions were recruited by WM in all three sensory modalities in individual subjects, including the precentral sulcus, inferior frontal sulcus, intraparietal sulcus, anterior insula, and presupplementary motor area. Supramodal regions exhibited substantial overlap with visual-biased regions in the frontal and parietal cortex and comparatively little overlap with tactile- or auditory-biased regions. Lastly, resting-state analyses revealed that auditory-, visual-, and tactile-selective WM regions segregate into modality-specific networks that span the frontal and posterior cortex. Together, these results shed light on the functional organization of sensory-selective and supramodal regions supporting higher-order cognition.
期刊介绍:
JNeurosci (ISSN 0270-6474) is an official journal of the Society for Neuroscience. It is published weekly by the Society, fifty weeks a year, one volume a year. JNeurosci publishes papers on a broad range of topics of general interest to those working on the nervous system. Authors now have an Open Choice option for their published articles