The Journal of Infectious Diseases最新文献_第5页

Population-based estimates of hepatitis E virus associated mortality in Bangladesh

The Journal of Infectious Diseases Pub Date : 2025-03-12 DOI: 10.1093/infdis/jiaf134

Repon C Paul, Heather F Gidding, Arifa Nazneen, Kajal C Banik, Shariful Amin Sumon, Kishor K Paul, Arifa Akram, M Salim Uzzaman, Alexandra Tejada-Strop, Saleem Kamili, Stephen P Luby, Andrew Hayen, Emily S Gurley

{"title":"Population-based estimates of hepatitis E virus associated mortality in Bangladesh","authors":"Repon C Paul, Heather F Gidding, Arifa Nazneen, Kajal C Banik, Shariful Amin Sumon, Kishor K Paul, Arifa Akram, M Salim Uzzaman, Alexandra Tejada-Strop, Saleem Kamili, Stephen P Luby, Andrew Hayen, Emily S Gurley","doi":"10.1093/infdis/jiaf134","DOIUrl":"https://doi.org/10.1093/infdis/jiaf134","url":null,"abstract":"Background Hepatitis E virus (HEV) is endemic in many resource-poor countries. Despite an available vaccine, data on HEV-associated mortality are scarce, hindering informed decisions. This study aims to estimate the population-based rate of HEV-specific mortality in Bangladesh. Methods During December 2014-September 2017, we conducted surveillance in six tertiary hospitals in Bangladesh. Patients aged ≥14 years with acute jaundice were recruited, tested for IgM anti-HEV, and followed up post-discharge. A mortality survey in the hospital catchment areas identified deaths associated with acute jaundice, including maternal, stillbirths and neonatal deaths delivered by a mother with acute jaundice during pregnancy, confirmed by two independent physicians reviewing verbal autopsy data. Results Out of 1,925 patients with acute jaundice identified and enrolled in the surveillance hospitals, 302 died, with 28 (9%) testing positive for IgM anti-HEV. In the hospital catchment areas, the team identified 587 jaundice-associated deaths, including 25 maternal deaths. Combining hospital-based surveillance and mortality survey data, the study estimated 986 (95% CI: 599-1338) HEV-associated deaths annually among individuals aged ≥14 years in Bangladesh, including 163 (95% CI: 57-395) maternal deaths. Additionally, 279 (95% CI: 101-664) stillbirths and 780 (95% CI: 365-1,297) neonatal deaths were attributed to HEV infection annually. Conclusions Prior Global Burden of Disease studies presented wildly varying modeling estimates of HEV-associated annual deaths, ranging from 50,000 in 2013 to 1,932 in 2019. This study is the first to directly measure population-based estimates of mortality in Bangladesh, which can be used to determine the cost-effectiveness of hepatitis E vaccination and other interventions.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic epidemiology of resurgent hepatitis A in Florida, 2018–2022 2018-2022 年佛罗里达州甲型肝炎复发的基因组流行病学

The Journal of Infectious Diseases Pub Date : 2025-03-11 DOI: 10.1093/infdis/jiaf127

Timothy J Doyle, Brian H Buck, Timothy J Locksmith, Brenna M McGruder-Rawson, Yury Khudyakov, Carina Blackmore

引用次数: 0

Epidemiology of invasive Haemophilus influenzae type A disease in Alaska, 2018–2022

The Journal of Infectious Diseases Pub Date : 2025-03-11 DOI: 10.1093/infdis/jiaf132

Tori L Burket, Heather M Scobie, Carolynn DeByle, Sara Bressler, Ian Blake, Laurie Orell, Stephanie Massay, Dana Bruden, Benjamin P Westley, Joseph B McLaughlin, Marc Fischer

引用次数: 0

The effect of COVID-19 vaccination on the risk of persistent post COVID-19 condition: Cohort study 接种 COVID-19 疫苗对 COVID-19 后遗症风险的影响：队列研究

The Journal of Infectious Diseases Pub Date : 2025-03-10 DOI: 10.1093/infdis/jiaf133

Pontus Hedberg, Suzanne Desirée van der Werff, Pontus Nauclér

引用次数: 0

Sex differences in risk factors for incident sepsis hospitalisations: a prospective cohort study using the UK Biobank

The Journal of Infectious Diseases Pub Date : 2025-03-06 DOI: 10.1093/infdis/jiaf122

Gary K K Low, Katie Harris, Mark Woodward, Kelly J Thompson

{"title":"Sex differences in risk factors for incident sepsis hospitalisations: a prospective cohort study using the UK Biobank","authors":"Gary K K Low, Katie Harris, Mark Woodward, Kelly J Thompson","doi":"10.1093/infdis/jiaf122","DOIUrl":"https://doi.org/10.1093/infdis/jiaf122","url":null,"abstract":"Background Sepsis is a leading cause of death worldwide. The presence of most chronic conditions and other lifestyle-related risk factors increase sepsis risk. Whether there are sex differences in risk factors associated with sepsis hospitalisation is unknown. Methods A prospective cohort study of participants aged 40-69 years recruited to the UK Biobank between 2006-2010. Sepsis was identified from hospitalisation records. Poisson regression was used to estimate sex-specific incidence. Cox proportional hazards models were used to estimate hazard ratios (HRs) and women-to-men ratio of HRs (RHR) with 95% confidence intervals (CIs) for risk factors associated with an incident sepsis hospitalisation. Findings Of 490,783 participants, 21,468 (47·6% women) experienced an incident sepsis hospitalisation. Age-standardised risk was higher in men compared to women (40.2 vs 31.2 per 10,000 person-years; HR 1.26, 95% CI 1.23-1.29). COPD conferred the highest risk for sepsis hospitalisation, with excess risk in women (RHR 1.23, 95% CI 1.10-1.38). Dyslipidaemia (RHR 1.08, 95% CI 1.02-1.16), myocardial infarction (RHR 1.22 95% CI 1.05-1.41) and smoking (RHR 1.19 95% CI 1.09-1.29) were associated with excess risk of sepsis hospitalisation in women, compared to men. Dementia was associated with more than twice the risk of sepsis hospitalisation in men: HR 2·21 (95% CI: 1·37-3·55). Conclusions The risk of sepsis hospitalisation was higher in the presence of most risk factors, with greater effects in women with a history of COPD, dyslipidaemia, myocardial infarction and smoking. Incorporating sex-specific risk factors in risk prediction modelling may facilitate targeted prevention efforts and support earlier recognition and treatment.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143570447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid, High Sensitivity Detection of Antibodies to Trypanosoma cruzi using a Recombinant Tc24 Antigen-based Magneto-Immunoassay: A Pilot Study

The Journal of Infectious Diseases Pub Date : 2025-03-06 DOI: 10.1093/infdis/jiaf123

Kavya L Singampalli, Bin Zhan, Rojelio Mejia, Peter B Lillehoj

引用次数: 0

Chemical targeting of prolyl-tRNA synthetase stalls ovarian development and kills malaria vectors

The Journal of Infectious Diseases Pub Date : 2025-03-06 DOI: 10.1093/infdis/jiaf095

Ritu Goswami, Yogavel Manickam, Jyoti Chhibber Goel, Swati Gupta, Shrinivasa B M, Amit Sharma

{"title":"Chemical targeting of prolyl-tRNA synthetase stalls ovarian development and kills malaria vectors","authors":"Ritu Goswami, Yogavel Manickam, Jyoti Chhibber Goel, Swati Gupta, Shrinivasa B M, Amit Sharma","doi":"10.1093/infdis/jiaf095","DOIUrl":"https://doi.org/10.1093/infdis/jiaf095","url":null,"abstract":"Objective Along with rising resistance to antimalarials, the emergence of insecticide resistance in Anopheles mosquito species also remains a serious concern. Here, we reveal two potent compounds that show larvicidal and endectocidal activity against malaria vectors, Anopheles culicifacies and Anopheles stephensi, respectively. Methods We investigated larvicidal activity of two inhibitors against III-instar larvae of Anopheles culicifacies. The survival and fertility of adult female Anopheles stephensi mosquitoes were assessed. Additionally, we purified recombinant prolyl-tRNA synthetase of Anopheles culicifacies and performed enzyme-based assays and structural analysis with the two inhibitors. Results Our study reveals that the Anopheles culicifacies prolyl-tRNA synthetase (AcProRS) is potently inhibited by halofuginone (HFG) and an ATP mimetic (L95). The evaluation of larvicidal activity of HFG against Anopheles culicifacies III-instar larvae showed a dose-dependent increase in mortality. In adult female Anopheles stephensi mosquitoes, ingestion of HFG via artificial blood feeding resulted in impaired ovary development, reduced egg laying, and decreased overall survival. The potent enzymatic inhibition of AcProRS thus drives the killing of larvae. The co-crystal structure of AcProRS with inhibitors provides a structural basis for improving their potency as future larvicides. Conclusion Our data suggest the potential for repositioning halofuginone (HFG) and pyrrolidine-based ATP-mimetics (L95) as larvicides. Targeting the vector-encoded aminoacyl-tRNA synthetases provides a new focus for developing effective agents that can control multiple mosquitoe-borne infectious diseases like malaria and dengue.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143570446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compromised Intestinal Barrier Resilience to Disruption in People with HIV

The Journal of Infectious Diseases Pub Date : 2025-03-06 DOI: 10.1093/infdis/jiaf119

Maliha W Shaikh, Shalini Singh, Leila B Giron, Lijuan Zhang, Shivanjali Shankaran, Phillip A Engen, Michelle Villanueva, Ashish Arunkumar Sharma, Rafick-Pierre Sekaly, Alan Landay, Ali Keshavarzian, Mohamed Abdel-Mohsen

引用次数: 0

Persistence of vaccine serotype carriage and differences in pneumococcal carriage by lab method and sample type in Indigenous individuals in the Southwest USA

The Journal of Infectious Diseases Pub Date : 2025-03-04 DOI: 10.1093/infdis/jiaf091

Lindsay R Grant, Catherine G Sutcliffe, Shea Littlepage, Ronika Alexander-Parrish, Ladonna Becenti, Raul E Isturiz, Michael R Jacobs, Katherine L O’Brien, Dennie Parker Riley, Mathuram Santosham, Carol Tso, Jorge E Vidal, Robert C Weatherholtz, Laura L Hammitt

{"title":"Persistence of vaccine serotype carriage and differences in pneumococcal carriage by lab method and sample type in Indigenous individuals in the Southwest USA","authors":"Lindsay R Grant, Catherine G Sutcliffe, Shea Littlepage, Ronika Alexander-Parrish, Ladonna Becenti, Raul E Isturiz, Michael R Jacobs, Katherine L O’Brien, Dennie Parker Riley, Mathuram Santosham, Carol Tso, Jorge E Vidal, Robert C Weatherholtz, Laura L Hammitt","doi":"10.1093/infdis/jiaf091","DOIUrl":"https://doi.org/10.1093/infdis/jiaf091","url":null,"abstract":"Background In the United States, the invasive pneumococcal disease incidence in Indigenous populations is higher than in the general population. Molecular detection and/or specimen sampling from multiple body sites could enhance our understanding of pneumococcal carriage, a prerequisite for disease. Methods Persons &lt;5 and ≥18 years of age from the Navajo Nation and White Mountain Apache Tribal lands were enrolled in an observational carriage study from October 2015 through September 2017. Swabs from the nasopharynx (all participants) and oropharynx (adults only) were collected and tested by enriched culture or molecular methods (lytA and piaB PCR). Cultured Streptococcus pneumoniae were serotyped by sequencing. PCR-positive samples were serotyped by PCV13-type PCR and TaqMan Array Card (TAC PCR). Results 1503 participants enrolled (&lt;5 years: n=600; ≥18 years: n=903). Among children, pneumococcal positivity was similar by culture (49.5%) and PCR (50.8%); PCV13-type carriage was 8.0% by any method. Among adults, oropharyngeal swab positivity by PCR was 18.5%, an increase compared to cultured oropharyngeal swabs (0.6%) and to nasopharyngeal swabs by culture (7.9%) or PCR 5.3%); PCV13-type carriage by any sample or method was 8.0%. Discussion PCV13-type carriage persists in Indigenous populations. Use of molecular methods and oropharyngeal swabs for adults increased carriage prevalence estimates.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seroepidemiological Reconstruction of Long-term Rift Valley Fever Virus Circulation in Nouakchott, Mauritania

The Journal of Infectious Diseases Pub Date : 2025-03-04 DOI: 10.1093/infdis/jiaf108

Meïli Baragatti, Bedia Abdoullah, Nicolas Gomez, Nazli Ayhan, Rémi Charrel, Leonardo K Basco, Ali Ould Mohamed Salem Boukhary, Sébastien Briolant

{"title":"Seroepidemiological Reconstruction of Long-term Rift Valley Fever Virus Circulation in Nouakchott, Mauritania","authors":"Meïli Baragatti, Bedia Abdoullah, Nicolas Gomez, Nazli Ayhan, Rémi Charrel, Leonardo K Basco, Ali Ould Mohamed Salem Boukhary, Sébastien Briolant","doi":"10.1093/infdis/jiaf108","DOIUrl":"https://doi.org/10.1093/infdis/jiaf108","url":null,"abstract":"Background Although Rift valley fever (RVF) is endemic in Mauritania, with eight epidemics documented since 1987, infections among human populations, particularly in Nouakchott, the capital city of Mauritania, remain limited. The objectives of the present study were to assess the seroprevalence of RVF in humans and reconstruct the epidemiological history of RVF virus (RVFV) circulation within the city. Methods Using data from a cross-sectional and descriptive serological study among asymptomatic subjects conducted in Nouakchott in 2021, a mathematical model was developed to trace the seroepidemiological evolution of RVFV between 1927 and 2020 in the capital city. Results A total of 1,319 participants were included, of whom 12.0% (158/1319) were positive for anti-RVFV IgG. Sex, age group, district of residence, use of mosquito nets or repellents at night were not statistically associated (p &gt; 0.05) with anti-RVFV IgG positivity. Using the Hamiltonian Monte Carlo algorithm, posterior estimates of annual infection rates and probabilities of annual outbreak were calculated. The model suggested the absence of RVFV circulation before 1960, and the estimated outbreaks were concentrated between 1960 and 1972 and between 2017 and 2020. Discussion The present study provides the first overview of the evolution of RVF epidemiology in Nouakchott and the serological evidence that RVFV has been circulating in human populations in Nouakchott for a longer period of time than previously thought. Therefore, close surveillance in animals, humans, and mosquito vectors is necessary to detect the presence of RVFV and interrupt any future epidemics in the country.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0